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A Revolutionary Approach to Clear Heavy Metals & ToxinsAll
of us are carrying around a LIFETIME of accumulated TOXINS!!!There
is now a simple, scientific and very effective means for
substantially reducing your risk of Toxic Induced Chronic
Degenerative Diseases!!!
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Abnormal pregnancy outcomes Atherosclerosis Broad mood swings
Cancer Chronic fatigue syndrome Chronic immune system depression
Contact dermatitis Fatigue Fertility problems Fibromyalgia
Headaches History of increasing sensitivity to exogenous exposures,
odors,or medications Joint pain Kidney dysfunction Learning
disorders Memory loss Mineral imbalances (particularly zinc and
calcium) Multiple chemical sensitivities Muscle pain and weakness
Nonresponsive or recurrent yeast infections Panic attacks
Parkinson's disease Tinnitus Unusual responses to medications or
supplementsWorsening of symptoms after anesthesia or pregnancyA
growing body of literature suggests an association betweentoxicant
exposure and the etiology of a number of chronicConditions. The
Role of Detoxification in the Prevention of Chronic Degenerative
Diseases BY DEANN J. LISKA, PH.D.of Chronic Degenerative DiseasesBY
DEANN J. LISKA, PH.D.
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TOXIC EFFECTS OF GENETICALLY MODIFIED ORGANISMSGMO OR GM
FOOD
We are confronted with what is undoubtedly the single most
potent technology the world has ever known - more powerful even
than atomic energy. Yet it is being released throughout our
environment and deployed with superficial or no risk assessments -
as if no one needs to worry an iota about its unparalleled powers
to harm life as we know it - and for all future generations. Nathan
Batalion, ND www.rawwisdom.com/genetically%20modified%20food
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statins are nothing more than isolated poisons derived from the
fungus known as red yeast rice Nowhere in theHistory of man has
anacknowledged poisonbeen touted as a dailyvitamin for every
manwoman and child.
Reuter Health News Wednesday,May 23, 2007
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Non- GMP certified supplements can be toxic!!!Of the 21 brands
of multivitamins on the market in the US and Canada, selected by
ConsumerLab.com and tested by by independent laboratories, just 10
met the stated claims on their labels or satisfied other quality
standards. In the report, test showed that the Vitamin Shoope
womens product conatined 15.3 micrograms of lead per daily serving
of two daily tablets. This amount of lead is more than 10 times the
amount permitted wothout a warning in California.
www.msnbc.msn.com/id/16655168/below
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WebMD with AOL HealthIn a study of newborn blood released by the
Environmental Working group, an average of 200 industrial chemicals
and pollutants were found in umbilical cord...Eighteen different
forms of dioxin were also found in the
sampleswww.my.webmd.com/content/article/10/8/109035.htm
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Scientist have found TOXIC compounds planet wide, in polar bears
in the Artic, cormorants in England and killer whales in the
Pacific.
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Dangers of Visceral Adipose Tissue Belly FatFat is a major
source of silent inflammation. It is a toxic waste dump full of
Arachidonic Acid and Toxins. Barry Sears, Ph.D.
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Research published in the International Journal of Obesity
indicates that liver toxicity can often lead to excess body fat
accumulation, and moderately obese people frequently suffer from
liver dysfunctionDue to theoverwhelming evidencelinking excess body
fat to an overstressed livercleansing and supporting yourliver may
be yourticket to a healthiermetabolism.Brad J. King, MS, MFS, is a
nutritional researcher and author
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Continuous exposure to dietary and environmental toxins may lead
to an impairment in the ability of patients to metabolize and clear
damage causing compounds from their bodyToxins from the environment
and diet usually can lead bodily stress and dis-ease
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Exposure to heavy metal toxicants is almost unavoidable in
todays world
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Elevated toxic burden is related to a number of different
chronic conditions There were striking dose-response relations
between serum concentrations of six selected POPs (persistent
organic pollutants) and the prevalence of type 2 diabetes. The
strong association could offer a compelling challenge to future
toxicological studies.
Diabetes Care 2006; 29: 1638-43.
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PCB production was banned in the 1970s due to the high toxicity
of most PCB congeners and mixtures. PCBs are classified as
persistent organic pollutants which bioaccumulate in animals.Many
POPs are currently or were in the past used as pesticides. Others
are used in industrial processes and in the production of a range
of goods such as solvents, polyvinyl chloride, and
pharmaceuticals.[1]
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Elevated toxic metal burden affects all organ systems Toxicity,
Heavy MetalsSoghoian S, MD, et alDepartment of Emergency Medicine,
State University of New York Downstate Medical Center
Background: Heavy metal toxicity represents an uncommon, yet
clinically significant, medical condition. If unrecognized or
inappropriately treated, heavy metal toxicity can result in
significant morbidity and mortality. The periodic table contains
105 elements, of which 80 are considered metals. Toxic effects in
humans have been described for less than 30 of these. Many metals
are essential to biochemical processes, and others have found
therapeutic uses in medicine. Iatrogenic metal toxicity may occur
with bismuth, gold, gallium, lithium, and aluminum species.
Intentional or unintentional ingestion of arsenic has been
notorious as a means of suicide and homicide. However, occupational
exposure to heavy metals has accounted for the vast majority of
poisonings throughout human history. Hippocrates described
abdominal colic in a man who extracted metals, and the pernicious
effects of arsenic and mercury among smelters were known even to
Theophrastus of Erebus (370-287 BC). The classic acute occupational
heavy metal toxicity is metal fume fever (MFF), a self-limiting
inhalation syndrome seen in workers exposed to metal oxide fumes.
MFF, or brass founders ague, zinc shakes, Monday morning fever as
it is variously known, is characterized by fever, headache,
fatigue, dyspnea, cough, and a metallic taste occurring within 3-10
hours after exposure. The usual culprit is zinc oxide, but MFF may
occur with magnesium, cobalt, and copper oxide fumes as well. A
neutrophil alveolitis ensues, with hypoxia, reduced vital capacity,
and diffuse bilateral infiltrates seen on radiographs. The
pathophysiology of MFF appears to be a direct toxic irritation.
Treatment is supportive and effects generally resolve within 24
hours. The diagnosis of MFF is based on a history of exposure and
must be clearly differentiated from the true chemical pneumonitis
that occurs after exposure to metal fumes from cadmium, manganese,
mercury, and nickel. These exposures are clinically
indistinguishable from MFF in the early stages but tend to progress
to ARDS and cause significantly more morbidity and mortality. Toxic
effects from chronic exposure to heavy metals are far more common
than acute poisonings. Chronic exposure may lead to a variety of
conditions depending on the route of exposure and the metabolism
and storage of the specific element in question. For example,
chronic exposure to cobalt dust has been associated with the
development of pulmonary fibrosis that can lead to cor pulmonale.
This hard metal pneumoconiosis has been described for other metal
dusts. Chronic inhalation of high levels of cadmium also causes
both fibrotic and emphysematous lung damage, but it also has major
effects in bone andhttp://www.emedicine.com/EMERG/topic237.htm
Nearly all organ systems are involved in heavy metal toxicity;
however, the most commonly involved organ systems include the
central nervous system, peripheral nervous system,
gastrointestinal, hematopoietic, renal, and cardiovascular.
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How do you recognize the symptoms of elevated toxicity in your
body? Some EARLY warning signs are:
Generalized muscle aches
Chronic fatigue
Fibromyalgia
Food allergies or chemical sensitivities
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Additional indications that may be linked to elevated heavy
metal burdenSome EARLY warning signs of heavy metal toxicity
are:
Difficulty concentrating, irritability, headache Lethargy,
fatigue, weakness (#1 physical complaint)Abdominal pain, tremors,
Kidney distress, elevated liver enzymes
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Simple diagnostics to evaluate toxicity in our patients
Detoxification Questionnaire Bio Impedance Analysis (Phase Angle
and ICW Vs. ECW) Urinary pH testing Hair analysisSimple in-office
surveys and tools that help us help identify patients in need
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Detoxification QuestionnaireQuantifies patient symptoms
(MSQ)Identifies Toxicant Tolerability (XTT)Simple metric to track
patient improvementUse the detoxification questionnaire to qualify
your patients needs
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Medical Symptoms Questionnaire (MSQ)Identifies symptoms in most
body systemsQuantifies patients level of symptomsProvides a simple
metric to track patient improvementUse the established MSQ to
quantify symptoms
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Increased urinary alkalinity has been associated with increased
rates of toxin excretion
Screen patients that may need additional support to excrete
toxinspH testing aids in identifying our patients that may benefit
from increased urinary alkalinity
We always recommend alkalizing support for patients with urinary
pH below 6.6
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By far the majority of toxins and toxic drugs are lipid soluble:
Therefore, to be efficiently and safely removed via urine must be
converted to a non-toxic water-soluble molecule during
metabolism
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Liver - The Detox MachineFilters 2 quarts of blood every
minuteRemoves and alters substancesPrepares them for
elimination
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Metabolic detoxification improves the process of
biotransformation and an alkaline urinary pH supports clearance of
toxinsSpecific nutrients are required to support all three phases
of detoxificationPhase IIIncreased alkalinity supports
excretionHelps to balance clearance enzymesPhase IIIPhase I
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Phase IConjugationPhase I enzymes activate toxins in preparation
for biotransformation Phase IIFunctionalizationToxinReactive
IntermediaryCytochrome P450 enzymes add reactive functional groups
to fat-soluble toxinsPhase IL-Cysteine, Magnesium and other
nutrients support proper expression of Phase I CYP450 enzymes
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Phase IConjugationPhase IIFunctionalizationReactive
IntermediaryNeutralizedToxinThe functional groups are then reacted
with conjugation molecules to neutralize the toxins and make them
water solublePhase IIPhase II enzymes neutralize the activated
toxin in preparation for elimination Glycine, taurine, sodium
sulfate and glutathione precursors support the creation of Phase II
enzymes
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Phase IConjugationElimination of toxins is supported by an
alkaline urinary pHPhase
IIFunctionalizationNeutralizedToxinPotassium citrate increases
urinary alkalinity which supports excretion of biotransformed
toxinsNeutralizedToxinAlkaline urine supports excretionPhase
III
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Intravenous Chelation TherapyEDTATypically heavy metals and
atherosclerosisHas not been shown effective in oral dosing
Side effects: Depletion of vitamins and minerals, including B
vitamins, vitamin C, and magnesium.
Other side effects that have been reported include low blood
sugar, diminished calcium levels, headache, nausea, dangerously low
blood pressure, kidney failure, organ damage, irregular heartbeat,
and seizures.There is a demonstrated need for a safer, more
convenient method of removing heavy metals
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One of the most important detoxification proteins in all
speciesIn absence of heavy metals, its primary role is to transport
zinc and copperProtection against and elimination of toxic metals
by metallothionein is well-described in literature
MetallothioneinAndrews GK. Regulation of metallothionein gene
expression by oxidative stress and metal ions. Biochem Pharmacol
2000;59(1):95-104. Lichtlen et al.. Bioessays. 2001;23(11):1010-7.A
new approach: stimulate the bodys natural ability to remove heavy
metals
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Andrews GK. Regulation of metallothionein gene expression by
oxidative stress and metal ions. Biochem Pharmacol
2000;59(1):95-104. Lichtlen et al.. Bioessays.
2001;23(11):1010-7.Known to efficiently bind several toxic metals
(particularly Cadmium and Mercury) and act as a transporter of
toxic metals to the liver or kidneys for conjugation and
excretionPrevents reaction of toxic metals with other biomolecules,
thus attenuating their toxicityMetallothioneinsNatural proteins
designed to transport and eliminate metals from cellsSources of
heavy metals include seafood, groundwater, smoking, dental
amalgams, pesticides and industrial exposure
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We can expect exceptional regenerative outcomes with a
nutrigenomic approach A complete system for
detoxificationMetabolismGene ExpressionCellular ExpressionSKRMS:
Modulate cell signals(Indirect)(Direct)Diet & Medical FoodKey
Nutritional Support for liver and kidneys
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The excretion of toxic metals is governed by a complex chain of
interwoven activities:Phytonutrients up-regulates expression of
MTF-1 (Metal-activated transcription factor-1)MTF-1 induces
creation of metallothionein (MT) in messenger RNAInduced
metallothionein (MT) bind to metals within the cellOnce metal is
mobilized by MT, it is transported through the cell membrane and
transported to the liver for Phase II detoxification and excretion
through urine or feces
A revolutionary mechanism for heavy metal detoxification
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Study patients experienced a significant increase in the
excretion of metalsIncrease over baselineElimination of arsenic
increased 124%Elimination of lead increased 200%Metabolism of
essential minerals was not significantly impacted in study
patients* *manganese was the one exception, consider additional
supplementation during program.All patients began with mercury
levels below detectable limits Two patients experienced a
significant increase in mercury excretionMercury Elimination
Through Urine
Day 0Day 10Patients 1-3 dl > dl >Patient 4 dl
>Significant IncreasePatients 5-8 dl > dl >Patient 9 dl
>Significant Increase dl > = Below Detectable limit
Chart4
1.282.11.25531914891.90476190482.48421052631.08403361341.08888888890.16
Arsenic
Lead
Barium
Cadmium
Cobalt
Aluminum
Lithium
Molybdenum
Increase over Baseline
% Imrovement
Increase of Urine Excretion of Clinically Relevant Metals
Raw Data
TestAluminumAntimonyArsenicBariumBismuthCadmiumCalciumCesiumChromiumCobaltCopperCreatinineGadoliniumGalliumIronLeadLithiumMagnesiumManganeseMercuryMolybdenumNickelNiobiumPlatinumPotassiumRubidiumSeleniumStrontiumSulfurThalliumThoriumTinTungstenUraniumUrine
TVUrineLofCollVanadiumZinc
Units0 - 22.30 - 0.1490 - 500 - 6.70 - 2.280 - 0.6437 - 3130 -
10.50.6 - 9.40.01 - 2.604.0 - 11.423.00 - 205.000 - 0.0190 - 0.0285
- 640 - 1.49 - 12941 - 2670.03 - 1.160 - 2.1915 - 1750 - 3.880 -
0.0840 - 0.033759 - 46530 - 226332 - 33347 - 346367 - 13280 -
0.2980 - 4.1890 - 2.040 - 0.2110 - 0.0260.1 - 3.263 - 688
Ref Rangeug/g creatug/g creatug/g creatug/g creatug/g creatug/g
creatug/g creatug/g creatug/g creatug/g creatmg/dLug/g creatug/g
creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g
creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g
creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g
creatug/g creatug/g creatmLhourug/g creatug/g creat
USUBJIDVISITVISITDTC
9V111/7/075.60.04387.2
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No significant side effects were seen in study patientsNo
changes in basic labs including hematology, electrolytes, and liver
and kidney function testsTwo subjects had minor symptoms:One
subject with history of migraines experienced a migraine and GI
upsetOne subject experienced mild headache
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Conclusions from study and clinical guidelinesCombination of
Polyphenol-rich hops, andrographis, curcumin and zincResulted in a
significant increase in the expression of metallothioneinIncreases
excretion of clinically relevant toxic metals (with minimal effect
on nutrient compounds)
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Research indicates this clinical breakthrough achieves dramatic
resultsOther considerations: Can be used to compliment a
comprehensive metabolic detoxification programSome patients may
experience mild headacheAdditional manganese supplementation may be
needed
Metagenics Functional Medicine Research Center dosage guidelines
3 tablets twice daily for 30 to 60 days
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The Intestinal TractA Natural Barrier to Toxic Substances
Leaky Gut Syndrome - passage of toxic substances into the
body
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Strategies to Prevent Leaky GutBalance microflora (good
bacteria) Limit use of NSAIDsEnlist nutritional supportMinimize use
of alcohol, caffeine, processed foods and additivesManage
stress
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Promote Balanced MicrofloraProbioticsLactobacillus
acidophilusBifidobacterium
PrebioticsFructooligosaccharides honey, onions, bananas,
oats
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Foods for DetoxificationCruciferous vegetablesBroccoli, cabbage,
bok choy, arugula, cauliflower
Limonene-containing fruitsOrange, tangerine, lemon (not
grapefruit)
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Nutrients for DetoxificationMagnesiumCopperZincVitamin CVitamin
B familyProtein
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Core Protocols for Comprehensive DetoxificationMetabolic
DetoxificationAlkalizing support for detoxification2 scoops twice
daily as recommended in Quick Start guideChoose 10 or 28 day
program based upon needSome people may need to be introduced to the
Medical Food slowly
Heavy Metal DetoxificationPolyphenol-rich hops, Andrographis,
Curcumin, Zinc3 tablets twice daily Continue therapy for 30 to 60
daysUse in conjunction with a comprehensive metabolic
detoxification program, or as a stand-alone therapy
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Research Summary
17 Years of clinical testing with tens of thousands of
patientsPublished clinical studies demonstrating efficacy Numerous
case studies establishing effectiveness in treating toxic-related
symptoms Significant reduction in patient symptoms is typical
Significant improvement in patients condition in just four weeksYou
can expect increased NRG and a dramatic increase in health with a
clinically proven approach to detoxificationCase Studies: MET1504,
MET1505Fibromyalgia, Peripheral Neuropathy, and
InsomniaFibromyalgia
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Hematopoietic stem cells (HSCs) are stem cells that give rise to
all the blood cell types The liver is the primary detoxification
organ in the body. It processes about 2 quarts of blood every
minute, removing particles and preparing them for elimination. This
makes the liver one of the hardest working organs in the body. You
can say that the liver protects the rest of the body from harmful
substances by reducing their toxicity and making them ready for
excretion. Its a good idea to treat your liver well in order for it
to keep you well. METALLOTHIONEIN. Metallothionein is a
cysteine-based protein that transports metals such as copper, zinc,
and cadmium in the body.Also used for AutisCd is CadmiumHg is
mercuryMercury: Doctor what is amazing about this study is that
these were individuals with below detectable levels of mercury in
their urine. During the course of therapy, enough mercury was
transferred out the cells that the urinary spill of mercury for two
of the patients increased significantly above the detection
threshold.
Same subject reported all those AEs Joe to check to see whether
migraines pre-existingThe intestinal tract is another very
important organ involved in preventing toxic overload. It acts as a
natural barrier to substances that are not supposed to enter the
circulation. If large particles are allowed to pass or leak into
the general circulation, they can promote inflammation. Keeping the
intestinal tract healthy is a good strategy to prevent leaky gut.
The gastrointestinal tract is susceptible to damage in a variety of
ways. Balancing the flora or good bacteria, limiting the use of
non-steroidal anti-inflammatory drugs, providing nutritional
support, minimizing the use of alcohol, caffeine, processed foods
and food additives, as well as managing stress, are all ways to
prevent leaky gut. Well be focusing mainly on balancing the
microflora by using probiotics and fiber. There are hundreds of
different species of microflora that live in our GI tracts.
Overgrowth of one kind relative to another can lead to a variety
health problems. One way to promote a healthy balance of intestinal
tract microflora is to use probiotics and prebiotics. Probiotic
means for life and is used to emphasize the healthy effects of
friendly bacteria, such as Lactobacillus acidophilus and
bifidobacteria. Taking antibiotic medications (anti-biotics means
anti-life) can wipe out the good as well as the bad bacteria.
Taking probiotics after a course of antibiotics can restore the
friendly bacteria. Homemade yogurt, sauerkraut, and acidophilus
milk will provide these probiotics. Or, you might want to take a
dietary supplement, as food sources are not reliable sources of
lactobacillus.Prebiotics refer to substances known as
fructooligosaccharides, a complex molecule that is healthful to the
gastrointestinal tract. You can get FOS from honey, onions,
bananas, and oats to name a few foods. Two very important groups of
fruits and vegetables for detoxification are the cruciferous
vegetables and citrus fruits that contain limonene. Broccoli,
cabbage, bok choy, arugula and cauliflower are part of the
cruciferous vegetable family. They contain substances called
indoles. These substances can reduce the toxicity of substances
that might otherwise lead to cancer. Studies are showing that
people that eat this group of vegetables regularly have fewer
hormone-related cancers. The citrus fruits contain limonene, which
we talked about in a previous session. Limonene supports the livers
detoxification process. Try to get something from the citrus group
every day. Grapefruit has a substance called naringenin that
reduces the ability of the liver to detoxify certain drugs. Talk to
your healthcare provider if you take medications and like to eat
grapefruit. Naringenin may reduce the effectiveness of the
medication. One way we can support the liver is to nourish it with
these important vitamins and minerals. We talked about these in the
last 2 sessions, and what foods provide good quantities of these.
Eating healthy, fresh fruits and vegetables, good quality whole
grains, legumes, and lowfat meat, poultry and fish provide these
nutrients. Andrographis is a shrub found throughout India and other
Asian countries that is sometimes called "Indian echinacea." may be
better than milk thistle for liver detoxCurcumin is the principal
curcuminoid of the popular Indian curry spice turmeric that is from
the ginger family