2C-B-BZP Monograph - SWGDRUG BZP.pdf · 2C-B-BZP The Drug Enforcement Administration's Special Testing and Research Laboratory generated this monograph using structurally confirmed

2C-B-BZPThe Drug Enforcement Administration's Special Testing and Research Laboratory

generated this monograph using structurally confirmed reference material.

Page 1 of 5SWGDRUG.org/monographs.htmLatest Revision: 12/16/2013

Form Chemical Formula Molecular Weight Melting Point (oC)

Base C13H19BrN2O2 315 Not Determined

di-HCl C13H19BrN2O2. 2HCl 388 Not Determined

Br

NO

O

CH3

CH3

NH

1. GENERAL INFORMATION

IUPAC Name: 1-(4-bromo-2,5-dimethoxybenzyl)piperazine

CAS#: Not Available

Synonyms: 4-bromo-2,5-dimethoxybenzylpiperazine; 4-bromo-2,5-dimethoxy-1-benzylpiperazine

Source: DEA Reference Material Collection

Appearance: White powder (di-HCl)

UVmax(nm): Not Determined

2. CHEMICAL AND PHYSICAL DATA

2.1 CHEMICAL DATA

2C-B-BZPThe Drug Enforcement Administration's Special Testing and Research Laboratory

generated this monograph using structurally confirmed reference material.

Page 2 of 5SWGDRUG.org/monographs.htmLatest Revision: 12/16/2013

3. QUALITATIVE DATA

3.1 NUCLEAR MAGNETIC RESONANCE

Method NMR D2O

Sample Preparation: Dilute analyte to ~10 mg/mL in D2O containing TSP for 0 ppm reference and maleicacid as quantitative internal standard.

Instrument: 400 MHz NMR spectrometerParameters: Spectral width: at least containing -3 ppm through 13 ppm Pulse angle: 90o

Delay between pulses: 45 seconds

Chemical Shift (ppm)7 6 5 4 3 2

0

2

4

6

8

10

86211

TSP

Maleic Acid HDO

1H NMR: 2C-B BZP di-HCl Lot # H-0416

Chemical Shift (ppm)7.4

0

1

2

3

11

Chemical Shift (ppm)4.5

862

2C-B-BZPThe Drug Enforcement Administration's Special Testing and Research Laboratory

generated this monograph using structurally confirmed reference material.

Page 3 of 5SWGDRUG.org/monographs.htmLatest Revision: 12/16/2013m/z30025020015010050

[x 1

04 ]In

tens

ity

0.5

1.0

1.5

2.0

314

285

272

258

242

229

216

199

192

17114

9

135

120

105

8577

56

42

EI+

3.2 Gas Chromatography/Mass Spectrometry

Sample Preparation: Dilute analyte ~1 mg/mL base extracted into chloroform.

Instrument: Agilent gas chromatograph operated in split mode with MS detectorColumn: DB-1 MS (or equivalent); 30m x 0.25 mm x 0.25 µmCarrier Gas: Helium at 1 mL/minTemperatures: Injector: 280oC MSD transfer line: 280oC MS Source: 230oC MS Quad: 150oC Oven program: 1) 100oC initial temperature for 1.0 min 2) Ramp to 300oC at 12 oC/min 3) Hold final temperature for 9.0 minInjection Parameters: Split Ratio = 20:1, 1 µL injectedMS Parameters: Mass scan range: 30-550 amu Threshold: 100 Tune file: stune.u Acquisition mode: scanRetention Time: 13.502 min

EI Mass Spectrum: 2C-B BZP di-HCl Lot # H-0416

2C-B-BZPThe Drug Enforcement Administration's Special Testing and Research Laboratory

generated this monograph using structurally confirmed reference material.

Page 4 of 5SWGDRUG.org/monographs.htmLatest Revision: 12/16/2013

3.3 INFRARED SPECTROSCOPY (FTIR)

Insrument: FTIR with diamond ATR attachment (3 bounce)Scan Parameters: Number of scans: 32

Number of background scans: 32Resolution: 4 cm-1

Sample gain: 8Aperture: 150

Wavenumber (cm-1)3500 3000 2500 2000 1500

%Tr

ansm

ittan

ce

20

30

40

50

60

70

3414

3014 2958

2712 2295

1606 158314971441

13941292

12151186

10781049

1024957

864795

727712

629577 436

Wavenumber (cm-1)1700 1600 1500 1400 1300 1200 1100 1000 900 800 700

%Tr

ansm

ittan

ce

20

30

40

50

60

70

1583

1497

14411394

13401304

12921269

12151186

10781049

1024

976957

889864

795

727712

663629

577

496

436

FTIR ATR (Diamond, 3 Bounce): 2C-B BZP di-HCl Lot # H-0416

2C-B-BZPThe Drug Enforcement Administration's Special Testing and Research Laboratory

generated this monograph using structurally confirmed reference material.

Page 5 of 5SWGDRUG.org/monographs.htmLatest Revision: 12/16/2013

http://en.wikipedia.org/wiki/2C-B-BZP

4. ADDITIONAL RESOURCES

Wikipedia