5-Fluoro-ADBICA The Drug Enforcement Administration's Special Testing and Research Laboratory generated this monograph using structurally confirmed reference material. Page 1 of 5 SWGDRUG.org/monographs.htm Latest Revision: 1/7/2015 N F NH NH 2 CH 3 C H 3 C H 3 O O 1. GENERAL INFORMATION IUPAC Name: N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1 H-indole-3-carboxamide CAS#: Not Available Synonyms: 5F-ADBICA Source: DEA Reference Material Collection Appearance: Solution UV max (nm): Not Determined 2. CHEMICAL AND PHYSICAL DATA 2.1 CHEMICAL DATA Form Chemical Formula Molecular Weight Melting Point ( o C) Base C 20 H 28 FN 3 O 2 361 Not Determined
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5-Fluoro-ADBICA - SWGDRUG · 5-Fluoro-ADBICA The Drug Enforcement Administration's Special Testing and Research Laboratory ... ADB-FUBINACA and ADBICA, and five synthetic cannabinoids
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5-Fluoro-ADBICAThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 1 of 5SWGDRUG.org/monographs.htmLatest Revision: 1/7/2015
Form Chemical Formula Molecular Weight Melting Point (oC)
Base C20H28FN3O2 361 Not Determined
5-Fluoro-ADBICAThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 2 of 5SWGDRUG.org/monographs.htmLatest Revision: 1/7/2015
3. QUALITATIVE DATA
3.1 NUCLEAR MAGNETIC RESONANCE
Sample Preparation: Dilute analyte to ~5 mg/mL in CDCl3 containing TMS for 0 ppm reference anddimethylsulfone as quantitative internal standard.
Instrument: 400 MHz NMR spectrometerParameters: Spectral width: at least containing -3 ppm through 13 ppm Pulse angle: 90o
Delay between pulses: 45 seconds1H NMR: 5-fluoro-ADBICA Lot # 0451075-15; CDCl3; 400MHz
8 7 6 5 4 3 2 1 0
0
1
2
3
4
5
6
722221111112111
CDCl3
solventsolvent
dimethylsulfone
TMS
1.15
7
7.35
21
CDCl3
6.300
1
1.75 1.50
222
5.750
1
6.750
1
8.025 8.000
1
4.50 4.25
2111
7.74
1 9
9
5-Fluoro-ADBICAThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 3 of 5SWGDRUG.org/monographs.htmLatest Revision: 1/7/2015
3.2 GAS CHROMATOGRAPHY/MASS SPECTROMETRY
Sample Preparation: Dilute analyte ~4 mg/mL in methanol.
Instrument: Agilent gas chromatograph operated in split mode with MS detectorColumn: DB-1 MS (or equivalent); 30m x 0.25 mm x 0.25 µmCarrier Gas: Helium at 1 mL/minTemperatures: Injector: 280oC MSD transfer line: 280oC MS Source: 230oC MS Quad: 150oC Oven program: 1) 100oC initial temperature for 1.0 min 2) Ramp to 300oC at 12 oC/min 3) Hold final temperature for 25.0 minInjection Parameters: Split Ratio = 25:1, 1 µL injectedMS Parameters: Mass scan range: 30-550 amu Threshold: 100 Tune file: stune.u Acquisition mode: scanRetention Time: 18.056 min
EI Mass Spectrum: 5-fluoro-ADBICA Lot # 0451075-15
Uchiyama N., et al. Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC,two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and fivesynthetic cannabinoids detected with a thiophene derivative a-PVT and an opioid receptor agonistAH-7921 identified in illegal products. Forensic Toxicol (2013) 31:223-240.