4-Methylamphetamine The Drug Enforcement Administration's Special Testing and Research Laboratory generated this monograph using structurally confirmed reference material. Page 1 of 5 SWGDRUG.org/monographs.htm Latest Revision: 01/15/2014 Page 1 of 5 CH 3 NH 2 C H 3 1. GENERAL INFORMATION IUPAC Name: 1-(4-methylphenyl)propan-2-amine CAS#: 22683-78-9 (Base), 41632-56-8 (HCl) Synonyms: 4-MA, PAL-313, Aptrol, p-TAP, p-methylamphetamine Source: DEA Reference Material Collection Appearance: White powder (HCl) UV max (nm): Not Determined 2. CHEMICAL AND PHYSICAL DATA 2.1 CHEMICAL DATA Form Chemical Formula Molecular Weight Melting Point ( o C) Base C 10 H 15 N 149 Not Determined HCl C 10 H 15 N . HCl 185 149.9
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4-MethylamphetamineThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 1 of 5SWGDRUG.org/monographs.htmLatest Revision: 01/15/2014 Page 1 of 5
CH3
NH2CH3
1. GENERAL INFORMATION
IUPAC Name: 1-(4-methylphenyl)propan-2-amine
CAS#: 22683-78-9 (Base), 41632-56-8 (HCl)
Synonyms: 4-MA, PAL-313, Aptrol, p-TAP, p-methylamphetamine
Source: DEA Reference Material Collection
Appearance: White powder (HCl)
UVmax (nm): Not Determined
2. CHEMICAL AND PHYSICAL DATA
2.1 CHEMICAL DATA
Form Chemical Formula Molecular Weight Melting Point (oC)
Base C10H15N 149 Not Determined
HCl C10H15N. HCl 185 149.9
4-MethylamphetamineThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 2 of 5SWGDRUG.org/monographs.htmLatest Revision: 01/15/2014 Page 2 of 5
3. QUALITATIVE DATA
3.1 NUCLEAR MAGNETIC RESONANCE
Sample Preparation: Dilute analyte to ~5 mg/mL in deuterium oxide (D2O) containing TSP for 0 ppmreference and maleic acid as quantitative internal standard.
Instrument: 400 MHz NMR spectrometerParameters: Spectral width: at least containing -3 ppm through 13 ppm
Pulse angle: 90o
Delay between pulses: 45 seconds1H NMR: 4-methylamphetamine HCl; Lot ALB238-18; D2O; 400 MHz
7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0
0
1
2
3
4
5
6
7
8
9
10
33214
Maleic acid (ISTD)
TSP
HDO
Chemical Shift (ppm)
0.575 0.550 0.525
01234
7.250 7.200
4
0.575 0.550 0.525
0
0.25
0.50
0.75
3.65 3.60 3.55
1
0.575 0.550 0.525
0
1
2
3
2.925 2.875
2
0.575 0.550 0.525
0
2.5
5.0
7.5
2.33
3
1.300
3
4-MethylamphetamineThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 3 of 5SWGDRUG.org/monographs.htmLatest Revision: 01/15/2014 Page 3 of 5
3.2 Gas Chromatography/Mass Spectrometry
Sample Preparation: Dilute analyte ~ 4 mg/mL base extracted into chloroform
Instrument: Agilent gas chromatograph operated in split mode with MS detectorColumn: DB-1 MS (or equivalent); 30m x 0.25 mm x 0.25 µmCarrier Gas: Helium at 1 mL/minTemperatures: Injector: 280oC
MSD transfer line: 280oCMS Source: 230oCMS Quad: 150oCOven program:
1) 100oC initial temperature for 1.0 min2) Ramp to 300oC at 12 oC/min3) Hold final temperature for 9.0 min
Injection Parameters: Split Ratio = 20:1, 1 µL injectedMS Parameters: Mass scan range: 30-550 amu
Threshold: 100Tune file: stune.uAcquisition mode: scan
Retention Time: 4.017 min
EI Mass Spectrum: 4-methylamphetamine HCl; Lot ALB238-18
m/z150140130120110100908070605040
[x 1
06 ]In
tens
ity
2
414
8
134
132
117
11510
510
391897977
65635351
444239
m/z150140130120110100908070605040
[x 1
05 ]In
tens
ity
2 14813
413
2117115
105
103
9189
7977
6563
5351
4442
39
4-MethylamphetamineThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 4 of 5SWGDRUG.org/monographs.htmLatest Revision: 01/15/2014 Page 4 of 5
3.3 INFRARED SPECTROSCOPY (FTIR)
Insrument: FTIR with diamond ATR attachment (3 bounce)Scan Parameters: Number of scans: 32
Number of background scans: 32Resolution: 4 cm-1
Sample gain: 8Aperture: 150
FTIR ATR (Diamond, 3 Bounce): 4-methylamphetamine HCl; Lot ALB238-18
Wavenumber (cm-1)3500 3000 2500 2000 1500
%Tr
ansm
ittan
ce
40
48
56
64
72
29802941
29102895
28022733 27022602
25092496
20652052
1616
14951383
12131084
10181003
847795
548411
Wavenumber (cm-1)1700 1600 1500 1400 1300 1200 1100 1000 900 800 700
%Tr
ansm
ittan
ce
40
48
56
64
72
1616
15141495
14601444
13831365
1313
12421213
11821134 1107
1084
10181003
939 893847
795756
548
494
445411
4-MethylamphetamineThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 5 of 5SWGDRUG.org/monographs.htmLatest Revision: 01/15/2014 Page 5 of 5
http://en.wikipedia.org/wiki/4-methylamphetamine
4. ADDITIONAL RESOURCES
Davis, S.; Blakey, K.; Rands-Trevor, K. GC-MS and GC-IRD analysis of 2-,3- and4-methylmethamphetamine and 2-, 3- and 4-methylamphetamine.Forensic Science International2012, 220, 67-73.
Westphal, F.; Schäfer, T.; Zechlin, L.; Stoll, S. Identification of 4-Methylamphetamine in a seizedAmphetamine Mixture. Toxichem Krimtech 2011, 78 (Special Issue), 306-315.
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