Sclera
Sclera
Anatomy of The Sclera
• Composed primarily of type I collagen and proteoglycans
• Avascular, execpt :– superficial vesels of the episclera– intrascleral vascular plexus at posterior of the
limbus
• Anteriorly, consists of dense vascular connective tissue
Hypersensitivity Reaction and Ocular Disease
• Type I ( Anaphylactic or Atopic Reactions)– An antigen binds with two adjacent IgE --->
release of histamine and other mediator
• Type II (Cytotoxic Hypersensitivity)– Interaction of immunoglobines with antigens
--> cell lysis by complement activation– Killer cells are involved in antibodydependent
cell cytotoxity
• Type III (Immune-Complex Reactions)– follows the deposition of antigen-antibody
complexes in ocular tissue with complement activation and neutrophil recruitment
• Type IV (Delayed Hypersensitivity)– Antigens inter act with receptors on the surface
of T lymphocytes and result in the release of lymphokines
Type Ocular Disease I Allergic conjungtivitis Atopic keratoconjungtivitis & dermatitis II Ocular cicatrical pemphigoid Mooren ulcer III Scleritis IV Contact dermatitis
Phlyctenulosis
Hypersensitivity Reactions and Ocular Disease
Inflammation of the Sclera
• Episcleritis– benign inflammatory of the deep
subconjungtival connective tissues– occasionally fleeting, frequently repeated
(episcleritis periodica fugax)
– E/ : allergic reaction to an endogenous toxin– Clinical finding :
• Dense lymphatic infiltration of the subconjunctival and episcleral tissues
• Little or no pain, usually there is a feeling of discomfort and tenderness on pressure, often severe neuralgia
• Treatment :– corticosteroid drops/ointment– NSAID drops
• Scleritis– bilateral, occurred most frequently in women– more rare than episcleritis– may extend entirely round the cornea, forming
a very serious condition known as annular scleritis
– sometimes extend to cornea causing slerosing keratitis
– E/: immune-mediated vasculitis that inflames and destroys the sclera
– associated with systemic disease :• SLE, polyarteritis nodosa
• Clinical presentation– The swelling is at first dark red or bluish, later
it becomes purple and semi transparent– Onset usually gradual over several days
Subtypes And Prevalence of Scleritis
Location Subtype PrevalenceAnterior sclera Diffuse scleritis 40%
Nodular scleritis 44%Necrotizing scleritis 14% with inflammation (10%) without inflammation (4%)
Posterior sclera 2%
• Diffuse or nodular anterior scleritis– characterized by scleral edema and redness zone– scleral nodule is a deep red to purple colour, immobile,
and separated from the overlying episcleral tissue which is elevated by the nodule
• Necrotizing scleritis– the most destructive form– a localized patch of inflammation with the edge of
lesion more inflamed than the center– sclera becomes blue-gray appearance and an altered
deep episcleral blood vessel pattern
• Necrotizing scleritis without signs of inflammation (scleromalacia perforans)– in patiens with long-standing rheumatoid
arthritis (55% of cases)– signs are minimal and generally no pain– sclera thins and the underlying dark uveal tissue
become visible --> uvea is covered with only thin connective tissue and conjunctiva
• Posterior scleritis– occur in isolation or concomitant with anterior scleritis– signs are pain, tenderness, proptosis, visual loss and
restricted motility, retraction of the lower eyelid caused by infiltration of muscle in the region of posterior scleritis
– pain maybe reffered to other other parts of head --> D/ can be missed
Complications of scleritis
• Complication are frequent and include :– peripheral keratitis (37%)– uveitis (30%)– cataract (7%)– glaucoma (18%)– scleral thinning (33%)
• anterior uveitis as spillover phenomenon : anterior scleritis
• posterior uveitis : ant and post scleritis
Management of Scleritis
• In mild cases of diffuse anterior & nodular scleritis : topical corticosteroid
• NSAID (indomethacine, naproxen, diclofenac, etc) are also effective
• Oral and high dose IV steroid may be effective in necroting sleritis sclerokeratitis
Congenital Anomalies of Sclera
• Blue Sclera– Related to generalized thinning with increased
visibility of underlying uvea– Syndromes associated with :
• Osteogenesis imperfecta type I
• Ehlers-Danlos syndrome type VI (EDS VI)
• EDS VI with normal lysyl hydroxylase
– Clinical findings : All three syndrome share each other
– Management : regular hearing evaluation after adolescence
Degenerative Process of the Sclera
• Senile Plaques– E/:
• scleral reigidity• decrease of scleral hydration• decrease of mucopolysaccharide
– Accompanied by subconjungtival deposition of fat
– The plaques do not elicit inflammation and rarely extrude