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2009

Flags of Cell-Dyn Sapphire on white cell abnormalitiesInspired to Innovate

Pioneering Achieving Caring

Enduring

2009 2 20 () :

Contents

CD Sapphire Overview CD Sapphire WBC Technology Flags of CD Sapphire on white cell abnormalities Q&A

Inspired to Innovate

Company Confidential 2008 Abbott

2

Abbott Hematology - Current Family of SystemsA family of Hematology instruments that improve patient care and lab efficiency by providing first-pass, accurate resultsHigh Volume All Size Laboratories

CELL-DYN SapphireTM

CELL-DYN SMS

Accelerator Automated Processing System* AcceleratorTM Decision ManagerTM

Med. Volume

CELL-DYN 3200SL

CELL-DYN 3700SL

CELL-DYN Ruby

Lower Volume

CELL-DYN 1800Inspired to Innovate

CELL-DYN Emerald*Company Confidential 2008 Abbott 3

*In Development

CELL-DYN Sapphire OverviewFlagship analyzerUsed in large, complex laboratories

MAPSS TechnologySuperior WBC Differential Two dimensional optical platelet analysis Automated random access retic with IRF Fluorescent NRBC & WBC Viability CD3/4/8, CD61 assays (MABs)

CELL-DYN Sapphire* High first pass reportable results Multiple platelet technologies Monoclonal analysis

Targeted Reduction in Labor Cost by:Higher percent of first pass reportable results Resolves difficult pathologyInspired to Innovate Company Confidential 2008 Abbott 4

CD Sapphire WBC Technology

Inspired to Innovate

Pioneering Achieving Caring

Enduring

CELL-DYN Sapphire WBC Technology MAPSS TechnologyCELL-DYN Morphometric Optical Light Scatter 0 Scatter Scattered Light in 3600 90 Scatter

Size Focused Laser Beam 7 Scatter Lobularity 90D Scatter

Complexity

GranularityCompany Confidential 2008 Abbott 6

Inspired to Innovate

The Optics Bench of CELL-DYN SapphireMorphometric features:ALLMirror Beam expander Filters MirrorPMTFL3 FL2

Cell size

IASComplexity

LaserPMTFL1

PSSLobularity.

DSSSeparates Eosinophils from Neutrophils)

Fluorescence characteristics :PMT

FL1 (530nm)FITC, CD4K530 Reticulocyte Analysis

FL2 (580nm)PE Monoclonal applications

Beam adjustment

FL3 (630nm)PI

Dichroic mirrors IAS detector ALL detector

NRBC counting and white cell viability

Optical flow cell

Inspired to Innovate

Company Confidential 2008 Abbott

7

CELL-DYN Sapphire WBC Technology

488nm blue diode laser

List mode data analysis on up to 20,000 events. Digitized scatter and fluorescent events fingerprints six nucleated cell sub-populations.

Inspired to Innovate

Company Confidential 2008 Abbott

8

Flags of CD Sapphire on white cell abnormalities (case study)

Inspired to Innovate

Pioneering Achieving Caring

Enduring

CD Sapphire Case study

Inspired to Innovate

Company Confidential 2008 Abbott

10

CD Sapphire Case study

Inspired to Innovate

Company Confidential 2008 Abbott

11

CD Sapphire Case study

Inspired to Innovate

Company Confidential 2008 Abbott

12

CD Sapphire Case study

Inspired to Innovate

Company Confidential 2008 Abbott

13

CD Sapphire Case study

Inspired to Innovate

Company Confidential 2008 Abbott

14

Atlas of Pediatric Morphology

Inspired to Innovate

Company Confidential 2008 Abbott

15

Thank YouInspired to InnovatePioneering Achieving Caring Enduring

Inspired to Innovate

Company Confidential 2008 Abbott

16