A longitudinal study of A longitudinal study of brain development brain development in autism in autism Heather Cody Hazlett, PhD Heather Cody Hazlett, PhD Neurodevelopmental Disorders Research Neurodevelopmental Disorders Research Center Center & UNC-CH Dept of Psychiatry & UNC-CH Dept of Psychiatry NA-MIC Core1 Mtg Boston, MA NA-MIC Core1 Mtg Boston, MA May 30, 2007 May 30, 2007
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A longitudinal study of brain development in autism Heather Cody Hazlett, PhD Heather Cody Hazlett, PhD Neurodevelopmental Disorders Research Center &
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A longitudinal study of A longitudinal study of brain development brain development
Neurodevelopmental Disorders Research CenterNeurodevelopmental Disorders Research Center& UNC-CH Dept of Psychiatry& UNC-CH Dept of Psychiatry
NA-MIC Core1 Mtg Boston, MANA-MIC Core1 Mtg Boston, MA May 30, 2007May 30, 2007
OverviewOverview
Summary of hypothesesSummary of hypotheses
Data available to NA-MICData available to NA-MIC
Specific requirements/constraints of projectSpecific requirements/constraints of project
Existing image processing of dataExisting image processing of data
ResourcesResources
Longitudinal MRI study of brain Longitudinal MRI study of brain development in autismdevelopment in autism
Features of AutismFeatures of Autism
Social deficits
Communicationdeficits
AtypicalBehaviors
Longitudinal MRI study of brain Longitudinal MRI study of brain development in autismdevelopment in autism
AIMS
• To characterize patterns of brain development longitudinally in autism cases versus controls (TYP, DD)
• To examine cross-sectional & longitudinal relationships between selected brain regions and behavioral characteristics associated with autism
Longitudinal MRI study of brain Longitudinal MRI study of brain development in autismdevelopment in autism
Hypotheses
• Brain enlargement will be present in autism cases compared to controls (TYP, DD)
• Brain differences in specific substructures of interest will be seen in autism cases compared to controls, and these differences will correlate with symptoms of autism and/or severity of features
Developmental StudiesDevelopmental Studies
Difficult for very young children and/or Difficult for very young children and/or lower functioning children to remain stilllower functioning children to remain still
May need to remain motionless for long May need to remain motionless for long periods of timeperiods of time
Sleep studies vary in success ratesSleep studies vary in success rates
Subjects may require training and practice Subjects may require training and practice – this adds to expense of project– this adds to expense of project
Processed pediatric longitudinal dataProcessed pediatric longitudinal data
Data* Data*
Structural MRIStructural MRI
TI:TI: coronal 3D SPGR IRprep, 0.78 x 0.78 x 1.5 mm, coronal 3D SPGR IRprep, 0.78 x 0.78 x 1.5 mm, 124 124 slices, 5 TE/12 TR, 20 FOV, 1 NEX, 256x192slices, 5 TE/12 TR, 20 FOV, 1 NEX, 256x192
PD/T2: coronal FSE, 0.78 x 0.78 x 3.0 mm, 128 slices, PD/T2: coronal FSE, 0.78 x 0.78 x 3.0 mm, 128 slices, 20 FOV, 17 TE/7200 TR, 1 NEX, 256x16020 FOV, 17 TE/7200 TR, 1 NEX, 256x160
DTI DTI
axial oblique 2D spin echo EPI, 0.93 x 0.97 x 3.8 axial oblique 2D spin echo EPI, 0.93 x 0.97 x 3.8 mm, 30 slices, 24 FOV, 12 dirmm, 30 slices, 24 FOV, 12 dir
*All scans collected on 1.5T GE scanner
Data Data
Processed datasets Processed datasets
Time1 (2 yr old) Time2 (4 yr old)EMS/lobes CN AMYG EMS/lobes CN AMYG