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A Review of Pharmaceutical Performance Johnson and Johnson 2008

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    A Review of Pharmaceutical Performance

    Johnson & Johnson 2008

    By: Emery James Baker MS, MBA

    November 8, 2009

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    Table of Contents

    ContentsScope ............................................................................................................................................................. 3

    Introduction .................................................................................................................................................. 3

    Pharmaceutical Division Overview ............................................................................................................... 4

    Organizational Structure ........................................................................................................................... 4

    Prescription Products ................................................................................................................................ 5

    Neuroscience (Including Pain) .............................................................................................................. 5

    Cardiovascular Disease and Metabolism .............................................................................................. 5

    Immunology .......................................................................................................................................... 5

    Infectious Disease ................................................................................................................................. 5

    Oncology ............................................................................................................................................... 5

    Research & Development (R&D) ............................................................................................................... 6

    Late Stage Pipeline ................................................................................................................................ 6

    Marketing & Sales ......................................................................................................................................... 7

    Summary Statement ................................................................................................................................. 7

    Recent Advancements .......................................................................................................................... 8

    Downturns and Challenges ................................................................................................................... 9

    Financials ..................................................................................................................................................... 10

    Growth .................................................................................................................................................... 10

    Pharmaceutical Sector Specifics ............................................................................................................. 10

    Functional Analysis ..................................................................................................................................... 11

    Additional Strategic Issues: ..................................................................................................................... 11

    Symptoms of business issues - Functional Analysis ................................................................................ 11

    Functional Analysis ................................................................................................................................. 11

    SWOT analysis ......................................................................................................................................... 12

    Recommendations .................................................................................................................................. 13

    Implementation ...................................................................................................................................... 14

    Appendices .................................................................................................................................................. 15Newly Approved and Released products (2008): ................................................................................... 15

    Values: ..................................................................................................................................................... 16

    References .................................................................................................................................................. 17

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    Scope

    This writing will examine the Pharmaceutical divisions of Johnson & Johnson Inc. Although some

    reference to the parent company is unavoidable, the objective is to examine the contributions and

    challenges faced by the traditional drug manufacturing sector and how they relate to a company profile.

    This writing will not address some of the associated over the counter (OTC) products made within theoperating companies that share Consumer and Pharmaceutical sectors. This separation is made possible

    by the segregation of financial information within the operating companies that span the two business

    sectors (i.e. McNeil inc. under the Ortho-McNeil-Janssen Pharmaceutical group). A major component of

    some business units financial information as well as all other supporting information will be divided by

    the sector being Pharmaceutical. The period of this analysis will cover fourth quarter 2007 through and

    including first quarter 2009 with financial reporting focused on the 2008 fiscal year.

    Introduction

    Johnson & Johnson (J&J) is a large global conglomeration consisting of over two hundred and fifty

    operating companies. The parent company develops, manufactures and provides products and services

    that enter into nearly all aspects of the health care industry. J&J practices the principle of decentralized

    management. J&J currently employees over one hundred and eighteen thousand employees worldwide

    with more than double that number of partner interfaces involved in close business to business

    operations. The operating companies of J&J primarily serve the:

    1. Consumer Healthcare sector

    2. Medical Devices and Diagnostics sector

    3. Pharmaceuticals

    As reported in year end 2008 the firm grossed over 63.7 billion dollars representing an increase of 4.3percent over the previous year this coupled with a corporate wide decrease in operational costs of 1.9

    percent yielded an adjusted earnings growth of 6.2 percent.

    J&J also took advantage of the low cost of borrowing during late 2007 and 2008. During this timeframe

    the A++ rated firm was able to secure low cost debt In order to continue and expand its ten billion dollar

    stock repurchase program. By the period end they reclaimed 8.1 billion dollars of common stock, re-

    patronizing the assets and redirecting profits internally while maintaining cash assets through low

    interest loans.

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    It is important to keep the diluted figures (due to roll-up accounting across operating companies) in

    mind when examining the pharmaceutical sector within Johnson & Johnson. On the whole the firm did

    well with conservative growth during severe global economic downturns. As we examine the

    microeconomic climates of the pharmaceutical division it will become apparent that the survivability of

    the business as a whole is made possible by the diversification of products and by the decentralization of

    the organization.

    Pharmaceutical Division Overview

    Within the Pharmaceutical sector of Johnson & Johnson the key division is Ortho-McNeil-Janssen

    Pharmaceutical Inc. (OMJPI). The Company was formed from the merger of Ortho Pharmaceutical and

    McNeil Pharmaceutical in 1993. Both of these pharmaceutical companies are pioneers and leaders in

    areas such as pain management, acid reflux disease, and infectious diseases. Ortho-McNeil and Janssen

    have been placed in the Ortho-McNeil-Janssen group within Johnson & Johnson.

    Also part of the pharmaceutical development group is Pharmaceutical Research & Development or J&J

    PRD. Although smaller operating companies exist outside of the group (i.e. Centocor reports into JJPRD

    Inc) Reporting, Financial Data, Marketing, Sales, Development are driven by OMJPI.

    Organizational Structure

    These Centers of Excellence support the business of (some Centers of Excellence also support other

    operating companies):

    Ortho-McNeil-Janssen Structure:

    Janssen, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

    McNeil Pediatrics, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

    Ortho-McNeil, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

    Ortho-McNeil Neurologics, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

    Ortho Women's Health & Urology, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

    PriCara, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

    Early stage pipeline and research falls under the prevue of J&J PRD as well as OMJPI. J&J PRD manages

    research and development from a number of downstream companies. J&J PRD is primarily made up of:

    J&J PRD Structure:

    Johnson & Johnson Pharmaceutical Research & Development, L.L.C., which focuses primarily onsmall molecules

    Centocor, center for development in biologics;

    ALZA, develops drug delivery technologies;

    Tibotec, focused on anti-virals;

    3-Dimensional Pharmaceuticals, offering drug discovery capabilities for R&D productivity;

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    Scios, research in oral protein-based compounds

    Prescription Products

    The division has experienced strong organic growth. Also J&J is well adapt at mergers and acquisitions

    as the divisions own history proves true (see appendices Mergers and acquisitions timeline). OMJPI is

    focused on scale and J&J PRD is centered on biopharmaceuticals and small molecules to drive discoveryand development.

    Biotech and subsequent product development is fueled by the mergers and acquisitions teams. This is a

    very strong advantage for OMJPI and J&J PRD. Johnson & Johnson as a whole as well as the

    Pharmaceutical operating companies are too large and conservative to excel in new formula discovery

    without the aid of smaller firms. Introduction of new fast paced science happens via one of 2 avenues,

    either Mergers & Acquisitions or strategic partnerships. Both of which OMJPI and J&J proper have down

    to the preverbal science. Unfortunately the M&A team does not take advantage of the Biotechnology

    sector as often as it invests in large acquisitions.

    J&J cooperate did invest over five billion dollars into R&D; however the lions share of new product

    realization has come from M&A over the past five years. The majority of that investment was in five

    therapeutic areas. The current product portfolio is as follows:

    Neuroscience (Including Pain)

    AXERT

    INVEGA

    RISPERDAL

    AXERT

    INVEGA

    RISPERDAL

    CONCERTA

    INVEGA SUSTENNA

    RISPERDAL CONSTA

    CONCERTA

    INVEGA SUSTENNA

    RISPERDAL CONSTA

    DURAGESIC

    REMINYL /RAZADYNE

    TOPAMAX

    DURAGESIC

    REMINYL /RAZADYNE

    TOPAMAX

    Cardiovascular Disease and Metabolism

    ACIPHEX/PARIET

    REOPRO

    ACIPHEX/PARIET

    NATRECOR

    REGRANEX

    Immunology

    SIMPONI STELARA REMICADE

    Infectious Disease

    DORIBAX

    PREZISTA

    INTELENCE

    LEVAQUIN

    Oncology

    DOXIL PROCRIT VELCADE

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    Research & Development (R&D)

    In the Pharmaceutical division several new products are either on file or will be filed with the FDA/ EU

    before year end 2010. The list below is managed by Ortho-McNeil-Janssen directly or via cooperative

    agreements with J&J PRD and other smaller operating companies within J&J.

    Late Stage PipelineCentral Nervous System

    1. INVEGA (paliperidone ER OROS) Bipolar mania/ recurrence prevention FDA- Phase III EU -File

    withdrawn 12/08, Schizoaffective disorder FDA- Approved 7/09 EU- Filed 8/09

    2. INVEGA SUSTENNA (paliperidone palmitate IM long acting injectable ) Schizophrenia FDA-

    Approved 7/09 Phase III

    3. RISPERDAL CONSTA (risperidone) Bipolar maintenance - long acting injectable FDA- Approved

    5/09 EU- Filed 12/08 Deltoid injection FDA- Approved 10/08 EU- Approved 7/09

    4. BAPINEUZUMAB Alzheimer's disease FDA- Phase III

    5. COMFYDE (carisbamate) Epilepsy FDA Complete Response letter 8/09 EU- Filed 8/096. CONCERTA (OROS methylphenidate) Adult attention deficit hyperactivity disorder FDA-

    Approved 6/08 EU- Phase III

    Gastrointestinal1. REMICADE (infliximab) Pediatric Ulcerative Colitis FDA- Phase III

    Hematology1. PROCRIT (epoetin alfa) Chronic Renal Function - extended dosing FDA- Phase III, Myelodysplastic

    Syndrome FDA- Phase III

    Infectious Disease1. ZEFTERA/ZEVTERA (ceftobiprole) Complicated Skin and Skin Structure Infections FDA Complete

    Response letter 11/08 CHMP Decision on hold 2/09

    2. Nosocomial Pneumonia FDA- Phase III EU- Phase III, Hospitalized community acquired

    pneumonia (CAP) FDA- Phase III EU- Phase III

    3. DORIBAX (doripenem) Nosocomial Pneumonia FDA Complete Response letter 8/08 EU-

    Approved 7/08

    Oncology1. DOXIL (doxorubicin HCl liposome injection) Breast Cancer (metastatic) FDA Complete Response

    letter 9/09

    2. VELCADE (bortezomib) Non-Hodgkin's Lymphoma FDA- Phase III, Mantle Cell Lymphoma 1st line

    EU- Phase III, Subcutaneous formulation EU- Phase III

    3. YONDELIS (trabectedin) Relapsed Ovarian Cancer FDA Complete Response letter 9/09

    4. ABIRATERONE Prostate cancer (chemo-refractory and chemo nave) FDA -Phase III EU- Phase III

    5. DACOGEN (decitabine) for Injection Myelodysplastic Syndromes (MDS) EU- Phase III Acute

    Myeloid Leukemia EU- Phase III

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    Anti-Viral1. TELAPREVIR Chronic hepatitis C virus (HCV) infection EU- Phase III

    2. TMC278 NNRTI HIV/AIDS treatment-naive patients FDA- Phase III EU- Phase III

    Pain Management1. NUCYNTA ER (tapentadol ) Moderate to severe chronic pain (Extended Release formulation)

    FDA- Phase III

    Cardiovascular/Metabolism1. RIVAROXABAN VTE Prophylaxis (Prevention of venous thromboembolism in hip and knee

    replacement surgery) FDA Complete Response letter 5/09

    a. Stroke prevention in atrial fibrillation FDA- Phase III

    b. VTE treatment FDA- Phase III

    c. Acute Coronary Syndrome FDA- Phase III

    d. Medically Ill FDA- Phase II

    2. CANAGLIFLOZIN Type 2 diabetes FDA- Phase III EU- Phase III

    Sexual Health1. PRILIGY (dapoxetine) Premature ejaculation FDA non-approvable letter 10/05 EU- Approved

    2/09

    Marketing & Sales

    Summary Statement

    As a unified organization across the member divisions that make up Ortho-McNeil-Janssen the sales and

    marketing organization is chartered with Business Operations, Sales Measurement and Compensationand Sales Analytics. The organizational structure within the group is unique. The Sales and Marketing

    division is funded as one entity but the reporting structures are unified at the vice president level.

    Across both Sales and Marketing there are common goals:

    1. To provide counsel to business partners based on clear and objective analysis of marketplace

    data, guided by the best interests of the business.

    2. To improve organizational effectiveness and productivity by adopting innovative solutions,

    leveraging best practices, reducing inefficiency, and implementing continuous process/program

    improvements.

    3. To train and develop both our team and our business partners to maximize performance, and

    attain aspirations.

    Clearly some objectives are more focused on sales vs. marketing however it is unique that common

    goals and objectives span the departments. The unified Sales and Marketing teams demonstrate a

    economy of scale for all of the Pharmaceutical products. This division is regional however spanning the

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    globe with multiple instances to best cater to the diverse needs of international products and

    campaigns.

    As stated earlier overall sales for Johnson & Johnson numbered in the $63.7 billion dollar range.

    Pharmaceutical sales figures are in the $24.6 billion dollar range with a total adjusted decrease of 1.2

    percent over the previous year.

    Recent Advancements

    The gross sales figure of 24.6 billion dollars was supported by a few major players. Overall International

    sales experienced an increase of 5.1% (adjusted for currency exchange, see Financials below) for a

    gross sales achievement 9.7 billion dollars in 2008.

    Remicade experienced a double digit increase in sales (domestic and International) to reach 12.7%

    improvement over the previous year. Topamax had exceptional gains as well, in 2008 the epilepsy drug

    improved over the preceding year by 11.3% to gross 2.7 billion dollars in sales.

    Surprisingly the off patent Adult Attention Deficit Disorder (ADHD) Concerta achieved a sales record of1.2 billion dollars in 2008. The increase was 21.3% over the previous years sales figures. 155 million

    dollars in accrued sales figures were attributed to the drug in 2008.

    Smaller success stories exist as well for Johnson & Johnson Pharmaceuticals. Under the category of

    Other Pharmaceutical fall Velicade, Prezista and Invega all of which contributed to the categories

    growth of 7.2 billion dollars representing a 10.9% increase over 2007. A breakdown by product/ sector

    can be seen below.

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    Downturns and Challenges

    Although the Phase III pipeline looks promising, getting a product approved from the FDA is never a sure

    thing. The problem is that there are several blockbuster drugs either off patent or close to losing their

    patent and this fact is a sure thing.

    Phase I & II data is sketchy from public sources which is an indication that the pharmaceutical sector for

    J&J may be in for some tough times in the next couple of years. The following is a list of obstacles J&J

    OMJPI and J&J PRD must overcome:

    Issues:

    Procit Market declining domestically

    Ionsys - never launched, R&D money invested 3 generations of product

    Ceftibiprole - never launched, research level discontinuance

    Levaquin Generic Threat

    Doripenum - lost bid for national contract

    Aciphex Market saturated.

    Ultram ER Generic Threat

    Nucynta Threat from Vicodin less expensive to customer

    Risperdal - Generic Threat

    Duragesic - Generic Threat

    Topamax - Generic Threat

    Ortho Tricyclen - Generic Threat in near future

    Rivoroxiban - No FDA approval to date, sales channel prepped and waiting

    Not all sales figures had great gains for Johnson and Johnson in 2008. Procrit, one of the firms

    mainstays for profitability had an overall decrease in sales revenue by 14.7% over 2007 sales. This

    erosion was due to a declining market in the US. Risperdallost its market exclusivity on June 29, 2008and fell victim to aggressive generic threats, decrease its overall sales returns by 37.8% to yield only 2.1

    billion in 2008. The rapid decline was a landmark event for J&J, losses due to Generic Threat are

    common but more than 35% decrease in sales over 6 months was a first for the firm.

    A good number of J&J blockbuster drugs are currently facing generic competition or will in the near

    future and J&J has mainstay drugs in the pipeline to replace the lost revenue but not a clear blockbuster.

    Of note is Topamax. Sales for Topamax were high and increased in 2008, now that the drug will be

    exposed to Generic Threat the decline is expected to be harsh and quick as was the case for Risperdal

    (see above). It is going to be interesting how the company handles this situation.

    The bad news does not end with Topamax, although Concerta experienced record sales in 2008 it has

    been off patent for 4 years without generic competition. Recently 2 ANDA filings have been made to

    compete with Concerta. Sales figure for 2009 are expected to plummet due to the almost certain

    Generic Threat. In addition Levaquin/Floxin decreased in sales of 3.3%,Aciphex/Parietdropped 14.7%

    and finally Duragesichad lost 11% sales to Generic Threats.

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    Financials

    Growth

    Johnson and Johnson as an entity showed sales growth of 4.3% yielding 63.7 billion dollars as stated

    previously. The earnings growth for the company was 6.8% and adjusted earnings per share were 9.6%.

    On the surface this would seem strong and even uncommon but it is important to keep in mind the 10

    billion dollar Stock Repurchase Program which led to the adjusted EPS value exceeding growth by

    slightly less than 3%. Also of significant interest was the firms ability to drive down overall operations

    costs to have an additional positive effect on operational profit. In 2008 operational profit on the whole

    was 17.3 billion dollars or 27.1 percent to sales. This represents an increase over 2007 which reported

    15.9 billion dollars or 26 percent to sales.

    Pharmaceutical Sector Specifics

    The Pharmaceutical segment had a good year in operational profit internal to J&J. The operating

    companies were able to achieve an increase of segment operating profit by 16.3%. The more relevant

    value was an increase of 31% in percent to sales for the firm. The 31% percent to sales value rivals J&J

    Medical Device sector which is always strong but not the firms leader.

    However in years past the Pharmaceutical segment lead the percent to segment sales race by a wide

    margin within Johnson & Johnson. 2008 represents the first year that Medical Devices and

    Pharmaceuticals reported near equal results with Medical devices squeaking out a lead. The results are

    attributed to massive restructuring within the OMJPI as seen below.

    On the whole however, the sector experienced a decrease over 2007 in the general marketplace.

    Earlier it was discussed that the decrease was adjusted to 1.2% lose in 2008. The key point is

    adjusted. Actual sales of 24.6 billion dollars in this sector represent 3.6% reduction over 2007. The

    adjustmentis the result of Currency Exchange.

    Due to the weak dollar in 2008 and the strong international sales of J&J products in this sector an

    unforeseen gain was realized. The gains made in currency exchange for domestically manufactured

    products as well as those manufacturing facilities that report in US dollars represented and additional

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    increase in value of 2.4% lessoning the impact of sales lost in 2008. This situation unfortunately is not

    sustainable and cannot be forecasted for 2009.

    Functional Analysis

    Additional Strategic Issues:

    How to maintain sustainable success and secure its future as the leader in the Pharmaceutical

    industry while:

    Restructuring the organization to increase cost and revenue transparency and toreduce fragmentation in decision processes.

    Focusing on continuing strategic cost savings in terms of creating global alliances.

    Combating exhaustion, change-tiredness, or even organizational burnout in anindustry that requires maintaining constant change momentum.

    Symptoms of business issues - Functional Analysis

    1. Not agile in relation to smaller firms2. Organizational structure very restrictive due to the parent companies size

    3. Loss of bottom-up development

    4. Customer service declining

    5. Too many partners and internal competitors6. Employee turnover

    7. Not promoting from within, reduced incentive buy vs. build issues

    8. May have expanded too far, more than divisional culture could handle

    9. Authority Vs. responsibility, Operating Companies do not feel empowered, often Opco

    management need to get authorization from corporate headquarters

    10.Narrow Marketing Channels, need to embrace DTC Internet opportunities

    11.Failures of acceptance other Opco technologies from one division to another

    12.Weak Pipeline, Poor sales due to Generic Threats

    Functional Analysis

    Management Functions/

    Business Functions

    Planning Organization Control

    Top Management 1, 8 2, 3, 9 2, 3, 4, 9

    Marketing 1 10

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    SWOT analysis

    Johnson & Johnson Strengths

    Strong presence in oncology market, low competition to date

    Financial strength, A++ rating

    Strong brand value

    Johnson & Johnson Weaknesses

    Few novel products

    Underperformance of pharmaceutical division

    Huge company moves to slow

    Johnson & Johnson Opportunities

    Smooth Acquisitions & IntegrationsGrowing global market

    Approval of Perzista, Doxil, Velicade and other Phase II emerging drugs

    Johnson & Johnson Threats

    Government Regulation, i.e. Health Care Bill

    Mergers and acquisitions costs, time

    Increased competition due to patent expiry

    Generic competition to Topamax and other mainstay drugs

    Finances 1

    Production/ Sourcing 12 5 5

    R&D/ Technology 11 11

    Human Resources 3, 7 7 6

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    Recommendations

    At this juncture it is recommend that the firm diversify its product base with new mergers and

    acquisitions Focus on a complimentary product set and use the existing distribution and sales

    channels to market and deliver these products. The current pipeline is in serious trouble, high

    levels of Generic Threat and with very few phase I and II drugs on the radar. The firm is

    financially strong and can acquire low cost debt easily. Leveraging this asset would seem the

    best choice.

    Due to the amount of time and dollars that associate research and development it is recommend

    that top level management begin to search out other firms that are receptive to a full or partialbuyout. Care is to be exercised in regards to corporate culture. J&J has a complex

    organizational structure that exudes a lot of product pride. It would be difficult to succeed in the

    integration of other businesses and products that do not come from the same type of corporate

    culture.

    Strengths

    1.Strong presence in oncologymarket, low competition to date2.Financial strength, A++ rating3.Strong brand value

    Weaknesses

    1.Organizational structure veryrestrictive2.Few novel products3.Underperformance of

    pharmaceutical division

    4.Huge company moves to slow

    Opportunities1. New markets developing in wake of

    consolidations

    2. Overseas expansion3. Form partnerships with overseas

    suppliers

    4. Use of newer technologies - such asthe Internet

    5. Smooth Acquisitions & Integrations6. Growing global market7. Approval of Perzista, Doxil, Velicade

    Threats

    1.Government Regulation, i.e.Health Care Bill

    2.Mergers and acquisitions costs,time

    3.Increased competition due topatent expiry

    4.Generic competition toTopamax and other mainstay

    drugs

    SWOT Analysis Template

    State what you are assessing here Johnson & Johnson Pharmaceuticals

    (Many criteria can apply to more than one quadrant. Identify criteria appropriate to a SWOT situation.)

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    In addition it is recommended that the firm engage in a new marketing relationship. The existing

    relationship does not appear to be conditioned to new emerging channels, (partially due to the

    long standing corporate culture). With the addition of new products the firm will have to market

    these more heavily than they are accustomed in non-traditional channels. In addition LATA and

    the Middle East should be more heavily targeted.

    On thefinancial front It is recommend that a more aggressive corporate investment policy andperhaps a new engagement with new advisory firms. The current financial operations

    management is very good however financial investment is currently lacking growth funds. The

    business treats market investments as a means to hold short term cash and not as growth

    vehicles.

    Implementation

    Johnson & Johnson Pharmaceuticals (both OMJPI and J&J PRD) will need to leverage multiple

    tiers in order to implement a change throughout its vast organization. The objectives of this shift

    in marketing and financial expansion are:

    Corporate Management Diversify products & begin new expansion/ acquisition policy Due to

    the time involved in discovery and the firms unyielding size It would be difficult to nurture new

    products other than niche offerings. To attempt to do so would most likely result in the demise

    of the acquired product. It is recommended that OMJPI & J&J PRD build upon its Phase III

    product suite instead of its aging products. In order to rebuild its pipeline the firm should acquire

    and partner with smaller more agile firms. Several companion products are uniquely aligned

    with OMJPI and J&J PRD especially in the Biotech field. Small development shops have the

    ability to move quickly without the overhead that Johnson & Johnson operations bring to the

    table. OMJPI and PRD should change focus to establish scale and managing emerging products

    and away from pure discovery. Its better to Buy than Build at this juncture.

    Marketing Management: Become swift in marketingThe unified marketing division withinOrtho-McNeil-Janssen is very familiar with the marketing needs and abilities within OMJPI and

    J&J PRD. The firm spends a good part of operating cash on international marketing and the

    results were notable. A review of the capabilities and new marketing needs are in order

    domestically and should be aided by an outside marketing firm. The new products that mergers

    and acquisitions will bring into the catalogue will require a fresh approach to marketing to

    stimulate sales. Expected margin from sales of existing products as well as mature additions

    should remain within the corporate sales objectives.

    Financial ManagementRework financial investments increase expansionsJ&J would benefit

    greatly from a new engagement with an advisory firm more aligned with growth investment. It

    is strongly recommended that an RFP be developed in order to begin interviewing candidatefirms. Techcaliber incorporated is a market leader in RFP development, solicitation and

    negotiation of vendor business agreements. First steps toward Financial RFP development

    should include Contacting this firm for aid in this task.

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    Appendices

    Newly Approved and Released products (2008):

    DOXIL (doxorubicin HCl liposome injection) in combination with VELCADE

    Once monthly INVEGA SUSTENNA (paliperidone palmitate) Extended-Release

    INTELENCE (etravirine)

    SIMPONI (golimumab)

    STELARA (ustekinumab)

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    Values:

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    References

    The Johnson & Johnson Corporation Annual Report 2008

    http://www.investor.jnj.com/investor-relations.cfmAnnual Report

    Johnson & Johnson

    Ward & Railroad Ave,

    New Brunswick, NJ 08901

    Ortho-McNeil-Janssen

    http://www.ortho-mcneilpharmaceutical.com/ortho-mcneilpharmaceutical/about/home.html

    Ortho-McNeil Janssen Scientific Affairs, LLCCustomer Communications Center

    1125 Trenton-Harbourton Road

    P.O. Box 200

    Titusville, NJ 08560-200

    Yahoo Finance!

    HTTP://www.finance.yahoo.com/

    J&J CO - Johnson & Johnson (NYSE: JNJ)

    (http://www.investor.jnj.com/investor-relations.cfm)

    Techcaliber Consulting llc.

    http://www.techcaliber.com/contact.cfm

    TechCaliber Consulting, LLC

    2001 L Street NW, Suite 900

    Washington, D.C. 20036

    Telephone: (202) 969-7870

    Fax: (202) 223-0833

    https://www.ortho-mcneilpharmaceutical.com/ortho-mcneilpharmaceutical/about/contactus_address.htmlhttps://www.ortho-mcneilpharmaceutical.com/ortho-mcneilpharmaceutical/about/contactus_address.htmlhttps://www.ortho-mcneilpharmaceutical.com/ortho-mcneilpharmaceutical/about/contactus_address.htmlhttps://www.ortho-mcneilpharmaceutical.com/ortho-mcneilpharmaceutical/about/contactus_address.htmlhttp://www.finance.yahoo.com/http://www.finance.yahoo.com/http://www.techcaliber.com/contact.cfmhttp://www.techcaliber.com/contact.cfmhttp://www.techcaliber.com/contact.cfmhttp://www.finance.yahoo.com/https://www.ortho-mcneilpharmaceutical.com/ortho-mcneilpharmaceutical/about/contactus_address.htmlhttps://www.ortho-mcneilpharmaceutical.com/ortho-mcneilpharmaceutical/about/contactus_address.html