3D Health Products: Shaping Healthcare through Innovation presented by Yeong Wai Yee Assistant Professor School of Mechanical and Aerospace Engineering Nanyang Technological University, Singapore Email: [email protected] Oct 2016
3D Health Products: Shaping Healthcare through Innovation
presented by
Yeong Wai Yee
Assistant Professor
School of Mechanical and Aerospace Engineering
Nanyang Technological University, Singapore
Email: [email protected]
Oct 2016
What is 3D Printing?
• Construct physical models directly from Computer-Aided Design (CAD) data.
• Other names: 3D printing, Additive Manufacturing, Rapid Prototyping, layered manufacturing, solid freeform fabrication
2
A HOT TOPIC
3D Printing machines
4
Different TechnologiesASTM F2792
What can you print: Materials
6
PlasticCeramics
Biomaterials
Glass
Metal
Wood
plastic and carbon composite
Solid filament, flakes Liquid resin Powder
Different Format of Materials:
In Biomedical and Healthcare
Scaffold for tissue
engineering
Bioprinting
Micro-tissue ,
mini-organ,
drug
Biomodel
Medical
Devices
Implant
3D Printing as Advanced Manufacturing Technology for Medical Devices
Intervertebral body fusion device(Credit: Joimax)
3D printed polymer, spinal load-bearing device
(Credit: OPM)
http://tissuesys.com/technology
TRS Scaffold Technology
Surgical guide
Porous load
bearing implant
Solid load bearing
implant
Porous
degradable
implant Hearing aid shell
3D printing of a tracheobronchial
splint (TBS)
3D Printing meets urgent medical needs
Umbilical cord clamps• 3D printed for direct use in local clinics at Haiti
http://reliefweb.int/report/haiti/field-ready-project-haiti
3D Printing meets global medical needs,
overcoming logistic challenges
Home-based printed assisted devices
http://enablingthefuture.org/
Open source design file available
3D Printing enables new co-creation,
open innovation platform in healthcare
Enables New Device Design : Customized Lattice Metal Implants for Enhanced Osteointegration
SL Sing, WY Yeong, FE Wiria. (2016). Selective laser melting of titanium
alloy with 50 wt% tantalum: Microstructure and mechanical properties.
Journal of Alloys and Compounds, 660, 461–470
SL Sing, WY Yeong, FE Wiria, BY Tay. (2015). Characterization of
Titanium Lattice Structures Fabricated by Selective Laser Melting using
an Adapted Compressive Test Method. Experimental Mechanics, ,
10.1007/s11340-015-0117-y
Sing, S. L., An, J., Yeong, W. Y. and Wiria, F. E. (2015). Laser and
electron-beam powder-bed additive manufacturing of metallic implants: A
review on processes, materials and designs. Journal of Orthopaedic
Research, Accepted, doi: 10.1002/jor.23075.
Creating New Materials :
Patent pending
New diagnostic and testing capability in pharma: 3D Printed Microfluidics Chip
Jia Min LEE, Meng ZHANG, Wai Yee YEONG. (2016). Characterization and evaluation of 3D printed
microfluidic chip for cell processing. Microfluidics and Nanofluidics, 20(1), 1-15
• 3D printing provides design freedom in micro-to-macro
fluidics chip features and designs.
• Enable new capabilities in cells processing, drug testing
and biosensor diagnostic testing .
New combinational medical device: 3D Printed Biodegradable Scaffold for Tissue Engineering
Yeong WY, et al: Porous polycaprolactone scaffold for cardiac tissue engineering fabricated by selective laser sintering.
Acta Biomater; 2010 Jun;6(6):2028-34
W.L Ng, S.Wang, W.Y.Yeong, M.W. Naing (2016) SKIN BIOPRINTING: IMPENDING REALITY
OR FANTASY, Trends in Biotechnology 2016 Sep;34(9):689-99
Emerging technologies: Bioprinting
Patterning and
printing of cells
inside/on
constructs
Cells as one of
the raw materials
to be printed
Complex regulatory future
http://www.rapidtoday.com/future.html
source: Google,
Organ Bioprinting = medical
device + drug + advanced
cell therapy
3D Systems, TNO
Emerging technologies: 3D Printed Food
Provide personalized food for the increasing global population ( Shape, colour, age, health requirements …)
3D Printed Drug- Spritam
• FDA Approves Spritam (levetiracetam) as the First 3D Printed Drug Product by Aprecia Pharmaceuticals
• to be available in the first quarter of 2016
• pill can be made more porous than typical pills, rapidly disintegrate, Support dose loading up to 1,000 mg
https://www.aprecia.com/zipdose-platform/zipdose-technology.php
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Current AM Standards
• ASTM International
Committee F42 on Additive
Manufacturing
Technologies, formed in
2009 and • ISO Technical Committee
261 on Additive
Manufacturing, formed in
2011
Summary
• 3D printing is a diverse technology with huge potential in shaping the future of healthcare.
• Enables new business operation, new business model, new technology creation and new solutions for patient and healthcare practitioners.
• Close collaboration among industry partners, healthcare practitioners and the researchers are necessary for maximum impact in the near future.
Thank you
Images from google and articles.
For education purpose only.
https://scholar.google.com.sg/citations?user=CgowDcwAAAAJ&hl=en
Wai Yee Yeong - Google Scholar Citations