4-Hydroxy-MIPT The Drug Enforcement Administration's Special Testing and Research Laboratory generated this monograph using structurally confirmed reference material. Page 1 of 5 SWGDRUG.org/monographs.htm Latest Revision: 2/5/2015 N H OH N C H 3 CH 3 CH 3 1. GENERAL INFORMATION IUPAC Name: CAS#: Synonyms: Source: Appearance: UV max (nm): 3-{2-[methyl(propan-2-yl)amino]ethyl}-1H-indol-4-ol 77872-43-6 4-OH-MIPT, 4-hydroxy-N-methyl-N-isopropyltryptamine, hats, miprocin DEA Reference Material Collection Gray powder (base) Not Determined 2. CHEMICAL AND PHYSICAL DATA 2.1 CHEMICAL DATA Form Chemical Formula Molecular Weight Melting Point ( o C) Base C 14 H 20 N 2 O 232 143.7 HCl C 14 H 20 N 2 O . HCl 268 Not Determined
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4-Hydroxy-MIPTThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 1 of 5SWGDRUG.org/monographs.htmLatest Revision: 2/5/2015
Form Chemical Formula Molecular Weight Melting Point (oC)
Base C14H20N2O 232 143.7
HCl C14H20N2O. HCl 268 Not Determined
4-Hydroxy-MIPTThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 2 of 5SWGDRUG.org/monographs.htmLatest Revision: 2/5/2015
3. QUALITATIVE DATA
3.1 NUCLEAR MAGNETIC RESONANCE
Sample Preparation: Dilute analyte to ~5 mg/mL in CD2Cl2 containing TMS for 0 ppm reference and methenamine as quantitative internal standard.
Instrument: 400 MHz NMR spectrometerParameters: Spectral width: at least containing -3 ppm through 13 ppm
Pulse angle: 90o
Delay between pulses: 45 seconds1H NMR: 4-OH-MIPT Lot # 0438458-25; CD2Cl2; 400MHz
8 7 6 5 4 3 2 1 0
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
63231212
CD2Cl2 TMS
8.05 8.00
2
6.95 6.85
21
6.425 6.400
1
2.33 2.31
3
2.9 2.8 2.7
23
0.975 0.950
6
methenamine
4-Hydroxy-MIPTThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 3 of 5SWGDRUG.org/monographs.htmLatest Revision: 2/5/2015
3.2 GAS CHROMATOGRAPHY/MASS SPECTROMETRY
Sample Preparation: Dilute analyte ~4 mg/mL in chloroform.
Instrument: Agilent gas chromatograph operated in split mode with MS detectorColumn: DB-1 MS (or equivalent); 30m x 0.25 mm x 0.25 µmCarrier Gas: Helium at 1 mL/minTemperatures: Injector: 280oC
MSD transfer line: 280oCMS Source: 230oCMS Quad: 150oCOven program:
1) 100oC initial temperature for 1.0 min2) Ramp to 300oC at 12 oC/min3) Hold final temperature for 9.0 min
Injection Parameters: Split Ratio = 20:1, 1 µL injectedMS Parameters: Mass scan range: 30-550 amu