264 | Page International Standard Serial Number (ISSN): 2319-8141 Full Text Available On www.ijupbs.com International Journal of Universal Pharmacy and Bio Sciences 4(6): November-December 2015 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO SCIENCES IMPACT FACTOR 2.093*** ICV 5.13*** Pharmaceutical Sciences REVIEW ARTICLE …………!!! “ NUTRACEUTICALS: A REVIEW ” Sheetal B. Gondkar 1 Nikhil P. Mahalpure* 1 R.B.Saudagar 2 1 Department of pharmaceutics, R.G.Sapkal college of Pharmacy Anjaneri, Nashik, Maharashtra,India. 2 Department of pharmaceutical chemistry, R.G.Sapkal college of Pharmacy Anjaneri, Nashik, Maharashtra, India. KEYWORDS: Nutrition, Disease and Treatment, bio-active constituents, food. For Correspondence: Nikhil P. Mahalpure * Address: Department of pharmaceutics, R.G.Sapkal college of Pharmacy Anjaneri, Nashik, Maharashtra,India. ABSTRACT Nutraceutical is regarded as the bio-active substance and the constituent are either of known therapeutic activity or are chemically defined substance generally accepted to contribute substantially to the therapeutic activity of the drug. The word nutraceutical was coined to present substance found in food and herbs that are not technically considered nutrients such as vitamins or minerals but which may have profoundly beneficial impact on the health of the body. Nutraceutical appear to be of benefit in both the treatment and prevention of disease. The entire world is fighting diseases characteristics of the modern age such as obesity, osteoporosis, cancer, diabetes, allergies and dental problems. With the global increase in the prevalence of obesity, both nutrition and exercise play key roles in its prevention and treatment. Nutrients, herbals and dietary supplements are major constituents of nutraceuticals which make them instrumental in maintaining health, act against various disease conditions and thus promote the quality of life.
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264 | P a g e International Standard Serial Number (ISSN): 2319-8141
Full Text Available On www.ijupbs.com
International Journal of Universal Pharmacy and Bio Sciences 4(6): November-December 2015
INTERNATIONAL JOURNAL OF UNIVERSAL
PHARMACY AND BIO SCIENCES IMPACT FACTOR 2.093***
ICV 5.13***
Pharmaceutical Sciences REVIEW ARTICLE …………!!!
“ NUTRACEUTICALS: A REVIEW ”
Sheetal B. Gondkar1 Nikhil P. Mahalpure*
1 R.B.Saudagar
2
1Department of pharmaceutics, R.G.Sapkal college of Pharmacy Anjaneri, Nashik,
Maharashtra,India.
2Department of pharmaceutical chemistry, R.G.Sapkal college of Pharmacy Anjaneri, Nashik,
Maharashtra, India.
KEYWORDS:
Nutrition, Disease and
Treatment, bio-active
constituents, food.
For Correspondence:
Nikhil P. Mahalpure *
Address:
Department of
pharmaceutics,
R.G.Sapkal college of
Pharmacy Anjaneri,
Nashik,
Maharashtra,India.
ABSTRACT
Nutraceutical is regarded as the bio-active substance and the constituent
are either of known therapeutic activity or are chemically defined
substance generally accepted to contribute substantially to the therapeutic
activity of the drug. The word nutraceutical was coined to present
substance found in food and herbs that are not technically considered
nutrients such as vitamins or minerals but which may have profoundly
beneficial impact on the health of the body. Nutraceutical appear to be of
benefit in both the treatment and prevention of disease. The entire world is
fighting diseases characteristics of the modern age such as obesity,
osteoporosis, cancer, diabetes, allergies and dental problems. With the
global increase in the prevalence of obesity, both nutrition and exercise
play key roles in its prevention and treatment. Nutrients, herbals and
dietary supplements are major constituents of nutraceuticals which make
them instrumental in maintaining health, act against various disease
conditions and thus promote the quality of life.
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INTRODUCTION:
About 2000 years ago, Hippocrates correctly emphasized “Let food be your medicine and medicine be
your food.” Currently there is an increased global interest due to the recognition that nutraceuticals
play a major role in health enhancement. The term nutraceutical was coined by combining the terms
“Nutrition” and “Pharmaceutical” in 1989 by Dr.StefenDefelice, Chairman of the Foundation for
Innovation in Medicine.1The term nutraceutical is a food or food products that provides health and
medical benefits, including the prevention and treatment of disease. Such product may range from
isolated nutrients, dietary supplements and specific diets to genetically engineered foods herbal
products and processed foods such as cereals,soups and beverages.2
Plants are one of the most important resources of human foods and medicines. Rapidly increasing
knowledge on nutrition, medicine, and plant biotechnology has dramatically changed the concepts
about food, health and agriculture, and brought in a revolution on them. With recent advances in
medical and nutrition sciences, natural products and health promoting foods have received extensive
attention from health professionals and public.
Foods and nutrients play a vital role in normal functioning of the body. They are helpful in
maintaining the health of the individual and in reducing the risk of various diseases. Nutraceuticals are
medicinal foods that play a role in maintaining well being, enhancing health, modulating immunity
and thereby preventing as well as treating specific diseases. Nutraceuticals are medicinal foods that
play a role in maintaining well being, enhancing health, modulating immunity and thereby preventing
as well as treating specific diseases. Thus the field of nutraceuticals can be envisioned as one of the
missing blocks in the health benefit of an individual. It has been scientifically proved and supported
by various research articles that nutraceutical are efficacious to treat and prevent various disease
conditions.3
CONCEPT OF NUTRACEUTICAL:4
In the pharmaceutical development process, it is a requirement to have clinical test results from
animal tests and studies, for verification of their therapeutic effects. But in the case of nutrition, there
was no verification method for foods in preventing diseases in the past. In recent years however, as
food composition has been scientifically proven cause life style related diseases, and has become a
social issue.
The nutraceutical products are recognized and produce health benefits like like alleviating the risk of
cancer and heart disease and also to prevent or treat hypertension, high cholesterol, excessive weight,
osteoporosis, diabetes, arthritis, macular degeneration (leading to irreversible blindness), cataracts,
menopausal symptoms, insomnia, diminished memory and concentration, digestive upsets and
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constipation, not to mention headaches, other products are touted as cures for thinning hair, lack of
confidence, poor complexion, varicose veins, alcoholism, depression, and lethargy.
The concept of nutraceuticals has been started to be acknowledged as one of the measures for
preventing such diseases.
Fig 1: Concepts of Nutraceuticals
CLASSIFICATION OF NUTRACEUTICALS: ( Table 1)6,7,8
Chemical constituent Source Potential benefit
1.Carotenoids (Isoprenoids)
a.Lycopene Tomatoes, pink grapefruit,
guava papaya, watermelon
Antioxidant activity, protects
against formation of cancer
mainly prostate, bladder
cervical, leukemia.
b.Lutin Corn, avocado, eggyolk,
spinach
Anticancer activity (colon),
cataracts, protects the eyes
against development of age
related muscular
degeneration.
c.β-Carotene
d.α-Carotene
e.α-Cryptoxanthin
g.Zeaxanthin
Carrots, various fruits and
vegetables
Carrots
Oranges, Tangerines
Corn, Avocado
Anticancer activity which
neutralizes free radical,
protect cornea against uvlight
.
2.Dietory fibres
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