A Randomized, Double-blind, Placebo- controlled, Phase IIIb Trial (ATLAS) Comparing Bevacizumab Therapy with or without Erlotinib, after Completion of Chemotherapy with Bevacizumab for 1st-line Treatment of Locally-advanced, Recurrent, or Metastatic Non-small Cell Lung Cancer (NSCLC)
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A Randomized, Double-blind, Placebo-controlled, Phase IIIb Trial (ATLAS) Comparing Bevacizumab Therapy with or without Erlotinib, after Completion of Chemotherapy.
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A Randomized, Double-blind, Placebo-controlled, Phase IIIb Trial (ATLAS) Comparing Bevacizumab Therapy with or without Erlotinib, after Completion
of Chemotherapy with Bevacizumab for 1st-line Treatment of Locally-advanced, Recurrent, or
Metastatic Non-small Cell Lung Cancer (NSCLC)
Background & Rationale
Adapted from: 1Sandler A, et al., N Engl J Med 2006; 2Shepherd FA, et al., N Engl J Med 2005; 3Ciuleanu T, et al., ASCO 2008; 4Herbst RS, et al., J Clin Oncol 2007; 5Hainsworth J, et al., IASLC 2008.
ATLAS Study Design
Carboplatin/paclitaxel; cisplatin/vinorelbine; carboplatin or cisplatin/gemcitabine; carboplatin or cisplatin/docetaxel.
ATLAS Objective
ATLAS: Randomized Patients by Region
ATLAS Statistical Considerations
ATLAS: Analysis Populations
<2% of patients were lost to follow-up or withdrew consent.
As of data cutoff date: 18 July 2008.
*The randomized safety population consists of all randomized patients who received at least one dose of bevacizumab, erlotinib or placebo during the post-chemotherapy phase.