A Naturopathic Perspective

A Naturopathic Perspective

Prostate Cancer Prevention and Treatment

Susan Fisher M.Sc.(Pharmacology), N.D.

A Message to my Audience:

• I enjoyed our discussion Wed night and wanted you to know my website (mahayacambridge.com) will be updated by mid-November.

• Also – of the veggies we discussed, choose to eat more of broccoli and cauliflower (I will explain more next time…)

In the next 45 minutes…

• Even the playing field

• Inspire Health (Vancouver)

• Inflammation

• Nutrients in a Tomato

• Whole Foods

• Some Tools in my Toolkit

Naturopathic Medicine

Naturopathic medicine is a distinct system of primary healthcare

Addresses the root cause of illness or disease

Promotes health and healing using natural therapies

ND vs MD / GP – Academic Background

Bachelor of ScienceBefore Entry toMedical School

ND vs MD/GP – Academic Background

Bachelor of ScienceBefore Entry toMed School

Naturopathic andConventional MedicineYears 1-3

Anatomy, Histology, PathologyPhysiology, Pharmacology, Radiology, Biochemistry, Clinical Nutrition, Differential DiagnosisClinical Diagnosis, Immunology,Embryology, Public Health

ND vs MD/GP – Academic Background

Bachelor of ScienceBefore Entry toMed School

Naturopathic andConventional MedicineYears 1-3

Naturopathic / Conventional MedicineYears 3-4: Clinic Intern

Anatomy, Histology, PathologyPhysiology, Pharmacology, Radiology, Biochemistry, Clinical Nutrition, Differential DiagnosisClinical Diagnosis, Immunology,Embryology, Public Health

Drugs / Surgery Natural Therapies etc.

ND vs MD/ GP – Academic Background

Clinical Nutrition

Examining the relationship between diet and health

Developing individualized diets

Treatments may include nutritional supplements like vitamins, minerals, enzymes and other nutraceuticals

Lifestyle Counseling

Helping patients to make informed choices to be healthy

Understanding the physical, emotional, nutritional and environmental factors affecting well-being

Body Mind SpiritBody Mind SpiritBODY

MIND

SPIRIT

SPIRIT

MIND

BODY

Root Cause of Disease

Botanical Medicine

Understanding the healing value of plant substances

Utilizing the plant substances and the knowledge of healing from around the world

Curcumin /Turmeric (Curcuma longa)

Green Tea (Camellia sinensis)

Asian Medicine

Balancing the flow of Chi (energy) through meridian pathways

Includes the use of acupuncture and Oriental herbs

Homeopathic Medicine

Stimulating self-healing mechanisms through the use of natural substances

Based on the principle that “likes cures like”

Reducing Cancer Risk and

Optimizing Survival

Dr. Hal Gunn, M.D.CEO InspireHealth

1-Year Survival Rates

60%

75%

53% 46%

20%

67%

0%10%20%30%40%50%60%70%80%90%

Stage 3B&4Lung

Stage 4Colorectal

Stage 4Breast

Su

rviv

al InspireHealth

BC

3-Year Survival Rates

41%

17%16%

4%

11%

32%

0%

10%

20%

30%

40%

50%

Stage 3B&4Lung

Stage 4Colorectal

Stage 4Breast

Su

rviv

al

InspireHealth

BC

Role of the Tumour Microenvironment• The pattern of gene expression of cells in the tumour

stroma is highly correlated with prognosis.• More highly correlated than tumour grade, whether the

patient was treated with chemotherapy, or whether the cancer had spread to the lymph nodes. – Finak, G et al. Nature Medicine 14 (5) May 2008 518-27

• In other words, the environment of our body and what our immune cells are doing is the most important factor in determining prognosis

The Human Macrophage

The Human Macrophage

M1:

FIGHTINGINVADERS

The Human Macrophage

M1:

FIGHTINGINVADERS

M2:

TISSUE REPAIR

The Human Macrophage

Invader Attacking Role Acute Inflammation eg. Cut yourself

Tissue Repair RoleChronic Inflammation eg. Arthritis, High Cholesterol, Obesity, Heart Disease, Diabetes, Autoimmune

OR

Ma J et al, The M1 form of tumor-associated macrophages in NSCLC is positively associated with survival time. BMC Cancer 2010 (10) 112

Positive Association of M1 Macrophages and Survival

M1 : Invader Attacking Role Tumor suppression and invader / cancer cell destruction

Inhibit cancer growth(acute inflammation)

MACROPHAGES: TWO IMPORTANT ROLES

M1 Cells Attacking Tumor

M2: Tissue Repair /Growth- Growth factor production Angiogenesis- Suppress immune function- Coordinate tissue growth

Promote cancer growth(chronic inflammation)

M2 Macrophages Help the Cancer Tumour to Grow

M2 Cells: Helping tumorto grow larger.

Prostate Cancer is an Inflammatory Condition!• Interleukin-6 (IL-6), tumour necrosis factor (TNF),

vascular endothelial growth factor (VEGF), fibroblast growth factors (FGF) are among the inflammatory substances believed contributing to growth of cancer

• These cytokines are all elevated in Prostate cancer.

• Extent of inflammation is monitored by CRP (C-reactive Protein level) and PSA levels

How to Reduce Inflammation

• Healthy alkaline diet (7+fruits/ veggies, water, omega-3 fats; limit alcohol /caffeine/ red meat)

• Regular exercise

• Absence of chronic diseases

• Healthy stress reduction

• Self-awareness and healthy emotional well being

• Control group: average 6% rise PSA 1 year.6 of 46 men progressed to surgery/radiation.

• Treatment group: average 4% decline PSA 1 year.None of the men progressed to surgery/radiation.

Journal of urology, 2005, 174:1065-1070

Reversing Rising PSA in Early Prostate Cancer

Vegetarian diet

Exercise

Meditation

HEALTHY LIFESTYLE CHANGES

Reversing Rising PSA in Early Prostate Cancer

• Control group: average 6% rise PSA 1 year.6 of 46 men progressed to surgery/radiation.

• Treatment group: average 4% decline PSA 1 year.None of the men progressed to surgery/radiation.

• Control group: average 6% rise PSA 1 year.6 of 46 men progressed to surgery/radiation.

• Treatment group: average 4% decline PSA 1 year.None of the men progressed to surgery/radiation.

• Growth of LNCaP prostate cancer cells inhibited 70% by treatment group serum vs. Only 9% by control group serum.

Reversing Rising PSA in Early Prostate Cancer

Mol NutrFood Res.

2009 Feb53(2): 227-39

Phytochemical and Ethnobotanical Databases

Nutrients in: A Tomato

www.Ars-grin.gov\duke

Phytonutrients in a Tomato (1)1',2'-EPOXY-1',2'-DIHYDRO-BETA-EPSILON-PSEUDOCAROTENE Fruit DUKE1992A 1',2'-EPOXY-1',2'-DIHYDRO-BETA-PSI-CAROTENE Fruit DUKE1992A 1,2-EPOXY-1,2-DIHYDRO-PSI,PSI-CAROTENE Fruit DUKE1992A 1-BUTYL-2-THIAZOL Fruit DUKE1992A 1-O-FERULOYL-BETA-D-GLUCOSE Fruit DUKE1992A 1-O-P-COUMAROYL-BETA-D-GLUCOSE Fruit DUKE1992A 10,16-DIHYDROXY-DECANOIC-ACID Fruit DUKE1992A 10,16-DIHYDROXY-HEXADECANOIC-ACID Fruit DUKE1992A 16-HYDROXY-HEXADECANOIC-ACID Fruit DUKE1992A 2,7-DIMETHYL-OCT-4-ENEDIOIC-ACID Shoot 1.2 DUKE1992A 2,7-DIMETHYL-OCTA-2,4-DIENOIC-ACID Shoot 1.8 DUKE1992A 2-BUTANONE Fruit DUKE1992A 2-PENTANONE Fruit DUKE1992A 2-PROPANONE Fruit DUKE1992A 24-(R)-ETHYL-LOPHENOL Seed DUKE1992A 24-METHYL-31-NOR-LANOST-9(11)-EN-3-BETA-OL Seed DUKE1992A 24-METHYL-LOPHENOL Seed DUKE1992A 24-METHYLENE-CYCLOARTANAL Seed DUKE1992A 24-METHYLENE-CYCLOARTENAL Plant DUKE1992A

Phytonutrients in a Tomato (2)• 3-BETA-HYDROXY-5-ALPHA-PREG-16-EN-20-ONE Shoot DUKE1992A • 3-O-FERULOYL-QUINIC-ACID Leaf DUKE1992A • 31-NOR-LANOST-8-EN-3-BETA-OL Seed DUKE1992A • 31-NOR-LANOST-8-EN-3-BETA-OL Seed DUKE1992A • 31-NOR-LANOST-9(11)-EN-3-BETA-OL Seed DUKE1992A • 31-NORCYCLOARTENAL Seed DUKE1992A • 4-ALPHA-24-DIMETHYL-CHOLESTA-7,24-DIEN-3-BETA-OL Seed

DUKE1992A • 4-ALPHA-METHYL-24-ETHYL-CHOLESTA-7,24-DIEN-3-BETA-OL Seed

DUKE1992A • 4-VINYL-GUAIACOL Leaf DUKE1992A • 4-VINYL-GUAIACOL Seed DUKE1992A • 5,6-EPOXY-5,6-DIHYDRO-PSEUDO-PSEUDOCAROTENE Fruit

DUKE1992A • 5-HYDROXYTRYPTAMINE Fruit DUKE1992A

Phytonutrients in a Tomato (3)• ABSCISIC-ACID-1',4'-TRANS-DIOL Fruit DUKE1992A • ABSCISIC-ACID-1',4'-TRANS-DIOL Leaf DUKE1992A • ABSCISIC-ACID-1'O-BETA-D-GLUCOPYRANOSIDE Stem DUKE1992A • ACETALDEHYDE Fruit DUKE1992A • 5ALPHA-FUROSTANE-3BETA,22,26TRIOL-3-O-BETA-D-

GLUCOPYRANOSYL... Plant DUKE1992A • 9,10,16-TRIHYDROXYHEXADECANOIC-ACID Fruit DUKE1992A • 9,10,18-TRIHYDROXY-OCTADECANOIC-ACID Fruit DUKE1992A • ABSCISIC-ACID Leaf DUKE1992A

ALUMINUM Fruit 0.3 1700 DUKE1992A

ARABIC-ACID Fruit DUKE1992A

ARGININE Fruit 1 3637 DUKE1992A

ARSENIC Fruit 0.003 0.043 DUKE1992A

ASCORBIC-ACID Fruit 50 2952 DUKE1992A

Phytonutrients in a Tomato (4)ACETIC-ACID Fruit DUKE1992A

ACETONE Fruit DUKE1992A

ADENOSINE Flower DUKE1992A

ALANINE Fruit 30 4132 DUKE1992A

ALPHA-AMYRIN Fruit DUKE1992A

ALPHA-CAPROLACTONE Fruit DUKE1992A

ALPHA-IONENE Fruit DUKE1992A

ALPHA-KETO-GLUTARIC-ACID Fruit DUKE1992A

ALPHA-LINOLENIC-ACID Fruit 30 496 DUKE1992A

ALPHA-NONALACTONE Fruit DUKE1992A

ALPHA-OCTALACTONE Fruit DUKE1992A

ALPHA-OXOGLUTARIC-ACID Fruit DUKE1992A

ALPHA-PINENE Fruit DUKE1992A

ALPHA-TOCOPHEROL Fruit 7 143 DUKE1992A

Phytonutrients in a Tomato (5)ASH Fruit 5700 105461 DUKE1992A

ASPARAGINE Fruit 300 DUKE1992A

ASPARTIC-ACID Fruit 1230 20332 DUKE1992A

AUROXANTHIN Fruit DUKE1992A BETA-ALANINE Fruit 6 DUKE1992A BETA-AMYRIN Fruit DUKE1992A BETA-CAROTENE Fruit 7 113 DUKE1992A BETA-D-GLUCOPYRANOSYL-PHASEIC-ACID Plant DUKE1992A BETA-IONENE Fruit DUKE1992A BETA-SITOSTEROL Fruit DUKE1992A BETAINE Root 23 DUKE1992A BETAINE Shoot 69 DUKE1992A BIOTIN Fruit DUKE1992A BORON Fruit 0 96 DUKE1992A BUTANOL-2-ON-3 Fruit DUKE1992A

Phytonutrients in a Tomato (6)BUTANOLS Fruit DUKE1992A BUTYROLACTONE Fruit DUKE1992A CADMIUM Fruit 0.005 1.7 DUKE1992A CAFFEIC-ACID Fruit 6 DUKE1992A CAFFEIC-ACID-4-O-BETA-D-GLUCOSIDE Fruit DUKE1992A CALCIUM Fruit 60 2400 DUKE1992A CALCIUM Leaf 60800 DUKE1992A CAMPESTEROL Fruit DUKE1992A CAPRYLIC-ACID Fruit DUKE1992A CARBOHYDRATES Fruit 43400 717400 DUKE1992A CARBOXYLIC-ACID Leaf DUKE1992A CELLULASE Fruit DUKE1992A CELLULOSE Fruit DUKE1992A CERIUM Fruit 7 60 DUKE1992A CHLORINE Fruit 510 DUKE1992A CHLOROGENIC-ACID Fruit 18 DUKE1992A

Phytonutrients in a Tomato (7)CHOLINE Root 36 DUKE1992A CHOLINE Shoot 48 DUKE1992A CHROMIUM Fruit 0 3 DUKE1992A CINNAMALDEHYDE Fruit DUKE1992A CIS-3-HEXENOL-1 Fruit 4 40 DUKE1992A CIS-5'-BETA-PSEUDOCAROTENE Fruit DUKE1992A CIS-5'-EPSILON-PSEUDOCAROTENE Fruit DUKE1992A CIS-5'-NEUROSPORENE Fruit DUKE1992A CIS-5,CIS-5'-LYCOPENE Fruit 1 20 DUKE1992A CIS-5-LYCOPENE Fruit 1 20 DUKE1992A CIS-HEXEN-3-AL Fruit DUKE1992A CITRAL Fruit DUKE1992A CITRIC-ACID Fruit DUKE1992A CITROSTADIENOL Seed DUKE1992A COBALT Fruit 0 1.4 DUKE1992A COPPER Fruit 0.4 100 DUKE1992A CUTIN Fruit DUKE1992A CYCLOARTANOL Seed DUKE1992A CYCLOARTENOL Seed DUKE1992A CYCLOEUCALENOL Seed DUKE1992A

ZEATIN-RIBOSIDE Flower DUKE1992A ZEAXANTHIN Fruit DUKE1992A ZETA-CAROTENE Fruit DUKE1992A ZINC Fruit 1 120 DUKE1992A ZIRCONIUM Fruit 0 4 DUKE1992A

Phytonutrients in a Tomato (8)CYCLOHEXANOL Fruit DUKE1992A CYSTINE Fruit 120 1984 DUKE1992A DAMASCENONE Fruit DUKE1992A DECADIEN-TRANS-2,TRANS-4-AL Fruit DUKE1992A DIACETYL Fruit DUKE1992A DIHYDROXYTARTARIC-ACID Fruit DUKE1992A DIHYDROZEATIN Flower DUKE1992A EPOXY-5,6-IONENE Fruit DUKE1992A EPOXY-LUTEIN Fruit DUKE1992A ETHANOL Fruit DUKE1992A ETHYL-PHENOL Fruit DUKE1992A ETHYLENE Fruit DUKE1992A EUGENOL Fruit DUKE1992A

FALCARINDIOL Seed DUKE1992A FALCARINOL Seed DUKE1992A FARNESAL Fruit DUKE1992A FARNESYL-ACETONE Fruit DUKE1992A FAT Fruit 1330 47441 DUKE1992A FAT Seed 150000 250000 DUKE1992A FERULIC-ACID Fruit DUKE1992A

TRIGONELLINE Root 69 DUKE1992A TRIMETHYL-2,6,6-HYDROXY-2-CYCLOHEXANONE Fruit DUKE1992A TRYPTAMINE Fruit DUKE1992A TRYPTOPHAN Fruit 1 1157 DUKE1992A TYRAMINE Fruit DUKE1992A TYROSINE Fruit 38 2479 DUKE1992A UBIQUINONE-10 Tissue Culture 60 DUKE1992A VALINE Fruit 1 3801 DUKE1992A VANADIUM Fruit 0 6 DUKE1992A VANILLIN Plant DUKE1992A VIOLAXANTHIN Fruit DUKE1992A VIT-B-6 Fruit 0 9 DUKE1992A WATER Fruit 910000 982000 DUKE1992A XANTHOPHYLL Fruit DUKE1992A YTTRIUM Fruit 0 6 DUKE1992A ZEATIN Fruit DUKE1992A ZEATIN-GLUCOSIDE Flower DUKE1992A

Phytonutrients in a Tomato (9)FALCARINDIOL Seed DUKE1992A FALCARINOL Seed DUKE1992A FARNESAL Fruit DUKE1992A FARNESYL-ACETONE Fruit DUKE1992A FAT Fruit 1330 47441 DUKE1992A FAT Seed 150000 250000 DUKE1992A FERULIC-ACID Fruit DUKE1992A

FERULIC-ACID-O-BETA-D-GLUCOSIDE Fruit DUKE1992A FIBER Fruit 4700 77691 DUKE1992A FLUORINE Fruit 0.02 1.7 DUKE1992A FOLACIN Fruit 0 2 DUKE1992A FORMIC-ACID Fruit DUKE1992A FRUCTOSE Fruit 11700 DUKE1992A TARTARIC-ACID Fruit DUKE1992A TETRA-DECA-CIS-6-ENE-1,3-DIYNE-5,8-DIOL Stem DUKE1992A THIAMIN Fruit 1 10 DUKE1992A THREONINE Fruit 65 3637 DUKE1992A TITANIUM Fruit 0 140 DUKE1992A

FUMARIC-ACID Fruit DUKE1992A FURFURAL Fruit DUKE1992A GABA Fruit 220 480 DUKE1992A GAMMA-CAROTENE Fruit DUKE1992A GENTISIC-ACID Leaf DUKE1992A GERANYL-ACETONE Fruit DUKE1992A

TOMATIDA-3,5-DIENE Shoot DUKE1992A

TOMATIDINE Plant DUKE1992A

TOMATINE Flower DUKE1992A

TOMATINE Leaf 6 8 DUKE1992A

TOMATOSIDE-A Seed DUKE1992A

TRANS-ACONITIC-ACID Fruit DUKE1992A

Phytonutrients in a Tomato (10)GIBBERELLINS Fruit DUKE1992A GLUCOSE Fruit 16300 DUKE1992A GLUTAMIC-ACID Fruit 90 54053 DUKE1992A GLYCERIC-ACID Fruit DUKE1992A GLYCINE Fruit 23 3637 DUKE1992A GLYCOLIC-ACID Fruit DUKE1992A GLYOXAL Fruit DUKE1992A GRAMISTEROL Seed DUKE1992A GUAIACOL Fruit DUKE1992A HEMICELLULOSE Fruit DUKE1992A HEPTADIEN-TRANS-2,CIS-4-AL Fruit DUKE1992A HEPTADIEN-TRANS-2,TRANS-4-AL Fruit DUKE1992A HEPTULOSE Fruit DUKE1992A HEXADIEN-TRANS-2-,TRANS-4-AL Fruit DUKE1992A

HEXANOLS Fruit DUKE1992A HISTIDINE Fruit 30 2149 DUKE1992A HYDROCINNAMALDEHYDE Fruit DUKE1992A I-VALERALDEHYDE Fruit DUKE1992A I-VALERIC-ACID Fruit DUKE1992A INDOLE-3-ACETIC-ACID Root DUKE1992A

SILICON Fruit DUKE1992A SILVER Fruit 0 1.4 DUKE1992A SODIUM Fruit 10 6600 DUKE1992A SOLADULCIDINE Shoot DUKE1992A SOLANINE Fruit DUKE1992A SQUALENE Fruit DUKE1992A STARCH Fruit 120 10000 DUKE1992A STEARIC-ACID Fruit 80 1322 DUKE1992A STIGMASTEROL Fruit DUKE1992A STRONTIUM Fruit 0 140 DUKE1992A SUCCINIC-ACID Fruit DUKE1992A SUCROSE Fruit DUKE1992A SUGARS Fruit 15000 45000 DUKE1992A SULFOQUINOVOSYL-DIACYL-GLYCEROL Leaf DUKE1992A SULFUR Fruit 107 2330 DUKE1992A SYRINGALDEHYDE Plant DUKE1992A

Phytonutrients in a Tomato (11)IODINE Fruit DUKE1992A IRON Fruit 1 800 DUKE1992A ISOAMYLOL Fruit 7 40 DUKE1992A ISOLEUCINE Fruit 210 3471 DUKE1992A ISOPENTENYL-ADENINE Root DUKE1992A ISOPENTENYL-ADENOSINE Root DUKE1992A ISOVALERALDEHYDE Fruit 0.006 DUKE1992A JSGGALACTURONIC-ACID Fruit DUKE1992A KAEMPFEROL Seed DUKE1992A KETOHEPTOSE Fruit DUKE1992A LACTIC-ACID Fruit DUKE1992A LANOSTEROL Seed DUKE1992A LEAD Fruit 0.003 60 DUKE1992A LEUCINE Fruit 330 5455 DUKE1992A LEUCINES Fruit 1 90 DUKE1992A LEUCIONPINE Tissue Culture DUKE1992A LEUCIONPINE-LACTAM Tissue Culture DUKE1992A LINALOL Fruit DUKE1992A LINOLEIC-ACID Fruit 830 13720 DUKE1992A

PROTOPECTIN Fruit 11700 24200 DUKE1992A PYRUVIC-ACID Fruit DUKE1992A QUERCETIN Fruit DUKE1992A QUERCETIN-3-O-RHAMNOSIDE Fruit DUKE1992A QUERCITRIN Fruit DUKE1992A RIBOFLAVIN Fruit 1 8 DUKE1992A RISHITIN Plant DUKE1992A RUBIDIUM Fruit 0.3 22 DUKE1992A RUTIN Fruit DUKE1992A RUTIN Leaf 24000 DUKE1992A RUTINOSIDE Fruit DUKE1992A S-METHYL-METHIONINE Fruit 16 35 DUKE1992A SALICYLALDEHYDE Fruit DUKE1992A SELENIUM Fruit 0.001 0.034 DUKE1992A SERINE Fruit 57 3967 DUKE1992A

Phytonutrients in a Tomato (12)LINOLENIC-ACID Fruit DUKE1992A LITHIUM Fruit 0.28 0.68 DUKE1992A LOPHENOL Seed DUKE1992A LUPEOL Plant DUKE1992A LUTEIN Fruit DUKE1992A LUTEIN-5,6-EPOXIDE Fruit DUKE1992A LUTEIN-EPOXIDE Fruit DUKE1992A LYCOPENE Fruit 1 20 DUKE1992A

LYCOPERSICONOL Root DUKE1992A LYCOPERSICONOLIDE Root 6.7 DUKE1992A LYCOPHYLL Fruit DUKE1992A LYCOXANTHIN Fruit DUKE1992A LYSINE Fruit 20 5455 DUKE1992A MAGNESIUM Fruit 70 6000 DUKE1992A MAGNESIUM Leaf 4300 DUKE1992A MALIC-ACID Fruit DUKE1992A MANGANESE Fruit 0.6 100 DUKE1992A MERCURY Fruit 0.001 0.002 DUKE1992A METHANOL Fruit DUKE1992A PHOSPHORUS Fruit 110 8400 DUKE1992A PHOSPHORUS Leaf 5500 DUKE1992A PHYLLOQUINONE Plant 0.06 JN128:785 PHYTOENE Fruit DUKE1992A PHYTOENE-1,2-OXIDE Fruit DUKE1992A PHYTOFLUENE Fruit DUKE1992A PHYTOSTEROLS Fruit 70 1157 DUKE1992A

PIPECOLIC-ACID Fruit DUKE1992A

POLYGALACTURONASE Fruit DUKE1992A

POTASSIUM Fruit 780 58800 DUKE1992A

POTASSIUM Leaf 47000 DUKE1992A

PROLINE Fruit 170 2810 DUKE1992A

PROLINE Root 541 DUKE1992A

METHIONINE Fruit 16 1322 DUKE1992A

Phytonutrients in a Tomato (13)LYCOPERSICONOL Root DUKE1992A LYCOPERSICONOLIDE Root 6.7 DUKE1992A LYCOPHYLL Fruit DUKE1992A LYCOXANTHIN Fruit DUKE1992A LYSINE Fruit 20 5455 DUKE1992A MAGNESIUM Fruit 70 6000 DUKE1992A MAGNESIUM Leaf 4300 DUKE1992A MALIC-ACID Fruit DUKE1992A MANGANESE Fruit 0.6 100 DUKE1992A MERCURY Fruit 0.001 0.002 DUKE1992A METHANOL Fruit DUKE1992A METHIONINE Fruit 16 1322 DUKE1992A

METHYL-2-BUTYRIC-ACID Fruit DUKE1992A METHYL-6-HEPTEN-5-ON-2 Fruit DUKE1992A METHYL-GLYOXAL Fruit DUKE1992A METHYL-SALICYLATE Fruit DUKE1992A MEVALONIC-ACID Fruit 3 4 DUKE1992A MOLYBDENUM Fruit 0 6 DUKE1992A MYRISTIC-ACID Fruit DUKE1992A N(6)-ISOPENT-2-ENYL-ADENINE Flower DUKE1992A N-DOTRIACONTANE Fruit DUKE1992A N-HENTRIACONTANE Fruit DUKE1992A N-HEXANOL Fruit DUKE1992A N-PENTANOL Fruit 7 40 DUKE1992A

N-TETRATRIACONTANE Fruit DUKE1992A N-TRITRIACONTANE Fruit DUKE1992A NARCOTINE Fruit DUKE1992A NARINGENIN Fruit DUKE1992A

NEO-BETA-CAROTENE-B Fruit DUKE1992A NEO-BETA-CAROTENE-U Fruit DUKE1992A NEO-CHLOROGENIC-ACID Leaf DUKE1992A NEODYMIUM Fruit 2 30 DUKE1992A NEOLYCOPENE-A Fruit DUKE1992A

Phytonutrients in a Tomato (14)

NEOLYCOPENE-B Fruit DUKE1992A NEOTIGOGENIN Tissue Culture 300 1500 DUKE1992A NEOXANTHIN Fruit DUKE1992A NESTIGOGENIN Fruit DUKE1992A NEUROSPORINE Fruit DUKE1992A NIACIN Fruit 6 99 DUKE1992A NICKEL Fruit 0.01 5 DUKE1992A NICOTIANAMINE Leaf DUKE1992A NITROGEN Fruit 1300 23330 DUKE1992A NITROGEN Leaf 26000 DUKE1992A NONACOSANE Fruit DUKE1992A O-CRESOL Fruit DUKE1992A O-HYDROXY-ACETOPHENONE Fruit DUKE1992A OBTUSIFOLIOL Seed DUKE1992A OLEIC-ACID Fruit 310 5124 DUKE1992A OXALIC-ACID Fruit 36 263 DUKE1992A P-COUMARIC-ACID Fruit DUKE1992A P-COUMARIC-ACID-O-BETA-D-GLUCOSIDE Fruit DUKE1992A P-HYDROXYBENZALDEHYDE Plant DUKE1992A PALMITIC-ACID Fruit 210 3471 DUKE1992A PALMITOLEIC-ACID Fruit 10 165 DUKE1992A

PANTOTHENIC-ACID Fruit 1 61 DUKE1992A PECTIN Fruit 100 31000 DUKE1992A PECTINESTERASE Fruit DUKE1992A PENTANOLS Fruit DUKE1992A PENTEN-1-OL-3 Fruit DUKE1992A PHENOL Fruit DUKE1992A PHENOLICS Fruit 27 570 DUKE1992A PHENYL-2-ETHANOL Fruit DUKE1992A PHENYL-ACETALDEHYDE Fruit DUKE1992A PHENYLACETONITRILE Fruit DUKE1992A PHENYLALANINE Fruit 72 3801 DUKE1992A PHOSPHATIDYL-GLYCEROL Leaf DUKE1992A

Psychoneuroimmunologyand Cancer

• Chronic stress promotes tumour growth and angiogenesis inanimal model of ovarian cancer.

Nature Medicine 2006; 12: 939-45

SPIRIT

MIND

BODY

Cortisol and your Immune System

IncreasedCortisol –(Stress Hormone)

Decreased BodyDefenses

Stress Reduction • 49 breast and 10 prostate patients

• 8 week mindfulness-based stress reduction program

• During follow-up period of 6 /12 months:– constant decline in cortisol levels / pro-

inflammatory cytokines– Enhance Q of L, less stress / mood disturbances

Brain Behav Immun. 2007 Nov; 21(8): 1038-49

Complementary Approaches• Lifestyle and Diet

• Anti-oxidants

• Melatonin

• Serenoa repens (Saw palmetto)

• Omega 3 fatty acids

• Pomegranate juice

• Vitamin D

Vitamin D and Cancer Prevention

Vitamin D supplementation reduces all-cancer risk by 60%

(by 78%, if supplementation continued for more than 1 year)

Lappe, JM, D. Travers-Gustafson, K.M. Davies, R.R. Recker and R.P. Heaney. Am J Clin Nutr. 2007 Jun; 856: 1586-1591

Fish Oil (omega 3 fats)• Research shows

effective in prevention and trx

• Key anti-inflammatory

• Omega 6 fats: increase inflammation

Management of Hormone Therapy Side Effects• Diet (focus on eating lots of F&V, whole grains)

• Black cohosh; increased intake of soy; Vit E and hesperidin

• Homeopathics (sepia, pulsatilla, apis)

• Avoidance of triggers

Foundations of Health and Healing

Will to Live

Hope

Spiritual Connection

Personal Autonomy

Conventional Medical Therapies

Joy and Laughter

Complementary Therapies

Body-Mind Awareness

Emotional Connection

Stress Reduction

Avoidance of Physical Toxins

Healthful Diet

Healthful Water

Sleep, Rest and Relaxation

Vitamins and Supplements

Exercise

In Summary…

Thank you!

Any Questions?….

Optimal Integrative Care Not Routinely Provided

• Only 15-19% of cancer survivors meet even the minimal standards for healthful diet (7 or more servings of fruit and vegetables per day).

• Only 30-47% meet minimum activity targets.

• Only 5% of cancer survivors meet minimum

standards for diet, exercise and smoking.

Agouti Mouse

Yellow Coat:

High riskcancer,diabetesobesity

Reduced lifespan

Yellow Coat:

High riskcancer,diabetesobesity

Reduced lifespan

Maternal Supplementswith folate / B12.

Brown Coat:

Lower riskcancer,diabetesobesity

Prolonged lifeAgouti Mice

Same genes /DNA

Cancer as a Turning Point by Dr. Lawrence LeShan

Psychologist working with cancer patients for over 35 yrs.

Majority of patients: Loss of hope in ever achieving a meaningful and satisfying way of living previous to first signs of cancer.

When cancer patients were encouraged to explore avenues for bringing meaning, fulfillment and joyinto their lives, they often became well.