9Carolyn Henry comparative oncology 2009.ppt

Oncology Research at the VMTH

Basic Science Research Graduate students and faculty are researching the

following areas Cancer Epidemiology as it relates to lymphoma,

skin tumors, pediatric cancer, mesothelioma, and gastrointestinal cancer

VMDB refined for MUMS classification Diagnostic Biomarkers for bladder cancer and

lymphoma Nuclear medicine and imaging of solid tumors

including lymphoma Developmental therapeutics – in vitro and in vivo

preclinical assessment of novel therapies Photoacoustic identification of tumor cells in lymph

nodes NEWS mutation assessment in Standard Poodles

Oncology Research at the VMTH

Current Clinical trials (client-owned pets): Satraplatin – new oral platinum chemotherapy agent Elsamitrucin – novel injectable chemotherapy agent with

lesser toxicity than similar drugs Intralesional yttrium and holmium - new

radiopharmaceutical technique to treat bone cancer SPI-1620- novel drug to increase blood flow (and drug

delivery) to tumors mTOR inhibitor to treat bone cancer that has

metastasized to lung Inhalant chemotherapy for primary and metastatic lung

cancer rhIL-2/IL-12 targeted therapy of melanoma Proteomic cancer screening – studies to identify

biomarkers for earlier cancer detection Comparative endoscopy- collaboration with Med School to

refine minimally-invasive tumor excision methods

Translational and Comparative Oncology

National Consortium Membership and Participation Comparative Oncology Trials Consortium –

translational research/clinical trial consortium under the NCI umbrella

Canine Comparative Oncology and Genomics Consortium – MU is one of seven institutions selected to participate in this biospecimen repository development