6 th International Conference on Polyphenols and Health University of Buenos Aires, Argentina 19 October 2013 The Road to Evidence-based Dietary Recommendations for Flavonoids: How Do We Get There? From Data to Databases to Adequate Intakes Jeffrey Blumberg, PhD, FASN, FACN, CNS Friedman School of Nutrition Science and Policy Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University Boston, MA USA
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6 th International Conference on Polyphenols and Health University of Buenos Aires, Argentina 19 October 2013 The Road to Evidence-based Dietary Recommendations.
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6th International Conference on Polyphenols and HealthUniversity of Buenos Aires, Argentina
19 October 2013
The Road to Evidence-based Dietary Recommendations
for Flavonoids: How Do We Get There?
From Data to Databases to Adequate Intakes
Jeffrey Blumberg, PhD, FASN, FACN, CNSFriedman School of Nutrition Science and Policy
Jean Mayer USDA Human Nutrition Research Center on AgingTufts UniversityBoston, MA USA
• Provide consumers with guidance about healthyfood choices via education and food product labeling
• Provide the nutrition industry with definitions to guideinnovative product development as well as truthful and non-misleading communications about products
Knowing is not enough; we must applyWilling is not enough; we must do.
- Johann Wolfgang von Goethe (1749-1832)
IOM FNB. DRI Coverpage 2000
From Data to Databases
Dataanalytical methods
experimental design nomenclature
quality control reporting
From Data to Databases
Data
Food Composition Analysiscultivar
environment geography
post-harvestpreparation sample size replication
From Data to Databases
Data
Food Composition Analysis
Database Classification and Organizationaccuracy
analytical methodologyaglycone vs. glycone
nomenclature incompleteness
Flavonoid Databases
USDA ARS Database for the Flavonoid Content of Selected Foods
USDA ARS Database for the Proanthocyanidin Content of Selected Foods
USDA ARS Database for the Isoflavone Content of Selected Foods
European Food Information Resource (EuroFIR) Bioactive Substances in Food Plants Information System (BASIS)
French National Institute for Agricultural Research Phenol-Explorer
From Data to Databases
Data
Food Composition Analysis
Database Classification and Organization
Dietary Intakeassessment tools
bioavailabilityreliability
Dietary Intake of Polyphenols in French AdultsSU.VI.MAX
Pérez-Jiménez et al. Am J Clin Nutr 2011
From Data to Databases
Data
Food Composition Analysis
Database Classification and Organization
Dietary Intake
Validation of Exposurematrix (blood, urine)pharmacokinetics
single vs. multiple exposures
Urinary (not Dietary) Polyphenols AreAssociated with Decreased Mortality
InCHIANTI Study
Zamora-Ros et al. J Nutr 2013
Total Urinary Polyphenols Total Dietary Polyphenols
From Databases to Function
Range of Intakeusual
national vs. internationalduration in cohort
From Databases to Function
Range of Intake
Functionmaintenance of physiological function
modification of intermediary biomarkersreduction of disease risk
Adequate Intake: When sufficient evidence is notavailable to set an EAR, the AI is a goal for theintake of individuals. The AI is expected to coverthe needs of most all people.
From Function to Reference Values
IOM Tolerable Upper Intake Level (UL): The highest level of daily intake likely to pose no riskof adverse health effects to almost all individualsin the general population.
FAO/WHO Highest Observed Intake (HOI): Where notoxicity has been observed, the highest dose testedthat can be confidently concluded as safe.