21st Century Health: Research to Support Personalised ... · PDF [email protected] Working with the NIHR and NHS • For support in undertaking clinical research in the NHS Contact

17th July 2017

Innovate UK Knowledge Transfer Network

Dr Louise Wood

Director of Science, Research and Evidence

Department of Health

@klouisewood

21st Century Health:

Research to Support Personalised Medicine

EC Definition of personalised medicine

Council Conclusions on personalised medicine for

patients (2015/C 421/03)

"Personalised medicine refers to a medical model using

characterisation of individuals’ phenotypes and genotypes

(e.g. molecular profiling, medical imaging, lifestyle data) for

tailoring the right therapeutic strategy for the right person at

the right time, and/or to determine the predisposition to

disease and/or to deliver timely and targeted prevention"

Definition developed by the Advisory group for the H2020 Health, demographic change and well-being challenge

http://www.ema.europa.eu/docs/en_GB/document_library/Presentation/2017/0

5/WC500227976.pdf

The National Institute for

Health Research

The National Institute for Health Research (NIHR):

improving the health and wealth of the nation through

research.

Established by the Department of Health, NIHR:

• funds high quality research to improve health

• trains and supports health researchers

• provides world-class research facilities

• works with the life sciences industry and charities to

benefit all

• involves patients and the public at every step

MedTech developers - NIHR can help

• Is there a need for your technology?

• Find users/patients help improve design

• Where does your technology best fit into patient care

pathways?

• Who are the key opinion leaders and rising stars in the

field?

• What clinical evidence will be needed to help in adoption?

• Help in managing timelines

• Who can help design and deliver my study?

EC Framework for Personalised Medicine

http://www.ema.europa.eu/docs/en_GB/document_library/Presentation/2017

/05/WC500227976.pdf

NIHR Supporting Personalised

Medicine

Collaboration with other funders e.g Innovate UK, MRC

To work with the NIHR

infrastructure contact the

team at:

[email protected]

Working with the NIHR and NHS

• For support in

undertaking clinical

research in the NHS

Contact the NIHR

Clinical Research

Network Support Team

• [email protected].

uk

• 0113 34 34 555

• Web:

www.supportmystudy.nihr

.ac.uk

NIHR –Supported Facilities

7

NIHR Biomedical Research Units

NIHR Health Protection Research Units

NIHR Biomedical Research Centres

NIHR Blood and Transplant Research Units

NIHR Healthcare Technology Co-operatives

NIHR Diagnostic Evidence Co-operatives

NIHR-supported Clinical Research Facilities

NIHR School for Public Health Research

NIHR School for Primary Care Research

NIHR/CR-UK Experimental Cancer Medicine Centres

NIHR Surgical Reconstruction and Microbiology Research Centre

NIHR Collaborations for Leadership in Applied Health Research and Care

Newcastle

Leeds

Sheffield

LeicesterOxford

Bristol

Brighton

Peninsula

London

Bradford

Manchester

Liverpool

Exeter

Southampton

Cambridge

Nottingham

Birmingham

NIHR Inflammatory Respiratory Disease TRC

https://www.nihr.ac.uk/life-sciences-

industry/documents/Brochures%20and

%20flyers/Inflammatory%20Respirator

y%20Disease%20TRC%20flyer.pdf

Stratified approaches in asthma

NIHR Diagnostic Evidence

Co-operative London

CoaguScan

Biomarkers and Diagnostics

Diagnostics Evidence Co-operatives

(DECs)

• Act as a catalyst for the generation of high-quality evidence of clinical

validity, clinical utility, cost effectiveness and care pathway benefits of

commercially-supplied IVDs.

NIHR DECs and SBRI

• 10 diagnostics companies secured nearly £2 million

funding by working with NIHR DECs in an Innovate UK

Stratified Medicine SBRI competition.

• Innovate UK provided funding for the development of

new diagnostic products and services for use in

stratified medicine.

• NOCRI worked with Innovate UK to shape the

competition and to help companies partner with the

NIHR Diagnostic Evidence Co-operatives (DECs) to

submit joint applications.

100,000 genomes project

Building a genomic medicine infrastructure

• Illumina - NHS Genomic Medicine

Sequencing Centre in Hinxton

• UK Data Infrastructure for Genomic

Medicine (with MRC)

• NIHR National Biosample Centre - £24

million state-of-the-art facility to store the

samples

• 13 NHS Genomic Medicine Centres in

England to enrol, validate and feedback

to patients

• Genomics England GeCIP

The MRC-NIHR National Phenome Centre

FEASIBILITY

Manage and deliver:

• Early Feedback

• Site Intelligence

• Site Identification

COMMERCIAL

COSTING

TEMPLATES

• Support use

• Manage templates

• Trust, Primary Care

& Device versions

HRA APPROVALS

SYSTEM FOR

GAINING NHS

PERMISSION

• Support use

MODEL

AGREEMENTS

• Support use

STUDY

MANAGEMENT

• Collect & collate

data

• Performance

manage study

Feasibility Set-up Delivery

NIHR Clinical Research Network

Service summary

Clinical Research Network