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DRY-EYE SYNDROMENIKA BELLARINATASARI
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DEFINITION
"a multifactorial disease of the tears and ocular surface thatresults in symptoms of discomfort, visual disturbance, andtear-film instability with potential damage to the ocularsurface. It is accompanied by increased osmolarity of thetear film and inflammation of the ocular surface" (DEWS,2007).
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Dry eye represents a disturbance of the lacrimalfunctional unit (LFU), an integrated system comprisingthe lacrimal glands, ocular surface (cornea, conjunctiva,and meibomian glands), and eyelids, as well as thesensory and motor nerves that connect them
Its overall functions are
to preserve tear-film integrity: lubricating, antimicrobial,and nutritional roles
ocular surface health: maintaining corneal transparency andsurface stem cell population
quality of image projected onto the retina
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MECHANISM OF DRY EYE
The core mechanisms of dry eye are driven by tearhyperosmolarity and tear-film instability
Tear hyperosmolarity causes damage to the surface
epithelium by activating a cascade of inflammatoryevents at the ocular surface and release of inflammatorymediators into the tears
Epithelial damage involves cell death by apoptosis, aloss of goblet cells, and disturbance of mucin expression
leading to tear-film instability The instability of tear film exacerbates oculer surface
hyperosmolarity and completes the vicious cycle.
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Tear-film instability can also be initiated by severaletiologies :
Xerosing medication
Xerophthalmia
Ocular allergy
Topical preservative use
Contact lens wear
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TEAR-FILM EVALUATION
The best approach
is to combine information from thehistory and examination with the results of one or moreof the fo llowing diagnostic tests.
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Inspection Signs of associated systemic disease (rheumatoid arthritis)
Indications of personal habits (smoking)
Signs of associated ocular disease (pseudoptosis,blepharospasm)
Characteristic facial telangiectasia & eyelid marginhyperemia associated with ocular rosacea
Tear meniscus between the globe and the lower eyelid(normally 1.0 mm in height and convex)
Tear breakup is a functional measure of tear stability; if
stability is perturbed (as in lipid or mucin deficiency), thetear breakup time (TBUT) can become more rapid
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Tear Breakup Time (TBUT)
The examiner moistens a fluorescein strip with sterile saline
and applies it to the tarsal conjunctiva (fluorescein-anesthetic combination drops are not suitable for thispurpose).
After several blinks, the tear film is examined using a broadbeam of the slit lamp with a blue filter.
The time lapse between the last blink and the appearanceof the first randomly distributed dry spot on the cornea isthe tear breakup time.
Dry spots appearing in less than 10 seconds are consideredabnormal.
TBUT should be measured before any eyedrops areinstilled and before the eyelids are man ipulated in any
way. It is best to wait at least 1 minute after fluorescein
instillation to evaluate the corneal su rface forfluorescein staining
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The eye should be carefully
Tear-film debris
Conjunctivochalasis (complain of epiphora)
Floppy eyelid syndrome
Multiple concretions (chronis blepharitis)
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TESTS OF TEAR PRODUCTION
Schirmer testing is performed by placing a thin strip offilter paper in the inferior cul-de-sac. The amount ofwetting can be measured to quanti fy aqueous tearproduction
The basic secretion test is performed following theinstillation of a topical anesthetic, followed by lightlyblotting residual fluid out of the inferior fornix. A thinfilter-paper strip (5 mm wide, 35 mm long) is placed atthe junction of the middle and lateral thirds of the lowereyelids to minimize ir ritation to the cornea during the
test. The test can be performed with open or closedeyes, although some recommend the eyes be closed tolimit the effect of blinking.
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The Schirmer I test, which is si milar to the basicsecretion test but without topical anesthetic, measu resboth basic and reflex tearing combined
The Schirmer II test, wh ich measures reflex secretion,is performed in a similar manner without topicalanesthetic. However, after the filter-paper strips havebeen inse rted into the in ferior fornices, a cotton-tippedapplicator is used to irritate the nasal mucosa.
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AQUEOUS TEAR DEFICIENCY
Definiton : decreased aqueous tear production, asmeasured by Schirmer testing, pattern of conjunctival &/corneal staining with lissamine green or rose bengal,corneal staining by fluorescein, and filamentarykeratopathy
Symptoms
Burning, photophobia, dry sensation, blurred vision, foreignbody sensation
Signs :
Conjunctival hyperemia, conjunctivochalasis, decreased tearmeniscus, iregular corneal surface, debreis in tear-film
Epithelial keratopathy
Filaments & mucous plaques , filamentary keratopathy,marginal or paracentral thinning & perforation corneal(more severe dry eye states)
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EVAPORATIVE TEARDYSFUNCTION
Increased tear-film evaporation is most commonlycaused by MGD but may also be caused by disease ofthe meibomian glands, poor apposition of the eyelids tothe ocular surface, increase of the palpebral aperture,
and contact lens wear.
Symptoms consist of burning, foreign-body sensation,redness ofthe eyelids and conjunctiva, filmy vision, andrecurrent chalazia.
Signs of ETD include decreased TBUT, MGD, abnormal
aqueous tear production, and a characteristic linearpattern of rose bengal/lissamine green staining of theinferior conjunctiva and cornea and eyelid margin.
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MEIBOM GLAND DYSFUNCTION
Meibom Gland Dysfunction
Terjadi akibat obstruksi progresif lubang kelenjar meibom karenakeratinisasi.
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Sehingga ada penurunan lapisan lipid permukaan mata
dan peningkatan inflamasi pada kelopak yang ditandai :
Hiperemia tepi kelopak dan konjungtiva tarsal
Sekresi meibom bisa jernih, keruh atau kental.
Lubang kelenjar meibom tertutup plug dan terletak lebih ke
posterior akibat terbentuk sikatrik pada tepi kelopak dantarsal
Patogenesis
Tjd obstr/hiposekresi akibat penyakit blefaritis anterior,rosacea acne, pemfigoid
Non obstr/ hipersekresi akibat meibomian seborrhea
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Pasien MGD akan menjadi defisiensi air mata lipid yang
akan menyebabkan instabil lapisan air mata,peningkatan penguapan tear film, dan peningkatanosmolaritas air mata
Gejala & tanda
Terasa terbakar/panas
Sensasi benda asing, merah kelopak dan konjungtiva
Filmy vision
Kalazion rekuren
Inflamasi tepi posterior kelopak mata, konjungtiva dan
kornea
Telangiectasi (brush marks) pada tepi anterior-posterior
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Plug putih protein keratin menutupi lubang kelenjarmeibom
Sekresi meibom berubah warna dan viskositasnya
Bila inflamasi berlangsung th, terjadi atrofi kelenjarmeibom
Terbentuh buih busa pada tear meniscus
Rapid TBUT
Bisa terjadi peradangan pd permukaan mata(konjungtivits, episcleritis, erosi epitel punctat kornea,
pannus kornea, penipisan kornea)
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Management
Eyelid hygiene (1-2x/hari), dengan cara :
kompres hangat beberapa menit dilanjutkan dg
Gentle massage dengan menekan sekresimeibom, diikuti dengan membersihkan denganwashcloth, cotton ball, atau pad
Shampo noniritasi atau pengenceran cairansodium bicarbonat (1 sdt dalam 0,5 liter airmendidih)
Antibiotika topikal
Tetrasiklin sistemik 250 mgx4/hari untuk 3-4 minggu
pertama, bila membaik dosis diturunkan 250-500mg/hari. Atau
Doxycyclin 100 mg dan minocyclin 50 mg diberikan2x/hari utk 3-4 minggu, ditaper 50-100 mg/hari
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Eritromisin bila anak2 atau alergi tetrasiklin dandoxycyclin
Pengobatan ini tujuannya utk mengontrol bukanmenyembuhkan penyakitnya
Steroid topikal diperlukan bila inflamasinya sedangsmp berat, terutama bila ada infiltrat kornea danvaskularisasi
Omega 3
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TERIM K SIH