9th JOINT MEETING OF ICS-ISICR CYTOKINES AND INTERFERONS ...cytokinesociety.org/wp-content/uploads/2016/11/A11_004_Definitive... · OF ICS-ISICR CYTOKINES AND INTERFERONS: FROM THE

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9th JOINT MEETINGOF ICS-ISICR

CYTOKINES AND INTERFERONS:FROM THE BENCH TO THE BEDSIDE

Florence, ItalyOctober 9-12, 2011

www.cytokines2011.it

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Platinum

Gold

www.interferonsource.com

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Silver

www.lifetechnologies.com

Bronze

www.biolegend.com www.eBioscience.com

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Others

www.elsevier.com/locate/cytokine

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SPONSORS

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ORGANIZED BYThe International Cytokine Society (ICS)The International Society for Interferon and Cytokine Research (ISICR)

CHAIRMAN: Santo Landolfo (Turin, Italy)

LOCAL ORGANIZING COMMITTEE:

Filippo Belardelli (Rome, Italy)Ferdinando Dianzani (Rome, Italy)Santo Landolfo (Turin, Italy)Enrico Maggi (Florence, Italy)

9th JOINT MEETING OF ICS-ISICRFlorence (Italy) October 9 -12, 2011 Firenze Fiera

SCIENTIFIC PROGRAM COMMITTEE:

Chair: Alberto Mantovani (Milan, Italy)Santo Landolfo (Turin, Italy)Nancy Reich (New York, USA)Nancy Ruddle (Yale, USA)John Schrader (Vancouver, Canada)Michael Tovey (Villejuif, France)Giorgio Trinchieri (Frederick, USA)David Wallach (Rehovot, Israel)Kathryn C. Zoon (Bethesda, USA)

INTERNATIONAL SCIENTIFIC COMMITTEE:

Chair: Alberto Mantovani (Milan, Italy)Ahizuo Akira (Osaka, Japan)Abul K. Abbas (San Francisco, USA)Ernest Borden (Cleveland, USA)Zhijian J. Chen (Dallas, USA)Robert Coffman (Berkeley, USA)Daniel Cua (Palo Alto, USA)Charles A. Dinarello (Denver, USA)Eleanor Fish (Toronto, Canada)Richard Flavell (New Haven, USA)Laurie Glimcher (Boston, USA)Otto A. Haller (Freiburg, Germany)John Hiscott (Montreal, Canada)Christopher A. Hunter (Philadelphia, USA)

Allan Lau (Hong Kong, China)Warren J. Leonard (Bethesda, USA)David Levy (New York, USA)Joe J. Oppenheim (Frederick, USA)Keiko Ozato (Bethesda, USA)Leonidas Platanias (Chicago, USA)Andreas Radbruch (Berlin, Germany)Stefan Rose-John (Kiel, Germany)Alexander Rudensky (Seattle, USA)Ganes Sen (Cleveland, USA)Alan Sher (Bethesda, USA)Bryan Williams (Victoria, Australia)Thomas A. Waldmann (Bethesda, USA)

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October, 09th 2011

Hall A17.00 Opening Remarks/Welcome

Santo Landolfo, Chair, Organizing CommitteeLeonidas Platanias, President, ISICRDavid Wallach, President, ICS

17.15 ISICR and ICS Awards PresentationsISICR Awards:Seymour and Vivian Milstein AwardHonorary MembershipDistinguished Service AwardChristina Fleischmann Award to Young Women InvestigatorsSeymour and Vivian Milstein Young Investigators AwardSidney & Joan Pestka Graduate and Post-Graduate AwardsISICR Herbert Tabor Award

ICS Awards:Honorary Life MembershipEd Leonard Prize Fund for Chemotaxis/Chemokine ResearchICS Young Investigator AwardPostdoctoral Investigator AwardOutstanding Scholar AwardICS Herbert Tabor Young Investigator Award

Honorary Lectures18.00 T-bet in Inflammatory Diseases

Laurie Glimcher, USAICS Honorary Life Membership Award

18.30 Negative Regulation of Cytokine Signal TransductionDouglas Hilton, AustraliaISICR Seymour and Vivian Milstein Award

19.00 Keynote LectureGut reactions: Immune pathways in the intestine in healthand diseaseFiona Powrie, UK

20.00 Welcome ReceptionComplimentary event for all registered attendees

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October, 10th 2011

Hall A - Plenary SessionInnate and Adaptive Lymphoid CellsCo-Chairs: Nancy Ruddle, USA - Katy Zoon, USA

08.30 Opening LectureIL-1 acts on T cells to enhance the magnitude of in vivo immuneresponsesWilliam E. Paul, USA

09.00 The role of inflammasome processed cytokines in driving Th17 cells andIL-17 producing γδ T cells in infection and autoimmunityKingston Mills, Ireland

09.30 Regulation of Th17 responses during protective or pathological responsesBrigitta Stockinger, UK

10.00 IL-22 and immune pathway against fungal infectionsMarco Colonna, USA

10.30 Coffee Break

11.00 Hall A - Concurrent SessionmiRNA and post-Transcriptional RegulationChair: Massimo Locati, Italy

The biological relevance of non-coding RNAsIrene Bozzoni, Italy

microRNAs positively regulate NFκB signallingM.P. Gantier, H. James Stunden, C. E. McCoy and B. R.G. WilliamsAustralia

An Ancient Parallel RNA Helix Element in TNF-α Pre-mRNAEnables Highly Efficient Splicing by Activating PKR through an RNAPseudoknotR. Kaempfer, L.S. Namer, F. Osman, Y. Banai, R. Jung andB. Masquida Israel, France

Aryl hydrocarbon receptor involves in the expression of severalmicroRNAs in dendritic cellsN.T. Nguyen, T. Nakahama, H. Hanieh, I. Chinen, K. Masuda andT. Kishimoto, Japan

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Stabilisation of human interferon-α1 mRNA by its antisense RNAT. Kimura, J. Shiwen, M. Nishizawa, E. Yoshigai, I. HashimotoJapan

MicroRNA expression in E6/E7 HPV-transformed humankeratinocytes. Effects of IFNβ treatmentG. Mangino, M.V.Chiantore, M. Iuliano, G. Fantasia, R. Accardi,M. Tommasino, Z.A. Percario, E. Affabris, G. Fiorucci and G. RomeoItaly

Influenza A Virus Infection of Human Respiratory Cells InducesPrimary MicroRNA ExpressionC.M. Horvath, W. Buggele, K. Johnson, USA

11.00 Hall B - Concurrent SessionCytokines in Lymphocyte BiologyChair: John Schrader, USA

Immune regulation at barrier surfacesDavid Artis, USA

Dichotomous consequences of IL-23 signaling in chemically inducedcolitis in miceJ.H. Cox, N.M. Kljavin, L. Diehl, W. Ouyang and N. Ghilardi, USA

In vivo IL-7 exposure of CD4 T cells during HIV induced lymphopenialeads to an enhanced Type-I IFN responseC. Le Saout, R. Hasley, L. Tcheung, H. Imamichi, J.H. Park, M. Sneller,G. Roby, C. Rehm, C. Lane and M. Catalfamo, USA

Modulation of cytokine receptors by IL-2 broadly regulates differentiationinto helper T cell lineagesW. Liao, J.X. Lin, L. Wang, P. Li and W.J. Leonard, USA

Retinoic acid enhances IL-22 production by γδ T cells and protects againstcolitisL.A. Mielke, A. Misiak, C.E. Sutton, K.H.G. Mills, Ireland

Aberrant transcriptional program regulating naive CD4 T-cellactivation defines a progressive Multiple Sclerosis subgroupE. Zastepa, E. Zastepa, L. Tao, L. Fitz-Gerald, M. Hallett, M. del PilarCortes, J. Antel, J. Livingstone, A. Bar-Or, Y. Lapierre, D.G. HaegertCanada

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11.00 Hall C - Concurrent SessionInterferons and Signal TransductionChair: Charles Samuel, USA

Regulation of Interferon and Cytokine Signalling byTranscription Factor PLZFBryan Williams, Australia

Differential negative regulation of type I and type III interferons by UBP43underlies extended antiviral effects of interferon-lambdas in epithelial cellsS.V. Smirnov, C. Burkart, W. Li, A. Lewis-Antes, J. Durbin, D. Er Zhangand S.V. Kotenko, USA

SOCS1 selectively regulates type I IFN signalingR. Piganis, N. de Weerd, J. Gould, B. Scott, S. Forster, S. Nicholson andP. Hertzog, USA

TRIM proteins regulate the innate immune responseG.A. Versteeg, R. Rajsbaum, M.T. Sánchez-Aparicio, J. Valdiviezo,M. Shi, K.S. Inn, J. J. and A. García-Sastre, USA

IRF-1 phosphorylation by I-kappa-B kinase epsilon impairs IFN betastimulation in activated CD4+ T cellsM. Sgarbanti, Giulia Marsili, Anna Lisa Remoli, Sun Qiang, E. Stellacci,A. Mai, D. Rotili, E. Perrotti, R. Orsatti, A. Borsetti, M. Ferrari, N. Iraci,J. Hiscott and A. Battistini, Italy, Canada

TLR9 and TLR7 mediate distinct type I IFN responses in humans and non-human primatesM. Puig, K.W. Tosh, L.M. Schramm, L.T. Grajkowska, K.D. Kirschman,C. Tami, J. Beren, R.L. Rabin, D. Verthelyi, USA

The complex relationship between interferons and their receptors dictatedifferential signalingG. Schreiber, Israel

13.00 Lunch

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14.30 Hall A - Concurrent SessionHost-Pathogen Interaction (I)Chair: Santo Landolfo, Italy

Systems Biology Approaches to Viral Pathogenesis and Immunity:Where are Google and IBM?Michael Katze, USA

Linear Ubiquitination Of Nemo Inhibits Rig-I Mediated Signalling ByDisrupting The Mavs-Traf3 InteractionS.M. Belgnaoui, R. Lin, J. Hiscott, Canada, USA

Mechanism of IL-8 induction by HCMV UL76 proteinH. Costa, R. Nascimento, J. Sinclair, R.M.E. Parkhouse, Portugal, UK

Constitutively active Stat3 triggers autoimmune myocarditis by regulatingboth innate and adaptive immunityA. Camporeale, F. Marino, S. Fornero, R. Levi, V. Poli, Italy

Conditional ablation of Stat1 reveals the antagonistic role of interferons inthe clearance of the intracellular bacterial pathogen ListeriamonocytogenesE. Kernbauer, A.M. Jamieson, C. Schneckenleithner, V. Sexl, U. Reichart,B. Strobl, M. Müller and T. Decker, Austria

Features Of Influenza A Virus Non-Structural Protein 1 That Contribute ToInhibiting An Interferon ResponseB.X. Wang, D. Jia and E.N. Fish, Canada

Innate immune response modulators control inflammation and improvesurvival in viral encephalitisD. Verthelyi, J. Pedras-Vasconcelos, C. Butts, Y. Jones, M. Puig,V. Wang, G. Trinchieri, C. Tami, USA

IL-1 signaling and the NLRP3 Inflammasome are required for CNS-specificprotective immunity against West Nile VirusH.J. Ramos, M. Suthar, A. Negash, G. Blahnick, M. Brassil, M. Gale Jr.USA

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14.30 Hall B - Concurrent SessionCytokines and Inflammation (I)Chair: Nancy Reich, USA

Interleukin-1beta in the modulation of the inflammatory processCharles A. Dinarello, USA

Genetic and functional analysis of a panel of truly human monoclonalantibodies against GM-CSF generated from idiopathic pulmonary alveolarproteinosis (IPAP) patients and potential therapeutic uses as an anti-inflammatory agentJ.W. Schrader, Y.Wang, L. Allan, C. Thomson, L. Jackson, A. Turner,G. Anderson, T. Waddell, J. Seymour, J. Hamilton, Canada, Australia

Interleukin 37 exerts its anti-inflammatory functions by associating withIL-18Rα and SIGIRRM.F. Nold, C.A. Nold-Petry, J.A. Zepp, C. Lo, C, Garlanda, A. Mantovani,P. Bufler, C.A. Dinarello, USA, Australia, Italy, Germany

Inflammatory Proteases Cleave and Activate IL-33, a novel alarmin from theIL-1 FamilyC. Cayrol, E. Lefrancais, S. Roga and J.P. Girard, France

Defective NOD2 Signaling And Innate Cytokine Production In Response ToMdp In Experimental Crohn’s Disease (CD)D. Corridoni, J. Marinis, D. Abbott and F. Cominelli, USA

Caspase-1–Processed Cytokines IL-1β and IL-18 Promote IL-17Production by γδ and CD4 T Cells That Mediate AutoimmunityL.S. Dungan, S.J. Lalor, C.E. Sutton, S.A. Basdeo, J.M. Fletcher,K.H.G. Mills, Ireland

14.30 Hall C - Concurrent SessionImmunoregulationChair: John Hamilton, Australia

Manipulating human dendritic cells by STAT3 silencing to implementtheir use in cancer immunotherapyI. Sanseverino, C. Purificato, L. Conti, B. Varano, L. Beltrame, D. Cavalieri,M.C. Gauzzi, S. Gessani, Italy

Activated Fibrocytes Contribute To The Pathogenesis of RheumatoidArthritisC.L. Galligan, E.N. Fish, Canada


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Identification of RLR-activating compounds as novel antiviral therapeutics orvaccine adjuvantsY.M. Loo, K. Bedard, M. Wang, M.K. Muramatsu, S. Proll, R. Green,R.C. Ireton, M.G. Katze, S.P. Iadonato and M. Gale Jr., USA

The Role of Interferon Epsilon in the Immune Response in the FemaleReproductive TractN.E. Mangan, K.Y. Fung, S. Stifter, P.J. Hertzog, Australia

IFN-β limits Th17 induction and regulates dendritic cell activation in EAEL.M. Pennell, C.L. Galligan and E.N. Fish, Canada

Human Alpha 1 Antitrypsin Modulates B lymphocyte Responses in Cultureand During Allogeneic TransplantationM. Mizrahi, D. Ochayon and E.C. Lewis, Israel

The role of TGF-β as tolerogenic cytokine in regulating dendritic cellfunctionM.L. Belladonna, F. Fallarino, M.T. Pallotta, C. Orabona, C. Volpi,C. Bianchi, C. Vacca, U. Grohmann and P. Puccetti, Italy

16.30 Coffee Break

17.00 Hall A - Special SymposiaInterferons and Multiple Sclerosis

17.00 Hall B - Special SymposiaTGF-beta - from bench to clinics

17.00 Hall C - Special SymposiaInterferons-lambda/IL-29

18.30 Poster Session


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October, 11th 2011

Hall A - Plenary SessionSystems Biology and Gene RegulationCo-Chairs: Scott Durum, USA - Alberto Mantovani, Italy

08.30 Opening LectureBottom-up and Top-Down Systems BiologyApproaches to Understanding ImmunityRonald N. Germain, USA

09.00 The innate immune interactome: Pathways leading to type Iinterferon productionMartin E. Dorf, USA

09.30 Molecular Switch between Pro- and Anti-Inflammatory Cytokine ActivitiesStefan Rose-John, Germany

10.00 Regulation of innate immunity by KIRLorenzo Moretta, Italy

10.30 Coffee Break

11.00 Hall A - Concurrent SessionCytokines and CarcinogenesisChair: David Levy, USA

Inflammatory cytokines and autocrine tumour-promoting networksFrances Balkwill, UK

Protein Kinase CK2 Functions as a Positive Regulator of the JAK/STATand NF-κB PathwaysE. Benveniste, Y. Zheng, USA

STAT3-Driven Upregulation Of TLR2 Promotes Gastric TumorigenesisB.J. Jenkins, H. Tye, C.L. Kennedy, M. Najdovska, L. Mcleod, A. Dev,W. Sievert, P. Tan, P.S. Bhathal, Australia, Singapore

Gastritis and potent gastric epithelial alterations in mice followingexogenous administration of recombinant IL-33L. Pastorelli, R.R. Garg, C. De Salvo, B. Mattioli, J.B. Meddings,M. Vecchi and T.T. Pizarro, USA


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Loss of p53 increases unphosphorylated STAT1, which induces resistanceto DNA damage in cancer cellsH.J. Cheon, E. Holvey-Bates, D. Junk, M. Jackson, G. Stark, USA

A Novel Requirement for Janus Kinases as Mediators of Drug ResistanceInduced by Fibroblast Growth Factor-2 in Human Cancer CellsA.P. Costa-Pereira, C. Ramos do Carmo, J. Lyons-Lewis, M.J. Seckl andA.P. Costa-Pereira, UK

11.00 Hall B - Concurrent SessionInterferons and Viral InfectionsChair: Eleanor Fish, Canada

Antiviral Actions of the IFIT Family of Interferon -Stimulated GenesGanes Sen, USA

IFN Regulation Of Metabolism Contributes To An Antiviral ResponseD. Burke, N. Sonenberg, L.C. Platanias, E.N. FishCanada, USA

ISG54 protects mice against VSV pathogenesisV. Fensterl, J.L. Rupert, S. Ramachandran, S.A. Stohlman,C.C. Bergmann, M.S. Diamond, H.W. Virgin, G.C. Sen, USA

The viral nucleocapsid protein determines sensitivity of influenza A virusesto MxA restrictionP. Zimmermann, B. Maenz, C. Patzina, M. Schwemmle, G. Kochs,O. Haller, Germany

Identification of interferon-β producing cells in La Crosse virus-infectedmouse brainsC. Kallfass, A. Ackerman, S. Lienenklaus, B. Heimrich and P. StaeheliGermany

Role for RNase L in the Induction of IFN-β by Influenza A VirusLacking NS1R.H. Silverman, S. Banerjee, A. Baum, A. García-Sastre, USA


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11.00 Hall C - Concurrent SessionPattern Recognition and Innate ImmunityChair: Filippo Belardelli, Italy

Title pendingJohn Hiscott, USA

The Regulation of Interleukin 10 and Interleukin 12 in MacrophagesA. Howes, X. Wu, J. Zhao, M. Saraiva, G.J. Bancroft, A. O’GarraUK, China, Portugal

14-3-3 epsilon and TRIM25 regulate a RIG-I translocon that mediatesmembrane-association and control of innate antiviral immunityH.M. Liu, M. Gale Jr., USA

Molecular Mechanism Of Poxviral Antagonism Of The TLR4 Complex ByVACV Protein A46J. Stack, T. Lysakova-Devine, A. Bowie, Ireland

DNA-dependent protein kinase is a DNA sensor for IRF-3-dependent innateimmunityB. Ferguson, D. Mansur, N. Peters, G. Smith, UK

Hepatitis C Virus Reveals a Novel Early Control in Acute ImmuneResponseN. Arnaud, S. Dabo, D. Akazawa, M. Fukasawa, F. Shinkai-Ouchi,J. Hugon, T. Wakita and E.F. Meurs, France, Japan

Unraveling the complexity of the type I interferon antiviral responseJ.W. Schoggins, S.J. Wilson, M. Panis, M.Y. Murphy, C.T. Jones,P. Bieniasz, C.M. Rice, USA

A Systems Biology approach to defining the host immune response toWest Nile virus infectionM.S. Suthar, M. Brassil, S. Proll, S. Belisle, M.G. Katze, M. GaleJrUSA

13.00 Lunch


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14.30 Hall A - Concurrent SessionCytokines and Inflammation (II)Chair: Joost J. Oppenheim, USA

Regulation of the Immune Response in Tuberculosis: Lessons Learnedfrom Mouse Models and Human DiseaseAnne O’Garra, UK

Thrombin mediates chemokinesis in human resting CD8 T cells throughspecific interaction with thrombin receptor (PAR-1)M. Smith, A. Hurley, T. Karpova, N. Belkina, S. Shaw, E. Nickel,B. Packard, H. Imamichi, J. MacNally, M. Sneller, C. Lane and M. CatalfamoUSA

IKKi is required for interleukin 17-dependent signaling associated withneutrophilia and pulmonary inflammationK. Bulek, C. Liu, S. Swaidani, L. Wang, R.C. Page, M.F. Gulen, T. Herjan,A. Abbadi, W. Qian, D. Sun, M. Lauer, V. Hascall, S. Misra, M. Chance,M. Aronica, T. Hamilton and X. Li, USA

Function of SOCS3 on Macrophage Polarization and InflammationH. Qin, A.T. Holdbrooks, Y. Liu, S.L. Reynolds, L.L. Yanagisawa,B.C. McFarland, W.I. Yeh, P. De Sarno, L.E. Harrington, C. Raman andE.N. Benveniste, USA

Deficient IL-1 Receptor antagonist production by monocytes from patientscarrying mutations in the NLRP3 geneA. Rubartelli, L. Delfino, A. Omenetti, M. Gattorno, S. Carta, Italy

Expression of Interleukin-37 in human pediatric inflammatory boweldiseaseS. Weidlich, A.M. Bulau, T. Schwerd, J. Helmbrecht, M. Lacher, D. Mayr,S. Koletzko and P. Bufler, Germany

IL-32 promotes angiogenesisC.A. Nold-Petry, M.F. Nold, J.A. Zepp, H. Dinkel, B.E. Palmer, C.D. Cool,L. Taraseviciene-Stewart, S.H. Kim, C.A. Dinarello and N.F. VoelkelUSA, Australia, South Korea

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14.30 Hall B - Concurrent SessionCytokines and Signal Transduction (I)Chair: Dan Kalvakolanu, USA

Role of the tyrosine Kinase FER in the activation of NFkappaB by mutatedgrowth factor receptors in cancerGeorge Stark, USA

Signaling by the IL-17RA/IL-17RC Complex: Impact on oral mucosalimmunityS. Gaffen, A.W. Ho, R. Onishi, F. Shen, A. Peterson,N. Hernández-Santos, A. Garg, W. Ouyang, E.E. Childs, USA

Mechanisms of mRNA Translation of ISGs in Malignant Cells.Implications for the Antitumor Effects of IFNSL.C. Platanias, USA

Cish degradation of Htra1 regulates TGF-b signalingD.C. Palmer, R.N. Reger, L.M. Garvin, D. Frasheri, Y. Ji, Z.J. Franco,C.A. Klebanoff, L. Gattinoni and N.P. Restifo, USA

Inhibition of Interleukin 6 classic signaling is a novel function of solublegp130 which is controlled by the ratio of Interleukin 6 and solubleInterleukin 6 receptorC. Garbers, W. Thaiss, G.H. Waetzig, G.W. Jones, D.M. Floss,I. Lorenzen, J. Grötzinger, S.A. Jones, S. Rose-John, J. SchellerGermany, UK

Repression of Inflammatory Cytokine Genes by TNF- and IFNg-regulatedSignaling and Epigenetic MechanismsL. Ivashkiv, S.H. Park, J. Chen, USA

IFN-autophagy and tumor suppression: a novel IFN-γ induced signalingcascade involving Activated transcription factor-6 (ATF-6) that collaborateswith C/EBP-beta and promotes tumor suppressionP. Gade, U.B. Machaani, D.V. Kalvakolanu, USA

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14.30 Hall C - Concurrent SessionChemokines and their ReceptorsChair: Amanda Proudfoot, Switzerland

Targeting CXCR4 in WHIM syndromePhilip M. Murphy, USA

Macrophages from patients with atopic dermatitis show a reduced CXCL10expression in response to staphylococcal α-toxinS. Kasraie, M. Niebuhr, O. Dittrich-Breiholz, M. Kracht, T. WerfelGermany

CCR5 32 and CCR5-59029 Allele Frequency among Hepatitis C VirusInfected and in Non-HCV Infected Saudi PopulationF.M. Al-Sharif, O.H. Jiffri and E.I. Azhar, Saudi Arabia

Understanding the WHIM syndrome: molecular analysis of CXCR4functions in lymphocyte activationM. Kallikourdis, A.E. Trovato, F. Anselmi, A. Sarukhan, L. Tassone,R. Badolato and A. Viola, Italy

Which chemokine receptor should we target in Rheumatoid ArthritisA. Garin, A. Hermant, S. Krohn, C. Gabay and A. ProudfootSwitzerland

16.30 Coffee Break

17.00 Hall A - Special SymposiaNew Interferons

17.00 Hall B - Special SymposiaCytokines and Autoimmunity

18.30 Poster Session

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October, 12th 2011

Hall A - Plenary SessionCell death and CancerCo-Chairs: Carl Ware, USA

09.00 Opening LectureInhibitors of the NFkappaB Pathway and inflammationMichael Karin, USA

09.30 Inflammation associated to cancerLisa Coussens, USA

10.00 STAT3 in cancer inflammation and as a target for cancer therapyHua Eleanor Yu, USA

10.30 Coffee Break

11.00 Hall A - Concurrent SessionGene RegulationChair: Howard Young, USA

SUMO Modification of IRF Family Proteins and Regulation ofAnti-Viral Innate ImmunityKeiko Ozato, USA

HDAC-sensitive transcriptional elongation checkpoint during interferon-stimulated gene expressionI. Marie, H.M. Chang, L. Gnatovskiy and D.E. Levy, USA

Role of lysine methylation of NFkB in differential gene regulationT. Lu, M. Yang, G.R. Stark, USA

Multi-layered cellular stochasticity and paracrine amplification shape theinterferon responseU. Rand, M. Rinas, J. Schwerk, H. Hauser, T. Höfer, M. KösterGermany

Anti-inflammatory actions of glucocorticoids: the role of transcriptionalcoregulator GRIP1 in shaping macrophage transcriptome and systemicinflammationI. Rogatsky, Y. Chinenov, R. Gupte, J.R. Flammer, J. Dobrovolna,M.A. Kennedy, B. Liu, USA

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Identification of NF-κB genes that contribute to reversible stimulation ofVSV oncolysis by histone deacetylase inhibitors (HDIs)L. Shulak, T. Di Lenardo, T.L. Anh Nguyen and J. HiscottCanada, USA

11.00 Hall B - Concurrent SessionCytokines and anti-tumor ImmunityChair: Leonidas C. Platanias, USA

Deconstructing Cancer ImmunoeditingRobert Schreiber, USA

A cancer-protective role of inflammationO.A. Werner Haabeth, K. Berg Lorvik, C. Hammarström, I.M. Donaldson,G. Haraldsen, B. Bogen and A. Corthay, Norway

Anti-tumor effect of a tumor cell vaccine expressing membrane-bound formof IL-12 subunit p35S.M. Park, S.A. Do, Y.S. Kim, South Korea

STAT1 independent cytokine responses in the immunosurveillance oftumoursN.L. Messina, K.M. Banks, B.P. Martin, A. Uldrich, A.J. Christiansen,M.J. Smyth, C.J.P. Clarke and R.W. Johnstone, Australia

Tumor cell induced immune evasion via loss of Type I IFN signallingpromotes breast cancer metastasisB.S. Parker, C.Y. Slaney, B.N. Bidwell, S. Forster, R.L. Anderson,P. Hertzog, Australia

Development of two IL15 immunocytokines targeting either GD2- or CD20-tumoral bearing cellsM. Vincent, G. Teppaz, V. Solé, A. Bessard, S. Loisel, H. Watier,B. Clémenceau, H. Vié, S. Birklé, L. Garrigue-Antar, A. Quéméner andY. Jacques, France

Combination therapy with IFN-alpha plus IFN-gamma and monocytesmediates synergistic antitumor effects against established human ovarianand melanoma tumors in mouse modelsK.C. Zoon, H. Nakashima, K. Miyake, C. Clark, J. Bekisz, S. Baron,S.R. Husain and R. K. Puri, USA

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11.00 Hall C - Concurrent SessionImmunopathologyChair: Enrico Maggi, Italy

The Role of Cytokines in T-Cell Tolerance and AutoimmunityAbul K. Abbas, USA

Mechanism of IRF5 constitutive activation in primary monocytes of SLEpatients is independent of type I IFNsR.C. Stone, D. Feng, J. Deng, S. Singh, L. Yang, P. Fitzgerald-Bocarsly,M.L. Eloranta, L. Rönnblom, Betsy J. Barnes, USA, Sweden

Basal Expression and Regulation by Pro-Inflammatory Cytokines ofHuman Endogenous Retroviruses of the W Family in Bood CellSubpopulations and in AstrocytesA. Mei, G. Mameli, L. Poddighe, E. Uleri, C. Serra, R. Manetti andA. Dolei, Italy

Impairment of IFN-α production, peripheral plasmacytoid dendritic cellnumber and susceptibility to MPO-ANCA-associated glomerulonephritisand vasculitisK. Uno, E. Muso, T. Ito-Ihara, K. Suzuki, Japan

Recruitment of bone marrow derived CD11c+ and c-Kit+ cells in pulmonaryfibrosisS.H. Phan, T. Liu, L. Ding, T. Nakashima, M.R. Ullenbruch, USA

IFN-γ signaling intrinsically regulates expansion of effectorencephalitogenic Th1 cells in experimental autoimmune encephalomyelitis(EAE)C. Raman, C.M. Sestero, R. Naves, B.J. Baker, T.M. DeSilva andP. De Sarno, USA, Chile

Decrease Of IL-17 and GM-CSF in Intestinal Mucosa of IBD Patients IsAssociated With Reduction Of CD68+ Macrophages And ClinicalRemission In Response To Anti-TNF TherapyF. Bosè, F. Caprioli, R. Rossi, Palazzo, C. Viganò, L. Raeli, M. Moro,G. Basilisco, S. Ferrero, M. Pagani, G. Altomare, S. Abrignani andE. Reali, Italy

13.00 Lunch

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14.30 Hall A - Concurrent SessionCytokines and Signal Transduction (II)Chair: Alan Lau, Honk Kong

Interferon epsilon is a novel immune regulator that acts independentlyof TLR activationPaul Herzog, Australia

The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor forHuman Cytomegalovirus ReplicationV. Dell’Oste, G.R. Gariano, M. Bronzini, D. Gatti, A. Luganini,M. De Andrea, G. Gribaudo, M. Gariglio and S. Landolfo, Italy

The extracellular domains of the IL-21 receptor are bridged by glycosylationthrough conserved anchor pointsO.J. Hamming, L. Kang, A. Svenson, J.L. Karlsen, H. Rahbek-Nielsen,S.R. Paludan, S.A. Hjorth, K. Bondensgaard and R. HartmannDenmark

STAT3 transcriptional activity is controlled by regulated acetylation.J. Tavernier, L, Icardi, V. Gesellchen, R. Mori, S. Lievens, S. Eyckerman,J. Bultynck, M. Boutros and K. De Bosscher, Belgium, Germany

IL-36R LIGANDS Are Potent Regulators Of Dendritic and T CellsS. Vigne, G. Palmer, C. Lamacchia, P. Martin, D. Talabot-Ayer,E. Rodriguez, F. Ronchi, F. Sallusto, H. Dinh, J.E. Sims, C. GabaySwitzerland

Plasmacytoid Dendritic Cells are infected by Epstein Barr virus andinduces TLR- dependent type I IFN productionM. Severa, E. Giacomini, E. Anastasiadou, V. Gafa, F. Rizzo,M. Corazzari, A. Romagnoli, R. Feederle, H.J. Delecluse, P. Trivedi,G.M. Fimia, E.M. Coccia, Italy, Germany

A novel autosomal recessive and autosomal dominant deficiency in theTLR3 pathway underlying susceptibility to Herpes Simplex EncephalitisV. Sancho Shimizu, R. Perez, L. Lorenzo, R. Halwani, S. Fabrega,A. Cardon, L. Abel, S.Y. Zhang, A. Puel, S. Al-Muhsen and J.L. CasanovaFrance, Saudi Arabia, USA

IKK603;-mediated STAT1 phosphorylation at S708 residue governs theexpression of Interferon-stimulated genes important for West Nile viruscontrolO. Perwitasari, H. Cho, M.S. Diamond, M. Gale Jr., USA

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14.30 Hall B - Concurrent SessionHost-Pathogen Interaction (II)Chair: Giorgio Trinchieri, USA

Cytokine pathways regulating the innate immune response tomycobacteriaAlan Sher, USA

Regulation of the Actin Modifier Gelsolin by Protein Kinase R EnforcesBasal Innate Immune DefenseA. Sadler, A.T. Irving, D. Wang, N. Kozer, A.H.A. Clayton, B.R.G. WilliamsAustralia

Vaccinia Virus Protein C6 is a Virulence Factor that Binds TBK1 AdaptorProteins and Inhibits Activation of IRF3R.P. Sumner, H. Ren, L. Unterholzner, A.G. Bowie, G.L. SmithUK, Ireland

Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA inthe phagosome of human monocytesJ.L. Cervantes, Carson J. La Vake, and Juan C. Salazar (1,2,3)USA

Arteri- and nairovirus OTU domain-containing proteases target ubiquitin-regulated factors in the RLR-mediated innate immune signaling pathwayM. Kikkert, P.B. van Kasteren, C. Beugeling, D. Ninaber, S. van Boheemen,A. Garcia-Sastre, E.J. SnijderThe Netherlands

A role for plasmacytoid dendritic cells in Th2 response induction againsthelminthsR.J. Lundie, L.M. Webb, L. Boon, A.S. MacDonald, UK

NS3 of bluetongue virus interferes with the innate antiviral responseD. Vitour, E. Lara, E. Chauveau, M. Adam, C. Sailleau, E. Breard,S. Zientara, France


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14.30 Hall C - Concurrent SessionCytokines and Cell DeathChair: David Wallach, Israel

In vitro and in vivo regulation of TNF-induced necroptosisPeter Vandenabeele, Belgium

Inhibition of Th17 differentiation and EAE development by tumorsuppressor death-associated protein kinaseM.Z. Lai, Y.T. Chuang, T.F. Chou, K.H. Lin, R.H. Chen, S.C. Miau,A. Kimchi, Taiwan, Israel

Modulation of apoptosis and pro-inflammatory signalling by vaccinia virusprotein N1C. Maluquer de Motes, S. Cooray, H. Ren, G.M.F. Almeida, K. McGourty,M.W. Bahar, D.I. Stuart, J.M. Grimes, S.C. Graham, G.L. Smith, UK

TWEAK/Fn14 Pathway in Colitis: Links to Interleukin-13-induced intestinalepithelial cell injury and promotion of chronic colitisL.C. Burkly, R. Kawashima, Y.I. Kawamura, T. Oshio, A. Son,M. Yamazaki, T. Hagiwara, T. Okada, P. Wu, S. Szak, Y.J. Kawamura,F. Konishi, O. Miyake, H. Yano, Y. Saito and T. Dohi, USA, Japan

Bounding Interferon Alpha To Apolipoprotein A-I: A Strategy To ReduceHematological Toxicity While Enhancing Immunostimulatory PropertiesJ. Fioravanti, I. González, J. Medina-Echeverz, E. Larrea, N. Ardaiz,G. González-Aseguinolaza, J. Prieto, P. Berraondo, Spain

Interferon stimulated gene 54 (ISG54) promotes apoptosisM. Stawowczyk, S. Van Scoy, K. Prasanna Kumar, N.C. Reich, USA

Cytokines, cell death and tumor suppression:a GRIM takes a central stageD.V. Kalvakolanu, S. Kalakonda, S.C. Nallar, D.J. Lindner, USA

17.00 Hall A - Closing Honorary LectureT helper 17 cellsSergio Romagnani, Italy

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GENERAL INFORMATION

Dates: 09-12 October 2011Congress Venue: Palazzo dei Congressi, Palazzo degli AffariFirenze, Italy (www.firenzefiera.it) - Piazza Adua 1 - 50123 Florence

REGISTRATION FEESThe registration fee for participants includes: congress bag, all congress materials,abstract book, daily coffee/tea, welcome reception.

General Registration On Site

MEMBERAcademic/Government Euro 500 NON MEMBERAcademic/Government Euro 700 Industry Euro 750 PhD Students (under 35)*Post-Doctarals (under 35)* Euro 300 Accompanying Guests** Euro 300

Opening Hours

Registration DeskThe Registration Desk is located in the Exhibition Area

Sunday 9 October 15:00-20:00Monday 10 October 08:30-19:30Tuesday 11 October 08:30-19:30Wednesday 12 October 08:30-19:30

Exhibition AreaSunday 9 October 15:00-20:00Monday 10 October 08:30-19:30Tuesday 11 October 08:30-19:30Wednesday 12 October 08:30-19:30

Registration Fees (Euro) VAT included*Graduate students (up to 35 years old & students): An official document prooving this statusand their age must be present to Registration Desk**Accompaning Guests fee includes: access to the Opening Ceremony and Welcome Reception atthe Palazzo dei Congressi, Palazzo degli Affari, Firenze, Italy

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Conference HallsExhibition AreaCoffee Breaks

Conference HallsCatering Area


FIRENZE FIERA - CONGRESS VENUE

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HOW TO REACH “FIRENZE FIERA”

BY PLANE - Florence International Airport “AmerigoVespucci” (connected to the main European cities) IATACODE: FLR www.aeroporto.firenze.itIt is located at 4 km (2.5 miles) from Florence and itcan be reached by taxi (20 minutes) or by the shuttlebus “Vola in bus”, a special connection service from/tothe Vespucci Airport and the Santa Maria Novella trainstation, jointly run by ATAF and SITA. For furtherinformation call “Pronto Ataf” toll free no. from Italy 800424500.

Pisa International Airport “Galileo Galilei” (connectedto the main European cities) IATA CODE: PSAwww.pisa-airport.itIt is located in Pisa, at 60 km (38 miles) from

Florence and it can be reached in 1 hour by train from the Santa Maria Novella trainstation, in Florence: three trains every hour for Pisa C.le and Pisa Airport from 06.00a.m. to 10.00 p.m.

BY CAR - An efficient motorway network connects Florence to the rest of Italy andEurope. Firenze Fiera is just at 4 km (2.5 miles) from the main Italian motorway (theA1: Autostrada del Sole - Exit Firenze Nord). Two large parking areas, respectivelyfor 600 and 800 cars, are just 100 meters away; another parking area for 400 carscan be reached by bus.

BY TRAIN - There are 4 train stations in Florence:• Santa Maria Novella Central Station: 80/100 meters from the “Palazzo deiCongressi” and from the “Palazzo degli Affari”, 50 meters from the “Fortezza da Basso”covering the access to railroad 16.• Rifredi: approximately 2 km (1.2 miles) away• Campo di Marte: 1,5 km ca.• Statuto

PUBLIC TRANSPORTATION - All town busses stop at “Piazza della Stazione”(Santa Maria Novella train station). Since they are just 50 meters far from the SantaMaria Novella train station, Firenze Fiera’s venues are within walking distance of anybus stop. In addition, a large number of bus services connect the centre of Florenceto its surroundings (Fiesole: ataf bus no. 7 - Settignano: Ataf bus no. 10).The regional coach lines (Cap, Lazzi, Sita) connect Florence to the other wonderfulTuscan cities such as San Gimignano, Pienza, Arezzo, Volterra, Forte dei Marmi,etc.


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BD BIOSCIENCES 18, 19

BIOLEGEND 22

CELL SIGNALING TECHONOLOGY 31

EBIOSCIENCE 26

GENPROBE 2

LIFETECHNOLOGY 8, 9

MERCK MILLIPORE 24

NANO INK 20

PBL INTERFERON SOURCE 30, 32

PEPROTECH 25

R&D SYSTEMS 27, 28

RANDOX 21

EXHIBITION AREA “PASSI PERDUTI”

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ORGANIZING SECRETARIAT

M.A.F. SERVIZI SrLCentro Direzionale Piero della Francesca - Corso Svizzera 185bis - 10149 Torino (Italy)

phone: ++ 39 011-505.900 fax: ++39 011-505.976e-mail: [email protected] web site: www.mafservizi.it

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9th JOINT MEETING OF ICS-ISICR CYTOKINES AND INTERFERONS ...cytokinesociety.org/wp-content/uploads/2016/11/A11_004_Definitive... · OF ICS-ISICR CYTOKINES AND INTERFERONS: FROM THE

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