7th Annual Trendlines Company Showcasetrendlines.com/wp-content/uploads/Trendlines-7th-Annual...7th Annual Trendlines Company Showcase Keynote Speaker A passionate serial entrepreneur

7th Annual Trendlines Company Showcase29 March 2017 Shefayim, Israel

agtech labsmedical

As we celebrate our 10th year – and our 7th Showcase – we remain committed to our vision of “creating and developing companies that improve the human condition.”

Over the past decade – following our model of invention, investment, and incubation in combination with intense support – we’ve created an ecosystem that encourages curiosity and promotes collaboration.

And it works. Since 2007, we’ve established 75 medical and agricultural technology companies, completed 6 exits, and taken 2 companies public. Our companies have received more than 15 awards, and Trendlines Medical has twice been honored as Best Incubator.

Our Showcase today is only one of the 28 conferences and road shows we’ve organized in Israel, China, Singapore, and the United States. These events are a key part of supporting our portfolio companies by exposing them to investors and strategic partners around the world.

We look forward to speaking with you about how you can be involved with Trendlines and our portfolio companies.

We invite you to speak with our entrepreneurs, talk with Trendlines’ professionals, and meet others from the global investment community. We look forward to working with you as we enter our second decade of creating and developing companies to improve the human condition.

We extend our thanks and appreciation to our companies, sponsors, program participants, and shareholders, who, along with our staff, serve to make this, our 7th Showcase, a success.

Todd Dollinger and Steve RhodesChairmen and CEOs

Welcome to the 7th Annual Trendlines Company Showcase.

Todd Dollinger & Steve Rhodes, Chairmen and CEOs

We are “intense” investors. Our 40 staff members in Israel, China, and Singapore provide business and technology development, finance, marketing communications, and administrative support to our portfolio companies.

Trendlines Medical & Trendlines Agtech Management

Nitza Kardish, Ph.D. CEO Trendlines Incubators Israel

Yuval Almougy VP New Ventures, Trendlines Medical

Jonathan Henen VP Trendlines Agtech

Bayer Trendlines Ag Innovation Fund

Barak Singer VP Business Development,

Trendlines Medical

Sarai Kemp VP Business Development,

Trendlines Agtech

If you are a passionate

entrepreneur or interested investor,

contact us.

7th Annual Trendlines Company ShowcaseSchedule

Registration8:30

Welcome and introductions9:15

Keynote address: “Passion for Entrepreneurship,” by Uri Levine, serial entrepreneur and co-founder of Waze

9:30

The Trendlines investment formula, presented by VP New Ventures Trendlines Medical Yuval Almougy and VP Trendlines Agtech Jonathan Henen

10:15

Company presentations* by Escala Medical, MetoMotion, Zeev Implants, atTerm Medical, BioFishency

10:25

Break11:15

Company presentations* by Tandem Technologies, InPlant Technologies, OrthoSpin, Gordian Surgical

11:50

Networking and meetings with entrepreneurs12:30

Buffet lunch13:00

Each 5-minute presentation is followed by a one-on-one conversation between the company CEO and a guest interviewer.

*

7th Annual Trendlines Company ShowcaseKeynote Speaker

A passionate serial entrepreneur and disruptor, Uri Levine has been involved in the high-tech industry for the last 30 years, with half of those in the start-up scene. He has “seen everything” from failure to middle success, to extreme success. Uri’s consumer services-focused agenda has one objective: to “create a lot of value to a lot of users” like saving money and time and empowering the consumer. In other words, doing good and doing well.

He co-founded Waze, the world’s largest driving traffic and navigation app, with more than 250 million drivers around the globe, which was acquired by Google in June 2013 for more than $1.1 billion.

After Waze, Uri co-founded and remains the active chairman at FeeX, which “addresses the biggest secret in the world”: the $600 billion of financial fees that no one knows they’re paying. FeeX enables users to recover hundreds of thousands of dollars in retirement savings and long-term investment plans.

In addition to FeeX, Uri is a co-founder and board member in half a dozen start-ups.

Uri Levine,serial entrepreneur and co-founder of Waze

7th Annual Trendlines Company ShowcaseGuest Interviewers

Lior AviramPartner; Head of Hi-Tech Practice,

Shibolet & Co. Law Firm

Robert GrossmanShareholder; Co-Chair, Israel Practice,

Greenberg Traurig

Limor GanotManaging Partner,

Gefen Capital

Prof. Dr. Boris HofmannDirector, Business Development,

B. Braun (Aesculap Division)

7th Annual Trendlines Company ShowcaseGuest Interviewers

Morris Laster, M.D.Biomedical Entrepreneur, Medical

Venture Partner, OurCrowd

Marshall SonenshineManaging Partner and Founder,

Sonenshine Partners

Gerald Ong CEO,

PrimePartners Corporate Finance

Hedva Schickler, Ph.D.Partner, Webb & Co.

Barry SchindlerShareholder; Co-Chair, Global Patent

Prosecution Group, Greenberg Traurig

zhiyi

701 CBD International Plaza, No.16 Yong'andongli, Jianguomenwai Avenue, Chaoyang District, Beijing 100022, China

Tel: +8610 8513 1818 Fax: +8610 8513 1919 Email: [email protected]

Total number of partners: 20

Total number of lawyers: 80

Year established: 2004

Languages spoken: Chinese, English, Japanese and Korean

Broad & Bright is a PRC law firm which provides a full range of legal services to multinational companies and other clients. We are based in Beijing and have a branch office in Shanghai, Guangzhou, HongKong, Tokyo and Los Angeles. Our firm has a number of lawyers experienced in the areas of Foreign Direct Investment, Corporate, Mergers and Acquisitions, International Trade, Antitrust, Dispute Resolution, Private Equity and Venture Capital, Banking and Finance, Capital Markets, Outbound, Intellectual Property, Energy & Infrastructure, Employment, Anti-corruption, Real Estate, Construction, Tax and Healthcare. Our firm continuously keeps abreast of China's legislative developments in all areas and maintains constant and active dialogues with the Chinese legislatures and regulatory authorities for the benefits of our clients. www.broadbright.com

Beijing · Shanghai · Guangzhou · Hong Kong · Tokyo · Los Angeles

1

PrimePartners Corporate Finance offers a broad range of investment

banking services to a diverse corporate clientele. We partner aspiring and

growing companies to tap the public markets; propose underwriting solutions for

public offerings; plan fund raising methods for your needs; and provide strategic

advice for mergers and acquisitions.

Based in Singapore, PPCF undertakes advisory and capital-raising projects for both

local and international clients. Since its inception, PPCF has completed over 50

listings and over 200 advisory engagements.

PPCF is the exclusive Singapore partner of Discount Capital Markets, the

investment banking division of Discount Group in Israel, the third largest banking

group in Israel.

We devote ourselves to providing M&A and restructuring advisory services to late-stage companies in the Chinese healthcare sector as well as providing financial advisory service to innovative and high-growth firms in the same field. During the process of providing investment banking services to our clients, we also incubate and invest in global firms that match our investment philosophies.

In order to offer our clients with well-rounded capital solutions, we are also engaged in private placement funds, government economic zones, tax planning services, and other unique businesses.

We are a private financial institution, focused on two core businesses: boutique investment banking and private equity investment.

Our mission is to utilize finance as a tool to facilitate industry development.

Shoushan Wealth Holdings Co. Ltd.

Shoushan Wealth Holdings Co. Ltd.Address：No. 96, 1883 Huamu Road, Pudong District, Shoushan Wealth Club, Shanghai, China

Boutique Investment BankingWe screen and evaluate potential targets or merger partners in accor-dance with clients’ strategic devel-opment plans. We advise our clients on M&A strategy, structure, financ-ing, pricing, and we assist in negoti-ating and closing transactions, as well as formulating buyout funds as needed.

Private Equity InvestmentWe invest in global firms that have core competitive advantages, high growth potential, advanced technol-ogies which shelter firms from rivalry, and are free of major policy, legal, and financial risks. We strategically focus on the healthcare sector.


Att: Miranda Xu Fax: +86-10-84855280 E-mail: [email protected]

Our Clients





Our Clients





Our Clients





Our Clients





Our Clients

Sonenshine Partners is a leading investment banking

and financial advisory firm focused on providing clients

with the highest quality advice on mergers, acquisitions,

corporate finance and other strategic matters,

distinguished by the following characteristics:

significant transaction experience, deep industry

knowledge and relentless client advocacy.

sonenshinepartners.com

Thank youto our

Diamond sponsors

7th Annual Trendlines Company Showcase

Trendlines Medtech Open 2017

Winning company will win a prize packagevalued at $50,000.

Application deadline: 6 April 2017

For details, contact [email protected]

The Trendlines Portfolio CompaniesTrendlines Medical

Company Name Year Est. Description

ApiFix 2011 Minimally invasive device for adolescent scoliosis

Arcuro Medical 2013 All-suture, all-inside meniscus repair system

atTerm Medical 2017 Device to prevent preterm birth

BioSight prior to 2007 Cancer-targeted pharmaceuticals

Breezy 2008 Oral hygiene technology platform

Ceretrieve 2016 Device for treating ischemic stroke

CorAlert 2016 Noninvasive heart failure monitoring device

CoreBone 2011 Bioactive coral-based bone graft material

ElastiMed 2015 Easy-to-wear compression stockings from smart materials

Escala Medical 2014 Nonsurgical, incision-free pelvic organ prolapse treatment

Fidmi Medical 2014 Device for improved nutrition delivery

Gordian Surgical 2012 Novel integrated port closure system

Headway prior to 2007 Computer-controlled treatment table for relief of head and neck pain

IonMed 2009 Surgical wound closure and healing

LapSpace Medical 2011 Inflatable laparoscopic retractor

Leviticus Cardio 2010 Wireless coplanar ventricular assist energy transfer device

liberDi 2016 Advanced peritoneal dialysis device

Magdent 2010 Miniature electromagnetic dental implant device

Note: Companies in bold are our 10 most valuable companies (as at 31 December 2016).

The Trendlines Portfolio CompaniesTrendlines Medical


Nephera 2008 Protecting kidneys while treating patients with acute heart failure

NeuroQuest 2008 Simple blood test for early diagnosis of Alzheimer’s

OB Smart 2016 Cervical dilation and effacement measurement

Omeq Medical 2013 Smart epidural needle

OrthoSpin 2014 Smart external fixation system

ProArc Medical 2010 Minimally invasive solution for enlarged prostate

Seger Surgical Solutions

2016 Anastomotic closure device for laparoscopic bowel resection

Stimatix GI 2009 Low-profile colostomy appliances

ST Stent 2013 Removable stent after sinus surgery

sZone 2016 Real-time, noninvasive hydration monitor

Tandem Technologies

2015 Precise removal and retrieval of polyps in the colon

Vensica Medical 2014 Ultrasound-assisted overactive bladder drug-delivery treatment

VisiDome 2013 Accommodative intraocular lens

Zeev Implants 2015 Modular dental implants

ZygoFix 2016 Miniature screwless spinal fusion implant

The Trendlines Portfolio CompaniesTrendlines Agtech


AquiNovo 2016 Accelerated growth of farmed fish

BioFishency 2013 All-in-one water treatment system for aquaculture

EdenShield 2012 Nontoxic odor-masking insect control solutions

Enolog Technologies

2015 Automatic, real-time monitoring for improving wine quality

GreenSpense 2011 Propellant-free dispensing technology

Hargol FoodTech 2016 Optimized methods for growing grasshoppers

InPlant Technologies

2016 Increased mobility of agrochemical actives in plants

MemTech 2010 Advanced water filtration membranes

MetoMotion 2016 Multipurpose robotic system for greenhouse vegetable production

MiRobot 2011 Multi-stall automatic robotic milking system

Saturas 2013 Stem water potential sensor for optimal irrigation

Sol Chip 2009 Maintenance-free, everlasting solar battery

Valentis Nanotech 2013 Coating platform for food packaging, agtech, and more

ViAqua Therapeutics

2014 Feed-based aquaculture drug delivery

Virentes 2014 Automation and innovation in plant grafting

Note: Companies in bold are our 10 most valuable companies (as at 31 December 2016).

atTerm Medical

7th Annual Trendlines Company Showcase Trendlines Medical

David Shashar, M.D., Acting [email protected]

Founded2017

InvestorsThe Trendlines Group, Sheba Medical Center

StageIn formation

The needPreterm birth (delivery at 23 to 36 weeks of pregnancy) is the leading cause of newborn death and illness. Worldwide, 15 million babies annually are preterm. One million will die and another million will suffer from substantial life-long complications, including neurodevelopmental delays, breathing disorders, blindness, hearing loss, or cerebral palsy.

Obstetricians are at a loss regarding how to prevent spontaneous preterm birth. Treatments such as medications, stitching the cervix, and pessaries are unsuccessful.

The productatTerm Medical is developing the OBSPRING, a novel device positioned around the uterine cervix that behaves as a shock absorber, allows transient shortening and dilation of the cervix during contractions while restoring the cervix to its initial state when contractions subside. OBSPRING maintains the natural resistance of the cervix thus preventing preterm birth. The small, disposable device is positioned by the physician in the outpatient clinic and removed at term.

Developing a device to prevent preterm birth

7th Annual Trendlines Company Showcase Trendlines Agtech

www.trendlines.com [email protected]

BioFishency


Cobi Levanon, [email protected] Magen, [email protected] www.biofishency.com

Founded2013

InvestorsThe Trendlines Group

StageRevenue

The needAround the world, the demand for fish is increasing, while the supply from the sea and natural fisheries has stagnated. With the limited availability of land and water, the only way for aquaculture to meet the growing demand is through intensification: producing more fish per unit of area and water.

Technologies that improve water quality are required for intensification. Current water treatment systems support high fish densities, but are complex and very expensive, making them accessible to only the small segment of high-end growers.

The product The BioFishency system operates with all different aquaculture methods and enables fish growers to upgrade their existing facilities while using existing infrastructure and operations.

The BioFishency system is easy to install and enhances water conditions to enable adding more feed to increase fish production.

● 95% reduction in water use (intensive tanks) ● 2-5 fold increase in yields (extensive ponds) ● 2x nitrification (ammonia removal) for improved water quality

AchievementsBioFishency launched Asia sales, with installations in multiple countries.

Developing a cost-effective, all-in-one water treatment system for land-based aquaculture



Trendlines Medical

Escala Medical


Edit Goldberg, D.M.D., [email protected]

Founded2014


StageBusiness development

IP1 National phase (U.S., EU, China, Brazil); 1 provisional

The needPOP is a clinical condition that affects millions of women worldwide. Associated with physical, psychological, and sexual problems, POP has a significant impact on quality of life, and treatment options are limited.

The productEscala’s novel system presents a long-overdue repair option for women with mild to moderate POP. Escala’s approach mirrors a gold standard surgery-based repair to fixate the vaginal apex to the sacrospinous ligament (SSL) in a safe, quick outpatient procedure.

● Incision- and mesh-free ● Safe, quick, easy-to-perform fixation ● Restores anatomy and preserves pelvic organ functionality

Developing the first repair device for the treatment of pelvic organ prolapse (POP) based on a nonsurgical, incision-free, mesh-free repair approach

Trendlines Medical



Trendlines Medical

Gordian Surgical


Zvi Peer, [email protected]

Founded2012

InvestorsThe Trendlines Group, B. Braun, private investment funds (China and Canada), private investors, including key opinion leaders (surgeons)

StageRevenue

IP3 patents (2 issued U.S. patents, 1 National phase)

The needWhile laparoscopic surgeries are less invasive, closing abdominal access ports remains a difficult and time-consuming task. Today, surgeons manually suture ports with a needle and thread, adding up to 20 minutes per operation, or use a dedicated closure device, adding significantly to procedure cost and presenting safety problems.

The productInstead of inserting closure sutures in the fascia at the end of a procedure, Gordian’s uniquely designed “two-in-one” trocar automatically inserts sutures into the tissue surrounding the trocar at the beginning of the procedure. When the trocar is removed, the physician easily closes the fascia by tying the sutures.

● Simple: requires only minimal training ● Safe: reduced risk of organ damage ● Saves time: up to 20 minutes per operation

AchievementsThirteen U.S. surgeons completed 17 successful procedures in January 2017 using the Gordian Surgical system, marking the first time the system had been used in the United States and bringing the total number of surgeries to nearly 75. Procedures were performed at a number of U.S. hospitals, including Mount Sinai in New York and Cleveland Clinic in Ohio and Florida.

Developing a novel integrated port closure system

Trendlines Medical



InPlant Technologies


Lenore Shoham, [email protected]

Founded2017


StageTechnologydevelopment

Developing a platform delivery technology to increase the mobility of active agrochemical ingredients in plants

The needTo ensure sustainable food production, it is essential to reduce the amounts of chemicals used for crop protection and fertilizing while maintaining their beneficial effects on yields. A key challenge is to improve the uptake of the agrochemicals into the plant and their mobility inside the plant to move the active ingredients (AI) from the site of application (for example, leaf or root) to the location in the plant where they produce the needed action.

The productInPlant’s delivery platform is the first to address the mobility of AIs within the plant. The technology is based on submicronic liposomes used as a carrier to enhance uptake and dispersion of AIs throughout the plant. The liposomes are comprised of inexpensive, GRAS materials that are compatible with factors in the agriculture environment including spraying, UV, and water.

● Lower doses, possibly fewer applications ● Reduced use of toxic formulation additives ● New synergetic AI combinations (magnesium and iron)

in a single product ● New application routes

AchievementsSigned a collaboration agreement with a multinational company to develop advanced crop protection products.



MetoMotion


Adi Nir, [email protected]

Founded2016


StageTechnology development

The needThe use of greenhouses to grow vegetables is expanding to meet the increasing demand for quality produce year-round. With rising labor costs and difficulties in finding and maintaining qualified workers, growers are moving toward technology to reduce costs and improve production efficiency.

The productMetoMotion is developing a multipurpose robotic system for labor-intensive tasks in greenhouses to reduce the reliance on and high costs of human labor in greenhouse vegetable production. The system is being designed for easy operation and smooth integration into existing greenhouse practices.

MetoMotion’s robotic harvester components:

● Autonomous guided vehicle (AGV) ● Multiple robotic arms ● Advanced vision system ● Proprietary harvesting component tailored to the

specific vegetables

The Company’s first application will be a robotic harvester for greenhouse tomatoes.

Developing a novel, multipurpose robotic system for labor-intensive tasks to reduce reliance on costly human labor in greenhouse vegetable production



Trendlines Medical

OrthoSpin


The needExternal fixation devices are often the first line of treatment for lengthening bone, setting complex fractures, and correcting deformities. For treatment to be effective, patients manually adjust the frame by turning the struts (rods) up to four times per day to promote bone distraction (slowly moving two segments of bone apart) and healing.

Manual adjustments and complicated patient training often result in misuse and non-compliance that leads to increased pain, poor clinical outcomes, and repeat surgeries.

The productComprised of a strut powered by a lightweight motor and a control box placed on top of the circular, hexapod fixation frame, OrthoSpin’s smart system automatically and continuously adjusts and lengthens the struts according to the prescribed treatment regimen — without patient involvement.

Proprietary software program allows physicians to chart patient progress and easily change the treatment schedule.

● Highly accurate frame adjustments ● Reduced dependency on patient compliance ● Real-time feedback on progress ● Reduced revision surgeries

Developing a smart external fixation system to allow real-time physician follow-up and to reduce dependency on patient compliance

Oren Cohen, [email protected]

Founded2014



IP1 National phase (U.S., EU, China); 1 provisional



Trendlines Medical

Tandem Technologies


The needPolyps in the colon larger than 6 millimeters are usually removed using a wire loop (snare) that encircles and cuts the polyp. Due to polyp shape, size, and location, snares may not securely encircle and remove the entire polyp in a single step, leaving parts intact and increasing the risk of developing cancer. A second tool — a basket- or net-shaped retrieval device — is used to “catch” the resected polyp and remove it from the body. Locating and retrieving the resected polyp inside the long colon with its many bends and folds is challenging.

The productTandem Technologies has developed one device for precise polyp removal and retrieval. The Tandem Snare’s™ two wire loops work together to securely hold, precisely cut, and efficiently retrieve the polyp — all in one step. With the Company’s device, large polyps are removed in a single piece, reducing resections and increasing the retrieval rate.

● Simplifies the procedure and saves time ● Offers fast, precise placement of the snare’s loop on the polyp ● Enables complete polyp removal in one piece ● Improves pathology

Developing a single device for precise removal and retrieval of polyps in the colon

Noam Hassidov, Founder & [email protected]

Founded2015



IPPCT patent



Trendlines Medical

Zeev Implants

Pinchas Kfir, D.M.D., Founder & [email protected]

Founded2015



IPIsrael patent issued January 2015; National phase

The needPeri-implant disease is an irreversible, inflammatory condition that affects the soft and hard gum tissue around dental implants.

Current nonsurgical and surgical treatment options to stop the progression of bone loss and kill off the bacteria are only partially effective. Often the dentist must completely remove the implant and replace it with a new one.

The productZeev Implants’ unique dental implant is based on a modular design that consists of multiple sections (rings) that can easily connect or separate to achieve a customized length. When peri-implant disease develops, dentists can simply remove the bacteria-infected upper ring(s) of the implant and replace it with a new sterile ring(s).

● Prevents the need to extract the entire infected implant ● Gives dentists greater confidence ● Presents dental implant treatment as an option for patients

who may otherwise be rejected due to health risks such as diabetics and heavy smokers

Developing a unique dental implant based on a modular design that can easily connect or separate to achieve a custom length

Trendlines Medical7th Annual Trendlines Company Showcase

©2017 The Trendlines Group Ltd. All rights reserved.

The Trendlines Group Ltd.

The Trendlines BuildingMisgav Business Park M.P. Misgav 2017400 IsraelOffice +972.72.260.7000

[email protected]

www.trendlines.com

Creating and developing companies to improve the human condition

7th Annual Trendlines Company Showcasetrendlines.com/wp-content/uploads/Trendlines-7th-Annual...7th Annual Trendlines Company Showcase Keynote Speaker A passionate serial entrepreneur

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