a person who lives to 100 years of age or olderimpaxworld.com/products/MPX100/MPX100_Information.pdf · 2017. 7. 21. · Long popular as part of the cuisine of South Asia and China,

IMPaX World Inc .

There are just a handful of true “longevity hotspots” in the world. One is Bama County, located in western China on the slopes of the Himalayas. Circa 2000, this location boasted at least 79 men and women over 100 years old and still very active out of a population of less than 230,000. Their ratio of 3.52 centenarians per 10,000 people is the highest found anywhere in the world. Bama County has a secret.... Japan’s residents have the longest average life span of any other country in the world. Amongst Japan’s many islands, the people of Okinawa are the longest lived. Okinawa has a secret.... In both Bama County and Okinawa medical researchers have found that key foods play a significant role in the longevity of the inhabitants. In Bama County much credit is given to the daily consumption of a plant they call shilianhua, or “rock lotus”. In Okinawa, a role similar to that of rock lotus is filled by wild bitter melon. Not the bitter melon found in vegetable markets, but a smaller and far more bitter version that grows wild.

Centenarian:

a person who lives to 100

years of age or older

Fomulated and Manufactured exclusively by

3J2 Group Inc.for

IMPaX World Inc.5070 Robert J. Mathews Pkwy

Suite 200El Dorado Hills, CA 95762

www.impaxworld.com

What do roCk lotus and

Wild bitter melon have

in Common that promote

longevity?

The answer involves caloric restriction and insulin. Only two mechanisms have been shown to be successful in promoting longevity in higher organisms. The first mechanism lowers the levels of insulin and insulin-like growth factor 1 (IGF-1). The second mechanism restricts calories, which usually has, as one result, a lowering of circulating insulin levels. Rock lotus influences both of these mechanisms. According to a Jutendo Medical University of Japan clinical trial, rock lotus improves liver function and fatty liver[i]. This action resembles that ofcompounds known to reduce insulin levels as an aspect of improved bloodglucose control[ii].

Wild bitter melon is similarly health promoting. For example, it has been found that extracts of the wild bitter melon activate cellular machinery to regulate energy production (technically AMPK-activated protein kinase) and the way that fats are handled by the liver[iii]. Activation of this metabolic pathway is important to aging. It is sometimes referred to as

“exercise in a bottle” because activation of AMPK is an aspect of the benefits derived from exercise. The effect of an extract from the wild genotype of bitter melon called Glycostat® has proved to be more powerful than others on the market and much more consistent in producingpositive results[iv].

In short, rock lotus and Glycostat® work better in combination. Both promote better blood sugar control with less insulin. Both promote healthy blood pressure. Both support healthy liver function. And both mimic changes in cellular energy metabolism typical of caloric restriction.

[i] Ei Ryu, Yasushi Fukuwatari, Nobuhiro Sato, Ryuzo Kawamori. Scientific approach to “mibyouigaku” [pre-symptomatic medicine] medicine. Prevention of lifestyle habit disease by Nikashou. Eastern Medicine 1998;14(4):9 – 22, Supplement. Jutendo Medical University Japan.

[ii] Clouatre D. Uncovering the Longevity Secrets of the Rock Lotus. Total Health Magazine online.

[iii] Tan MJ, Ye JM, Turner N, Hohnen-Behrens C, Ke CQ, Tang CP, Chen T, Weiss HC, Gesing ER, Rowland A, James DE, Ye Y. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol. 2008 Mar;15(3):263-73. Erratum in: Chem Biol. 2008 May;15(5):520.

[iv] Clouatre DL, Rao SN, Preuss HG. Bitter melon extracts in diabetic and normal rats favorably influence blood glucose and blood pressure regulation. J Med Food. 2011 Dec;14(12):1496-504.

Even if you can’t live in a longevity

hotspot such as Bama County or

Okinawa, MPX100 can bring the

longevity hotspot to you!

The MPX100 proprietary formula

synergises the clinically proven

benefits of rock lotus and Glycostat

to support:

• healthy liver function

• blood sugar regulation

• healthy body fat levels

• factors associated with longevity

The Fountain of Youth is now

accessible and affordable.

You too can be a centenarian!

This product and statements are not evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat or cure any disease.

Care of product: Store in a cool, dry place. Do not refridgerate. Unopened good for up to three years.

Opened must be used within 45 days.

Directions: Take one capsule twice daily 3o minutes before morning and evening meal.

You too can now benefit from the nutritional secrets of the world’s “blue zones”—rare longevity hotspots that yield the world’s highest percentage of centenarians!

The MPX100 supports:

• healthy liver function

• blood sugar regulation

• healthy body fat levels

• promotes factors associated with longevity

Fomulated by and Manufactured for IMPaX World Inc.

El Dorado Hills, CA 95762 www.impaxworld.com

Supplement Facts:Serving Size: 2 capsules Servings Per container: 30

Amount Per Serving % Daily Value

Proprietary Blend of Kingsun™ Rock Lotus and Glycostat® Wild Bitter Melon.............1560 mg*

* Daily Value not established

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IMPaX WORLD Inc .

Important Links

http://totalhealthmagazine.com/Vitamins-and-Supplements/Going-WILD-with-Bitter-Melon-for-Blood-Sugar-Support.html

http://totalhealthmagazine.com/Anti-Aging/Uncovering-the-Longevity-Secrets-of-the-ROCK-LOTUS.html

http://totalhealthmagazine.com/Anti-Aging/Is-the-Metabolic-Syndrome-a-Consequence-of-Aging.html

http://totalhealthmagazine.com/Anti-Aging/Aging-and-the-Mitochondria.html

11/28/12TotalHealth Magazine - Going WILD with Bitter Melon f or Blood Sugar Support

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Wild Bitter Melon Extract

(Glycostat®) A full spectrum

extract that is stable with a light

color and mild aroma. Most bitter

melon extracts darken with age

and develop harsh aromas. (Image

courtesy of Glykon Technologies

Group, LLC.)

Going WILD with Bitter Melon for Blood Sugar SupportWritten by Dallas Clouatre, PhD

Not long ago, ScienceDaily published an article entitled, “A Ton of Bitter

Melon Produces Sweet Results For Diabetes.” This headline is but one of

many recent announcements regarding the benefits of an ancient vegetable

that is a culinary treat throughout much of the world. Unfortunately, bitter

melon and its many benefits remain unknown to most Americans.

Bitter melon grows in the tropical and subtropical areas of the East Africa,

Asia, India, South America and the Caribbean. It is used traditionally as both

food and medicine in all of these areas. Momordica charantia goes by many

names and is known as bitter melon, bitter gourd, balsam pear, karela, and

pare. Most Westerners will identify bitter melon as looking like a pale green

or green cucumber with warts. Indian varieties may be whitish to gray-green,

as well. Commercial cultivars can range up to a foot or more in length,

whereas wild bitter melon varieties may measure only an inch or so, more

than making up for their small size with greater bitterness and intense flavor.

The gourd becomes more bitter as it ripens. As a food, unripe bitter melon is

used fresh in salads, cooked into soups and curries, employed as a flavoring

for eggs, meat and so forth.

Long popular as part of the cuisine of South Asia and China, bitter melon today is conquering new gastronomic

territories. Okinawans, renowned for longevity, are extremely fond of a small local variety reputed to confer health

benefits. From Okinawa and other sources, bitter melon is becoming increasingly widespread on the Japanese

mainland. This reflects an East Asian trend typical of Korea as well as Japan: Highly flavored and colored nutrient-

dense foods are being adopted as everyday sources of health. Hence black and red rice, black garlic, bitter melon

and other such foods and condiments are being embraced.

A Plethora of Benefits

Almost every part of the Momordica charantia plant has been used in traditional medical practices, including not

just the fruit, but also the leaves/vines, seeds and roots. Folk and traditional systems often suggest bitter melon

for microbial infections, sluggish digestion and intestinal gas, menstrual stimulation, wound healing, inflammation,

fever reduction, hypertension, and as a laxative and emetic. All these benefits are from a plant with fruit that has

been proven safe by centuries of oral consumption. The only concern generally of note is that bitter melon seed

consumption is not recommended for those seeking to become pregnant.

In South Asia, bitter melon is recommended to support immune health. Some of the effects are direct and some

are indirect. Benefits include the inhibition of the growth of a variety of gram-negative and gram-positive bacteria,

including E. coli, Salmonella, Staphylococcus, Streptococcus and H. pylori. Extracts, similarly, according to in

vitro studies, appear to have an impact on a number of viruses. For instance, bitter melon constituents may

prevent viral penetration of the cell wall. Immune effects include support for healthy T-helper cell ratios, natural killer

cell populations and related mechanisms.

With current problems involving overweight and obesity, some of the more attractive actions of bitter melon involve

controlling weight gain in the face of the consumption of excessive calories. Animal studies have demonstrated

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that bitter melon can reduce insulin resistance and visceral obesity caused by a high-fat diet. Similarly, bitter

melon may be protective against many damaging results of high fructose diets, including diet-induced

hyperglycemia, hyperleptinemia, hyperinsulinemia, and hypertriglyceridemia. The American Medical Association

currently is recommending that added sugars should not account for more than five percent of the diet, yet added

sugar, especially fructose and “corn” sugars, are found everywhere in the American food supply, although often

hidden. Bitter melon may offer some nutritional protection against these added sugars.

Traditional uses and preclinical research provide a very positive picture of bitter melon. Human trials have confirmed

many of these findings. In clinical trials, the fresh fruit, its freshly squeezed juice and the homogenized suspension

of bitter melon have led to significant reductions in both fasting and postprandial blood glucose. The caveat is that

the successful trials in the literature as a rule have used almost exclusively fresh preparations. For whatever

reasons, dry extracts have not fared well in clinical trials. Perhaps this is due to the fact that dry extracts usually

are concentrated for charantins even though, according to some research, charantins, the saponins commonly

selected for “standardized” preparations, may be inactive or only weakly active. Another possibility is that the most

active compounds in bitter melon rapidly deteriorate in most dried powders and extracts.

If you like the taste of bitter melon, the success of freshly prepared materials in clinical trials is great news

because it means that the vegetable may deliver not just a taste treat, but also health benefits when consumed

raw and cooked in salads, soups, curries, egg and meat dishes, etc. There also remains another option. Recent

research suggests that a special form of bitter melon, especially with proper handling, may deliver on the promise

of the fresh material even when dried and delivered in capsules and tablets.

Sometimes Wild Is Better!

With many grains, fruits and vegetables, wild genotypes retain healthful qualities that have been bred out of

cultivated varieties. For instance, Khorasan wheat (Kamut), a much older form of wheat, provides more protein,

minerals and more complex carbohydrates with lower gluten levels than is true of modern wheat. Similarly, carrots

initially most often were purple rather than orange because of the vastly greater amounts of phytonutrients in the

form of anthocyanidins. Lettuce was more bitter, and so forth and so on.

With bitter melon, much the same is true. There are literally hundreds of different forms of bitter melon found in

China and India. In many ways, the most interesting of these nutritionally are the “wild” forms found in India.

Recently, a comparative trial in animals looked specifically at the differences among commercial herbal

extracts of bitter melon of Chinese, Indian and Indian wild genotype origin. The goal was to establish

benefits with regard to blood sugar and insulin regulation and also parameters linked to blood pressure.

Very little work has been performed with wild genotypes of bitter melon, even though there are a great

many of these in India alone. Most information available tends to cover topics such as the effect of the

wild forms on inflammatory responses. Hints in the literature suggest that the blood sugar effects of

some of these wild genotypes could be more potent than in the cultivars commonly used for extraction.

For instance, it has been found that extracts of bitter gourd activate cellular machinery to regulate

energy production (technically, Amp-activated protein kinase) and the way that fats are handled by the

liver. These components can account for as much as 7.1 g/ kg of the dried wild material.

In a just published trial that did look at wild bitter melon, over a period of 60 days the effect of an extract from the

wild genotype of bitter melon offered commercially under the name Glycostat proved to be more efficacious than

the varietals typically used in Chinese and Indian preparations and certainly more consistent in influencing all the

health parameters tested. Wild bitter melon was compared with two commercially available Chinese and Indian

preparations in an animal model with a standard test called a Glucose Tolerance Test (GTT). In this test, a fixed

amount of glucose is consumed and then the amount that accumulates in the blood (Area Under the Curve/AUC)

is measured and the change (delta) is calculated. A smaller change is good because it means that the body is

rapidly taking the glucose into the tissues and that there is good insulin sensitivity. All the bitter melon extracts

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reduced the increase in blood sugar. However, wild bitter melon was superior to both the Chinese and Indian

extracts and it was the only extract to deliver statistically significant results. Of particular note, this greater benefit

was achieved without elevating insulin levels.

Other interesting findings included the wild extract’s significant influence on the nitric oxide system (influencing

whether the blood vessels can dilate), a system that controls blood fluid volume known as the renin-angiotensin

system (RAS) and the closely related angiotensin converting enzyme (ACE) activity. These three systems and

activities influence blood pressure and cardiovascular health and in each of them, wild bitter melon either was the

only extract that exhibited significant activity or it was more active compared to the Chinese and Indian extracts.

Concluding Thoughts

Bitter melon is yet another example of a traditional food and health aid that has made good when tested against

modern Western standards. The benefits are real in areas such as blood glucose and blood pressure support—

with the caveat that until now bitter melon needed to be eaten in large amounts or the freshly prepared juice

consumed regularly in order for the benefits to be realized. Extracts and dried powders have been less successful,

perhaps because unstable or for other reasons. A specially prepared wild bitter melon extract produced with

special processing appears to have solved this limitation. Wild bitter melon extract supports both blood sugar and

blood pressure health, all without the bitter taste.

Dallas Clouatre, PhD

Dallas Clouatre, Ph.D. earned his A.B. from Stanford and his Ph.D. from the University of

California at Berkeley. A Fellow of the American College of Nutrition, he is a prominent

industry consultant in the US, Europe, and Asia, and is a sought-after speaker and

spokesperson. He is the author of numerous books. Recent publications include

"Tocotrienols in Vitamin E: Hype or Science?" and "Vitamin E – Natural vs. Synthetic" in

Tocotrienols: Vitamin E Beyond Tocopherols (2008), "Grape Seed Extract" in the Encyclopedia Of Dietary

Supplements (2005), "Kava Kava: Examining New Reports of Toxicity" in Toxicology Letters (2004) and Anti-Fat

Nutrients (4th edition).

Website: www.dallasclouatre.com

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11/28/12TotalHealth Magazine - Insulin, the Real Cause of Weight Gain—Discov ering Assam Gelugur

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Insulin, the Real Cause of Weight Gain—Discovering AssamGelugurWritten by Dallas Clouatre, PhD

No one doubts that obesity is a problem in the United States. According to

figures released by the Centers for Disease Control (CDC) in January 2010

analyzing the period 2007–2008, the prevalence of obesity was 32.2 percent

among adult men and 35.5 percent among adult women. The age-adjusted

prevalence of overweight and obesity combined was 68.0 percent overall; 72.3

percent among men, and 64.1 percent among women. That’s right: in 2008 an

estimated 68 percent of Americans were overweight or obese! To put this in

perspective, from 1960–2 to 2005–6, the prevalence of obesity increased from

13.4 to 35.1 percent in U.S. adults 20 to 74.7 years of age. Statistics for those

overweight were in the same range. Within living memory, the proportion of

Americans who are overweight and obese has more than doubled. Quite

obviously, there has been no massive shift in genetics in the U.S. in the last 50

years, so what has caused such weight gain?

In his book, Good Calories, Bad Calories: Challenging the Conventional Wisdom on Diet, Weight Control and

Disease, Gary Taubes points out that under real life conditions, prior to the advent of refined carbohydrates, human

beings appear to have suffered from no chronic diseases that can be linked directly to the consumption of fats.

Apparently, eating fat does not make us fat. Among his ten “inescapable” conclusions (p. 454) is this. “Dietary fat,

whether saturated or not, is not a cause of obesity, heart disease, or any other chronic disease of civilization…“

(Taubes is a contributing correspondent for Science magazine and a contributing editor at Technology Review.)

In contrast, Taubes documents the thesis that with the advent of the age of refined carbohydrates, built-in

mechanisms for regulating appetite, on the one hand, and regulating energy use, on the other hand, have become

dysfunctional. Sucrose and high-fructose corn syrup are particularly harmful to metabolic regulation. Evidence from

Taubes and others shows over the last 100 years, consumption of simple, refined and processed carbohydrates

has increased between 50 – 60 percent. Some authorities estimate that perhaps 15 percent of the calories in the

American diet now come from fructose alone!

To the fundamental question of what regulates fat accumulation, which is to say, weight gain, Taubes answers

simply. “This was elucidated by 1965 and has never been controversial. Insulin is the principle regulator of fat

metabolism...”

INSULIN AND THOSE EXTRA POUNDS

Let’s start with evidence from diet trials. Low carbohydrate versus low fat diets for the most part boils down to low

insulin versus high insulin diets. Large comparative trials have demonstrated convincingly high protein and Atkins-

style diets can be used quite successfully for weight loss and weight maintenance. Moreover, low carbohydrate

diets are more successful than low fat diets in terms of delivering health benefits unless there is very careful

attention in the carbohydrate-based diets to what is termed the “glycemic load.” After several decades of refusals

in medical circles even to test the low carbohydrate diet hypothesis, the tide may be turning. Researchers

conducting a recent trial concluded, “Reducing glycemic load may be especially important to achieve weight loss

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among individuals with high insulin secretion...”

Other researchers were more direct after a short-term trial of diabetics on a very low carbohydrate diet. “When we

took away the carbohydrates, the patients spontaneously reduced their daily energy consumption by 1,000

calories a day. Although they could have, they did not compensate by eating more proteins and fats and they

weren’t bored with the food choices.”

Put differently, even if it remains subject to debate as to which is more responsible for the current epidemic of

obesity — fat or carbohydrates in the diet — it has become indisputable that insulin makes us fat and

carbohydrate consumption powerfully influences insulin levels.

High blood insulin levels after meals decrease the ability to access fuels, especially fats, for energy for several

hours, leading to hunger and overeating as well as reducing natural increases in caloric expenditure. For instance,

the thermic response to food that should account for a full 10 percent of all calories metabolized during the day is

blunted in the overweight. Low-glycemic load foods include non-starchy vegetables, legumes, and temperate fruits

in contrast to high-glycemic load foods, such as refined grains, starchy vegetables, fruit juices and sweets. The

former cause only small fluctuations in serum insulin levels whereas the latter can cause large swings. A low-

glycemic diet by reducing insulin fluctuations not only reduces hunger, weight gain and belly fat storage, but also

reduces triglyceride levels while improving the levels of “good” high-density lipoprotein cholesterol (HDL). This

hypothesis has been borne out by a study lasting six years. The highest insulin secretors exhibited the largest

change in weight and belly fat compared to the lowest insulin secretors. Those who were high insulin secretors

and ate low-fat diets did even worse.

REDUCING INSULIN REDUCES HUNGER AND WEIGHT

Insulin controls blood sugar clearance—and a lot more. Testing blood sugar levels and even glucose tolerance is

easy and inexpensive, whereas testing insulin levels, and especially testing insulin sensitivity, is time consuming

and costly. Not surprisingly, the medical world largely has shunned insulin testing and often pretends other tests

can be substituted. Such attitudes have limited some important research. One of those areas is the impact of

directly reducing insulin levels—not blood glucose levels!—on weight loss.

Such an experiment was performed more than a dozen years ago with remarkable results. Researchers reasoned

that hyperinsulinemia is a possible preceding event in the development of obesity. Rather than treating blood

glucose levels, they reduced insulin levels with a pharmaceutical inhibitor of insulin secretion called diazoxide. In a

double-blind placebo-controlled clinical trial with hyperinsulinemic obese adults lasting eight weeks and utilizing a

low calorie diet, it was determined that reducing insulin output increased weight loss significantly without causing

hyperglycemia.

This was not a fluke finding. A clinical trial conducted at a hospital in the Netherlands and published in 2008

reduced insulin levels through diazoxide treatment while prescribing moderate caloric restriction. Researchers

expected a 15 percent drop in starting body weight after six months. (Even ten percent is considered a great

success.) They were not disappointed. Body weight decreased by almost 21 pounds, total body fat mass

decreased by 23.3 percent and yet there was no loss of lean body mass or bone mass. Fat loss was inversely

related to fasting insulin levels achieved at six months—the lower the insulin, the greater the fat loss. Diastolic

blood pressure (the bottom figure) decreased by 10.9 mmHg. Fasting and post-meal peak insulin levels were

reduced by about 65 percent, which is to say, they decreased to the normal range for non-obese men.

Haemoglobin A1c (glycosolated haemoglobin, an indicator of blood glucose control) increased slightly by 0.5

percent to 5.9 +/- 0.2 percent, which is still within the normal range. The weight loss was judged to be clinically

significant.

11/28/12TotalHealth Magazine - Insulin, the Real Cause of Weight Gain—Discov ering Assam Gelugur

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Reducing insulin levels without any attempt to reduce blood sugar levels powerfully affects both appetite and

weight regulation. Why. As mentioned earlier, elevated insulin levels seriously interfere with normal metabolism

and reduce the ability to take fat out of storage and use it for energy. Something similar happens with appetite. In

those who are overweight, the signal to the brain from the meal-induced release of insulin often is disrupted,

making it more difficult for the brain to register that sufficient calories have been ingested for same-meal satiety.

One result is over-eating. Insulin resistance actually causes a change in the microcirculation between the body

and the brain. Other results are uneven energy levels, increased between-meal snacking and binge eating.

CAN INSULIN LEVELS BE REDUCED NATURALLY?

Has the reader ever seen a dietary supplement marketed for reducing insulin levels. Probably not. There are many

natural products marketed for supporting blood glucose regulation, but insulin regulation is another story. Indeed,

many products sold for blood glucose control work by increasing insulin levels in order to reduce blood glucose

levels. However, elevated serum insulin is the fundamental driver for Syndrome X / the Metabolic Syndrome.

Increasing natural insulin output in diabetics who have lost the ability to produce normal amounts of insulin may be

beneficial, but doing so in non-diabetics and in those who already produce too much insulin is another matter.

An example of this is the popular herb Gymnema sylvestre. G. sylvestre does not reduce insulin resistance, but

rather increases insulin output. It also reduces the absorption of ingested fats, an action that may appear to be

beneficial until one considers the implications for nutrients such as vitamins A, D, E, K, CoQ10, tocotrienols,

omega-3 fatty acids, etc. There is some evidence that extracts of G. sylvestre may improve the functioning of

insulin-producing beta-cells in the pancreas, which can be a good thing in some diabetics. On a less positive note,

there also is evidence G. sylvestre, most likely by elevating blood insulin levels, can raise blood pressure.

Fortunately, there is at least one natural item that has been shown to reduce insulin levels as well as reduce both

hunger and weight gain. That item is known colloquially as Assam Gelugur.

ASSAM GELUGUR

“Assam” means “sour.” Assam Gelugur (variously spelled) is a Southeast Asian name for a family of very sour

fruits used for flavoring, in cooking, preserving and as herbal medicine. One local use is for weight loss. In Thailand

and throughout the Malay Peninsula, the primary species is Garcinia atroviridis. Related species used for much

the same purposes are G. cambogia and G. indica. The active constituent in the fruit is its acid, which has the

formidable chemical name 1,2-dihydroxypropane-1,2,3-tricarboxylic acid.

As is true of many herbal products, the benefits of Assam Gelugur extracts are highly dependent upon how they

are prepared. The acid must be stabilized generally by the addition of high pH ions (basic or alkali), such as those

of potassium, magnesium or calcium — using the wrong stabilizer results in little or no activity. Employing only

potassium as the cation, if the material is properly reacted, results in a liquid, not a powder, hence leads to a

product that is commercially unusable. In the case of the acid derived from Assam Gelugur, adding any calcium at

all reduces some desired benefits and blocks other benefits entirely.

At the 2005 Annual Meeting of the American College of Nutrition, for the first time it was reported that a proprietary

potassium-magnesium salt of the Assam Gelugur acid in an animal model gave the same blood glucose regulation

as found in the control arm of the test while almost literally cutting insulin levels in half ! The same study

demonstrated this salt dramatically improved glucose clearance from the blood, lowered systolic blood pressure

and also lowered several key indicators of inflammation, including C-reactive protein and tumor necrosis

factor-alpha (TNF-alpha). In contrast, the potassium-calcium salt exerted no effect upon insulin and blood sugar

regulation and only very poorly influenced blood pressure. In the areas of insulin metabolism, glucose regulation

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and blood pressure, the proprietary potassium-magnesium salt was between five and ten times as active as the

potassium-calcium salt of the fruit acid.

Extracts of Assam Gelugur in clinical trials repeatedly have shown to be safe and to improve weight loss and

appetite control. The new wrinkle is the discovery of the proper technique for producing a stable extract that

dramatically reduces insulin levels while at the same time improving blood glucose regulation. The validity of this

material (a combination of proper extract plus unique delivery system), which is marketed under the name

Leptisol®, soon will be explored decisively at a major university. This particular extract and delivery of Assam

Gelugur has been chosen by the National Institutes of Health for a National Center for Complementary and

Alternative Medicine clinical trial expected to begin at the end of the year.

Conclusion

Modern diets typically contain refined carbohydrates, especially sugars. These diets increase the storage of

consumed fats and other calories while at the same time preventing the utilization of stored and consumed fats for

energy. The mechanism involved is an elevated release of insulin, which leads to lessened meal satiety, poor

regulation of appetite and weight gain. The solution. Low-glycemic load foods (remember, vegetables can be your

primary sources of carbohydrates in place of bread, rice, etc.), higher protein consumption (not necessarily all from

animal sources) and, perhaps, an extract from an Asian fruit called Assam Gelugur.

Dallas Clouatre, PhD

Dallas Clouatre, Ph.D. earned his A.B. from Stanford and his Ph.D. from the University of

California at Berkeley. A Fellow of the American College of Nutrition, he is a prominent

industry consultant in the US, Europe, and Asia, and is a sought-after speaker and

spokesperson. He is the author of numerous books. Recent publications include

"Tocotrienols in Vitamin E: Hype or Science?" and "Vitamin E – Natural vs. Synthetic" in

Tocotrienols: Vitamin E Beyond Tocopherols (2008), "Grape Seed Extract" in the Encyclopedia Of Dietary

Supplements (2005), "Kava Kava: Examining New Reports of Toxicity" in Toxicology Letters (2004) and Anti-Fat

Nutrients (4th edition).

Website: www.dallasclouatre.com

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“The Insulin Effects on Health” with MPX100

Dialog from September 17th Teleconference:

Cary: “When is comes to aging we are all experts! We are all aging. We can’t stop it.

We are talking about “age-management”. IMPaX understands people’s desire to move

forward in a healthy way. There is a big difference living a long life and a long active

life! Major challenges we face today: obesity threatening to derail opportunity to live

longer than parents? First time in history this serious concern that this generation will

not outlive their parents?”

Dr. Dallas Clouatre: “First off, it’s nice to have ‘high science’. Even better to have ‘high science’ that is test-

ed on human beings! What’s to be released October 13th has both! Formulation based on ingredients actu-

ally worked in real life in areas known for extreme longevity.

Unfortunately, in this country, our life expectancy is artificial and our last 10-15 years are not good. Obesity,

diabetes and high blood pressure do no lead to a good old age!

A few years ago a study was done in Eastern Europe. They followed people with extreme longevity – took

blood tests and identified what distinguished longevity versus all other (current day) average lifespan indi-

viduals including those who lived longer but experienced illness, disease and. What they found wasn’t

smoking or drinking, eating habits or even exercise. The real distinguishing point was whether they had nat-

urally high insulin levels or low insulin levels.

Insulin was revealed to be the key factor in health and old age and also a key factor in areas we don’t look –

take the group of apparently healthy individuals blood pressure, lipids, etc. all tested within normal range.

This group was followed for 13 years. It was determined that the group had the lowest levels of insulin or

highest level of insulin sensitivity level had the lowest levels of coronary heart disease. Those with the worst

insulin sensitivity had the highest level of coronary heart disease.

Insulin sensitivity refers to how effective insulin is at disposing of glucose from blood, e.g. 2 individuals both

with fasting blood sugar, say normal of 90, both have roughly same rate of increase blood sugar after a

meal. The one controls blood sugar with one-half the insulin than the other . The one who uses little insulin

to control is ‘insulin sensitive’. The one who uses a lot of insulin to control blood sugar is ‘insulin resistant’.

This does NOT include diabetics, but those who appear to be normal and healthy. They discovered a random

group of apparently healthy individuals, 25-30% will have most insulin resistance and will have serious risk

of coronary heart disease! This tells us insulin is NOT your friend!

1Inflammation - the way to regulate blood sugar has a large role in how much inflamma-

tion generating directly to the arteries.”

Cary: “A recent study determined people in high normal range for blood sugar also had

greater risk for cognitive decline.”

Dr. Dallas Clouatre: “What people refer to as Alzheimer’s is actually diabetes type 3! Discovery was

made if the body has poorly regulated blood sugar, it also affects the brain. If one has a lot of blood

sugar in the system – you will have a depressed amount of glucose getting into the brain. Brain runs

on glucose – because insulin influences circulation into the brain (even high normal blood glucose

level) because of insulin being used to regulate and influences the circulation into the brain – little

is getting into the brain. If glucose is not getting into the brain, processes don’t work right.”

Cary: When you have proper insulin sensitivity – weight regulates itself – a key factor in maintain-

ing ideal weight.

Dr. Dallas Clouatre: “Insulin is a storage hormone. Insulin regulates fat storage – so ‘wear it rather

than use it’ applies. High insulin levels inhibit your ability to use fat: your ability to metabolize fat

for fuel.” This results in low energy levels. Also what is hunger level? The real regulator for hunger

is insulin. If having to count calories and portion control to maintain weight, it’s probably an insulin

issue.

Cary: “What’s important in terms of October 13th is the difference of doing externally (as in phar-

maceutically) to get insulin under control is not health promoting. The difference here is finding

something that complements the overall health of the body.”

Dr. Dallas Clouatre: “With this new formula people will be able to improve insulin sensitivity, cut

down on inflammation, hunger control, weight management and seriously be contributing to their

longevity. ‘Exercise in a bottle’ can help a body move in the same direction as caloric restriction and

exercise do.”

Cary: “You are saying components of the formula will regulate same genes as when people incor-

porate a healthy lifestlyle?”

Dr. Dallas Clouatre: “What we are doing is helping the body do the right thing.”

Cary: “Dr. Clouatre, you have wetted our appetite! I can’t wait to hear more at the IMPaX WORLD

Vision 100 Event and get the products into my hands! This is key to laying a foundation for our

health in our future.”

Please Note: Individual experiences with IMPaX products may vary. IMPaX WORLD makes no therapeutic claims on any of its products. Information contained in this website should not be used as a substitute for personal medical attention, diagnosis or hands-on treatment. If you are concerned about your health or that of a loved one, please consult your family's health provider immediately.