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【医歯薬学総合研究科(医学系)】 形態制御解析学(解剖学第一) Yasuda K, Takahashi M, Mori N: Mdm20 modulates action remodeling through the mTORC2 pathway via its effect on Rictor expression, PLoS One, e0142943, 2015 ◇ 組織細胞生物学(解剖学第三) Muraoka I, Takatsuki M, Sakai Y, Tomonaga T, Soyama A, Hidaka M, Hishikawa Y, Koji T, Utoh R, Ohashi K, Okano T, Kanematsu T, Eguchi S: Transplanted fibroblast cell sheets promote migration of hepatic progenitor cells in the incised host liver in allogeneic rat model. J Tissue Eng Regen Med, 9(11): 108-115, 2015 ★ Yamamoto-Fukuda T, Akiyama N, Shibata Y, Takahashi H, Ikeda T, Koji T: In vivo over-expression of KGF mimic human middle ear cholesteatoma. Eur Arch Otorhinolaryngol, 272(10): 2689-2696, 2015 ★ Tobinaga S, Matsumoto K, Nagayasu T, Furukawa K, Abo T, Yamasaki N, Tsuchiya T, Miyazaki T, Koji T: Keratinocyte growth factor gene electroporation into skeletal muscle as a novel gene therapeutic approach for elastase-induced pulmonary emphysema in mice. Acta Histochem Cytochem, 48(3): 83-94, 2015 ★ Kitamura M, Nishino T, Obata Y, Oka S, Abe S, Muta K, Ozono Y, Koji T, Kohno S: The kampo medicine Daikenchuto inhibits peritoneal fibrosis in mice. Biol Pharm Bull, 38(2): 193-200, 2015 ★
Io K, Nishino T, Obata Y, Kitamura M, Koji T, Kohno S: SAHA suppresses peritoneal fibrosis in mice. Perit Dial Int, 35(3): 246-258, 2015 ★
Dai L, Endo D, Akiyama N, Yamamoto-Fukuda T, Koji T: Aberrant levels of histone H3 acetylation induce spermatid anomaly in mouse testis. Histochem Cell Biol, 143(2): 209-224, 2015 ◇ Endo D, Koji T: Testis-specific knockdown of Dnmt1 induced mislocalization of rRNA genes in the nuclei of mouse spermatocytes. Microscopy, 64: i63, 2015 ◇ EndoD, FukudaT, AkiyamaN, KojiT: Aberrant formation of synaptonemal complex induced by Dnmt1knockdown with in vivo electroporation of shRNA expression vectorin mouse testes. J Physiol Sci, 65: S221, 2015 ◇
医科薬理学
So G, Nakagawa S, Morofuji Y, Hiu T, Hayashi K, Tanaka K, Suyama K, Deli MA, Nagata I, Matsuo T, Niwa M. Candesartan improves ischemia-induced impairment of the blood-brain barrier in vitro: Cell Mol Neurobiol, 35(4):563-72, 2015 ★◇Fukuda S, Nakagawa S, Takeshita T, Morofuji Y, Hayashi K, Nagata I, Niwa M: A search for protective drugs against diabetic blood-brain barrier dysfunction model in vitro. J Pharmacol Sci, 128: 235, 2015 ◇
探索病理学(病理学第一)
Kim SE, Mori R, Komatsu T, Chiba T, Hayashi H, Park S, Sugawa MD, Dencher NA, Shimokawa I: Upregulation of cytochrome c oxidase subunit 6b1 (Cox6b1) and formation of mitochondrial supercomplexes: implication of Cox6b1 in the effect of calorie restriction. Age(Dordr), 37, 9787, 2015 ★◇ Shimokawa I, Komatsu T, Hayashi N, Kim SE, Kawata T, Park S, Hayashi H, Yamaza H, Chiba T, Mori R: The life-extending effect of dietary restriction requires Foxo3 in mice. Aging Cell, 14, 707-709, 2015 ★◇
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Kamohara R, Yamaza H, Tsuchiya T, Komatsu T, Park S, Hayashi H, Chiba T, Mori R, Otabe S, Yamada K, Nagayasu T, Shimokawa I: Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect. Exp Gerontol, 64, 46-54, 2015 ★◇ Okita N, Tsuchiya T, Fukushima M, Itakura K, Yaguchi K, Narita T, Hashizume Y, Sudo Y, Chiba T, Shimokawa I, Higami Y: Chronological analysis of caloric restriction-induced alteration of fatty acid biosynthesis in white adipose tissue of rats. Exp Gerontol, 63:59-66, 2015 ★
Nunan R, Campbell J, Mori R, Pitulescu ME, Jiang WG, Harding KG, Adams HG, Nobes CD, Martin P: Ephrin-Bs drive junctional downregulation and actin stress fiber disassembly to enable wound re-epithelialisation. Cell Rep, 13, 1380-1395, 2015 ◇
免疫学(医動物学) Tamura, T, Kimura, K, Yui, K, Yoshida, S, Reduction of conventional dendritic cells during Plasmodium infection is dependent on activation induced death by type I and II interferons, Exp Parasitol., 159: 127-135, 2015 ★ Akazawa, S, Kobayashi, M, Kuriya, G, Yu, L, Kawasaki, E, Yamasaki, H, Nagayama, Y, Matsuyama, M. Akbari, T, Yui, K, Kawakami, A, Abiru, N, Haplotype infufficiency of interferon regulatory factor 4 strongly protects against autoimmune in non-obese diabetic mice, Diabetologia, 58: 2606-2614, 2015 ★ リウマチ免疫病態制御学(内科学第一)
Akazawa S, Kobayashi M, Kuriya G, Horie I, Yu L, Yamasaki H, Okita M, Nagayama Y, Matsuyama T, Akbari M, Yui K, Kawakami A, Abiru N. Haploinsufficiency of interferon regulatory factor 4 strongly protects against autoimmune diabetes in NOD mice. Diabetologia, 58(11):2606-2614, 2015 ★ 内分泌代謝病態病態制御学(内科学第一) Akazawa S, Kobayashi M, Kuriya G, Horie I, Yu L, Yamasaki H, Okita M, Nagayama Y, Matsuyama T, Akbari M, Yui K, Kawakami A, Abiru N. Haploinsufficiency of interferon regulatory factor 4 strongly protects against autoimmune diabetes in NOD mice. Diabetologia, 58(11):2606-2614, 2015 ★ 呼吸器病態制御学(内科学第二)
Iwanaga N, Nakamura S, Oshima K, Kajihara T, Takazono T, Miyazaki T, Izumikawa K, Yanagihara K, Sugawara A, Sunazuka T, Omura S, Kohno S. Macrolides Promote CCL2-Mediated Macrophage Recruitment and Clearance of Nasopharyngeal Pneumococcal Colonization in Mice. J Infect Dis, 212(7):1150-9, 2015 ★ Tanaka A, Nakamura S, Seki M, Iwanaga N, Kajihara T, Kitano M, Homma T, Kurihara S, Imamura Y, Miyazaki T, Izumikawa K, Kakeya H, Yanagihara K, Kohno S. The effect of intravenous peramivir, compared with oral oseltamivir, on the outcome of post-influenza pneumococcal pneumonia in mice. Antivir Ther, 20(1):11-9, 2015 ★ Kitamura M, Nishino T, Obata Y, Oka S, Abe S, Muta K, Ozono Y, Koji T, Kohno S: The kampo medicine Daikenchuto inhibits peritoneal fibrosis in mice. Biol Pharm Bull, 38(2): 193-200, 2015 ★ Io K, Nishino T, Obata Y, Kitamura M, Koji T, Kohno S: SAHA Suppresses Peritoneal Fibrosis in Mice. Perit Dial Int, 35(3): 246-258, 2015 ★ 眼科・視覚科学(眼科)
Uematsu M, Mohamed YH, Onizuka N, Ueki R, Inoue D, Fujikawa A, Kitaoka T: A novel in vivo corneal trans-epithelial electrical resistance measurement device. J Pharmacol Toxicol Methods, 76: 65-71, 2015 ★
形成再建外科学(形成外科学) Yoshida S, Hamuy R, Hamada Y, Yoshimoto H, Hirano A, Akita S. Adipose-derived stem cell transplantation for therapeutic lymphangiogenesis in a mouse secondary lymphedema model. Regen Med, 10(5):549-62. 2015 ★ 腫瘍外科学(第一外科)
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Tomoshige K, Matsumoto K, Tsuchiya T, Oikawa M, Miyazaki T, Yamasaki N, Mishima H, Kinoshita A, Kubo T, Fukushima K, Yoshiura K, Nagayasu T: Germline mutations causing familial lung cancer. J Hum Genet, 60(10): 597-603, 2015 ◇ Tsuchiya T, Arai J, Matsumoto K, Miyazaki T, Honda S, Tagawa T, Nakamura A, Taniguchi H, Sano I, Akamine S, Muraoka M, Hisano H, Yamasaki N, Nagayasu T: Prognostic Impact of the ABCC11/MRP8 Polymorphism in Adjuvant Oral Chemotherapy with S-1 for Non-Small Cell Lung Cancer. Chemotherapy, 61(2): 77-86, 2015 ◇ 産科婦人科学 Miura K, Higashijima A, Hasegawa Y, Abe S, Miura S, Fuchi N, Murakami Y, Kinoshita A, Yoshida A,Kaneuchi M, Yoshiura KI, Masuzaki H. Circulating levels of maternal plasma cell-free miR-21 areassociated with maternal body mass index and neonatal birth weight. Prenat Diagn, 235: 509-511, 2015 ◇ Miura K, Higashijima A, Mishima H, Miura S, Kitajima M, Kaneuchi M, Yoshiura KI, Masuzaki H.Pregnancy-associated microRNAs in plasma as potential molecular markers ofectopicpregnancy. Fertil Steril, 103: 1202-1208, 2015 ◇ Miura K, Higashijima A,Murakami Y, Tsukamoto O,Hasegawa Y, Abe S, Fuchi N, Miura S, Kaneuchi M, Masuzaki H. Circulating levels of C19MC-cluster microRNAs in pregnant women with severe pre-eclampsia. J Obstet Gynecol Res, 41: 1526-1532, 2015◇ Miura K, Higashijima A, Hasegawa Y, Miura S, Yoshiura KI, Masuzaki H. Microarray screening of amniotic fluid-specific genes in maternal plasma. The proceedings of The ISPD 18th International Conference on Prenatal Diagnosis and Therapy. Prenat Diagn, 34: 60, 2014 ◇ 整形外科学 島内誠一郎,富田雅人,下川功,伊東昌子, 尾崎誠:ラットではマイクロ CT による骨微細構造解析の結果と組織形態計測の結果で乖離が生じる.日本整形外科学会雑誌 89(8): S1678, 2015 ◇ 皮膚病態学 宇谷厚志: 弾性線維性仮性黄色腫. 南山堂医学大辞典,南山堂, 1572-1573, 2015 宇谷厚志: 弾性線維性仮性黄色腫. 皮膚疾患最新の治療 2015-2016,南江堂, 155, 2015 小池雄太, 八木洋輔, 宇谷厚志: 創傷後瘢痕における細胞外マトリックス沈着への bFGF の影響. 皮膚の科学, 13(Suppl): 28-33, 2015 ★ 病態解析・診断学(臨床検査医学)
Iwanaga N, Nakamura S, Oshima K, Kajihara T, Takazono T, Miyazaki T, Izumikawa K, Yanagihara K, Sugawara A, Sunazuka T, Omura S, Kohno S.: Macrolides Promote CCL2-Mediated Macrophage Recruitment and Clearance of Nasopharyngeal Pneumococcal Colonization in Mice, J Infect Dis, 212(7):1150-9, 2015 ★ 臨床感染症学 Iwanaga N, Nakamura S, Oshima K, Kajihara T, Takazono T, Miyazaki T, Izumikawa K, Yanagihara K, Sugawara A, Sunazuka T, Omura S, Kohno S: Macrolides promote CCL2-mediated macrophage recruitment and clearance of nasopharyngeal pneumococcal colonization in mice. J Infect Dis, 212:1150-9, 2015 ★
Tanaka A, Nakamura S, Seki M, Iwanaga N, Kajihara T, Kitano M, Homma T, Kurihara S, Imamura Y, Miyazaki T, Izumikawa K, Kakeya H, Yanagihara K, Kohno S: The effect of intravenous peramivir, compared with oral oseltamivir, on the outcome of post-influenza pneumococcal pneumonia in mice. Antivir Ther, 20:11-9, 2015 ★ 神経機能学(生理学第二) Sasaki K, Omotuyi OI, Ueda M, Shinohara K, Ueda H: NMDA receptor agonists reverseimpairedpsychomotor and cognitive functions associated with hippocampal Hbegfdeficiency in mice. Mol Brain, 8: 83, 2015 ◇
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感染分子解析学 Homma T, Ishibashi D, Nakagaki T, Fuse T, Mori T, Satoh K, Atarashi R, Nishida N: Ubiquitin-specific protease 14 modulates degradation of cellular prion protein. Sci Rep, 5: 11028, 2015 ◇ Fukuda Y, Horie N, Satoh K, Yamaguchi S, Morofuji Y, Hiu T, Izumo T, Hayashi K, Nishida N, Nagata I: Intra-Arterial Transplantation of Low-Dose Stem Cells Provides Functional Recovery Without Adverse Effects After Stroke. Cell Mol Neurobiol, 35(3):399-406, 2015★ Takatsuki H, Satoh K, Sano K, Fuse T, Nakagaki T, Mori T, Ishibashi D, Mihara B, Takao M, Iwasaki Y, Yoshida M, Atarashi R, Nishida N: Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases. PLoS One, 10: e0126930, 2015 ★ Fuchigami T, Yamashita Y, Kawasaki M, Ogawa A, Haratake M, Atarashi R, Sano K, Nakagaki T, Ubagai K, Ono M, Yoshida S, Nishida N, Nakayama M: Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits. Sci Rep, 5:18440, 2015 ★ 法医学 Yamamoto T, Mishima H, Mizukami H, Fukahori Y, Umehara T, Murase T, Kobayashi M, Mori S, Nagai T, Fukunaga T, Yamaguchi S, Yoshiura K, Ikematsu K. Metabolic autopsy with next generation sequencing in sudden unexpected death in infancy: Postmortem diagnosis of fatty acid oxidation disorders, Mol Genet Metab Rep, 26-32, 2015 ◇ 山本琢磨, 梅原敬弘, 深堀友希,村瀬壮彦,池松和哉 脂肪酸代謝異常症からみた乳幼児突然死症例の遺伝子解析DNA多型23巻 171-173 ◇ 【病院(医学系)】 臨床薬物動態学(薬剤部) Kodama Y, Ohkubo C, Kurosaki T, Egashira K, Sato K, Fumoto S, Nishida K, Higuchi N, Kitahara T, Nakamura T, Sasaki H: Secure and effective gene delivery system of plasmid DNA coated by polynucleotide. J Drug Target, 23(1): 43-51, 2015 ★ Kodama Y, Yatsugi Y, Kitahara T, Kurosaki T, Egashira K, Nakashima M, Muro T, Nakagawa H, Higuchi N, Nakamura T, Sasaki H: Quaternary complexes modified from pDNA and poly-l-lysine complexes to enhance pH-buffering effect and suppress cytotoxicity. J Pharm Sci, 104(4): 1470-1477, 2015 ★ Kurosaki T, Nakasone C, Kodama Y, Egashira K, Harasawa H, Muro T, Nakagawa H, Kitahara T, Higuchi N, Nakamura T, Sasaki H: Splenic gene delivery system using self-assembling nano-complex with phosphatidylserine analog. Biol Pharm Bull, 38(1): 23-29, 2015 ★ Mbanefo EC, Kumagai T, Kodama Y, Kurosaki T, Furushima-Shimogawara R, Cherif MS, Mizukami S, Kikuchi M, Huy NT, Ohta N, Sasaki H, Hirayama K: Immunogenicity and anti-fecundity effect of nanoparticle coated glutathione S-transferase (SjGST) DNA vaccine against murine Schistosoma japonicum infection. Parasitol Int, 64(4):24-31, 2015 ★ Uematsu M, Mohamed YH, Onizuka N, Ueki R, Inoue D, Fujikawa A, Sasaki H, Kitaoka T: Acute corneal toxicity of latanoprost with different preservatives. Cutan Ocul Toxicol, 1-6, 2015 ★ 【医学部保健学科】 理学療法学 Morimoto Y, Kondo Y, Kataoka H, Honda Y, Kozu R, Sakamoto J, Nakano J, Origuchi T, Yoshimura T, Okita M: Heat treatment inhibits skeletal muscle atrophy of glucocorticoid-induced myopathy in rats. Physiol Res, 64(6): 897-905, 2015 ★ Hamaue Y, Nakano J, Sekino Y, Chuganji S, Sakamoto J, Yoshimura T, Okita M, Origuchi T: Effects of vibration therapy on immobilization-induced hypersensitivity in rats. Phys Ther, 95(7): 1015-1026, 2015 ★
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Chuganji S, Nakano J, Sekino Y, Hamaue Y, Sakamoto J, Okita M: Hyperalgesia in an immobilized rat hindlimb: Effect of treadmill exercise using non-immobilized limbs. Neurosci Lett, 584: 66-70, 2015 ★ Honda Y, Sakamoto J, Nakano J, Kataoka H, Sasabe R, Goto K, Tanaka M, Origuchi T, Yoshimura T, Okita M: Upregulation of interleukin-1β/transforming growth factor-β1 and hypoxia relate to molecular mechanisms underlying immobilization-induced muscle contracture. Muscle Nerve, 52(3): 419-427, 2015 ★ Akazawa S, Kobayashi M, Kuriya G, Horie I, Yu L, Yamasaki H, Okita M, Nagayama Y, Matsuyama T, Akbari M, Yui K, Kawakami A, Abiru N: Haploinsufficiency of interferon regulatory factor 4 strongly protects against autoimmune diabetes in NOD mice. Diabetologia, 58(11): 2606-2614, 2015 ★ 【医歯薬学総合研究科(歯学系)】 細胞生物学(口腔解剖学第二)
Miyazaki T, Baba TT, Mori M, Moriishi T, Komori T: Microtubule-associated protein tau (Mapt) is expressed in terminally differentiated odontoblasts and severely downregulated in morphologically disturbed odontoblasts of Runx2 transgenic mice. Cell Tissue Res, 361 (2): 457-66, 2015 ★◇ Nilsson P, Sekiguchi M, Akagi T, Izumi S, Komori T, Hui K, Sörgjerd K, Tanaka M, Saito T, Iwata N, Saido TC: Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi. Am J Pathol, 185 (2): 305-13, 2015 ★ Qin X, Jiang Q, Matsuo Y, Kawane T, Komori H, Moriishi T, Taniuchi I, Ito K, Kawai Y, Rokutanda S, Izumi S, Komori T: Cbfb regulates bone development by stabilizing Runx family proteins. J Bone Miner Res, 30 (4): 706-14, 2015 ★◇ Komori T: Animal models for osteoporosis. Eur J Pharmacol, 759:287-94, 2015 ★ Komori T. The functions of Runx family transcription factors and Cbfb in skeletal development. Oral Sci Int, 12 (1): 1-4, 2015 ★ 小守壽文:顕微学的アプローチによる骨の細胞機能の解明: 骨細胞ネットワークのメカニカルストレス応答. Clin Calcium, 25 (10): 1467-74, 2015 ★ 口腔分子生化学 Nemoto TK, Ohara-Nemoto Y: Porphyromonas gingivalisexopeptidases as prerequisitesfor its amino acid metabolism. Jpn Dent Sci Rev, 2015. 08: 002, 2015 ◇ 歯科薬理学 Shimada-Sugawara M, Sakai E, Okamoto K, Fukuda M, Izumi T, Yoshida N, Tsukuba T: Rab27A regulates transport of cell surface receptors modulating multinucleation and lysosome-related organelles in osteoclasts. Sci Rep, 5: 9620, 2015 ◇ 口腔病原微生物学(口腔細菌学) Nakayama M, Inoue T, Naito M, Nakayama K, Ohara N: Attenuation of the phosphatidylinositol 3-kinase/Akt signaling pathway by Porphyromonas gingivalis gingipains. RgpA, RgpB, and Kgp. J Biol Chem, 290 (8): 5190-5202, 2015 ◇ 分子硬組織生物学
Nagatake T Fukuyama S, Sato S, Okura H, Tachibana M, Taniuchi I, Ito K, Shimojou M, Matsumoto N, Suzuki H, Kunisawa J, Kiyono H. Central role of core binding factor b2 in mucosa-associated lymphoid tissue organogenesis in mouse. PLoS ONE, 10 (5): e0127460, 2015 ★ Qin X, Jiang Q, Matsuo Y, Kawane T, Komori H, Moriishi H, Taniuchi I, Ito K, Kawai Y, Rokutanda S, Izumi S, Komori T. Cbfb regulates bone development by stabilizing Runx family proteins. J Bone Miner Res, 30 (4), 706-714, 2015 ★◇ Suda T, Masuyama R, Bouillon R, Carmeliet G. Physiological functions of vitamin D: what we have learned from global and conditional VDR knockout mouse studies. Curr Opin Pharmacol, 22, 87-99, 2015 ★
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Lieben L, Verlinden L, Masuyama R, Torrekens S, Moermans K, Schoonjans L, Carmeliet P, Carmeliet G: Extra-intestinal calcium handling contributes to normal serum calcium levels when intestinal calcium absorption is suboptimal. Bone, 81, 502-512, 2015 ◇ 歯科矯正学
Fujishita A, Koga Y, Utsumi D, Nakamura A, Yoshimi T, Yoshida N: Effects of feeding a soft diet and subsequent rehabilitation on the development of the masticatory function. J Oral Rehabil, 42(4):266-74, 2015 ★◇
Shimada-Sugawara M, Sakai E, Okamoto K, Fukuda M, Izumi T, Yoshida N, Tsukuba T: Rab27A regulates transport of cell surface receptors modulating multinucleation and lysosome-related organelles in osteoclasts. Sci Rep, 5:9620, 2015 ★◇ Yoneshima E, Okamoto K, Sakai E, Nishishita K, Yoshida N, Tsukuba T: The Transcription Factor EB (TFEB) Regulates Osteoblast Differentiation Through ATF4/CHOP-Dependent Pathway. J Cell Physiol, 231(6): 1321-1333, 2015 ★◇ Uchino K, Okamoto K, Sakai E, Yoneshima E, Iwatake M, Fukuma Y, Nishishita K, Tsukuba T: Dual Effects of Liquiritigenin on the Proliferation of Bone Cells: Promotion of Osteoblast Differentiation and Inhibition of Osteoclast Differentiation. Phytother Res, 29(11):1714-21, 2015 ★◇ 歯周病学 Yamashita Y, Ukai T, Nakamura H, Yoshinaga Y, Kobayashi H, Takamori Y, Noguchi S, Yoshimura A, Hara Y: RANKL pretreatment plays an important role in the differentiation of pit-forming osteoclasts induced by TNF-α on murine bone marrow macrophages. Arch Oral Biol, 60 (9):1273-1282, 2015 ★
中村弘隆, 鵜飼 孝, 吉永泰周, 白石千秋, 吉永美穂, 吉村篤利, 原 宜興: T細胞は咬合性外傷で起こる骨吸収 に関与しない: 日歯保誌 58 (1): 35-41, 2015 ★ 齲蝕学 Hayashi Y, Yanagiguchi K, Yamada S. Editorial, Fish collagen as a scaffold. Austin J Biomed Eng, 2 (1), 1029-1030, 2015 ★ 顎・口腔再生外科学 Kawasaki T, Sumita Y, Egashira K, OhbaS, Kgami H, Tran SD, AsahinaI: Transient exposure to hypoxic and anoxic oxygen concentration promotes either osteogenic or ligamentogenic characteristics of PDL-cells. Bio Res, 4: 175-187, 2015★ Ohba S, Sumita Y, Umebayashi M, Yoshimura H, Yoshida H, Matsuda S, Kimura H, Asahina I, Sano K: Onlay bone augmentation on mouse calvarial bone using a hydroxyapatite/collagen composite material with total blood or platelet-rich plasma. Arch Oral Biol, 61: 23-27, 2016 ★
Umebayashi M, Sumita Y, Kawai Y, Watanabe S, Asahina I; Gene-Activated Matrix Comprised of Atelocollagen and Plasmid DNA Encoding Bmp4 or Runx2 Promotes Rat Cranial Bone Augmentation, Bio Res, July: 164-174, 2015 ◇ 口腔インプラント学(含クラウンブリッジ補綴学) Kuroshima S, Yasutake M, Tsuiki K, Nakano T, Sawase T: Structural and Qualitative Bone Remodeling around Repetitive Loaded Implants in Rabbits. Clin Implant Dent Relat Res, Suppl 2: e699-e710, 2015 ★◇
Sasaki M† , Kuroshima S†*, Aoki Y, Inaba N, Sawase T: Ultrastructural Alterations of Osteocyte Morphology via Loaded Implants in Rabbit Tibiae. J Biomech, 48(15): 4130-4141. 2015 ( * Corersponding author, † Authors contributed equally to this work.)★◇
Miyahara K, Watamoto T, Uto Y, Sawase T: Effect of Macroscopic Grooves on Bone Formation and OsteoblasticDifferentiation. Implant Dent, 24 (4): 370-376, 2015 ◇
黒嶋伸一郎,澤瀬 隆:ビスフォスフォネート製剤に起因する顎骨壊死と歯科治療.(歯界展望 125 (3),医歯薬 出版,東京,pp. 446-456 所収) 2015 ★ 黒嶋伸一郎,澤瀬 隆:ビスフォスフォネート製剤に起因する顎骨壊死と歯科治療.(歯界展望 125 (3),医歯薬 出版,東京,pp. 710-721 所収) 2015 ★ 黒嶋伸一郎,澤瀬 隆:ビスフォスフォネート製剤に起因する顎骨壊死と歯科治療.(歯界展望 125 (3),医歯薬 出版,東京,pp. 952-965 所収) 2015 ★ 【医歯薬学総合研究科(薬学系)】 衛生化学 Fuchigami T, Ogawa A, Yamashita Y, Haratake M, Watanabe H, Ono M, Kawasaki M, Yoshida S, Nakayama M: Development of alkoxy styrylchromone derivatives for imaging of cerebral amyloid-β plaques with SPECT. Bioorg Med Chem Lett, 25(16):3363-7, 2015 ▽ Fuchigami T, Yamashita Y, Kawasaki M, Ogawa A, Haratake M, Atarashi R, Sano K, Nakagaki T, Ubagai K, Ono M, Yoshida S, Nishida N, Nakayama M. Sci Rep, 5:18440, 2015 ▽★
医薬品情報学分野 El Hamd MA, Wada M, Ikeda R, Kawakami S, Kuroda N, Nakashima K: Simultaneous determination of propofol and remifentanil in rat plasma by liquid chromatography-tandem mass spectrometry: application to preclinical pharmacokinetic drug-drug interaction analysis. Biomed Chromatogr, 29(3):325-327, 2015 ★
Fuchigami Y, Fu X, Ikeda R, Kawakami S, Wada M, Kikura-Hanajiri R, Kuroda N, Nakashima K: Evaluation of the neurochemical effects of methoxetamine using brain microdialysis in mice, Forensic Toxicology, 33 (2), 374-379 , 2015 ★
El Hamd MA, Wada M, Ikeda R, Kawakami S, Nakashima K: Validation of an LC-MS/MS method for the determination of propofol, midazolam, and carbamazepine in rat plasma: effect of drug-drug interactions on their pharmacokinetics, Biol Pharm Bull, 38 (8), 1250-1253, 2015 ★ 薬物治療学分野 Urabe S, Isomoto H, Ishida T, Maeda K, Inamine T, Kondo S, Higuchi N, Sato K, Uehara R, Yajima H, Machida H, Chen CC, Fukuda Y, Takeshima F, Nakao K, Tsukamoto K. Genetic polymorphisms of IL-17F and TRAF3IP2 could be predictive factors of the long-term effect of infliximab against Crohn’s disease. Biomed Res Int, ID 416838, 1-12, 2015 ◇ 稲嶺達夫,中村稔,塚元和弘: CYP7A1遺伝子多型が影響する原発性胆汁性肝硬変進行メカニズムの解明. 臨床薬理の進歩 36: 91-99, 2015.◇ 薬剤学 Kodama Y, Ohkubo C, Kurosaki T, Egashira K, Sato K, Fumoto S, Nishida K, Higuchi N, KitaharaT, Nakamura T, Sasaki H: Secure and effective gene delivery system of plasmid DNA coated bypolynucleotide. J Drug Target, 23 (1): 43-51, 2015 ◇ 創薬薬理学分野 Omotuyi OI, Matsunaga H, Ueda H: Evidence for ProTα-TLR4/MD-2 binding: Molecular dynamics and gravimetric assay studies. Expert Opin Biol The 15, S1, 223-229, 2015 ◇ Omotuyi OI, Ueda H: Molecular dynamics study-based mechanism of nefiracetam-induced NMDA receptor potentiation. Comput Biol Chem, 55: 14-22, 2015 ◇ Sumitani M, Ueda H, Hozumi J, Inoue R, Kogure T, Ogata T, Yamada Y: Minocycline Does Not Decrease Intensity of Neuropathic Pain, but Improves Its Affective Dimension. J Pain Palliat Care Pharmacother 1-6, 2015 ◇
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Mukae T, Uchida H, Ueda H:Donepezil reverses intermittent stress-induced generalized chronic pain syndrome in mice. J Pharmacol Exp Ther, 353:471-479, 2015 ◇ Uchida H, Matsushita Y, Araki K, Mukae T, Ueda H: Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain afterperipheral nerve injury. J Pharmacol Sci, 128(4): 208-211, 2015 ◇ Omotuyi OI , Ueda H: Inter-helical Electrostatic Interaction and Rotameric Signatures in Activated Sphingosine-1-Phosphate Receptor 1. Chem Informatics, 1(1):2, 2015 ◇ Omotuyi OI, Nagai J , Ueda H: Lys39-Lysophosphatidate Carbonyl Oxygen Interaction Locks LPA1 N-terminal Cap to the Orthosteric Site and partners Arg124 During Receptor Activation. Sci Rep, 5(13343), 2015 ◇ Sasaki K, Omotuyi OI, Ueda M, Shinohara K, Ueda H: NMDA receptor agonists reverse impaired psychomotor and cognitive functions associated with hippocampal Hbegf-deficiency in mice. Mol Brain, 8(1):83, 2015 ◇ Omotuyi OI, Ueda H: Energetics and Protomer Communication in the dynamical Structure of S100A13 in Free and Protein-Bound States. Mol Simulation, 10, 2015 ◇ 機能性分子化学 Yin S, Dragusha S, Ejupi V, Shibata T, Kabashima T, Kai M: Sensitive and Selective Determination of Orotic Acid in Biological Specimens Using a Novel Fluorogenic Reaction. J Fluoresc, 25: 1005-1011, 2015 ◇ 【水産・環境科学総合研究科】 魚病学 Tu C, Suga K, Kanai K: Structure of genetic loci for capsular polysaccharidebiosynthesis in Streptococcus parauberis isolated from Japanese flounder. Fish Pathol, 50:192-199, 2015◇ 【原爆後障害医療研究所】 幹細胞生物学(原研幹細胞) Tanaka T, Li TS, Urata Y, Goto S, Ono Y, Kawakatsu M, Matsushima H, Hirabaru M, Adachi T, kitasato A, Takatsuki M, Kuroki T, Eguchi S:Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma. J Gastroenterol, 20(9):975-983, 2015 ★ Guo CY, Luo L, Urata Y, Goto S, Huang WJ, Takamura S, Hayashi F, Doi H, Kitajima Y, Ono Y, Ogi T, Li TS:Sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells in mice. Sci Rep, 5:8055, 2015 ▽★ Kugiyama N, Nishimoto A, Hosoyama T, Ueno K, Enoki T, Li TS, Hamano K:The c-MYC-ABCB5 axis plays a pivotal role in 5-fluorouracil resistance in human colon cancer. J Cell Mol Med, 19(7):1569-1581, 2015 ★ Ono Y, Urata Y, Goto S, nakagawa S, Patrik O.Humbert, Li TS, and Peter S. Zammit:Muscle stem cell fate is controlled by the cell-polarity protein scrib. Cell Rep, 10(7):1135-1148, 2015 ★
Masuda S, Hisamatsu T, Seko D, Urata Y, Goto S, Li TS, Ono Y:Time- and dose-dependent effects of total-body ionizing radiation on muscle stem cells. Physiol Rep, 3(4):e12377, 2015 ★
Kitajima Y, Doi H, Ono Y, Urata Y, Goto S, Kitajima M, Miura K, Li TS, Masuzaki H:Estrogen deficiency heterogeneously affects tissue specific stem cells in mice. Sci Rep, 5:12861, 2015 ★
Hosoyama T, Samura M, Kudo T, Nishimoto A, Ueno K, Murata T, Ohama T, Sato K, Mikamo A, Yoshimura K, Li TS, Hamano K:Cardiosphere-derived cell sheet primed with hypoxia improves left ventricular function of chronically infarcted heart. Am J Transl Res, 7(12):2738-2751, 2015 ★ 放射線災害医療学(原研医療)
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Rogounovitch TI, Bychkov A, Takahashi M, Mitsutake N, Nakashima M, Nikitski AV, Hayashi T, Hirokawa M, Ishigaki K, Shigematsu K, Bogdanova T, Matsuse M, Nakahara E, Minami S, Yamanouchi K, Ito M, Kawaguchi T, Kondo H, Takamura N, Ito Y, Miyauchi A, Matsuda F, Yamashita S, Saenko VA. The common genetic variant rs944289 on chromosome 14q13.3 associates with risk of both malignant and benign thyroid tumors in the Japanese population. Thyroid 25(3): 333-340, 2015 ◇ Guo C, Nakazawa Y, Woodbine L, Björkman A, Shimada M, Fawcett H, Jia N, Ohyama K, Li TS, Nagayama Y, Mitsutake N, Pan-Hammarström Q, Gennery AR, Lehmann AR, Jeggo PA, Ogi T. XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency. J Allergy Clin Immunol, 136(4): 1007-1017, 2015 ◇ Mitsutake N, Fukushima T, Matsuse M, Rogounovitch T, Saenko V, Uchino S, Ito M, Suzuki K, Suzuki S, Yamashita S. BRAFV600E mutation is highly prevalent in thyroid carcinomas in the young population in Fukushima: a different oncogenic profile from Chernobyl. Sci Rep, 5: 16976, 2015 ◇ 分子医学(原研分子) Akazawa S, Kobayashi K, Kuriya G, Horie I, Yu L, Yamasaki H, Okita M,Nagayama Y, Matsuyama T, Akbari M, Yui K, Kawakami A, Abiru N: Haploinsufficiency of interferon regulatory factor 4 strongly protects against autoimmune diabetes in non-obese diabetic mice. Diabetologia, 58 (11): 2606-2014. 2015 ★ Matsuu-Matsuyama M, Shichijo K Okaichi K, Kurashige T, Kondo H, Miura S, Nakashima M: Effect of age on the sensitivity of the rat thyroid gland to ionizing radiation. J Radiat Res, 56 (3): 493-501, 2015 ★ ゲノム機能修復学(原研修復) Guo C, Nakazawa Y, Woodbine L, Bjorkman A, Shimada M, Fawcett H, Jia N, Ohyama K, Li TS, Nagayama Y, Mitsutake N,Pan-Hammarstrom Q, Gennery AR, Lehmann AR, Jeggo PA, Ogi T. XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency. J Allergy Clin Immunol, 136(4): 1007-1017, 2015 ▽ ★ Tamura S, Higuchi K, Tamaki M, Inoue C, Awazawa R, Mitsuki N, Nakazawa Y, Mishima H, Takahashi K, Kondo O, Imai K, Morio T, Ohara O, Ogi T, Furukawa F, Inoue M, Yoshiura K, Kanazawa N. Novel compound heterozygous DNA ligase IV mutations in an adolescent with a slowly- progressing radiosensitive-severe combined immunodeficiency. J Clin Immunol, 160(2): 255-260, 2015 ◇Jia N, Nakazawa Y, Guo C, Shimada M, Sethi M, Takahashi Y, Ueda H, Nagayama Y, Ogi T. A rapid comprehensive assay system for DNA repair activity and cytotoxic effects of DNA damaging reagents by measuring unscheduled DNA synthesis and recovery of RNA synthesis after DNA damage. Nat Protoc, 10(1): 12-24, 2015 ◇ 放射線分子疫学(原研リスク)
Mitsutake N, Fukushima T, Matsuse M, Rogounovitch T, Saenko V, Uchino S, Ito M, Suzuki K, Suzuki S, Yamashita S. BRAFV600E mutation is highly prevalent in thyroid carcinomas in the young population in Fukushima: a different oncogenic profile from Chernobyl. Sci Rep, 5: 16976, 2015 ◇ 国際保健医療福祉学(原研国際) Nakashima K, Orita M, Fukuda N, Taira Y, Hayashida N, Matsuda N, Takamura N. Radiocesium concentrations in wild mushrooms collected in Kawauchi Village after the accident at the Fukushima Daiichi Nuclear Power Plant. Peer J, 3: e2417,2015 ▽ 人類遺伝学(原研遺伝) Tomoshige K, Matsumoto K, Tsuchiya T, Oikawa M, Miyazaki T, Yamasaki N, Mishima H, Kinoshita A, Kubo T, Fukushima K, Yoshiura KI, Nagayasu T. Germline mutations causing familial lung cancer. J Hum Genet, 60(10): 597-603, 2015 ◇ Oikawa M, Yano H, Matsumoto M, Otsubo R, Shibata K, Hayashi T, Abe K, Kinoshita N, Yoshiura KI, Nagayasu T. A novel diagnostic method targeting genomic instability in intracystic tumors of the breast. Breast Cancer, 22(5): 529-535, 2015 ◇ Hasegawa Y, Miura K, Higashijima A, Abe S, Miura S, Yoshiura KI, Masuzaki H. Increased Levels of Cell-Free miR-517a and Decreased Levels of Cell-Free miR-518b in Maternal Plasma Samples From Placenta Previa Pregnancies at 32 Weeks of Gestation.
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Reprod Sci, 22(12): 1569-1576, 2015 ◇ Miura K, Higashijima A, Mishima H, Miura S, Kitajima M, Kaneuchi M, Yoshiura K, Masuzaki H. Pregnancy-associated microRNAs in plasma as potential molecular markers of ectopic pregnancy. Fertil Steril, 10(5): 1202-1208.e1, 2015 ◇ Miura K, Higashijima A, Hasegawa Y, Abe S, Miura S, Kaneuchi M, Yoshiura KI, Masuzaki H. Circulating levels of maternal plasma cell-free miR-21 are associated with maternal body mass index and neonatal birth weight. Prenat Diagn, 35 (5): 509-511, 2015 ◇ 放射線生物・防護学* Tullayakorn P, Matsuda N, Karbwang J, Viyanant V, Hirayama K, Na-Bangchang K: Anticancer activity of Atractylodes lancea (Thunb.) DC in a hamster model and application of PET-CT for early detection and monitoring progression of cholangiocarcinoma. Asian Pac J Cancer Prev, 16, 6279-6284, 2015 ▽ Nakashima K, Orita M, Fukuda N, Taira Y, Hayashida N, Matsuda N, Takamura N: Radiocesium concentrations in wild mushrooms collected in Kawauchi Village after the accident at the Fukushima Daiichi Nuclear Power Plant. Peer J, 3:e1427, 2015 ▽ 腫瘍・診断病理学(原研病理) Matsuu-Matsuyama M, Shichijo K, Okaichi K, Kurashige T, Kondo H, Miura S, Nakashima M: Effect of age on the sensitivity of the rat thyroid gland to ionizing radiation. J Radiat Res, 56 (3):493-501, 2015 ★
Rogounovitch TI, Bychkov A, Takahashi M, Mitsutake N, Nakashima M, Nikitski AV, Hayashi T, Hirokawa M, Ishigaki K, Shigematsu K, Bogdanova T, Matsuse M, Nishihara E, Minami S, Yamanouchi K, Ito M, Kawaguchi T, Kondo H, Takamura N, Ito Y, Miyauchi A, Matsuda F, Yamashita S, Saenko VA. The common genetic variant rs944289 on chromosome 14q13.3 associates with risk of both malignant and benign thyroid tumors in the Japanese population. Thyroid, 25(3): 333-340, 2015 ◇ 放射線・環境健康影響共同研究推進センター・共同研究推進部 Nakashima K, Orita M, Fukuda N, Taira Y, Hayashida N, Matsuda N, Takamura N. Radiocesium concentrations in wild mushrooms collected in Kawauchi Village after the accident at the Fukushima Daiichi Nuclear Power Plant. Peer J, 3:e1427,2015 ▽ 【熱帯医学研究所】
病原原虫学
Mutungi JK, Yahata K, Sakaguchi M, Kaneko O. Isolation of invasive Plasmodium yoelii merozoites with a long half-life to evaluate invasion dynamics and potential invasion inhibitors. Mol Biochem Parasitol, 204(1): 26-33, 2015 ★ 熱帯寄生虫学 Kalenda YD, Kato K, Goto Y, Fujii Y, Hamano S.: Tandem repeat recombinant proteins as potential antigens for the sero-diagnosis of Schistosoma mansoni infection. Parasitol. Int, 64(6): 503-512, 2015 ★
Bao LQ, Nhi DM, Huy NT, Kikuchi M, Yanagi T, Hamano S, Hirayama K.: Splenic CD11c+ cells derived from semi-immune mice protect naive mice against experimental cerebral malaria. Malar J, 14(1): 23, 2015 ★
新興ウイルス感染症学 Narahara C, and Yasuda J: Roles of the three L-domains inβ-retrovirus budding. Microbiol Immunol, 59, 545-554, 2015 ◇ 【先導生命科学研究支援センター】 放射線生物・防護学 *原爆後障害医療研究所内業績欄に記載 比較動物医学
Yamanaka H, Nakanishi T, Takagi T, Ohsawa M, Kubo N, Yamamoto N, Takemoto T, Ohsawa K: Helicobacter sp. MIT 01-6451 infection during fetal and neonatal life in laboratory mice. Exp Anim, 64(4):375-82, 2015 ★◇