5) Dr.abbas (Lipid Metabolism)

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BiochemistryLipid Metabolism

2nd Year Medical Students

2075

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Di(.hafy lipi J s ;-- TA6 u IV\Q~~ u

fhospholi p,ds_ cho \este(oL e.ore(s- Fq t- So \~ble.. \1', \-qrr1~()S

IMpo( rClt'\Cc:.. or d,ehl('j~pids :-I _ S OU(C~ c f e.Y\e.1ljj :- ]j Fa f > 3- 3 K CCi>L

_ S "pp I;1%! ~ Esseot;QL rA u Lrrvcle .c. A L;i\Ol{ic.. 4c..~s ~a\- SO\\4b\alJt. .A h.elfs (jf bi/}(/~ e Subsf,tltLe Emu Ts.IJ'''j jel/1j:- t surFQCL as/ea -1 "elt! aciisn 1 /;fMe.

jl)c1udeo ~ BiI~ salts\.)l phos pho/i p,'d 1 \Y5D phosph"/"p"J

NoootA 0J 13r Lerol:., p,rodlJcts t>( d'f&/dY1 ) r2 % : 2- HA G --t 2 rA

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L - /(q- By pnospA6J;P~e. Az w nequlf~ ~ Bile Sq\r.s [l-u;u Ih7 it1 'J.fC>phosph6J'fld ~ hdr-' e..m~\Si fi Cahoo'"l

\-hc> tt /a,/ IL fA Lph05 pho lipid \ CeI UJ (.fa r t) YS6fhosfha lip})fhoJpho JiPQl)L. A 2-

~ Di1-tot;(5n 0 F c.h,\~i(6r ~e(.s :-- By chol ~teroJ .-0te(~e.-

\ho Ffchol eoreroJ .esters , I ;> cho/wkJ0L

Cholu.>i"tfJL 0te{"a/.)I'l ,,( lipids, tAs

G \YCe:YOI.,7 shor/- ~ mccJi(}tYl chail) FA afL WQ1er 56/ub/.. ---> dN(.c.1- Qbsorpfionto portal C((Cv.laf; C1Yl 111(.;\ 1-0 live, W COYltt;(it'}S qctt'l/

(j) LOflJ cha;1} rA ay~ GmVert,J Py FA htJoKiJa/Je t: dfJl eolJ6J A Cj I (cA is ne:u ti It'zed For .e0te(j fi (qti 0":-0 flt:.~A1Ii(;()iS ~ tAG./ pL -1eE.@ j- HAG aft.. hydro tyzd !:f ;rrif:/)tit1aL lipa,oe.- to JlyCet'tJ!-'\ fA(j) 6 \yCetoJ is Cclve{teJ to :;IyCero/ 3P by ;J\yIer6 Ki(Jc./.)e..(j) Z - HA G is e.-J-fe(J' f"ecl to TA G0-@; LY50 pho 5ph./ipiJ i1 01er,(teJ t;, ph.sph";piJ

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ChyloWlict'oflS h.v

> DeFiCit:t1, 7; LPL 1e.w1st6 type. '1 Vfe-tI'l6pfi>f~'lJelY1!q,. Hyd(olys i5 '2 -rAG j tvco '\ G 'Yw'oL- : - uptaKe", b.'f I,v

IA"G or C~/0Yl1iC~6n5 itJto .,9lyCer()L I) fA felll),"" c~J()M/CYunS' (It:.Mo,,tJ4ffW uptaKe"., ~ Liven- J 5D hepa(,'I"J C.leafS -r= plMma

2. Utili 1.aTton b:J ti5SUtI.) :_G\ o"k\ dahaYl For e..ncr1uraductiDr1

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IiiJ}"dud ionG/ucoCortiCoid.s

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" phpsphoy laj.-ofJ 0 CCuf"S by c AMP def1 album,'V')th(:r'\ up+a KCIl ~ ti ~SI.A~ .0 0~\J;.z:.e.J-,

f Tyr= 0 ~ FA Cl)( ~Ja t ioY\ :-1- P a'k; dat i01\ It VV\ a"" !Jpt- I,2. - D( 0 ~\ Jah OY\ 1r ~0 \\ow-t.d 'by J3 o'k~do f"ot')3 - 4) 0 i~ddt;Orl J

Bci-rc(\ol~ tt\e.. liverS \ef.s ;. CD A ~. v l' r +C \ Q IDf) or ~A ..'\ ~o{"'Q ior') of as\C6A

(V IV'o.nS 06 (t o r rA L 1.. 1- "\ 1 'i\ r r ,D lY)qOCnof\o{IQ mOi(. I1r ('1. I illr::;, \...Q (J,T')

W /lctil/ofi6t1 of FA .IS ='0(,.,0+;"" or d~1 Cc>A @- 0 CCu(s bj FA ~jr1a1.) t-; Co N s COF"A ATf' CoI-JsH A\-\P-t ppi A~l (oA

- ATP is uti\i'Z..c.d 1\ C6t'lVertc.d t6 AM? ~ fP\_ pPi is rapid~~d(oJ'l.

- 11'01 CMf); ttn is t'QI15pode.d /h('o"'jh 11\ .. i~Iler rY\i to ch."dv;J ~m.(.rnblor}~ by tn~ hc../p "f aT] (J/,,-hporfcr, CaI'I1 hlJ~ a~\ Cayl]lf,(J~~r"r1sloCcu?

. ~e6(t4IlC~ of f' 0)(; dClti6fl of FA \10 \CDO~~datioY'\ of fA is a major SC>IJ(Cc.. of eoeGj JU{i, s.ta(VQt;o~ rD{rYlat;OI"\ 0 f Ace~\ CoP. W ho.s mC1~ ~mpo(tGll)t tUIlc1'ioYlSEt1e(,5 Y Yicld

-t- ot,datioY\ o~ ~ J I r L _., [ ,.J.. yY\o ~Cu e, Or p"lrYIir;c. ~c....d C\6 J wi\\.3iV lo6ltTrr

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I\ate.... o~ u\\\i"l.aTioV'\ c:.t AlP DU(i~ 11>1;- t All' /ADP -"> ,vAoHIi'iAD y,,4iO -- ~ J'> o1..dof;"", D,,(i~ \Jo(K:- i AI?I ADP -'S j'JADfi J tJA D '(aliO ----" t P 6..;d.~;V1

MQ\D~\ CoA~\\~ Yc>{Yn-uJ d()(j~ FA-r=:: Mhjbds crTI

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