6th July 2009, N 6th July 2009, N ZIP ZIP Where’s the Physics in Where’s the Physics in Medicine? Medicine? Richard Watts Richard Watts Director of MR Research, Van der Veer Director of MR Research, Van der Veer Institute Institute Dept. of Physics and Astronomy Dept. of Physics and Astronomy University of Canterbury University of Canterbury
20
Embed
6th July 2009, NZIP Where’s the Physics in Medicine? Richard Watts Director of MR Research, Van der Veer Institute Dept. of Physics and Astronomy University.
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
6th July 2009, NZIP6th July 2009, NZIP
Where’s the Physics in Where’s the Physics in Medicine?Medicine?
Richard WattsRichard WattsDirector of MR Research, Van der Veer Director of MR Research, Van der Veer
InstituteInstitute
Dept. of Physics and AstronomyDept. of Physics and Astronomy
University of CanterburyUniversity of Canterbury
6th July 2009, NZIP6th July 2009, NZIP
MRI X-Ray NuclearImaging
Therapy
DiagnosticImaging
Therapy
6th July 2009, NZIP6th July 2009, NZIP 13th March 200713th March 2007
X-Ray ImagingX-Ray ImagingContrast: Density, Atomic NumberContrast: Density, Atomic Number
X-raysource
Object
Detector
Phil and Anthony Butler, UC and MARS Bioimaging
December 22nd, 1895Wilhelm Roentgen
“Builder survives nailgun accident”
6th July 2009, NZIP6th July 2009, NZIP
PneumoencephalographyPneumoencephalography
Pneumoencephalogram from Moore et al (1935) 'Encephalographic studies in mental disease' - American Journal of Psychiatry
Magnetic Resonance Imaging, Magnetic Resonance Imaging, (n)MRI(n)MRI
Hydrogen Hydrogen NNuclei are uclei are aligned by a big aligned by a big MMagnetic agnetic FieldField
RResonant frequency given esonant frequency given by Larmor equationby Larmor equation
Nuclei absorb Nuclei absorb radiofrequency energy at radiofrequency energy at that frequency and then that frequency and then re-emit energyre-emit energy
Magnetic field gradient Magnetic field gradient coils allow the field (and coils allow the field (and resonant frequency) to resonant frequency) to vary with location in x,y,z – vary with location in x,y,z – IImagingmaging
“You know, what these people do is really clever. They put little spies into molecules and send radio signals to them, and then they have to radio back what they are seeing.”
Niels Bohr
B
6th July 2009, NZIP6th July 2009, NZIP
Guess who?Guess who?
6th July 2009, NZIP6th July 2009, NZIP
Structural Brain Imaging with Structural Brain Imaging with MRIMRI
T1 T2 T2 FLAIR
Apparent Diffusion Coefficient
Fractional Anisotropy
T2*
6th July 2009, NZIP6th July 2009, NZIP
Functional MRI of Language – Functional MRI of Language – Passive Listening, RhymingPassive Listening, Rhyming
Magnetic properties of oxyhemoglobin and deoxyhemoglobin Magnetic properties of oxyhemoglobin and deoxyhemoglobin L. Pauling and C. Coryell, PNAS USA 22:210-216 (1936)L. Pauling and C. Coryell, PNAS USA 22:210-216 (1936)