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MEDICAL POLICY – 7.01.50
Placental and Umbilical Cord Blood as a Source of Stem
Cells BCBSA Ref. Policy: 7.01.50
Effective Date: April 1, 2020
Last Revised: March 19, 2020
Replaces: N/A
RELATED MEDICAL POLICIES:
None
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POLICY CRITERIA | DOCUMENTATION REQUIREMENTS | CODING
RELATED INFORMATION | EVIDENCE REVIEW | REFERENCES | HISTORY
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Introduction
Stem cells are cells in our body that have the ability to
develop into many different kinds of cells.
Stem cells have been used to treat many conditions including
such things as diabetes, heart
disease, arthritis, spinal cord injuries, and some types of
cancer.
Stem cells are found in embryos, adults, and the umbilical cords
of newborn babies. They are
also found in the placenta (the “after birth”) of a pregnant
woman. Stem cells that have been
retrieved from the placenta or umbilical cord have been
transplanted into patients in order to
treat some specific diseases. This policy discusses when the
transplantation of placental or
umbilical cord stem cells might be considered to be medically
necessary.
Note: The Introduction section is for your general knowledge and
is not to be taken as policy coverage criteria. The
rest of the policy uses specific words and concepts familiar to
medical professionals. It is intended for
providers. A provider can be a person, such as a doctor, nurse,
psychologist, or dentist. A provider also can
be a place where medical care is given, like a hospital, clinic,
or lab. This policy informs them about when a
service may be covered.
Policy Coverage Criteria
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Service Medical Necessity Transplantation of cord
blood stem cells
Transplantation of cord blood stem cells from related or
unrelated donors may be considered medically necessary in
patients with an appropriate indication for allogeneic stem
cell
transplant.
Transplantation of cord blood stem cells from related or
unrelated donors is considered investigational in all other
situations.
Collection and storage of
cord blood
Collection and storage of cord blood from a neonate may be
considered medically necessary when an allogeneic transplant
is imminent in an identified recipient with a diagnosis that
is
consistent with the possible need for allogeneic transplant.
Prophylactic collection and
storage of cord blood
Prophylactic collection and storage of cord blood from a
neonate may be considered not medically necessary when
proposed for some unspecified future use as an autologous
stem cell transplant in the original donor, or for some
unspecified future use as an allogeneic stem cell transplant in
a
related or unrelated donor.
Documentation Requirements The patient’s medical records
submitted for review for all conditions should document that
medical necessity criteria are met. The record should include
the following:
• For the use of the of stem cells retrieved from the umbilical
cord and placenta:
o Documentation that the stem cells will be used in patients who
qualify for a stem cell
transplant using donor cells
• For collection and storage of cord blood:
o Documentation that a transplant using donor cells is imminent
for a person diagnosed with
a disease that can be treated by using donor cells
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Coding
Code Description
HCPCS
S2140 Cord blood harvesting for transplantation, allogeneic
S2142 Cord blood-derived stem-cell transplantation,
allogeneic
S2150 Bone marrow or blood-derived stem-cells (peripheral or
umbilical), allogeneic or
autologous, harvesting, transplantation, and related
complications; including: pheresis
and cell preparation/storage; marrow ablative therapy; drugs,
supplies, hospitalization
with outpatient follow-up; medical/surgical, diagnostic,
emergency, and rehabilitative
services; and the number of days of pre-and post-transplant care
in the global
definition
Note: CPT codes, descriptions and materials are copyrighted by
the American Medical Association (AMA). HCPCS
codes, descriptions and materials are copyrighted by Centers for
Medicare Services (CMS).
Related Information
Benefit Application
Through the National Marrow Donor Program’s Be the Match,
eligible families within the United
States can collect and store their neonate’s cord blood unit
free of charge. When the stored unit
is transplanted, a fee is charged. A family is considered
eligible if:
• The sibling of the neonate has been diagnosed with a disease
treatable by a related cord
blood transplant
• The neonate does not have the same disease as the affected
biological sibling (determined
after birth)
• The affected sibling and the neonate have the same biological
parents
OR
• An affected biological parent is enrolled in a clinical or
research trial that would accept a
haploidentical, related, allogeneic cord blood unit as a
treatment option
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Evidence Review
Description
This policy addresses the collection, storage, and
transplantation of placental and umbilical cord
blood (“cord blood”) as a source of stem cells for allogeneic
and autologous stem cell
transplantation. Potential indications for the use of cord blood
are not addressed in this policy.
Background
Hematopoietic Cell Transplantation
HCT is a procedure in which hematopoietic stem cells are
intravenously infused to restore bone
marrow and immune function in cancer patients who receive bone
marrow-toxic doses of
cytotoxic drugs with or without whole-body radiotherapy.
Hematopoietic stem cells may be
obtained from the transplant recipient (autologous HCT) or a
donor (allogeneic HCT [allo-HCT]).
They can be harvested from bone marrow, peripheral blood, or
umbilical cord blood shortly
after delivery of neonates. Cord blood transplantation is
discussed in detail in a separate policy.
Immunologic compatibility between infused hematopoietic stem
cells and the recipient is not an
issue in autologous HCT. In allogeneic stem cell
transplantation, immunologic compatibility
between donor and patient is a critical factor for achieving a
successful outcome. Compatibility
is established by typing of human leukocyte antigens (HLA) using
cellular, serologic, or
molecular techniques. HLA refers to the gene complex expressed
at the HLA-A, -B, and -DR
(antigen-D related) loci on each arm of chromosome six. An
acceptable donor will match the
patient at all or most of the HLA loci.
Conditioning for Hematopoietic Cell Transplantation
Conventional Conditioning
The conventional (“classical”) practice of allo-HCT involves
administration of cytotoxic agents
(eg, cyclophosphamide, busulfan) with or without total body
irradiation at doses sufficient to
cause bone marrow ablation in the recipient. The beneficial
treatment effect of this procedure is
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due to a combination of the initial eradication of malignant
cells and subsequent graft-versus-
malignancy effect mediated by non-self-immunologic effector
cells. While the slower graft-
versus-malignancy effect is considered the potentially curative
component, it may be
overwhelmed by existing disease in the absence of pretransplant
conditioning. Intense
conditioning regimens are limited to patients who are
sufficiently medically fit to tolerate
substantial adverse effects. These include opportunistic
infections secondary to loss of
endogenous bone marrow function and organ damage or failure
caused by cytotoxic drugs.
Subsequent to graft infusion in allo-HCT, immunosuppressant
drugs are required to minimize
graft rejection and graft-versus-host disease, which increases
susceptibility to opportunistic
infections.
The success of autologous HCT is predicated on the potential of
cytotoxic chemotherapy, with
or without radiotherapy, to eradicate cancerous cells from the
blood and bone marrow. This
permits subsequent engraftment and repopulation of the bone
marrow with presumably normal
hematopoietic stem cells obtained from the patient before
undergoing bone marrow ablation.
Therefore, autologous HCT is typically performed as
consolidation therapy when the patient’s
disease is in complete remission. Patients who undergo
autologous HCT are also susceptible to
chemotherapy-related toxicities and opportunistic infections
before engraftment, but not graft-
versus-host disease.
Reduced-Intensity Conditioning Allogeneic Hematopoietic Cell
Transplantation
RIC refers to the pretransplant use of lower doses of cytotoxic
drugs or less intense regimens of
radiotherapy than are used in traditional full-dose
myeloablative conditioning treatments.
Although the definition of RIC is variable, with numerous
versions employed, all regimens seek
to balance the competing effects of relapse due to residual
disease and non-relapse mortality.
The goal of RIC is to reduce disease burden and to minimize
associated treatment-related
morbidity and non-relapse mortality in the period during which
the beneficial graft-versus-
malignancy effect of allogeneic transplantation develops. RIC
regimens range from nearly total
myeloablative to minimally myeloablative with lymphoablation,
with intensity tailored to specific
diseases and patient condition. Patients who undergo RIC with
allo-HCT initially demonstrate
donor cell engraftment and bone marrow mixed chimerism. Most
will subsequently convert to
full-donor chimerism. In this review, the term reduced-intensity
conditioning will refer to all
conditioning regimens intended to be nonmyeloablative.
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Summary of Evidence
For individuals who have an appropriate indication for
allogeneic stem cell transplant who
receive cord blood as a source of stem cells, the evidence
includes a number of observational
studies, a meta-analysis of observational studies, and a
randomized controlled trial (RCT)
comparing outcomes after single- or double-cord blood units. The
relevant outcomes are
overall survival, disease-specific survival, resource
utilization, and treatment-related mortality.
The meta-analysis of observational studies found similar
survival outcomes and lower graft-
versus-host disease after cord blood transplantation than bone
marrow transplantation. In the
RCT, survival rates were similar after single- and double-unit
cord blood transplantation. The
evidence is sufficient to determine that the technology results
in a meaningful improvement in
the net health outcome.
For individuals who have an unspecified potential future need
for stem cell transplant who
receive prophylactic collection and storage of cord blood, the
evidence includes no published
studies. The relevant outcomes are overall survival,
disease-specific survival, resource utilization,
and treatment-related mortality. No evidence was identified on
the safety or effectiveness of
autologous cord blood transplantation from prophylactically
stored cord blood for the
treatment of malignant neoplasms. The evidence is insufficient
to determine the effects of the
technology on health outcomes.
Ongoing and Unpublished Clinical Trials
Some currently unpublished trials that might influence this
review are listed in Table 1.
Table 1. Summary of Key Trials
NCT No. Trial Name Planned
Enrollment
Completion
Date
Ongoing
NCT01728545 The Collection and Storage of Umbilical Cord Blood
for
Transplantation
250,000 Apr 2099
NCT00012545 Collection and Storage of Umbilical Cord Stem Cells
for
Treatment of Sickle Cell Disease
99,999,999 Not reported
NCT: national clinical trial
https://www.clinicaltrials.gov/ct2/show/NCT01728545?term=NCT01728545&rank=1https://www.clinicaltrials.gov/ct2/show/NCT00012545?term=NCT00012545&rank=1
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Practice Guidelines and Position Statements
American Academy of Pediatrics
A position statement on cord blood banking for potential future
transplantation was published
by the American Academy of Pediatrics in 2017.22 The Academy
recommended cord blood
banking for public use, with a more limited role for private
cord blood banking for families with
a known fatal illness that could be rescued by cord blood
transplant.
American College of Obstetricians and Gynecologists
The American College of Obstetricians and Gynecologists (2015;
updated 2019) published an
opinion on umbilical cord blood (UCB) banking.24 The statement
discussed counseling patients
about options for UBC banking, as well as benefits and
limitations of this practice. The relevant
recommendations include the following:
• “[UCB] collected from a neonate cannot be used to treat a
genetic disease or malignancy in
that same individual.”
• The routine collection and storage of [UCB] with a private
cord blood bank is not supported
by the available evidence.
• “Private [UCB] banking may be considered when there is
knowledge of a family member with
a medical condition (malignant or genetic) who could potentially
benefit from cord blood
transplantation.”
• “Public [UCB] banking is the recommended method of obtaining
[UBC] for use in
transplantation, immune therapies, or other medically validated
indications.”
• “Umbilical cord blood collection should not compromise
obstetric or neonatal care or alter
routine practice for the timing of umbilical cord clamping.”
• “The current indications for cord blood transplant are limited
to select genetic, hematologic,
and malignant disorders.”
• “If a patient requests information about [UCB] banking,
balanced and accurate information
regarding the advantages and disadvantages of public and private
[UCB] banking should be
provided.”
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American Society for Blood and Marrow Transplantation
On behalf of the American Society for Blood and Marrow
Transplantation, Ballen et al (2008)
published recommendations related to the banking of umbilical
cord blood25.
• Public banking of cord blood is “encouraged.”
• Storing cord blood for autologous (ie, personal) use is “not
recommended.”
• “Family member banking (collecting and storing cord blood for
a family member) is
recommended when there is a sibling with a disease that may be
successfully treated with an
allogeneic transplant. Family member banking on behalf of a
parent with a disease that may
be successfully treated with an allogeneic transplant is only
recommended when there are
shared HLA [human leukocyte-antigens] between the parents.”
Medicare National Coverage
There is no national coverage determination.
Regulatory Status
According to the U.S. Food and Drug Administration, cord blood
stored for potential use by a
patient unrelated to the donor meets the definitions of “drug”
and “biological products.” As
such, products must be licensed under a biologics license
application or an investigational new
drug application before use. Facilities that prepare cord blood
units only for autologous and/or
first- or second-degree relatives are required to register and
list their products, adhere to Good
Tissue Practices issued by the Food and Drug Administration, and
use applicable processes for
donor suitability determination.1
References
1. Food and Drug Administration (FDA). Cord Blood Banking:
Information for Consumers. 2012 July 23;
http://www.fda.gov/biologicsbloodvaccines/resourcesforyou/consumers/ucm236044.htm
Accessed March 2020.
2. Blue Cross and Blue Shield Association Technology Evaluation
Center (TEC). Placental and Umbilical Cord Blood as a Source of
Stem Cells for Hematopoietic Support. TEC Assessments.
1996;Volume 11:Tab 17.
http://www.fda.gov/biologicsbloodvaccines/resourcesforyou/consumers/ucm236044.htm
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Page | 9 of 12 ∞
3. Blue Cross and Blue Shield Association Technology Evaluation
Center (TEC). Transplanting Adult Patients with Hematopoietic
Stem Cells from Placental and Umbilical Cord Blood TEC
Assessments. 2001;Volume 16:Tab 17.
4. Wall DA. Regulatory issues in cord blood banking and
transplantation. Best Pract Res Clin Haematol. Jun
2010;23(2):171-177.
PMID 20837328
5. NetCord-FACT. International standards for cord blood
collection banking and release of information accreditation manual.
Sixth
Edition Draft. 2015 September;
http://www.factwebsite.org/uploadedFiles/Standards/NetCord%20FACT%206th%20Ed%20Manual%20Draft.09.01.15.p
df Accessed March 2020.
6. Gluckman E, Broxmeyer HA, Auerbach AD, et al. Hematopoietic
reconstitution in a patient with Fanconi's anemia by means of
umbilical-cord blood from an HLA-identical sibling. N Engl J
Med. Oct 26 1989;321(17):1174-1178. PMID 2571931
7. Wagner JE, Rosenthal J, Sweetman R, et al. Successful
transplantation of HLA-matched and HLA-mismatched umbilical
cord
blood from unrelated donors: analysis of engraftment and acute
graft-versus-host disease. Blood. Aug 1 1996;88(3):795-802.
PMID 8704232
8. Broxmeyer HE, Douglas GW, Hangoc G, et al. Human umbilical
cord blood as a potential source of transplantable
hematopoietic stem/progenitor cells. Proc Natl Acad Sci U S A.
May 1989;86(10):3828-3832. PMID 2566997
9. Kurtzberg J, Cairo MS, Fraser JK, et al. Results of the Cord
Blood Transplantation (COBLT) study unrelated donor banking
program. Transfusion. Jun 2005;45(6):842-855. PMID 15934981
10. Martin PL, Carter SL, Kernan NA, et al. Results of the Cord
Blood Transplantation Study (COBLT): outcomes of unrelated
donor
umbilical cord blood transplantation in pediatric patients with
lysosomal and peroxisomal storage diseases. Biol Blood Marrow
Transplant. Feb 2006;12(2):184-194. PMID 16443516
11. Kurtzberg J. Update on umbilical cord blood transplantation.
Curr Opin Pediatr. Feb 2009;21(1):22-29. PMID 19253461
12. Zhang H, Chen J, Que W. Meta-analysis of unrelated donor
umbilical cord blood transplantation versus unrelated donor
bone
marrow transplantation in acute leukemia patients. Biol Blood
Marrow Transplant. Aug 2012;18(8):1164-1173. PMID 22289799
13. Rocha V, Cornish J, Sievers EL, et al. Comparison of
outcomes of unrelated bone marrow and umbilical cord blood
transplants in
children with acute leukemia. Blood. May 15
2001;97(10):2962-2971. PMID 11342418
14. Kato K, Choi I, Wake A, et al. Treatment of patients with
adult T cell leukemia/lymphoma with cord blood transplantation:
a
Japanese nationwide retrospective survey. Biol Blood Marrow
Transplant. Dec 2014;20(12):1968-1974. PMID 25172635
15. Liu HL, Sun ZM, Geng LQ, et al. Similar survival, but better
quality of life after myeloablative transplantation using
unrelated
cord blood vs matched sibling donors in adults with hematologic
malignancies. Bone Marrow Transplant. Aug 2014;49(8):1063-
1069. PMID 24842525
16. Mo XD, Tang BL, Zhang XH, et al. Comparison of outcomes
after umbilical cord blood and unmanipulated haploidentical
hematopoietic stem cell transplantation in children with
high-risk acute lymphoblastic leukemia. Int J Cancer. Nov 1
2016;139(9):2106-2115. PMID 27356906
17. Hsu J, Artz A, Mayer SA, et al. Combined Haploidentical and
Umbilical Cord Blood Allogeneic Stem Cell Transplantation for
High-Risk Lymphoma and Chronic Lymphoblastic Leukemia. Biol
Blood Marrow Transplant. Feb 2018;24(2):359-365. PMID
29128555
18. Barker JN, Weisdorf DJ, DeFor TE, et al. Transplantation of
2 partially HLA-matched umbilical cord blood units to enhance
engraftment in adults with hematologic malignancy. Blood. Feb 1
2005;105(3):1343-1347. PMID 15466923
19. Wagner JE, Jr., Eapen M, Carter S, et al. One-unit versus
two-unit cord-blood transplantation for hematologic cancers. N Engl
J
Med. Oct 30 2014;371(18):1685-1694. PMID 25354103
20. Scaradavou A, Brunstein CG, Eapen M, et al. Double unit
grafts successfully extend the application of umbilical cord
blood
transplantation in adults with acute leukemia. Blood. Jan 31
2013;121(5):752-758. PMID 23223509
http://www.factwebsite.org/uploadedFiles/Standards/NetCord%20FACT%206th%20Ed%20Manual%20Draft.09.01.15.pdfhttp://www.factwebsite.org/uploadedFiles/Standards/NetCord%20FACT%206th%20Ed%20Manual%20Draft.09.01.15.pdf
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Page | 10 of 12 ∞
21. Baron F, Ruggeri A, Beohou E, et al. Single- or double-unit
UCBT following RIC in adults with AL: a report from Eurocord,
the
ALWP and the CTIWP of the EBMT. J Hematol Oncol. Jun 21
2017;10(1):128. PMID 28637512
22. Shearer WT, Lubin BH, Cairo MS, et al. Cord Blood Banking
for Potential Future Transplantation. Pediatrics. Nov
2017;140(5).
PMID 29084832
23. Thornley I, Eapen M, Sung L, et al. Private cord blood
banking: experiences and views of pediatric hematopoietic cell
transplantation physicians. Pediatrics. Mar
2009;123(3):1011-1017. PMID 19255033
24. ACOG committee opinion no. 771: umbilical cord banking.
Obstet Gynecol. 2019 Mar;133(3):e249e253. PMID: 30801478.
25. Ballen KK, Barker JN, Stewart SK, et al. Collection and
preservation of cord blood for personal use. Biol Blood Marrow
Transplant. Mar 2008;14(3):356-363. PMID 18275904
History
Date Comments 05/05/97 Add to Surgery Section - New Policy
04/09/02 Replace policy - Policy updated and revised based on
2001 TEC Assessment; cord
blood as a source of stem cells no longer restricted to
children, considered medically
necessary in adults.
09/12/03 Replace policy - Policy updated; statement added about
storing cord blood stem cells
for later possible use as autologous transplant.
06/09/06 Disclaimer and Scope update - No other changes.
12/11/07 Replace policy - Reviewed with literature search; no
change to policy statement;
references added. Reviewed and recommended by OAP on November
15, 2007.
05/13/08 Cross Reference Update - No other changes
12/08/09 Replace policy - Reviewed with literature search; no
change to policy statement;
Reviewed by OAP November 2009. Benefit Application language
regarding storage
added.
08/10/10 Replace policy - Policy updated with literature review
and extensive revisions.
References 1, 2 and 5-19 have been added. The intent of the
policy statements has not
changed.
11/10/11 Replace policy – Policy updated with literature review;
policy statement unchanged.
References 3 and 4 added. Related Policies updated.
01/25/12 Code 38232 added.
09/10/12 Update Related Policy – Remove 7.01.503 as it was
deleted; Add 8.01.21 and 8.01.22.
ICD-10 codes are now effective 10/01/2014.
10/01/12 Update Related Policies – Add 8.01.20, 8.01.29,
8.01.23, 8.01.27, 8.01.28, 8.01.30.
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Date Comments 10/26/12 Update Related Policies. Add 8.01.26.
12/19/12 Replace policy. Policy updated with literature review;
policy statements unchanged.
References 5, 9-11 added. Add Related Policies 8.01.24, 8.01.31
and 8.01.35.
02/01/13 Update Related Policies, change title of policy
8.01.21.
02/15/13 Update Related Policies, change title of policy
8.01.30.
07/25/13 Update Related Policies. Change title of policy
8.01.35, add 8.01.511.
09/30/13 Update Related Policies. Change title of policy
8.01.31.
12/04/13 Replace policy. Rationale updated based on a literature
review through July 25, 2013.
References 4, 5, 19, 20, 26, 29, 30 added; others renumbered or
removed. Policy
statements unchanged.
01/20/14 Update Related Policies. Change title to 8.01.21.
02/27/14 Update Related Policies. Change title to 8.01.30.
03/21/14 Update Related Policies. Add 8.01.15 and delete
8.01.514.
04/18/14 Update Related Policies. Delete 8.01.20 and add
8.01.529.
06/24/14 Update Related Policies. Delete 8.01.35, 8.01.42 and
8.01.54, then add 8.01.530,
8.01.531 and 8.01.532.
11/20/14 Annual Review. Policy updated with literature review
through July 21, 2014. Policy
statements unchanged. References 4, 16-17, and 23 added. ICD-9
and ICD-10
procedure codes removed; these are not utilized in adjudication
of the policy.
11/10/15 Annual Review. Policy updated with literature review
through August 10, 2015;
reference 23 added. Policy statements unchanged.
03/08/16 Annual Review. Policy updated with literature review
through December 6, 2015;
reference 27 added. Policy statements unchanged.
08/09/16 Update Related Policies. Remove 8.01.27 as it was
archived.
03/14/17 Annual review. Policy updated with literature review
through November 9, 2016;
references 17 and 23 added. Removed Related Policies. Removed
CPT codes 38232
and 38240. Policy statements unchanged.
10/27/17 Policy moved to new format; no change to policy
statements.
04/01/18 Annual Review, approved March 20, 2018. Policy updated
with literature review
through November 2017; references 20-21 added; note 2 updated.
Policy statements
unchanged.
08/01/19 Annual Review, approved July 25, 2019. Policy updated
with literature review through
November 2018; reference 17 added. Policy statements
unchanged.
04/01/20 Annual Review, approved March 19, 2020. Policy updated
with literature review
through November 2019; no references added. Policy statements
unchanged.
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Page | 12 of 12 ∞
Disclaimer: This medical policy is a guide in evaluating the
medical necessity of a particular service or treatment. The
Company adopts policies after careful review of published
peer-reviewed scientific literature, national guidelines and
local standards of practice. Since medical technology is
constantly changing, the Company reserves the right to review
and update policies as appropriate. Member contracts differ in
their benefits. Always consult the member benefit
booklet or contact a member service representative to determine
coverage for a specific medical service or supply.
CPT codes, descriptions and materials are copyrighted by the
American Medical Association (AMA). ©2020 Premera
All Rights Reserved.
Scope: Medical policies are systematically developed guidelines
that serve as a resource for Company staff when
determining coverage for specific medical procedures, drugs or
devices. Coverage for medical services is subject to
the limits and conditions of the member benefit plan. Members
and their providers should consult the member
benefit booklet or contact a customer service representative to
determine whether there are any benefit limitations
applicable to this service or supply. This medical policy does
not apply to Medicare Advantage.
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የ Premera Blue Cross ሽፋን አስፈላጊ መረጃ ሊኖረው ይችላል። በዚህ ማስታወቂያ ውስጥ ቁልፍ
ቀኖች ሊኖሩ ይችላሉ። የጤናን ሽፋንዎን ለመጠበቅና በአከፋፈል እርዳታ ለማግኘት በተውሰኑ የጊዜ ገደቦች
እርምጃ መውሰድ ይገባዎት ይሆናል። ይህን መረጃ እንዲያገኙ እና ያለምንም ክፍያ በቋንቋዎ እርዳታ እንዲያገኙ
መብት አለዎት።በስልክ ቁጥር 800-722-1471 (TTY: 800-842-5357) ይደውሉ።
( ةالعربي :(. امةھ ماتولعم اإلشعار ھذا يحوي
خالل من ھاعلي صولحلا تريد لتيا التغطيةلل أو ةصحيلاكطيتتغ لىع
اظلحفل نةعيم يخراوت في إجراء خاذتال تحتاج وقد .اإلشعار ھذا في
تكلفة أية بدتك دون بلغتك مساعدةوال تاوملالمع ھذه على ولحصال لك
يحق .800-722-1471 (TTY: 800-842-5357)
أو طلبك وصخصب مةمھ ماتوعلم عارشإلا ھذا ويحي قدةمھم يخراوت ھناك
تكون قد .Premera Blue Cross
اعدةمس تصلايفكالتال دفع فيبـ
.
Arabic
Oromoo (Cushite): Beeksisni kun odeeffannoo barbaachisaa qaba.
Beeksisti kun sagantaa yookan karaa Premera Blue Cross tiin
tajaajila keessan ilaalchisee odeeffannoo barbaachisaa qabaachuu
danda’a. Guyyaawwan murteessaa ta’an beeksisa kana keessatti
ilaalaa. Tarii kaffaltiidhaan deeggaramuuf yookan tajaajila fayyaa
keessaniif guyyaa dhumaa irratti wanti raawwattan jiraachuu
danda’a. Kaffaltii irraa bilisa haala ta’een afaan keessaniin
odeeffannoo argachuu fi deeggarsa argachuuf mirga ni qabaattu.
Lakkoofsa bilbilaa 800-722-1471 (TTY: 800-842-5357) tii
bilbilaa.
Français (French): Cet avis a d'importantes informations. Cet
avis peut avoir d'importantes informations sur votre demande ou la
couverture par l'intermédiaire de Premera Blue Cross. Le présent
avis peut contenir des dates clés. Vous devrez peut-être prendre
des mesures par certains délais pour maintenir votre couverture de
santé ou d'aide avec les coûts. Vous avez le droit d'obtenir cette
information et de l’aide dans votre langue à aucun coût. Appelez le
800-722-1471 (TTY: 800-842-5357).
Kreyòl ayisyen (Creole): Avi sila a gen Enfòmasyon Enpòtan
ladann. Avi sila a kapab genyen enfòmasyon enpòtan konsènan
aplikasyon w lan oswa konsènan kouvèti asirans lan atravè Premera
Blue Cross. Kapab genyen dat ki enpòtan nan avi sila a. Ou ka gen
pou pran kèk aksyon avan sèten dat limit pou ka kenbe kouvèti
asirans sante w la oswa pou yo ka ede w avèk depans yo. Se dwa w
pou resevwa enfòmasyon sa a ak asistans nan lang ou pale a, san ou
pa gen pou peye pou sa. Rele nan 800-722-1471 (TTY:
800-842-5357).
Deutsche (German): Diese Benachrichtigung enthält wichtige
Informationen. Diese Benachrichtigung enthält unter Umständen
wichtige Informationen bezüglich Ihres Antrags auf
Krankenversicherungsschutz durch Premera Blue Cross. Suchen Sie
nach eventuellen wichtigen Terminen in dieser Benachrichtigung. Sie
könnten bis zu bestimmten Stichtagen handeln müssen, um Ihren
Krankenversicherungsschutz oder Hilfe mit den Kosten zu behalten.
Sie haben das Recht, kostenlose Hilfe und Informationen in Ihrer
Sprache zu erhalten. Rufen Sie an unter 800-722-1471 (TTY:
800-842-5357).
Hmoob (Hmong): Tsab ntawv tshaj xo no muaj cov ntshiab lus tseem
ceeb. Tej zaum tsab ntawv tshaj xo no muaj cov ntsiab lus tseem
ceeb txog koj daim ntawv thov kev pab los yog koj qhov kev pab cuam
los ntawm Premera Blue Cross. Tej zaum muaj cov hnub tseem ceeb uas
sau rau hauv daim ntawv no. Tej zaum koj kuj yuav tau ua qee yam
uas peb kom koj ua tsis pub dhau cov caij nyoog uas teev tseg rau
hauv daim ntawv no mas koj thiaj yuav tau txais kev pab cuam kho
mob los yog kev pab them tej nqi kho mob ntawd. Koj muaj cai kom
lawv muab cov ntshiab lus no uas tau muab sau ua koj hom lus pub
dawb rau koj. Hu rau 800-722-1471 (TTY: 800-842-5357).
Iloko (Ilocano): Daytoy a Pakdaar ket naglaon iti Napateg nga
Impormasion. Daytoy a pakdaar mabalin nga adda ket naglaon iti
napateg nga impormasion maipanggep iti apliksayonyo wenno coverage
babaen iti Premera Blue Cross. Daytoy ket mabalin dagiti importante
a petsa iti daytoy a pakdaar. Mabalin nga adda rumbeng nga
aramidenyo nga addang sakbay dagiti partikular a naituding nga
aldaw tapno mapagtalinaedyo ti coverage ti salun-atyo wenno tulong
kadagiti gastos. Adda karbenganyo a mangala iti daytoy nga
impormasion ken tulong iti bukodyo a pagsasao nga awan ti
bayadanyo. Tumawag iti numero nga 800-722-1471 (TTY:
800-842-5357).
Italiano ( ):Questo avviso contiene informazioni importanti.
Questo avviso può contenere informazioni importanti sulla tua
domanda o copertura attraverso Premera Blue Cross. Potrebbero
esserci date chiave in questo avviso. Potrebbe essere necessario un
tuo intervento entro una scadenza determinata per consentirti di
mantenere la tua copertura o sovvenzione. Hai il diritto di
ottenere queste informazioni e assistenza nella tua lingua
gratuitamente. Chiama 800-722-1471 (TTY: 800-842-5357).
Italian
中文 (Chinese):本通知有重要的訊息。本通知可能有關於您透過 Premera Blue Cross
提交的申請或保險的重要訊息。本通知內可能有重要日期。您可能需要在截止日期
之前採取行動,以保留您的健康保險或者費用補貼。您有權利免費以您的母
語得到本訊息和幫助。請撥電話 800-722-1471 (TTY: 800-842-5357)。
037338 (07-2016)
https://www.hhs.gov/ocr/office/file/index.htmlhttps://ocrportal.hhs.gov/ocr/portal/lobby.jsfmailto:[email protected]
-
日本語 (Japanese):この通知には重要な情報が含まれています。この通知には、 Premera Blue
Crossの申請または補償範囲に関する重要な情報が含まれている場合があります。この通知に記載されている可能性がある重要な日付をご確認くだ
さい。健康保険や有料サポートを維持するには、特定の期日までに行動を
取らなければならない場合があります。ご希望の言語による情報とサポー
トが無料で提供されます。800-722-1471 (TTY: 800-842-5357)までお電話ください。
한국어 (Korean): 본 통지서에는 중요한 정보가 들어 있습니다 . 즉 이 통지서는 귀하의 신청에 관하여 그리고
Premera Blue Cross 를 통한 커버리지에 관한 정보를 포함하고 있을 수 있습니다 . 본 통지서에는 핵심이
되는 날짜들이 있을 수 있습니다. 귀하는 귀하의 건강 커버리지를 계속 유지하거나 비용을 절감하기 위해서 일정한 마감일까지
조치를 취해야 할 필요가 있을 수 있습니다 . 귀하는 이러한 정보와 도움을 귀하의 언어로 비용 부담없이 얻을 수 있는
권리가 있습니다 . 800-722-1471 (TTY: 800-842-5357) 로 전화하십시오 .
ລາວ (Lao): ແຈ້ງການນີ້ ນສໍ າຄັນ. ແຈ້ງການນີ້ອາດຈະມີ ນສໍ
າຄັນກ່ຽວກັບຄໍ າຮ້ອງສະ ກ ຫຼື ຄວາມຄຸ້ມຄອງປະກັນໄພຂອງທ່ານຜ່ານ Premera
Blue Cross. ອາດຈະມີ ນທີ າຄັນໃນແຈ້ງການນີ້. ທ່ານອາດຈະຈໍ າເປັ ນຕ້ອງດໍ
າເນີ ນການຕາມກໍ ານົດ ເວລາສະເພາະເພື່ອຮັກສາຄວາມຄຸ້ມຄອງປະກັນສຸຂະພາບ ຫຼື
ຄວາມຊ່ວຍເຫຼື ອເລື່ອງ າໃຊ້ າຍຂອງທ່ານໄວ້ . ທ່ານມີ ດໄດ້ ບຂໍ້ ນນີ້ ແລະ
ຄວາມຊ່ວຍເຫຼື ອເປັ ນພາສາ ຂອງທ່ານໂດຍບ່ໍ ເສຍຄ່າ. ໃຫ້ໂທຫາ 800-722-1471
(TTY: 800-842-5357).
ູຂໍ້
່
ສໍ ັ
ຈ
ໝ
ສິ
ັ
່
ວ
ຄ
ມ
ມູຮັ
ູມີ ມຂໍ້
ភាសាែខមរ ( ): ឹ
រងរបស់
Premera Blue Cross ។ របែហលជាមាន កាលបរ ិ ឆ ំខានេនៅកងេសចក
េសចកតជី ូ
ជាមានព័ ៌ ៉ ងសំ ់អពី ់ ៉ ប់
នដំ ងេនះមានព័ ី
តមានយា ខាន ំ ទរមងែបបបទ ឬការរា
ណ ត៌មានយ៉ា ំ ់ តងសខាន។ េសចក
េចទស ់ ន ុ ត
ណងេនះ។ អ វការបេញញសមតភាព ដលកណតៃថ ចបាស
កតាមរយៈ
ដំ ឹ នករបែហលជារតូ ច ថ ់ ំ ់ ងជាក់ ់
នដ
ន
ី ន
ូ
អ
ូ
ជ
ជ
ំណឹងេនះរបែហល
នានា េដើ ីនងរកសាទុ ៉ បរងស់ ុ ់ ក ឬរបាក់ ំ
អ
មប ឹ កការធានារា ខភាពរបស ជ
ធនកមានសិ ទទលព័ មានេនះ និ ំ យេនៅកុងភាសារបសទិ ួ ត៌ ងជ ននួ
ន
់ កេដាយម
អ
នអ
យេចញៃថល។ ួ
នអស
ន
ិ
លុ ើ ូ ូយេឡយ។ សមទ ទ រស័ព 800-722-1471 (TTY: 800-842-5357)។
Khmer
ਕਵਰਜ ਅਤ ਅਰਜੀ ਬਾਰ ਮਹ ਤਵਪਰਨ ਜਾਣਕਾਰੀ ਹ ਸਕਦੀ ਹ . ਇਸ ਨ ਿਜਸ ਜਵਚ
ਖਾਸ
ਤਾਰੀਖਾ ਹ ਸਕਦੀਆ ਹਨ. ਜੇਕਰ ਤਸੀ ਜਸਹਤ ਕਵਰਜ ਿਰਖਣੀ ਹਵ ਜਾ ਓਸ ਦੀ ਲਾਗਤ
ਜਿਵਚ ਮਦਦ ਦ ੇਇਛ ੁਕ ਹ ਤਾਂ ਤਹਾਨ ਅ ਤਮ ਤਾਰੀਖ਼ ਤ ਪਿਹਲਾਂ ਕੁ ਝ ਖਾਸ ਕਦਮ ਚ ਕਣ
ਦੀ ਲੜ ਹ ਸਕਦੀ ਹ ,ਤਹੁਾਨ ਮਫ਼ਤ ਿਵਚ ਤ ਆਪਣੀ ਭਾਸ਼ਾ ਿਵ ਚ ਜਾਣਕਾਰੀ ਅਤ ਮਦਦ ਪਾਪਤ
ਕਰਨ ਦਾ ਅਿਧਕਾਰ ਹ ,ਕਾਲ 800-722-1471 (TTY: 800-842-5357).
ਪ ਜਾਬੀ (Punjabi): ਇਸ ਨ ਿਟਸ ਿਵਚ ਖਾਸ ਜਾਣਕਾਰੀ ਹ. ਇਸ ਨ ਿਟਸ ਿਵਚ
Premera Blue Cross ਵਲ ਤੁਹਾਡੀ
ੰ
ੰ
ੇ ੇ ੇ ੱ ੂ ੋ ੈ ੋੋ ਂ ੁ ੇ ੱ ੋ ੇ ੱੱ ੁ ੱ ੂੁ ੱ ੇ ੱ ੇ ੍ਰ ੈ
ੋ ੰ ੂ ੱ ੁ ੋ ੋ ੈ ੰ
ੋ ੈ ੋ
(Farsi): فارسی فرم بارهدر ھمم اطالعات حاوی است ممکن يهمالعا اين.
ميباشد ھمم اطالعات یوحا يهمالعا اين
در ھمم ھای خيتار به باشد.پ رایبستاکنممماش زينهھ اختدپر در مککيا
تان بيمهوشش حقظ
Premera Blue Cross طريق از ماش مهبيوشش يا و تقاضا ای پ. يدماين
جهتو يهمالعا اين
حق شما. يدشاب داشته اجتياح صیاخ کارھای امانج برای صیمشخ ایھ
خيتار به تان، انیمدر ھای کسب برای .نماييد دريافت گانيرا ورط به ودخ
زبان به را کمک و اطالعات اين که داريد را اين
استم ) 5357-842-800 مارهباش ماست TTY انکاربر(800-722-1471 مارهش
با اطالعات .اييدنم برقرار
้
Polskie (Polish): To ogłoszenie może zawierać ważne informacje.
To ogłoszenie może
zawierać ważne informacje odnośnie Państwa wniosku lub zakresu
świadczeń poprzez Premera Blue Cross. Prosimy zwrócic uwagę na
kluczowe daty, które mogą być zawarte w tym ogłoszeniu aby nie
przekroczyć terminów w przypadku utrzymania polisy ubezpieczeniowej
lub pomocy związanej z kosztami. Macie Państwo prawo do bezpłatnej
informacji we własnym języku. Zadzwońcie pod 800-722-1471 (TTY:
800-842-5357).
Português (Portuguese): Este aviso contém informações
importantes. Este aviso poderá conter informações importantes a
respeito de sua aplicação ou cobertura por meio do Premera Blue
Cross. Poderão existir datas importantes neste aviso. Talvez seja
necessário que você tome providências dentro de determinados prazos
para manter sua cobertura de saúde ou ajuda de custos. Você tem o
direito de obter e sta informação e ajuda em seu idioma e sem
custos. Ligue para 800-722-1471 (TTY: 800-842-5357).
Română (Romanian): Prezenta notificare conține informații
importante. Această notificare poate conține informații importante
privind cererea sau acoperirea asigurării dumneavoastre de sănătate
prin Premera Blue Cross. Pot exista date cheie în această
notificare. Este posibil să fie nevoie să acționați până la anumite
termene limită pentru a vă menține acoperirea asigurării de
sănătate sau asistența privitoare la costuri. Aveți dreptul de a
obține gratuit aceste informații și ajutor în limba dumneavoastră.
Sunați la 800-722-1471 (TTY: 800-842-5357).
Pусский (Russian): Настоящее уведомление содержит важную
информацию. Это уведомление может содержать важную информацию о
вашем заявлении или страховом покрытии через Premera Blue Cross. В
настоящем уведомлении могут быть указаны ключевые даты. Вам,
возможно, потребуется принять меры к определенным предельным срокам
для сохранения страхового покрытия или помощи с расходами. Вы
имеете право на бесплатное получение этой информации и помощь на
вашем языке. Звоните по телефону 800-722-1471 (TTY:
800-842-5357).
Fa’asamoa (Samoan): Atonu ua iai i lenei fa’asilasilaga ni
fa’amatalaga e sili ona taua e tatau ona e malamalama i ai. O lenei
fa’asilasilaga o se fesoasoani e fa’amatala atili i ai i le tulaga
o le polokalame, Premera Blue Cross, ua e tau fia maua atu i ai.
Fa’amolemole, ia e iloilo fa’alelei i aso fa’apitoa olo’o iai i
lenei fa’asilasilaga taua. Masalo o le’a iai ni feau e tatau ona e
faia ao le’i aulia le aso ua ta’ua i lenei fa’asilasilaga ina ia e
iai pea ma maua fesoasoani mai ai i le polokalame a le Malo olo’o e
iai i ai. Olo’o iai iate oe le aia tatau e maua atu i lenei
fa’asilasilaga ma lenei fa’matalaga i legagana e te malamalama i ai
aunoa ma se togiga tupe. Vili atu i le telefoni 800-722-1471 (TTY:
800-842-5357).
Español ( ): Este Aviso contiene información importante. Es
posible que este aviso contenga información importante acerca de su
solicitud o cobertura a través de Premera Blue Cross. Es posible
que haya fechas clave en este
tiene derecho a recibir esta información y ayuda en su idioma
sin costo
aviso. Es posible que deba tomar alguna medida antes de
determinadas fechas para mantener su cobertura médica o ayuda con
los costos. Usted
alguno. Llame al 800-722-1471 (TTY: 800-842-5357).
Spanish
Tagalog (Tagalog): Ang Paunawa na ito ay naglalaman ng
mahalagang impormasyon. Ang paunawa na ito ay maaaring naglalaman
ng mahalagang impormasyon tungkol sa iyong aplikasyon o pagsakop sa
pamamagitan ng Premera Blue Cross. Maaaring may mga mahalagang
petsa dito sa paunawa. Maaring mangailangan ka na magsagawa ng
hakbang sa ilang mga itinakdang panahon upang mapanatili ang iyong
pagsakop sa kalusugan o tulong na walang gastos. May karapatan ka
na makakuha ng ganitong impormasyon at tulong sa iyong wika ng
walang gastos. Tumawag sa 800-722-1471 (TTY: 800-842-5357).
ไทย (Thai): ประกาศนมขอมลสาคญ
ประกาศนอาจมขอมลทสาคญเกยวกบการการสมครหรอขอบเขตประกน สขภาพของคณผาน
Premera Blue Cross และอาจมกาหนดการในประกาศน คณอาจจะตอง
ดาเนนการภายในกาหนดระยะเวลาทแนนอนเพอจะรกษาการประกนสขภาพของคณหรอการชวยเหลอท
มคาใชจาย คณมสทธทจะไดรบขอมลและความชวยเหลอนในภาษาของคณโดยไม่มคาใชจาย
โทร 800-722-1471 (TTY: 800-842-5357)
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