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“Have we got it right”? Surgical An6bio6c Prophylaxis M. Leadsom Infec/on Preven/on Prac//oner M. Griesel Ward Clinical Pharmacist M. Barnes Theatre Matron
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49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Jun 08, 2020

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Page 1: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

“Have  we  got  it  right”?  Surgical  An6bio6c  Prophylaxis  

 M.  Leadsom    Infec/on  Preven/on  Prac//oner    M.  Griesel    Ward  Clinical  Pharmacist  M.  Barnes    Theatre  Matron  

Page 2: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Context

This  quality  improvement  project  was  conducted  in  the  main  theatres  and  was  led  by    •  the  infec/on  preven/on  prac//oner    •  the  ward  pharmacist    In  collabora/on  with  •  key  members  of  staff  in  theatre  •  a  senior  anaesthe/st  

Page 3: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Support & Collaboration

•  Senior  Hospital  Management  •  An/bio/c  Stewardship  CommiIee  •  Microbiologists  •  Physicians  Advisory  Board    •  Theatre  Forum  (chair  held  by  senior  surgeon)  •  Infec/on  Preven/on  CommiIee  •  Individual  surgeons  &  anaesthe/sts  

Page 4: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Problem

There  was:    •  no  previous  research  into  compliance.    •  no  evidence  to  prove  pa/ents  were  receiving  prophylac/c  an/bio/cs  in  line  with  best  prac/ce.    

 •  no  local  guidelines  available  for  reference.  

Page 5: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Obstacles to measurement

•  incision  /me  oOen  not  recorded  in  peri-­‐opera/ve  document  (no  prompt  reques/ng  staff  to  do  so).  

 •  an/bio/c  dose  and  /me  of  administra/on  not  always  recorded.  

   

Page 6: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Our Mission

•  the  aim  of  the  interven/on  is  to  ensure  each  and  every  pa/ent  receives  the  correct  an/bio/c  at  the  correct  dose  at  the  right  /me  and  for  the  right  dura/on  of  /me.  

 “  Perfect  Prophylaxis”    

•  and  to  ensure  this  is  integrated  into  the  surgical  site  bundle,  whilst  addressing  all  aspects  of  an/bio/c  stewardship.  

 

Page 7: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Our Vision

   

 Our  mission  is  aligned  with  Netcare’s  triple  aim  goal  in  providing  

 Best  pa2ent  experience  &  outcome  in  the    

most  cost  effec2ve  way    

Page 8: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Interventions

•  All  peri-­‐opera/ve  documents  are  ink-­‐stamped  with  incision  /me  on  arrival  in  theatre  receiving.  

•  There  is  a  cuUng  /me  prompt  on  the  theatre  board.    •  Designated  person    calls  out  the  cuUng  /me  for  logging.  •  Ensure  /me  and  dose  of  an/bio/c  administered  is  clearly  

documented.  •  Prescrip/on  charts  are  followed  up  to  measure  if  an/bio/c  

stopped  at  24  hours  (or  sooner).  •  Local  guidelines  made  available  to  all.  •  Aspects  of  non-­‐compliance  addressed  with  relevant  surgical  

team.    

Page 9: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Change Strategy

Ins/tute  of  Healthcare  Improvement    •           “Collabora/ve  Model”  2003  •           “Going  Lean  in  Healthcare”  2005    

Page 10: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

A Series of PDSA Cycles (learning, action.... PDSA)

•  .    

Page 11: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Quantifying Data

•  Data  was  collected  from  the  case  notes  of  major  (adult  )surgical  cases,  to  measure  compliance  to  the  four  aspects  of  surgical  an/bio/c  prophylaxis  &  distributed  to  each  discipline  so  areas  of  non-­‐compliance  could  be  addressed.    

   

Page 12: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

 Percentage  of  Peri-­‐opera/ve  documents  with  NO  incision  /me  recorded                (9  April  2013  –  31  July  2013).    

0,0  

10,0  

20,0  

30,0  

40,0  

50,0  

60,0  

70,0  

80,0  

Week  1  

Week  3  

Week  5  

Week  7  

Week  9  

Week  11  

Week  13  

Week  15  

Week  17  

Week  19  

Week  21  

Week  23  

Week  25  

Week  27  

Week  29  

Week  31  

Week  33  

Week  35  

Week  37  

Week  39  

Week  41  

Week  43  

Week  45  

Week  47  

Week  49  

Week  51  

Week  53  

Week  55  

%  peri-­‐o

pera6v

e  do

cumen

ts  with

 NO  incision

 6me  

Weekly  Run  Chart:  %  of  Peri-­‐Opera6ve  documents  with  NO  incision  6me  

%  of  peri-­‐opera/ve  documents  with  NO  incision  /me  

Median:  %  peri-­‐opera/ve  documents  with  NO  incision  /me  

GOAL:  10%  of  peri-­‐opera/ve  documents  with  NO  incision  /me.  

Median:  39%  

Start  date:  9/4/2013  

Week  10:  STAMP  

Improvement  made  

Week  6:  Team  leader  involvement  

 

Week  14:Posters  in  theatre:  “Timing  of  

an/bio/c”  

Page 13: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

   Percentage  of  an/bio/cs  administered  <  60min  before  incision                                          

(4  April  –  31  July  2013).    

0,0  

20,0  

40,0  

60,0  

80,0  

100,0  

120,0  

Week  1  

Week  3  

Week  5  

Week  7  

Week  9  

Week  11  

Week  13  

Week  15  

Week  17  

Week  19  

Week  21  

Week  23  

Week  25  

Week  27  

Week  29  

Week  31  

Week  33  

Week  35  

Week  37  

Week  39  

Week  41  

Week  43  

Week  45  

Week  47  

Week  49  

Week  51  

Week  53  

Week  55  

%  AB  ad

ministered  <  60min  before  incision

 6me  

   

Weekly  Run  Chart:  %  AB  administered  <  60min  before  incision  6me  

%  Compliance  to  prophylaxis:  <  60  min  

Median:  %  Compliance  to  prophylaxis:    <  60min  

GOAL:  90%  compliance  to  an/bio/cs    given  60min  before  incision  /me.  

Median:  55%  

Start  date:  9/4/2013  

Week  6:  Team  leader  involvement  

 

Week  14:Posters  in  theatre:  “Timing  of  

an/bio/c”  

Improvement  made  

Week10:  Ink  Stamp  implemented  

Page 14: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Percentage of antibiotics administered before incision (n=147). (9 April 2013 – 31 July 2013).

129  

4  87,70%   2,72%  0  

20  

40  

60  

80  

100  

120  

140  

0-­‐60min  before  incision   >  60min  before  incision  

Page 15: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Percentage of antibiotics administered prior to incision per discipline

0  

10  

20  

30  

40  

50  

60  

70  

0-­‐30min   31-­‐60min   >60min  

Series1  

Page 16: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Antibiotic choices prescribed for surgical prophylaxis

152  

30  

10   8  17  

11  66,66%   13,16%   4,39%   3,50%   7,46%   4,82%  

0  

20  

40  

60  

80  

100  

120  

140  

160  

Cefazolin   Amoxicillin/Clavulanic  acid  

Cefuroxime   Cefazolin+gentamycin   Clindamycin   Other  

Page 17: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

   

 Dosage  of  cefazolin  prescribed  for  surgical  prophylaxis    (n=152).    

(9  April  2013  –  31  July  2013).    

22,88%  

75,82%  

0,00%  

10,00%  

20,00%  

30,00%  

40,00%  

50,00%  

60,00%  

70,00%  

80,00%  

1g   2g  

Page 18: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Percentage of Duration of Prophylaxis < 24 hours

192  

26  11  

84,21%   11,40%   4,82%  0  

50  

100  

150  

200  

250  

dura/on  <  24hours  post  op   Dura/on  <48hours  post  op   dura/on  >48hours  post  op  

   

Page 19: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

     Days between surgical site infections (94)

(August 2012 - August 2013)    

0  

10  

20  

30  

40  

50  

60  

70  

80  

90  

100  

 Days  B

etween  

CBMH  Days  between  Graph  for  SSI  August  2012-­‐2013    

Days  Between()   Median  ()  

94  days  in  between  

Page 20: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Message for those who wish to start a similar project!

•  A  project  of  this  size  can  be  daun/ng,  be  prepared  to  drive  it  relentlessly.  

 •  Get  surgeons,  anaesthe/sts  &  guidelines  (inc  dosages)  

together  at  the  beginning  (if  you  haven’t  done  so  already)!  

•  Weekly  huddles  &  regular  formal  mee/ngs  are  essen/al.    •       Publish  informa/on  &  results  regularly  on  the  theatre      no/ce  board  &  electronically  distribute.    

Page 21: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

In Summary

We  have  laid  the  founda/ons  of    

 ‘ge;ng  it  right’!    

but  need  to  further  drive  improvements  and  ensure  sustainability  before  we  can  say  

   ‘we  have  got  it  right’!  

 

Page 22: 49 Marilyn Leadsom Surgical Antibiotic Prophylaxis Podium HASA Marilyn Leadsom Surgical... · Thank You For Your Time! No!conflicts!of!interestto!declare!!! References:& & 1. David

Thank You For Your Time!

No  conflicts  of  interest  to  declare!    

References:    1.  David N Gilbert, R. C. (2012). The Sanford Guide to Antimicrobial Therapy 42nd

edition . Sperryville: ANTIMICROBIAL THERAPY INC. 2.  Cunha, B. (2012). Antibiotic essentials. New York: Jones & Barlett Learing.  3.  Bratzler, D.W.,. 2013. Clinical practice guidelines for antimicrobial prophylaxis in

surgery. Americal Journal of Health-System Pharmacists: (70), pp.195-283 4.  Elliot, G. 2013. Guidelines for Surgical prophylaxis in Netcare Hospitals.