A ‘MOLECULAR DEAL’ between lipophilic peptides and hydrophilic nucleic acids helped to overcome the major selection obstacle of each class of compounds : Too low mobility and irreversible precipitation of peptides. Too high mobility and infinite dilution of nucleic acids. Basic Questions about the Origin of Life ON THE GENETIC CODE A proposition by Peter Strazewski, Lyon
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A ‘M OLECULAR D EAL ’ between lipophilic peptides and hydrophilic nucleic acids helped to overcome the major selection obstacle of each class of compounds.
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A ‘MOLECULAR DEAL’ between lipophilic peptides and hydrophilic nucleic acids helped to overcome the major
selection obstacle of each class of compounds : Too low mobility and irreversible precipitation of peptides.
Too high mobility and infinite dilution of nucleic acids.
Basic Questions about the Origin of Life
ON THE GENETIC CODE
A proposition by Peter Strazewski, Lyon
Angewandte Chemie
International Edition in English,
1972, 11, 798-8301972
Angewandte Chemie
International Edition in English,
1981, 20, 500-520
Angewandte Chemie
International Edition in English,
1981, 20, 500-520
Journal of
Molecular Evolution,
1989, 29, 465-474
A) 3'-aminoacyl-RNA
B) Uncoded peptidyl transfer
C) mRNA-encoded peptidyl transfer (PT)
D) ribosome-catalysed and mRNA-encoded PT
Eörs Szathmáry in:
«Evolution: from
Cosmogenesis to Biogenesis»
(B. Lukacs et al. eds.)
KFKI 1990, 50/C, 77-83
Origin of genetically encoded protein synthesis : A model based on selection for RNA peptidation
Origin of Life and
Evolution of the Biosphere,
1991, 21, 165-176
A) 3'-aminoacyl-AMP + 3'-peptidyl-RNA
B) Uncoded peptidyl transfer
C) mRNA-encoded peptidyl transfer
Jeffrey Tze-Fei Wong
Early Middle Late
A1-AMP A3-tRNA3 A3-tRNA3
+ A2-A3-tRNA3 + A1-A2-tRNA2 + A1-A2-tRNA2
A1-A2-A3-tRNA3
===
===
TemplateRNA
III
On the origin of protein synthesis : A speculative model based on hairpin RNA structures
Journal of
Theoretical Biology,
1994, 171, 303-8
A) Uncoded peptidyl transfer through (bulged) double-strand formation between