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Pharmacotherapi of Endocrine
dr. R. Setiadji, M.Sc
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The related drugs
• Hipolipidemik
• Hipoglikemik oral - Insulin
• Antiobesit
• Antit!roid
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Memilih obat P
$etapkan diagnosis$etapkan diagnosis
$etapkan tujuan pengobatan$etapkan tujuan pengobatan
Susun da%tar obat manjur Susun da%tar obat manjur
&ili! obat manjur berdasar tujuan&ili! obat manjur berdasar tujuan
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(!oose e%ecti)e drug based on
IndicationIndication
Side e%%ectSide e%%ect
A)ailabilit*&osolog A)ailabilit*&osolog
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Mengobati Pasien
. $etapkan masala!na
2. $egaskan tujuan terapi
3. &eriksa kecocokan obat &
". $uliskan resepna#. &enjelasan tentang aturan pakai dan
keaspadaan
'. &antau !entikan/ pengobatan
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List of NIDDM Drugs
• &arenteral1 Insulin
• ral1
Sul%onliurea
4iguanida $!ia5oldinedion
– Farmakologi dan Terapi Edisi 4, hal 467-481
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List of Thyroid Drugs
• Hormon $iroid
• Anti tiroid
Antitiroid
&eng!ambat transport ion odida 7odida
7odium radioakti%
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Pharmacotherapy of Dyslipidemia
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Drug Therapy
HMG Co !eductase Inhibitors "#tatins$
• Reduce 898-( 0##: ; $< +3=:
• Raise H98-( ##:
• Major side e%%ects
Mopat!
Increased li)er en5mes
• (ontraindications
Absolute1 li)er disease
Relati)e1 use it! certain drugs
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HMG Co !eductase
Inhibitors "#tatins$
#tatin Dose !ange
8o)astatin 2=0= mg
&ra)astatin 2="= mg
Sim)astatin 2=0= mg
>lu)astatin 2=0= mg
Ator)astatin =0= mg
(eri)astatin =."=.0 mg
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HMG Co !eductase
Inhibitors "#tatins$ "continued$
Demonstrated Therapeutic %enefits
• Reduce major coronar e)ents
• Reduce (H9 mortalit
• Reduce coronar procedures &$(A*(A4
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Drug Therapy
%ile cid #e&uestrants
• Major actions
Reduce 898-( # – 3=:
Raise H98-( 3 – #:
Ma increase $<• Side e%%ects
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%ile cid #e&uestrants
Drug Dose !ange
(!olestramine "' g
(olestipol #2= g
(olese)elam 2.'3.0 g
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%ile cid #e&uestrants "continued$
Demonstrated Therapeutic %enefits
• Reduce major coronar e)ents
• Reduce (H9 mortalit
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Drug Therapy
Nicotinic cid
• Major actions
8oers 898-( # 2#:
8oers $< 2= #=: Raises H98-( # 3#:
• Side e%%ects1 %lus!ing, !perglcemia, !peruricemia,
upper
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Nicotinic cid
Drug 'orm Dose !ange
Immediate release .#3 g
crstalline/
@tended release 2 g
Sustained release 2 g
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Nicotinic cid "continued$
Demonstrated Therapeutic %enefits
• Reduces major coronar e)ents
• &ossible reduction in total mortalit
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Drug Therapy
'ibric cids
• Major actions
8oer 898-( #2=: it! normal $
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'ibric cids
Drug Dose
•
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'ibric cids "continued$
Demonstrated Therapeutic %enefits
• Reduce progression o% coronar lesions
• Reduce major coronar e)ents
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List of antiobesity(
