57114643 GPAT 16 Medicinal Chemistry(1)

MEDICINAL CHEMISTRY

Q1. Identify the synthesis of following compound

a. Acetyl choline

b. Carbachol

c. Methacholine

d. Neostigmine

Q2. Identify the synthesis of following compound

a. Edrophonium

b. Pyridostigmine

c. Methacholine

d. Neostigmine

Q3. Cyclohexyl nitrile and N, N-diethylamino is used as starting product in the synthesis of

a. Glycopyrrolate

b. Dicyclomine

c. Homatropine

d. Cyclopentolate

(i ) NH3 

CH3 Br 

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Q4. Xanthene 9-carboxylic acid N,N-diethylamino cholroethane is used in the synthesis of

a. Tropicamide

b. Propantheline

c. Procyclidine

d. Dicyclomine

Q5. Which of the following is the structure of Tropicamide

a.

b.

c.

d.

Q6. Identify the synthesis of following compound

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a. Salbutamol

b. Terbutaline

c. Amphetamine

d. Isoprenaline

Q7. Identify the synthesis of following compound

a. Salbutamol

b. Noradrenaline

c. Amphetamine

d. Phenylephrine

Q8. Identify the synthesis of following compound

a. Salbutamol

b. Phenoxybenzamine

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c. Tolazoline

d. Naphthazoline

Q9. Identify the synthesis of following compound

a. Salbutamol

b. Propranolol

c. Prazocin

d. Ephedrine

Q10. Identify the synthesis of following compound

a. Phenetolamine

b. Phenoxybenzamine

c. Prazocin

d. Ephedrine

Q11. Identify the synthesis of following compound

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a. Phenetolamine

b. Phenoxybenzamine

c. Prazocin

d. Propranolol

Q12. Identify the synthesis of following compound

a. Diphenhydramine

b. Doxylamine

c. Mepyramine

d. Pheniramine

Q13. Identify the synthesis of following compound

a. Diphenhydramine

b. Doxylamine

c. Mepyramine

d. Pheniramine

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Q14. Identify the synthesis of following compound

a. Promethazine

b. Cyclizine

c. Pheniramine

d. Methdilazine

Q15. Identify the synthesis of following compound

a. Promethazine

b. Cyclizine

c. Pheniramine

d. Meclizine

Q16. Identify the synthesis of following compound

a. Phenindamine

b. Cyproheptadine

c. Triprolidine

d. Indomethacin

NaH2 

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Q17. Identify the synthesis of following compound

a. Cimetidine

b. Ranitidine

c. Nizatidine

d. Famotidine

Q18. Which heterocyclic ring is present in Amiloride?

a. Pyrimidine ring

b. Pteridine ring

c. Pyrazine ring

d. Pyridine

Q19. Which diuretic have steroid nucleus?

a. Amiloride

b. Chlorthalidone

c. Triamterene

d. Spironolactone

Q20. Diphenhydramine belongs to antihistaminic class of

a. Ethylene diamine

b. Amino alkyl ether

c. Alkyl amine

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d. Phenothiazine

Q21. Phenindamine belongs to class of

a. Piperidine

b. Piperazine

c. Ethylene diamine

d. Amino alkyl ether

Q22. Identify the synthesis of following compound

a. Naproxen

b. Ketoprofen

c. Naphthazoline

d. Phenacetin

Q23. Identify the synthesis of following compound

a. Sulindac

b. Indomethacin

c. Phenylbutazone

d. Mefenamic acid

Q24. Identify the synthesis of following compound

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a. Diclofenac

b. Piroxicam

c. Phenylbutazone

d. Mefenamic acid

Q25. Identify the synthesis of following compound

a. Diclofenac

b. Aminopyrine

c. Phenylbutazone

d. Mefenamic acid

Q26. Hydantoin posses the heterocyclic ring

a. Imidazoline 3,5-dione

b. Imidazoline 2,4-dione

c. Pyrazoline 3,5-dione

d. Thiazoline 2,4-dione

Q27. Phenytoin is

a. 5,5-diphenylimidazoline-2,4 dione

b. 4,4-diphenylimidazoline-2,4-dione

c. 4,4-diphenylimidazoline-3,5-dione

d. 5,5-diphenylpyrazoline-3,5-dione

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Q28. Antipyretic activity of NASIDS is mostly exhibited due to inhibition of

a. PGE2

b. PGD2

c. PGI2

d. PGF2α

Q29. Which enantiomers of profens are more active?

a. S(+)

b. S(-)

c. R(+)

d. R(-)

Q30. Ephedrine how has many Chiral center

a. 2

b. 3

c. 1

d. 0

Q31. Antazoline a NASID have

a. Imidazoline ring

b. Pyrazoline ring

c. Thiazoline ring

d. Oxazoline ring

Q32. Which of the following is tertiary amine and crosses the BBB?

a. Pyridostigmine

b. Physostigmine

c. Neostigmine

d. Edrophonium

Q33. 4-chloro-6-amino-1,3-benzenesulfonamide and formic acid are starting material for synthesis of

a. Hydrochlorthiazide

b. Chlorthiazide

c. Benzthiazide

d. Polythiazide

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Q34. 2,4-dichloro benzoic acid and furfurylamine are starting product for synthesis of

a. Furosemide

b. Bumetanide

c. Chlorthalidone

d. Chlorthiazide

Q35. Pthalic anhydride and chlorobenzene are starting product for synthesis of

a. Phenindamine

b. Cyproheptadine

c. Chlorthalidone

d. Chlorthiazide

Q36. 2,3-dichlorophenoxyacetic and butrylchloride are stating product for the synthesis of

a. Ethacrynic acid

b. Triamterene

c. Amiloride

d. Furosemide

Q37. Pteridine ring is present in

a. Amiloride

b. Triamterene

c. Chlorthalidone

d. Spirolactone

Q38. Benzylnitrile and nitrosopyrimidine are the starting product for

a. Amiloride

b. Triamterene

c. Chlorpheniramine

d. Naphthazoline

Q39. 2,6-dichloro5-formylpyrimidine and hydrazine are starting product of

a. Allopurinol

b. Colchicine

c. Probenecid

d. Sulfinpyrazone

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Q40. 4-hydroxy-3-hydroxymethyl Benzaldehyde and tertiary butylbenzylamine are involved in the synthesis

of

a. Terbutaline

b. Salbutamol

c. Isoprenaline

d. Albuterol

Q41. Identify the synthesis of following compound

a. Halothane

b. Enflurane

c. Isoflurane

d. Methoxyflurane

Q42. Identify the synthesis of following compound

a. Phenobarbitone

b. Mephobarbitone

c. Secobarbitone

d. Pentobarbitone

Q43. Identify the synthesis of following compound

a. Amobarbitone

b. Secobarbitone

c. Pentobarbitone

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d. Phenobarbitone

Q44. Identify the synthesis of following compound

a. Glutethimide

b. Methqualone

c. Meprobamate

d. Paraldehyde

Q45. Identify the synthesis of following compound

a. Diazepam

b. Nitrazepam

c. Flurazepam

d. Alprazolam

Ethylisopentylethylmalonate urea  

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Q46. Identify the synthesis of following compound

a. Phenytoin

b. Trimethadione

c. Phensuximide

d. Primidone

Q47. Identify the synthesis of following compound

a. Imipramine

b. Carbamazepine

c. Amitriptyline

d. Primidone

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Q1. Which of the following anthelmintics is not a carbamic methyl ester?

1. Cyclobendazole 2. Thiabendazole 3. Albendazole 4. Parbendazole

Q2. Acyclovir is a analogue of

1. Uracil 2. Adenine 3. Guanine 4. Thymidine

Q3. Sulfamethoxazole is having

1. Isoxazole ring 2. Oxazole ring 3. 1, 3, 4 thiadiazole 4. Imidazole

Q4. Which of the following drug is amphoteric in nature?

1. Chloramphenicol 2. Amphotericin B 3. Macrolides 4. Penicillins

Q5. Which isomer of Chloramphenicol is more active?

1. R, R 2. R, S 3. S, S 4. All are equally active

Q6. Which of the following is not true about cycloserine?

1. It is derived from amino acids 2. It inhibits cell wall synthesis 3. Having oxazolidine ring 4. Highly

nephrotoxic

Q7. How many chiral centers are present in oxytetracycline?

1. 4 2. 5 3. 6 4. 7

Q8. Which of the following drug is para-hydroxy acetanilide derivative?

1. Niclosamide 2. Diloxanide 3. Pyrazinamide 4. Teclozan

Q9. How many chiral centers are present in steroid nucleus?

1. 4 2. 5 3. 6 4. 7

Q10. Primaquine is derivative of-

1. 8-aminoquinoline 2. 4-aminoquinoline 3. Biguanides 4. Napthaquinone

Q11. In steroid nucleus A/B, B/C, C/D rings are fused in the manner of-

1. Cis- Cis -Trans 2. Trans-Cis-trans 3. Cis-Trans-Cis 4. Trans-Cis-Cis

Q12. Which of the following is not having steroid nucleus?

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1. Finastride 2. Nondrolone 3. Flutamide 4. Megestrol

Q13. 9α fluoro - 11β,17,21-trihydroxy -16α-methyl pregna1,4-diene 3,20 dione is

1. Paramethsone 2. Triamcinolone 3. Prednesolone 4. Betamethasone

Q14. . 9α fluoro - 11β,16α,17,21-tetrahydroxy pregna1,4-diene 3,20 dione is

1. Paramethsone 2. Triamcinolone 3. Fludrocortisone 4. Betamethasone

Q15. Which of the following is antiandrogenic?

1. Tamoxifen 2. Mifepristone 3. Clomiphene 4. Flutamide

Q16. Which heterocyclic ring is present in Amiloride?

1. Pyrimidine ring 2. Pteridine ring 3. Pyrazine ring 4. Pyridine

Q17. Which diuretic have steroid nucleus?

1. Amiloride 2. Chlorthalidone 3. Triamterene 4. Spironolactone

Q18. Benorylate is condensation product of ……………………………………………………………….

Q19. Diphenhydramine belongs to antihistaminic class of

1. Ethylene diamine 2. Amino alkyl ether 3. Alkyl amine 4. Phenothiazine

Q20. Match the following heterocyclic ring present in drugs-

1. Imidazole a. Cimetidine

2. Thiazole b. Ranitidine

3. Furan c. Astemizole

4. Benzimidazole d. Terfenadine

5. 1,1 dioxothiazine e. Thiazolidine

6. Sulbactam f. Oxazolidine

7. Clavulinic acid g. Albendazole

h. Piroxicam

Q21. Choose the correct statement for estrogen

1.

2.

3.

4.

5.

6.

7.

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1. Ring D is benzenoid and have OH grp at C17 Phenolic

2. Ring A is quinonoid and have OH grp at C3 alcoholic

3. Ring A is benzenoid and have OH grp at C3 Phenolic

4. Ring D is quinonoid and have OH grp at C17 alcoholic

Q22. Phenindamine belongs to class of

1. Piperidine 2. Piperazines 3. Ethylene diamine 4. Amino alkyl ether

Q23. Match the following

1. Benzimidazole Zalcitabine

2. Imidazole Metronidazole

3. Thymidine Stavudine

4. 17β hydroxy- 17α methyl 3 oxo androst-4ene Meconazol

5. Salicylic acid derivative Nondrolone

6. Piperazine ring Mthyltestosterone

7. Morpholino Diloxanide

8. Ethanol derivative Niclosamide

9. Acetanilide derivative Nitrofurazone

10. Oxazolidine Nimorazole

Citerizine

Mebendazole

Q24. Which of the moiety is responsible for diuretic activity in acetazolamide?

1. 1, 3, 4-thiazole ring 2. N-acetyl grp 3. Sulphamoyl grp 4. Secondary amino grp

Q25. Which isomer of diethyl stilbosterol is more active?

1. Cis 2. Trans 3. E 4. Z

Q26. Identify True/False (T/F) statement

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

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1. In steroid nucleus confirmation is boat shape (T/F)

2. Paramethsone have 9α fluoro, 16α-methyl-17α-hydroxy grp (T/F)

3. Halofantrine is quinoline methanol (T/F)

4. Sesquiterpene lactone is artimisnin (T/F)

5. Ciprofloxacin have Piperazine ring attached to 1st position (T/F)

6. Vidarabine is adenine analogue (T/F)

7. Pyrantel is pyridine analogue (T/F)

8. Trimethoprim is pyrimidine analogue (T/F)

9. Sulphalene have Pyrazine ring (T/F)

10. Azteonam is monobactam (T/F)

11. Clavulinic acid thiazolidine ring (T/F)

12. Active anti inflammatory metabolite of sulfasalazine is pyridyl sulphanilamide (T/F)

13. Phenyl butazone is synthesized from hydrazine derivative (T/F)

14. Fenbufen is carbonyl propionic acid (T/F)

15. Mefenamic acid is arylacetic acid derivative (T/F)

16. Oxicams are N-heteroaryl carboxamide derivatives (T/F)

17. Chlorthiazide have 1,1 dioxo 1,2 thiazine ring (T/F)

Synthesis of some important drugs

1. Acetazolamide 14. Allopurinol

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2. Polythiazide 15. Phenylbutazone

3. Mebendazole 16. Indomethacin

4. Niclosamide 17. Mepyramine

5. Metronidazole 18. Promethazine

6. Diloxanide 19. Cimetidine

7. Mefenide 20. Nalixidic acid

8. Meconazol

9. Proquanil

10. Trimethoprim

11. Clofazimine

12. Chlorthalidone

13. Mefenamic acid

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