2016 - University of Queensland · 2016 was again a fruitful year for BTCCRC and a year of much growth. We welcomed Dr Benjamin Snow, Dr Helmet Shoengen, Lizanne Dalgleish, Dr Adrian

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2016 RESEARCH REPORT

Structure and Governance 1

Mission and Aims 2

Report - Chair 3

Metrics 5

Executive Profiles 6

Staff Research Interests 7

Research Themes 12

Researcher Showcase 22

Research Funding 23

Research Students 25

Research Supervision 31

Graduations 33

Research Theme Reports 34

Publications 37

Conferences 46

Workshops/Courses 51

Achievements/Awards 52

Teaching Activities 53

Professional Activities 54

CRE REDUCE Update 55

HeARTfelt Dinner 56

Visitors, News & Events 57

Collaborators 58

Enquiries 64

Level 3 Ned Hanlon Building and Level 7 UQCCR Royal Brisbane & Women’s Hospital

Herston QLD 4029

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Our Partners

Our Structure and Governance The Burns Trauma & Critical Care Research Centre (BTCCRC) was established in 2004 in response to the Bali bombings. The devastation and tragedy of this event focused national and international attention on burns victims and emphasized that there was a critical need to improve the early and on-going treatment and outcomes of burns and critically ill patients. The outstanding response from the critical care, burns, emergency medicine and anaesthetics teams of the RBWH and UQ highlighted the skill and expertise we possess in this area. Our Centre is directed by Prof Jeffrey Lipman and co-directed by Dr Michael Rudd, who are directors of their respective hospital departments and carry an extensive clinical and administrative load. The Chair is Prof André van Zundert, Professor of Anaesthesia within the School of Medicine (SOM) and the research manager is Dr Sia Athanasas. The Director, Chair, research manager and research theme leaders meet regularly to discuss the running of the centre and to ensure that all obligations to UQ/SOM are met. The governance structure of the Centre has been formalised through the creation of an advisory board to steer the Centre’s strategic direction, and to clarify accountability with collaborators and funding bodies in order to attract large-scale and international funding. The stability of the BTCCRC exists by virtue of our major supporter, the RBWH Foundation and our major partners the Queensland Government and the Australian Defence Force. The research within the centre is continually expanding and is now divided up into six core themes. Critical Care—Management and outcomes of critically ill patients. Drug Dosing and Pharmacokinetics—Antibiotic dosing, distribution and pharmacokinetics in critically ill patients. Burns — the overall management and outcomes of burns patients. Anaesthesia—evaluating new procedures and safety of procedures for anaesthetising critically ill patients. Emergency Medicine—improving outcomes and evaluating new processes for treating patients in the Emergency Department. Military Medicine—managing pre-hospital care, trauma and rehabilitation medicine.

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MISSION AND AIMS

Our Mission The BTCCRC was established to further advance and improve the level of treatment and care given to burns and critically ill patients through world-class research-based clinical practice. It began as a collaborative venture between the Royal Brisbane & Women’s Hospital (RBWH) Burns and Intensive Care Units, The University of Queensland (UQ) and has incorporated the Departments of Anaesthesia and Emergency Medicine. In recent years the centre has undertaken research into military medicine.

Our Aims The main aims of our research centre are to: Improve both the survival and outcome of patients by

conducting high quality research in the area of Burns, Trauma, Critical Care, Emergency Medicine, Military Medicine and Anaesthesia in general.

Provide a research-driven evidence base that informs clinical practice and policy in the above research themes.

Establish local, national and international collaboration in these areas thereby increasing research opportunities.

Enhance the research training and knowledge base of postgraduate students and staff in the above areas.

Researchers Creating Change in Patient Care The Laureate of the 1937 Nobel Prize in Physiology or Medicine for the discovery of vitamin C, Albert von Szent-Györgyi, stated: “Research is four things: 1) brains with which to think; 2) eyes with which to see; 3) machines with which to measure; and 4) money.” Healthcare is struggling worldwide due to increasing demands, escalating economic constraints and unsatisfactory quality despite the hard work of well-trained and well-intentioned clinicians. It’s time to change our strategy fundamentally: maximising value for patient-centred care which is organised and tailored around what patients need. This will allow healthcare to achieve best patient outcomes as efficiently as possible and at the lowest cost. Important outcomes in a high value health care delivery system, based on team work. Few doctors can tell you about their patients’ outcomes, especially their long term quality of life. When these outcomes – that matter to patients – are collected, measured comprehensively and reported publicly, other providers face tremendous pressure to improve and adapt their practices. The transformation to value-based healthcare can be further enhanced through fundamental good research. Rapid improvement in any field requires measuring results. Team work improves and excels by tracking progress over time and comparing their performance to that of peers. Health care organisations (e.g. hospitals) are flying blind and battle over arbitrary cuts in deciding how to improve processes and redesign care while trying to improve its value. Researchers can make a huge difference as the community benefits from patient-oriented research. Every industry knows that investment in research provides new ideas and new products that are needed in the pipeline to contribute to their survival. Good medical research provides a huge economic return on investment, measured in terms of jobs created, saved health costs, reduced morbidity and disability and the substantial gains in life expectancy (mean age for Japanese people nowadays is 83 years!), resulting in longer and more productive lives. This dramatic increase in life expectancy (3 additional months each year) results in a numeric surge in the aging population, which brings with it, an increasing burden of chronic non-communicable diseases. The sheer number of people entering old age will challenge national infrastructures, such as healthcare. The longer we delay adequate steps, the more costly and less effective the solutions are likely to be. But if you think research is expensive, try disease. Rapid advances in medical knowledge constantly improve state of the art healthcare. Researchers are stakeholders in overall healthcare of patients. Without research there is no progress in medicine. Research needs to be better coordinated if we are to discover the most cost-effective ways to maintain healthy lifestyles. The question that needs to be answered remains to be: what is the value of good research? Value is the ratio of the quality (or good outcome) conferred to cost expended. Rigorous systematic measurement of results is the single most important step in improving health care outcome. Data-driven, outcome-oriented practice will be instrumental in the quest for sustainable healthcare in the future. Furthermore, collaborative research pairs science and clinic to the benefit of patients. We at BTCCRC are cultivating leaders in the field who will champion translational research and bring the professional medical standard to the highest level. Yet, we also need young researchers, driven by intellectual curiosity, and passion for quality and research. Research is exciting and fun, and each contribution counts in solving the sheer endless mystery of medicine. However, life is not always a bed of roses. The burden of finding funds can result in headaches, sleepless nights, disappointment and frustration. We, as scientists, need to inform the community (e.g. politicians, institutions, benefactors) regarding the importance and benefits of investing in research through funding. As medical researchers we aim for better, longer and healthier lives and are dedicated to the most important person we care for, our patient. What matters in healthcare is excellence in outcomes and pride in the value we deliver. People who are driven by passion in research, will change the world.

CHAIR’S REPORT

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2016 was again a fruitful year for BTCCRC and a year of much growth. We welcomed Dr Benjamin Snow, Dr Helmet Shoengen, Lizanne Dalgleish, Dr Adrian Chin, Dr Gareth Collins, Dr Elizabeth McLellan, Dr Alexandra Markwell, Dr Nathan Brown, Kimberley Ryan, Dr Anthony Bell, Dr John Burke and Dr Daniel Bodnar. To further enhance opportunities for research, BTCCRC and RBWH ICU staff have formalised research collaborations with RBWH anaesthesiology staff. These collaborations which are facilitated by monthly meetings have already resulted in two pharmacokinetic-based projects that have enrolled patients. Furthermore, Dr Rochelle Ryan, an anaesthesiology registrar, has commenced an MPhil as part of this research endeavour. We look forward to seeing more successes from this collaboration in the future. Our funding success rate was 59% this year, an increase of 17% from last year. We were awarded grants from NHMRC, RBWH Foundation, ANZCA, UQ, Intensive Care Foundation, the Ian Potter Foundation, National Blood Authority (NBA), Emergency Medicine Foundation, QLD Genomic Health Alliance, RBWH, The Prince Charles Foundation, Queensland Health (QH), Merck, Sharpe & Dohme (MSD), Rebecca Cooper Medical Research Foundation, Australian Society of Anaesthetists (ASA), the Flemish Society for Critical Care Nurses, National Heart Foundation and The Australian Centre for Health Services Innovation (AusHSI). Congratulations to Prof Jason Roberts who was awarded an NHMRC Practitioner Fellowship and to Dr Despoina Koulenti and Dr Fekade Sime who were both awarded UQ Research Fellowships, to Dr Kerina Denny and Dr Dylan Flaws who won QH Junior Doctor Fellowships. Congratulations also goes to the following staff and students on being awarded grant funding this year, Jeffrey Lipman, Jason Roberts, Suzanne Parker, Os Cotta, Louise Cullen, Rebecca Christensen, Victoria Eley, Rochelle Ryan, Dwayne Jackson, Andre van Zundert, Julie Lee, Anthony Bell, Kevin Chu, Despoina Koulenti, Claire Roger, Martha Druery, Jenny Paratz, Tavey Dorofaeff, Michael Rudd, Gareth Collins, Lizanne Dalgleish, Michael Muller, Anita Plaza, Kersi Taraporewalla, Heather Reynolds, Stijn Blot, Jaimi Greenslade, Gladness Nethathe. Overall, our researchers won over $11 million in research funding. We proudly congratulate our Research Higher Degree students who graduated this year – Dr Hafiz Abdul-Aziz PhD, Dr Aziz Alobaid PhD, Dr Bernie Bissett PhD, Ms Michelle Donovan MPhil, Dr Suzanne Parker PhD and Dr Natasha van Zyl PhD. Our NHMRC Centre of Research Excellence (CRE) REDUCE program enjoyed its first 12 months with an official launch on 29th July by the Honourable Doctor Anthony Lynham MP, Minister for State Development and Minister for Natural Resources and Mines. The first workshop titled “POPULATION PK MODELLING AND DOSE OPTIMISATION: PMETRICS/BESTDOSE WORKSHOP” was held in October at the UQ St Lucia campus with international guest speakers Prof Michael Neely from the USA and Prof William Hope from the UK attending. We thank all of our industry colleagues who demonstrated that they value high-quality research, understand that it must be independent, free of bias, know that it does cost money and that research results must be 'pushed' for uptake! Special thanks to the Turkington Family, the Bayer Family, Red Blanket Miracle for their continued support of our research efforts and to our funding partners the RBWH Foundation and the Australian Defence Force for their continued support. We wish to also thank the Australasian Hellenic Educational Progressive Association (AHEPA) and Dr Benjamin Cohney for their generous support of our centre. The year culminated in our 3rd Annual Heartfelt Dinner which again was a success, thanks to the organising talents of Karen Gallagher, Jennifer Tucker, Elizabeth Peat, Ben Zabel, Gerry Kucharski, Lucy Barnes and Sia Athanasas. We raised just under $28,000 through the sale of art works, auction items and raffles. We sincerely thank our prize donors, sponsors and volunteers who helped make this an evening to remember. I wish to thank our talented and hard-working staff and students for making this yet another great year and I wish you all the very best for 2017. Prof Andre van Zundert

RESEARCH METRICS

As one of the top performing research centres within the SOM, we again in 2016 have continued our rising trajectory. This year saw our highest publication record to date, with 191 journal articles, 10 book chapters, 1 book and 5 conference proceedings published. The funding arena was extremely competitive again this year, however our grant success rate increased markedly from 42% in 2015 to 59% in 2016. This is the second highest success rate in the history of BTCCRC. In total, we submitted 78 grant applications this year—the largest submission to date (up by 15 compared to 2015). This year our staff supervised 16 PhD, 3 Masters and 1 MBBS/Hons students enrolled within our centre. Seven of these PhD students, 2 of these Masters students and our MBBS/Hons student completed their degree this year. In addition, many of our research staff supervised students outside the School of Medicine and/or outside UQ. More enrolments are expected in 2017 as our collaborations increase and as interest in our research grows. Our international collaborating institutions number 121 with 225 collaborators and our national and local collaborating institutions stand at 53 with 184 collaborators.

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Professor Jeffrey Lipman MBBCh DA (SA) FFA (SA) FFA (CritCare) (SA) FCICM MD Director of BTCCRC; Director of Department of Intensive Care Medicine (DICM), RBWH; Professor, Anaesthesiology & Critical Care, The University of Queensland Jeff is the Director of the BTCCRC, Director of Department of Intensive Care (DICM), RBWH and Professor of Anaesthesiology & Critical Care, University of Queensland and Honorary Professor, Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong. He has qualifications in anaesthesia and intensive care and has set up and run a number of Intensive Care and Trauma Units in South Africa before coming to Australia in 1997. He is the author of over 455 peer reviewed publications, 30 book chapters, has been invited to present

at many national and international conferences and is a reviewer for a number of high quality international journals and granting committees, including the NHMRC. Jeff has been instrumental in developing the anaesthesiology & critical care component of the graduate medical program for Queensland and continues to lecture to medical and postgraduate students. He is site Principal Investigator for numerous multi-national and international trials. Research interests include all aspects of management in intensive care, resuscitation of burns and pharmacokinetics of antibiotic dosage. His research into antibiotic usage in acute situations has received international recognition whilst he has received multiple national and international awards. Jeff is involved in most research projects, oversees the direction of the research centre, mentors staff and supervises 10 postgraduate students.

Dr Michael Rudd

MBBS FACS OAM PhD

Co-Director BTCCRC, Director of Burns Unit, RBWH

Michael is the Co-Director of the BTCCRC and the current Director of the Adult Burns Unit at RBWH. He has fellowships in Burns and General Surgery. Michael has completed a PhD in transplantation immunobiology. His research interests are in all aspects of burn management, burn pathophysiology and immunobiology. His clinical and research background make him uniquely qualified to work as a burns surgeon and scientist at both the bedside and in the laboratory.

Professor André van Zundert MD, PhD, FRCA, EDRA, FANZCA Professor & Chairman, Anaesthesiology & Critical Care; Chair of BTCCRC, The University of Queensland; Snr Staff Specialist Department of Anaesthesia & Perioperative Medicine, RBWH; Professor of Anesthesiology at the Universities of Ghent (Belgium) and Maastricht (Netherlands). André has qualifications in anaesthesia, intensive care and trauma care, graduating as a medical doctor cum laude, at the University of Leuven (Belgium) in 1978, and with a PhD in obstetric anaesthesia from the University of Leyden (Netherlands) in 1985. He is the author of over 300 peer-reviewed publications including 6,123 citations [Hirsch Factor: 35; Google Scholar i10-index: 85], 57 book chapters and three standard textbooks, of which his book, the ‘Atlas Functional Anatomy for Regional Anaesthesia and Pain Medicine’ was published in

2015. He has been invited to present at hundreds of international conferences and is a reviewer for a number of highly regarded international journals. He has held several positions (Secretary-General, President and Honorary Member) in Anaesthesia Societies and was President of several international congresses, including world congresses. André has been instrumental in developing the UQ ‘Centre of Excellence and Innovation in Anaesthesia’ at RBWH, which underpins the importance of teaching, training via simulation, testing anaesthesia equipment, quality care and research. His aim is to boost research in anaesthesia within the department, but also to collaborate with other departments and colleagues from all over Australia and beyond. André is a strong believer in ‘Teach the teacher’ and ‘Problem oriented education’. His research interest is in airway management, regional anaesthesia and obstetrics, for which he received international recognition (13 awards) and two Royal Distinctions (from HRH Queen Beatrix, The Netherlands & HRH King Albert II, Belgium). He was a founding member of The European Society of Anaesthesiology (convenor of the first two conferences in Brussels, Belgium) and founder of the Pain Society (Netherlands). He has been greatly acknowledged for his contributions to: 1) Pain Relief in Childbirth (the suggested technique is still practiced all over the world in the labour ward); 2) providing safe and effective airway management using videolaryngoscopy; and 3) Pain therapy. For the ‘Centre for Excellence & Innovation in Anaesthesia,’ Professor van Zundert received the University of Queensland 2014 Innovation Award.

EXECUTIVE MEMBERS

INTENSIVE CARE MEDICINE Prof Jeffrey Lipman MBBCh DA FFA FFA (CritCare) FCICM MD management in intensive care, resuscitation of burns and pharmacokinetics of antibiotic dosage. Dr Jennifer Paratz MPhty FACP PhD Grad Cert Ed (Medical & Health Sciences) management and outcome of critically ill and burns patients, myocardial dysfunction, exercise and metabolism, diagnosis of sepsis in burns patients. Dr Joel Dulhunty BSc (Hons) MTH MBBS PhD FRACMA epidemiology of critical illness and sepsis, burn injury prevention, health services research. A/Prof Jeremy Cohen MBBS BSc MRCP FRCA FCICM critical care endocrinology; tissue corticosteroid resistance and adrenal insufficiency; gene expression in septic shock; epidemiology of sub

arachnoid haemorrhage. A/Prof Robert Boots MBBS (Hons) FRACP FCICM PhD Grad Dip Clin Epi MMedSci MHealth Admin IS clinical epidemiology, management of burns; prevention of ventilator associated pneumonia. Dr John Gowardman BSc BHB MBChB FRACP FCICM intra vascular device associated infections and diagnosis, Biofilm formation on vascular devices, epidemiology.

Dr Judith Bellapart MD ESICM FCICM neurotrauma and neurocritical care focusing on management and research on acute head injury and subarachnoid haemorrhage. Dr Anthony Holley BSc MBBCh DipPaeds DipDHM FACEM FCICM

trauma, transfusion, cryopreserved blood products, microcirculation.

Dr Steve O’Donoghue MBChB FANZCA FCICM microcirculation in shocked critically ill patients during resuscitation and prevention of ventilator associated pneumonia. Prof Michael Reade MBBS(Hons) BSc(Med)(Hons) DPhil MPH PGCertAME DIMCRCSEd DMCC FHEA FCCP FANZCA FCICM AFRACMA Fluid resuscitation and coagulopathy in trauma, clinical trials of cryopreserved blood products and tranexamic acid, and the management of delirium.

Dr Neil Widdicombe MBBS FRCA (UK) FCICM trauma, ethics in intensive care and air medical retrieval, documentation of death for transplants. Dr Jayesh Dhanani MBBS MD FCICM antimicrobial therapy, lung infections, inhaled/aerosol therapy. Dr Gladness Nethathe MBBCh Neuroendocrine stress response in critical illness. Dr Kerina Denny PhD MBBS BSc (Hons) markers that distinguish between sepsis and non-infectious systemic inflammatory response syndrome in critically ill patients at the time of antibiotic prescribing. Dr Alexis Tabah MD HAI; antimicrobial resistance, stewardship and quality improvement; hyperbaric oxygen treatment (HOT) Renae Deans BNurs Cert Crit Care clinical trilas co-ordinator involved in all aspects of co-ordination for the SMARRT and CLIP studies. Melissa Lassig-Smith Dip App Sc (Nurs) Grad Dip (Adv Nursing) Grad Dip (Crit Care) MNurs (Crit Care) involvement in all aspects of studies in intensive care from initial proposal to completion.

Janine Stuart BNurs

involved with all ICU research, writing proposals, obtaining ethics approvals, writing grants, data collection and publishing research articles. Therese Starr Grad Cert Crit Care, Grad Dip Health Prom certified clinical research co-ordinator involved in major clinical trials. Dr Despoina Koulenti MD PhD hospital-acquired infections (HAI); infections by multi-drug resistant pathogens; severe forms of pneumonia; high fidelity simulation for medical education

Jenie Butler BNurs PGDipACN (Crit Care) MClinicalNurs Clinical nurse research co-ordination; advancing critical care through innovation and collaborative research.

Avi Chikatamarla validation of microsampling versus traditional blood sampling

for antibiotic pharmacokinetics.

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Amelia Livermore BN, GradCertNursing(IntCareNursing), MHM research coordination; establishing good clinical practice that is evidence based within the critical care environment.

Honorary Member Prof Stijn Blot BNurs/BMid MNSc PhD clinical epidemiology of severe infections in critically ill patients, infection prevention, education in quality improvement interventions.

Bioanalysis Laboratory Dr Steve Wallis BSc (Hons) PhD bioanalysis and measurement of drug levels in biological fluids in support of local, national and international clinical trials Dr SuzanneParker BSc (Hons) PhD innovating clinical trials with the introduction of lower impact microsampling Yarmarly Guerra Valero BChem (Hons) MTIM measurement and bioanalysis of antibiotic and anaesthetic drugs in pharmacokinetic studies using microsampling techniques.

Jenny Ordóñez Mejia BSc measurement and bioanalysis of drugs in pharmacokinetic

studies, particularly extracorporeal membrane oxygenation (ECMO) studies.

Saurabh Pandey analytical method development and validation of antimicrobials in biological and microbiological matrices, reporting data for pharmacokinetic application.

Clinical Pharmacokinetics and Pharmacodynamics Group

Prof Jason Roberts BAppSc BPharm (Hons I) PhD drug dosing in critically ill, burns and transplant patients; in vitro infection models; ex vivo models of renal replacement therapy and ECMO; clinical pharmacokinetic studies; clinical outcome

interventional studies. Dr Darren Roberts BPharm MBBS PhD FRACP application of extracorporeal therapies in acute poisoning and appropriate use of medications in critically ill patients with or without kidney disease.

Dr Menino Osbert Cotta BPharm (Hons) PhD antimicrobial stewardship, antimicrobial dosing in critically ill patients and dosing of drugs in neurotrauma. Dr Fekade Sime BPharm MSc PhD pharmacokinetics/pharmacodynamics of antibiotics, in vitro infection models, ex vivo and clinical evaluation of antibiotic dosing during extracorporeal therapies.

NHMRC Centre of Research Excellence (CRE REDUCE) Nermin Karamujic BN, Grad Cert ICU provides research, administrative and management support to CRE REDUCE; designs and manages data collection instruments within Research Electronic Data Capture (REDCap) related to research

studies coordinated by RBWH Intensive Care Services Research Office.

RESEARCH INTERESTS

ANAESTHESIA AND PERI-OPERATIVE MEDICINE

Prof André van Zundert MD, PhD, FRCA, EDRA, FANZCA a i r w a y m a n a g e m e n t i n c l u d i n g videolaryngoscopy; laryngeal masks, regional anaesthesia and general anaesthesia.

A/Prof Michael Steyn MBChB DRCOG MRCGP FFARCSI FANZCA MSc burns anaesthesia, information technology and performance, quality and system design, professional upskilling. A/Prof Kerstin Wyssusek MBChB MSc PhD PGCertQM FAAnae FANZCA acute kidney injury; airway management; quality improvement. A/Prof Kersi Taraporewalla MBBS FANZCA MClinEd high fidelity simulation training for crisis management and medical education. Dr David Belavy BMedSc MBBS FANZCA PGDipCU Ultrasound in anaesthesia, clinical risk prediction in surgery. Dr Paul Gray MBBS PhD FANZCA FFPMANZCA pain of burn injury including mechanism, treatment and prevention. Dr Heather Reynolds BA BHlthSc MN MAP PhD intravascular access. Dr Susannah Sherlock BSc MBBS FANZCA sudden sensorineural hearing loss and HOT; CNS toxicity and HOT.

Dr Victoria Eley MBBS (Hons) BMedSc FANZCA obstetric anaesthesia and obesity; antibiotic dosing in obesity; quality assurance in obstetric anaesthesia. Cienwen Town BN RN GCertEdu burns, regional analgesia and acute pain in the perioperative setting.

Dr Julie Lee AAGM BPharm MBBS FANZCA ROTEM(R) thromboelastometry in obstetric patients, regional anaesthesia and difficult airway management. Dr Benjamin Snow BSc MBBS FRACGP FANZCA trauma, regional anaesthesia, anaesthetic equipment. Dr Helmet Shoengen MBBS FANZCA DESA MMed Inform PhD communication in critical care. Lizanne Dalgleish BN RN Microcirculation and trauma management.

Dr Adrian Chin MBBS FANZCA ultrasound, regional anaesthesia.

Dr George Pang MBBS FANZCA FCICM

lipid rescue from anaesthetic overdose. Dr Antony Hade MBBS FANZCA Dr Michael Edwards BSc MBBS FANZCA DIP ECHO

head and neck audit; anaesthetic depth. Dr Gareth Collins FANZCA MBBCh

raised Intracranial pressure and its relationship with the optic nerve sheath.

Dr Elizabeth McLellan MBBS

regional anaesthesia, harm minimisation and safety.

RESEARCH INTERESTS

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BURNS UNIT

Dr Michael Rudd MBBS FACS OAM PhD aspects of burn management, burn pathophysiol-ogy and immunobiology. Prof Michael Muller MBBS MMedSci FRACS physiological response to injury and its modula-tion- beta blockers, anabolic steroids, scar modula-tion, burn prevention. Michelle Donovan BOccThy Acc OT MPhil burns donor site scarring and compression gar-ment therapy; wound healing through tissue support. Sharon Forbes BSc GradDipNut&Diet APD changes in energy and nutritional requirements during recovery from burns. Dr Angus Hann BSc MBBS (Hons) GDipEpi MRCS trauma and hepatobiliary surgery.

Dr Jason Brown MBBS FRACS BDS(Hon)

measurement of donor site wound healing using ultrasound; transepidermal water loss and clinical assessment.

Anita Plaza BPhty (Hons I)

exercise and metabolism following adult burn injuries. Madonna Puglisi BPhty (Hons)

maximising function following burn injury. Brooke Hoskin BPhty (Hons)

investigating resources to assist and improve the motivation of patients and adherence to their therapy programs.

EMERGENCY MEDICINE

Prof Anthony Brown MBChB FRCP FRCSEd FACEM FCEM anaphylaxis epidemiology; Acute Coronary Syn-drome (ACS) risk; Sepsis epidemiology; medical writ-ing and editing. Prof Louise Cullen MBBS (Hons) FACEM diagnosis and management of patients presenting with acute cardiac diseases including ACS, heart fail-ure and biomarkers; Health Services Research and Translational Research

A/Prof Kevin Chu MBBS MS FACEM utility of diagnostic tests in clinical decision making, subarachnoid haemorrhage and multi-centre clinical trials in emergency medicine. Dr Catherine Hurn MBBS FACEM massive transfusion in trauma and team training for trauma, thromboelastometry (ROTEM). A/Prof Jaimi Greenslade BPsych (Hons) PhD how workplace stress, culture and fatigue influ-ences nurses performance and patient outcomes, in-volved in all research projects in ED. Dr William Lukin MBBS FACEM palliative care, aged care. Dr Julian Williams MBBS FACEM sepsis epidemiology and outcomes in ED. Dr Philip Richardson MBChB FACEM LLB medico-legal issues confronting the medical field. Tegwen Howell BEcon MEc St subarachnoid haemorrhage. Tracey Hawkins BNurs Grad Dip Nurs (Critical Care & Emergency) ACS, Syncope, TEG. Dr Duncan McAuley MBBS FACEM

spontaneous pneumothorax study.

Dr Dylan Flaws MBBS MSc BSc BA risk stratifying chest pain presentations and how to communicate patients about this, applying these concepts to include predicting delirium at presentation. Dr Alexandra Markwell MBBS (Hons I) FACEM BSc doctors' health and wellbeing, medical education. Dr Nathan Brown PhD provides research management support to the Emergency Medicine department. Kimberley Ryan BNurs Grad Dip Nurs triage, endoscopy.

Kate Parker BNurs BHSci (Psych) ACS, syncope, mental health issues, particularly in the

elderly population. Dr Frances Williamson MBBS (Hons) FACEM CCPU trauma and ultrasound research; involved in the RIB study.

Dr David Rosengren MBBS FACEM FAWM medical administration, environmental medicine. Dr Sean Rothwell MBBS FACEM environmental medicine. Dr Anthony Bell MBBS FACEM MBA MPH FRACMA medical administration. Dr John Burke MBBS FACEM patient flow. Dr Daniel Bodnar MBBS FACEM pre-hospital emergency care. Dr Trent Lipp MBBS FACEM trauma, ultrasound.

RESEARCH MANAGEMENT

Dr Sia Athanasas BSc MSc (Qual) PhD provides research co-ordination, research support and

management support to the Centre whilst maintaining research and financial databases.

ACADEMIC ADMINISTRATION

Maree Campbell provides administrative support and co-ordinates medical student teaching for the Discipline of Anaesthesiology & Critical Care.

RESEARCH INTERESTS

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Our multi-disciplinary approach towards addressing clinically relevant questions and our broad national and international collaborations underpin our centre’s research success and assures our research is globally relevant. Globalisation of our research is evident in the extensive number of international collaborations that our researchers have forged over the years, in particular, our NHMRC funded Centre of Research Excellence program titled “REdefining antimicrobial use to reDUce resistanCE and prolong the clinical utility of antimicrobials” (CRE REDUCE). This program of research headed by Prof Jason Roberts, involves chief investigators and associate investigators from Australia, Belgium, Hong Kong, USA, Spain and France. Our expertise includes intensivists, burns surgeons, anaesthetists, cardiologists, neurosurgeons, emergency physicians, scientists, physiologists, nutritionists, physiotherapists, intensive care nurses, psychologists, social workers and military medical personnel. Throughout 2016 our centre was successful in receiving funding from NHMRC, RBWH, RBWH Foundation, ANZCA, UQ, Intensive Care Foundation, MSD, Ian Potter Foundation, Rebecca Cooper Medical Research Foundation, Emergency Medicine Foundation, QLD Genomic Health Alliance, QH, NBA, The Prince Charles Hospital Foundation, Flemish Society for Critical Care Nurses, ASA, National

Heart Foundation and AusHSI.

Our laboratory research is closely allied with our clinical research. The major themes developing within the centre are:

1) Critical Care

2) Drug Dosing and Pharmacokinetics

3) Burns

4) Anaesthesia

5) Emergency medicine

6) Military medicine (including trauma medicine)

RESEARCH PROJECTS

1. Pharmacokinetics, drug distribution and antibiotic resistance in critically ill patients.

Critically ill patients often have varying physiological needs to an average patient and often require different dosages of antibiotics and other drugs, particularly if they are on renal replacement therapies. There is also a controversy over whether bolus dosing or continuous infusion of β-lactams is more effective in antibiotic delivery in critically ill patients. Prof Lipman has pioneered work that demonstrates that patients in intensive care are not receiving adequate doses of antibiotics to achieve optimal levels to kill pathogens. This in turn leads to poorer health outcomes for patients and antibiotic resistance. Antibiotic resistant infections commonly occur in long stay, debilitated patients and contribute to increased risk of death, longer ICU and hospital stay, further weakness and long term dysfunction. This problem also contributes to patients being unable to be discharged from ICU or hospital and so exacerbating the shortage of acute hospital beds and increases in surgery waiting time. Projects include: Identifying a cost-effective approach to MRSA control in Australia. Halton K, Robotham J, Nimmo G, Barnett A, Graves N, Lipman J. Funder: NHMRC Non-Haemolytic Friulimicins for the Treatment of Multi-Drug Resistant Bacteria. Cooper M, Roberts J, Butler M. Funder: NHMRC Pharmacokinetics of Enteric Coated Mycophenolate Sodium in Lupus Nephritis (POEMSLUN). Ranganathan D, Roberts J, John G, Fassett R, Healy H, Lipman J, Kubler P, Ungerer J. Funder: RBWH Imaging of the microcirculation using the Microscan (orthogonal polarization spectral imaging) and providing improved quality of drug analysis for PK studies in critically ill patients. Lipman J, Paratz J, Boots R, Muller M, Dalley A. Funder: NHMRC/UQ, RBWH Foundation/Wormald C r e a t i n i n e c l e a r a n c e o f c r i t i c a l l y i l l Australian Indigenous patients - a longitudinal study (CROC Study). Tsai D, Udy A, Stewart P, Gourley S, Morick N, Lipman J, Roberts J. Funder: NHMRC Postgraduate Scholarship (D Tsai); Australian Academy of Science (D Tsai) Epidemiology of Pneumonia in the Central Australian Intensive Care Unit. Tsai D, Goud R, Hewagama S, Stewart P, Hnin K-M, Tin K-S, Sun H, Roberts J. Funder: NHMRC Postgraduate Scholarship (D Tsai); Australian Academy of Science (D Tsai) Pharmacokinetics of broad spectrum antibiotics in extracorporeal membrane oxygenation (ECMO) - using plasma concentrations to optimize antibiotic therapy. Welch S, Roberts J, Burrows F, Levkovich B, Ray J, Pellegrino V, Bui T, Wallis S, Marriott D, Rudham S.

Antibiotic, sedative and analgesic drug pharmacokinetics during ovine ECMO - understanding altered pharmacokinetics to improve patient outcomes. Shekar K, Roberts J, Smith M, Fung Y, Fraser J, Wallis S, Mullany D, Diab S, McDonald C, Barnet A, Ghassabian S, Platts D, Dunster K. Funder: ANZCA, TPCH Foundation, ANZICS The Pharmacokinetics of Vancomycin and Ticarcillin-Clavulanate in Critically Ill Patients undergoing Sustained Low-Efficiency Dialysis (SLED). Economou C. Funder: RBWH Scholarship Ketorolac pharmacokinetics in joint replacements. Roberts J, Wallis S, Gurunathan U. Sampling Antibiotics in Renal Replacement Therapy (SMARRT Study). Roberts J, Lipman J, Roberts M, Paul S, Peake S, Turnidge J, Joynt G, Lee A, Gomersall C, Choi G Funder: NHMRC; Chinese University of Hong Kong Does inhaled antibiotics deliver optimal concentrations to the lung to improve treatment of pneumonia. An animal in vivo study using the microdialysis technique. Dhanani J, Paterson D, Roberts J, Chew M, Fraser J. Funder: RBWH

Dosing to maximise bacterial killing and prevent resistance in ICU. Roberts J, Lipman J, Wallis S, Kirkpatrick C, Landersdorfer C, Bulitta J, Bergen P. Funder: NHMRC Piperacillin and cefazolin pharmacokinetics in sepsis and trauma. Roberts J, Lipman J, Udy A, Wallis S, Kirkpatrick C, Kruger P, Roberts M. PARITY: Paracetamol in Traumatic Brain Injury. Principal Investigator: Gowardman J, Roberts J, Lipman J, Wallis S, Saxena M Continuous vs bolus cefazolin in abdominal surgery patients (collaboration with University of Virginia). Roberts J, Lipman J, Wallis S, Naik B, Ikeda K, Todorovic M. Antibiotic pharmacokinetic study in renal replacement therapy – CVVHF vs CVVHDF (collaboration with CHU Nimes). Roberts J, Lipman J, Wallis S, Lefrant J-Y, Roger C, Muller L. Funder: Le Centre Hospitalier Universitaire de Nimes (CHU Nimes)

RESEARCH PROJECTS

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Comparison of voriconazole population pharmacokinetic models. Roberts J, Farkas A, Dolton M, Han K. Comparison of piperacillin population pharmacokinetic models. Roberts J, Lipman J, Wong G, Farkas A. Antibiotic pharmacokinetics in Slow Low Efficiency Dialysis (piperacillin, meropenem and vancomycin; collaboration with The Ottawa Hospital). Roberts J, Kanji S, Zelenitsky S. Teiciplanin pharmacokinetics and protein binding in methicillin resistant S. aureus infection (collaboration with Trinity College Ireland). Roberts J, D’Arcy D, Byrne C. CAMERA: Combination antibiotic treatment for Methicillin Resistant Staphylococcus Aureus Bacteraemia - an RCT. Davis J, Tong S, Paterson D, Fowler V, Howden B, Cheng A, Chatfield M, Lipman J, van Hal S, O’Sullivan M. Funder: NHMRC A Biomarker for Sepsis to Thwart Antibiotic Overuse in the Intensive Care Unit . Denny K, Cohen J, Paterson D, Lipman J, Evans D, Dulhunty J, Paratz J, Ungerer J, McWhinney B. Funder: RBWH Foundation Validation Of Microsampling Versus Traditional Blood Sampling For Antibiotic Pharmacokinetics. Chikatamarla A, Parker S, Wallis S, Lipman J, Presneill J, Roberts J, Dorofaeff T, Jarrett P Funder: RBWH Foundation; AHEPA Pharmacokinetics of Antibiotics in the critically unwell children. Dorofaeff T Funder: AHEPA Population pharmacokinetics of meropenem in critically ill patients and development of dosing software (Collaboration with University of Liverpool ). Roberts J, Hope W, Belen A. Meropenem and ciprofloxacin pharmacokinetics in ICU patients with shock (MaC-DIPPS). Roberts J, Lipman J, Sjovall F, Christrup L, Kreilgaard M, Perner A, Frimodt-Møller N. Plasma and tissue pharmacokinetics of lincomycin in patients with burn wound infection. Muller M, Wang L, Roberts J, Lipman J. Funder: RBWH Foundation An Investigation of the Pharmacokinetics of Piperacillin/Tazobactam, Meropenem and Fluconazole in Critically Ill Obese Patients (PHANCO). Alobaid A, Roberts J, Lipman J, Roberts M. Funder: Saudi Arabian Cultural Mission Incidence, Risk Factors, Consequences and Treatment of Ventilated Patients with Nosocomial Infection with Pandrug Resistant Organisms in Hospitals in Asia. McGloughlin S, Webb S, Lipman J, Paterson D, Roberts J, Phua J. Funder: ICF; University of Western Australia-UQ Collaboration Pharmacokinetic Australasian Collaborative. Lipman J, Roberts J, Joynt G, Udy A, Nichols M. Funder: ICF

Optimising benzylpenicillin dosing for critically ill patients with severe pneumonia. Roberts J, Cotta O, Boots R Funder: RBWH Foundation A Phase III Randomized Controlled Trial of Continuous β-Lactam Infusion Compared with Intermittent β-Lactam Dosing in Critically ill patients. Dulhunty J, Starr T, Lipman J. Funder: RBWH Foundation Levetiracetam pharmacokinetics in critically ill patients with severe traumatic brain injury and subarachnoid haemorrhage. Cotta O, Roberts J, Presneill J Funder: ICF, RBWH Foundation Optimising ceftriaxone dosing for critically ill patients with severe pneumonia. Roberts J, Cotta O, Boots R Funder: RBWH Foundation Improving piperacillin/tazobactam dosing in critically ill Australian Indigenous patients with severe sepsis. Tsai D, Stewart P, Goud R, Gourley S, Hewagama S, Krishnaswamy S, Wallis S, Lipman J, Roberts J. Funder: NHMRC Postgraduate Scholarship (D Tsai); Australian Academy of Science (D Tsai) Improving meropenem dosing in critically ill Australian Indigenous patients with severe sepsis. Tsai D, Stewart P, Goud R, Gourley S, Hewagama S, Krishnaswamy S, Wallis S, Lipman J, Roberts J. Funder: NHMRC Postgraduate Scholarship (D Tsai); Australian Academy of Science (D Tsai) Improving vancomycin dosing in critically ill Australian Indigenous patients with severe sepsis. Tsai D, Stewart P, Goud R, Gourley S, Hewagama S, Krishnaswamy S, Wallis S, Lipman J, Roberts J. Funder: NHMRC Postgraduate Scholarship (D Tsai); Australian Academy of Science (D Tsai) Improving ceftriaxone dosing in critically ill Australian Indigenous patients with severe sepsis. Tsai D, Stewart P, Goud R, Gourley S, Hewagama S, Krishnaswamy S, Wallis S, Lipman J, Roberts J. Funder: NHMRC Postgraduate Scholarship (D Tsai); Australian Academy of Science (D Tsai) A preliminary investigation of the pharmacokinetics and pharmacodynamics of amikacin/fosfomycin combination against Acinetobacter baumannii using a dynamic in vitro hollow-fiber infection model. Roberts J. Funder: Cardeas Pharma Residual antibiotics post reconstitution:REPORT Study. Jarrett P, Coyer F, Cook J, Wallis S, Cotta O, Cohen J.

2. Management and outcome of critically ill, head injury, renally dysfunctional and long stay ICU patients Patients who survive intensive care often are weak, debilitated and with a poorer quality of life compared to their pre morbid status. We are actively investigating methods to prevent weakness and loss of function in long stay intensive care patients. There are also many projects investigating the optimum delivery of standard procedures to ensure that the best quality of care is offered to intensive care patients. Project include: A point prevalence survey of venous thromboembolism prophylaxis management in the critically ill and an epidemiological observational audit of venous thromboembolism prophylaxis management in critically ill patients with severe sepsis (VTE AUDIT). Gowardman J. Optimal pattern of manual hyperinflation in the ventilated patient. Paratz J, Thomas P, Savian C, Lipman J The clinical experience of nitric oxide use in the adult ICU at the RBWH. Boots R A RCT of the effect of hydrocortisone on mortality in critically ill patients with septic shock (ADRENAL Study). Venkatesh B, Myburgh J, Finfer S, Webb S, Cohen J. Funder: NHMRC Assessment of Functional Adrenal Status in Patients with Septic Shock. Cohen J, Venkatesh B. Funder: RBWH Developing a research base for intravenous peripheral catheter resites. The DRIP trial. Rickard C, Webster J, Gowardman J, Wallis M, McCann D. Funder: NHMRC SAVED - Study of practices and complications associated with central venous and arterial catheterisation in an ICU population. Gowardman J, Rickard C. An exploratory study of perceived risks, benefits and barriers to the use of Selective Decontamination of the Digestive Tract in Australasian ICUs (SuDDICU). Seppelt I, Marshall A, Myburgh J, Lipman J, Francis J, Cuthbertson B, Glass P. Funder: ANZCA, NHMRC Endothelin, a marker of severity in subarachnoid hemorrhage vasospasm. Bellapart J, Fourie C, Stuart J, Boots R, Paratz J. Exogenous melatonin in critically ill patients: the impact on sleep and ICU psychosis. Bellapart J, Boots R, Zappala C, Paratz J, Morrison S, Brown M. Funder: RBWH Inspiratory Muscle Training for ventilated patients. Bissett B, Paratz J, Boots R, Leditschke A. i-PERFORM Trial—Mobilising the Critically Ill: Physiological and

Functional Outcomes following Early Rehabilitation in Sepsis. Kayambu G, Paratz J, Boots R. Intravascular Device administration sets: Replacement after standard versus prolonged use (RSVP Trial). Rickard C, Wallis M, Young J, Gowardman J, Whitby M, Fraser J, McMillan D, Zhang L. Funder: NHMRC A Real-time and Self-Adaptive Stream Data Analyser for Intensive Care Management. Zhang Y, Yi X, He J, Pang C, Steyn M. Funder: ARC Exercise testing in the chronic critically ill patient. Paratz J, Stockton K, Boots R. Low molecular weight heparin in critically ill trauma patients: a dosing study. O’Donoghue S, Lipman J, Udy A. Funder: RBWH 11-β-hydroxysteroid dehydrogenases activity in critical illness. Cohen J Funder: ANZCA Cerebral microcirculation in head injury during normovolemic anemia: an experimental model. Bellapart J, Boots R, Reade M, Fraser J. Funder: RBWH Foundation Improving outcomes in sepsis: a randomized controlled trial. Boots R, Paratz J, Kenardy J, Mitchell G, Coyer F, Comans T, Thomas P, Iwashyna J, Martin-Loaches I, Hodgson C, Bissett B. Funder: RBWH Foundation Functional electrical stimulation assisted cycling (eStimCycle): A novel intervention to improve outcomes in the critically ill. Berney S, Denehy L, Needham D, Paratz J, Koopman R, Hopkins R. Funder: NHMRC Identification and location of secretion retention in mechanically ventilated patients. Paratz J, Thomas P, Ntoumenopolous G, Jones A, Li Bassi G, Torres A. Funder: RBWH Foundation Centre for Research Excellence in Advanced Cardio-respiratory Therapies Improving OrgaN Support (ACTIONS). Fraser J, McGiffin D, Lovell N, Bannon P, Tansley G, Pellegrino V, Roberts J, Barnett A, Gregory S. Funder: NHMRC CRE Saline installation in respiratory therapy in ICU, a crossover study. Paratz J, Thomas P, Stockton K. Identifying Ventilator Associated Torticollis and the significance in long term mechanically ventilated patients. Blatchford S, Paratz J, Coyer F, Thomas P. IMproving Physical ACtivity with Treadmill training following stroke: the stroke-IMPACT trial. Brauer S, Paratz J.

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Saving blood and money - introduction of laboratory testing guidelines and its effect on blood loss and cost of therapy in an intensive care unit. Dhanani J, Barnett A, Lipman J, Boots R, Ford M, Jarrett P. Funder: AusHSI Stimulus Grant INFlammation and Augmented Renal Clearance in Traumatic brain injury (INFARCT) Study. Udy A, Lipman J, Jarrett P. Funder: RBWH Determinants of Urinary Output Response to Intravenous Frusemide in Patients with Acute Kidney Injury. Ho K, Corcoran T, Lipman J, Roberts J, Barden A, Mori T. Funder: ANZCA Assessment of the Microcirculation in Shocked Critically Unwell Patients during the First 24 hours of Resuscitation. Holley A, Udy A, Boots R, Paratz J, O’Donoghue S, Douglas A, Roberts J, Hurn C, Lukin B, Lipman J. Funder: RBWH Foundation/Wormald Gene expression profiling in critically ill patients with septic shock: The ADRENAL-GEPS Study. Evans D, Cohen J. Funder: NHMRC 3. Management and outcome of burns patients encompassing prevention, acute injury and long term outcomes Thermal injury is a devastating injury, not only for the immediate concern of risk of loss of life and extreme pain, but in the long term cosmetic and functional issues. As a means of improving the treatment and outcomes of these patients, the Burns Unit at RBWH, one of the largest in Australia, has instituted a large number of studies investigating initial cardiac function, management of pain, antibiotic efficacy, nutrition issues, exercise post burns, and prevention of scaring. With increased collaboration with other burns units in Australia, improvement in both the survival and health outcomes of burns patients will be achieved. Projects include: Improving donor site epithelisation and scar maturation times following split skin grafting in burns patients: a novel research study using compression therapy. Rudd M, Spermon M, Muller M. Funder: RBWH & RBWH Foundation/Wormald Myocardial function post-burn injury. Paratz J, Lipman J, Boots R, Muller M, Rudd M, Deans R, Widdicombe N, Parsonage W Funder: RBWH Inhalation Injury. Paratz J, Boots R, Hegde R, Pang G, Younger J. Can adrenergic blockade improve outcome in burns? Muller M, Paratz J, Roberts J, Dhanani J, Towsey K, Younger J. Funder: RBWH Improving the physical and psychological healing of children with burns and trauma. Kimble R, Upton Z, Kenardy J, Cuttle L, Paratz

J, Watt K. Funder: Queensland Children’s Medical Research Institute (QCMRI) IMPACT – IMproving Psychological health And decreasing Cardiovascular risk in patienTs post burns. Paratz J, Druery M, Plaza A, Cohen J, Muller M, Stockton K, Younger J, Flores O. Funder: RBWH Foundation Are burns patients at increased risk of cardiovascular disease? Paratz J, Paul S, Younger J, Stockton K. Funder: RBWH Foundation Measurement of skin donor site healing with clinical assessment, high resolution ultrasound and transepidermal water loss. Brown J, Muller M, Miller J, O'Donoghue S, Towsey K. Funder: RBWH Prevention of burn injury - the neural correlates of risk-taking behavior. Muller M, Dulhunty J, Paratz J, Harrison J, Redman B, Burianová H, Reutens D. Funder: RBWH Foundation Reversing Metabolic Changes Post Burn Injury. Flores O, Paratz J, Stockton K, Muller M, Brown J, Younger J. Funder: Becas Chile program, CONICYT, Chilean government.

Inhalation and right heart failure in burns. Paratz J, Boots R, Muller M, Hegde R. Beta blocker therapy in burns: a randomized controlled trial. Paratz J, Roberts J, Muller M, Boots R, Flores O. Mortality in burns survivors. Paratz J, Younger J, Paul S, Stockton K. Quality of life outcomes post-major burn injuries in adults – a longitudinal exploratory study. Druery M Funder: RBWH Foundation—Red Blanket funding; Professor Stuart Pegg Adult Burns Centre, RBWH Scholarship Burn prevention, an advertising campaign utilizing functional MRI. Muller M, Paratz J, Reutens D, Burianova H, Dulhunty J. Microcirculation as an endpoint to burn resuscitation. Paratz J, Muller M, Boots R.

RESEARCH PROJECTS

4. Anaesthesia Anaesthetising a patient is said to be just as important as the surgery that they will undergo and the types of anaesthesia/analgesia used will vary from patient to patient and condition. Research is continuing on improving methods of anaesthesia and analgesia, intubation, catheterisation and laryngoscopy. Projects include: Hyperbaric Oxygen Therapy for Radiation Induced Xerostomia (HOTRIX trial). Sherlock S, Reid D, Webb R, Bourke A, Acton C, Dickie G, King D, Atkinson P. Funder: ANZCA, RBWH What is the failure rate in extending epidural analgesia to anaesthesia for emergency Caesarean section in women with a body mass index ≥40 kg.m-2 compared with women with a body mass index <30 kg.m-1? A prospective observational case-control study. Eley V, Callaway L, van Zundert A, Chin A, Howes M. Anaesthetist knowledge of guidelines regarding management obese parturients – their experiences of providing anaesthetic care to these women. Eley V, Gallois C, Callaway L, van Zundert A. Anaesthesia for Category 1 Caesarean Section: An Audit of Practice at the RBWH 2010-2013. Lee K, Eley V, Owen T, Pelecanos A. Does the subcutaneous fat measured at 18-22 weeks predict difficulty of epidural insertion or ability to palpate landmarks? A pilot study. Chin A, Eley V, Crooke B, Sekar R. Effectiveness of Mindfulness Training in Sustaining Multidisciplinary Weight Loss in obesity. Jayamaha S, Bambing M, Lee T-K, van Zundert A. NIRVANA (Near Infra Red Venous ANAlysis) - A trial of a vessel finder vs standard technique for peripheral placement of intravenous catheters. van Zundert A, Higgins N, Taraporewalla K, Belavy D, Watson M, Ware R. Funder: UQ Academic Title Holder Research Fund Can a novice in peri operative care locate a peripheral vessel for optimum PIVC placement prior to anaesthesia? Vein Finders. van Zundert A, Higgins N, Tarraporewalla K, Belavy D, Watson M, Ware R. Airway management in patients with oral cancers. van Zundert A , Inaido-Lee E, Wake P Comparison of the diameter, cross-sectional area and position of the left and right internal jugular vein and carotid artery in adults using ultrasound. Bos M, van Loon F, Heywood L, Morse M, van Zundert A. Tracheal Extubation of the Patient with a Difficult Airway in ICU. Part 1.Greenland K, Sturgess D, Senthuran S, Ajvadi F, Edwards M, Van Zundert A, Irwin M.

Indirect videolaryngoscopy using Macintosh blades in patients with non-anticipated difficult airways, results in significantly lower forces exerted on maxillary teeth relative to classic direct laryngoscopy; a randomized crossover trial. Pieters B, Maassen R, van Eig E, Maathuis B, van den Dobbelsteen J, van Zundert A. Comparison of different videolaryngoscopes when used in a manikin by experienced and novice personnel: a randomized crossover trial. Pieters B, Pieters M, Wilbers N, Huijzer M, Winkens B, van Zundert A. Large differences in illumination among videolaryngoscopes. Pieters B, van Zundert A. Pharmacokinetics of sugammadex in morbid obese patients: gas chromatographic levels of rocuronium and sugammadex. Morse M, Wallis S, van Zundert A Prevention of epistaxis and nasotracheal intubation. A Review. Vernon V, Pardon C, van Zundert A. Audit of dressing and securement of IV cannulae. Reynolds H, Chalk T, van Zundert A, Rickard CM. Does the size of the tongue matter in difficult airways? van Zundert A, Cervin D, Coulthard A, Frip J, Lee J. PACE (Preventing Arterial Catheter failurE) Trial : Arterial Catheters. Rickard C, Reynolds H, AVATAR group (Griffith University).

Compliance with CPR guidelines by anaesthetists in simulated peri-operative cardiac arrests. Taraporewalla K, van Zundert A. An Audit of Compliance with a Pre-Block Safety Checklist by a Dedicated Regional Anaesthesia Service at the Royal Brisbane and Women’s Hospital. McLellan E Auditory display of respiratory status of anaesthetised patients: Longitudinal study of varied cases. Taraporewalla K, Sanderson P, Watson M, Reynolds H, van Zundert A. Funder: RBWH Foundation Arterial catheter bundle: A scoping review and procedure development. Reynolds H, Gowardman J, van Zundert A, Rickard C. Development of Cochrane Protocol: Dressings, Securements and Integrated Dressings to Prevent Complications in Peripheral Arterial Catheters. Reynolds H, Ullman A, Culwick M, Mihala G, Alexandrou E, Rickard C

RESEARCH PROJECTS

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Novel Technologies can provide effective dressing and securement for peripheral arterial catheters: A pilot RCT. Reynolds H, Taraporewalla K, Tower M, Mihala G, Tuffaha H, Fraser J, Rickard C. Reconstruction of the human spine & spinal canal for anaesthetists – different positions. van Zundert A, Rose S. Hyperbaric oxygen therapy for foot ulcers in diabetes. Sherlock S, Smith D, Thistlethwaite K, Coleman K. Funder: ANZCA Epidural extension for Category 2 Caesarean-Section. Eley V, Kamp R, Blain S, Hoy M. Positioning during Neuraxial Blocks. Goldsmith D, van Zundert A. Does subcutaneous fat measured at 18-20 weeks predict difficulty inserting an epidural or adverse pregnancy outcomes? Eley V, Chin A, Sekar R, van Zundert A. Funder :UQ Academic Title Holder Research Fund Incident Data Bowtie Analysis—Clarke D Aspiration – Casey P Chewing gum and airway obstruction – Shanmugam S Drug Errors – Peters N Anaphylaxis – Beck A Antibiotic timing - Lee K WebAIRS airway data – Lee J Obstetric data – Goulding G Equipment trials for SABEA. Roets M Laryngoscopes Ultrasound machines Continuous IV pumps Anaesthetic machines Cell Salvage Transfusion in Theatre. Roets M, Casey P. ROTEM usage of blood products before and after implementation. Roets M, Lee J. ROTEM - obstacles to implementation. Roets M, Lee J. A Real-time and Self-Adaptive Stream Data Analyser for Intensive Care Management. Zhang Y, Yi X, He J, Pang C, Steyn M Funder: ARC Linkage Strength of different fixation tapes of ETTs/LMs/IV/IJV/art line. Higgins N, van Zundert A. DEVELOPMENT OF APP: Anaphylaxis Arrhythmias such as SVT / AF with a puls CICO - can't intubate or oxygenate Cardiac arrest Cuff Pressure Measurement ETTs and LMAs. van Zundert A, Reynolds H, Lee J.

ROTEM® thromboelastometry in obstetrics: baseline parameters in normal and complicated pregnancies. A prospective observational study on labour ward inpatients. Lee J, Eley V, van Zundert A, Kimble R, Rowell J. Funder: Study, Education and Research Committee, Pathology Queensland ROTEM® thromboelastometry in obstetrics: baseline parameters in normal and complicated pregnancies. A prospective observational study on elective Caesarean patients. Lee J, Eley V, van Zundert A, Rowell J. Funder: UQ Anaesthesia for paediatric liver transplantation: a review of 10 years of experience. Lee-Archer P, Lee J, Ganska A. Pre-operative Evaluation of the Airway. Lee J, van Zundert A. MERT Criteria. Fung D. PACU Audit. Fung D. PACU Time/Delays Hypothermia Un-expected ICU Admission PONV Pain un-manageable by pain protocol Tracheal Extubation of the Patient with a Difficult Airway in ICU. Part 1.Greenland K, Sturgess D, Senthuran S, Ajvadi F, Edwards M, Van Zundert A, Irwin M. Audit of Recording of Height, Weight and BMI. van Zundert A , Reynolds H. Regional anaesthesia for rib fracture management. Snow B Funder: RBWH PONS Study (Raised Intracranial Pressure and its relationship with the Optic Nerve Sheath). Collins G, Dalgleish L Funder: RBWH Foundation International audit of outcomes and risks for cerebral oxygen toxicity events whilst treated with hyperbaric oxygen therapy. Sherlock S. PDPH: Pregabalin for the management of post-dural puncture headache after unintentional dural puncture in obstetric patients: a randomised, double-blind, placebo-controlled trial. Eley V. Analgesic Requirements for Burns Patients Undergoing Surgical Grafting to Upper Limbs. Town C, Lee J, Johnson J. Audit of characteristics and intraoperative treatments associated with complications in maxillofacial free flap surgery. Edwards M, Christensen R, Town C. Does Cefazolin Prophylaxis During Elective Bariatric Caesarean Section Achieve Therapeutic Concentration in Plasma & Interstitial Fluid. Christensen R, Eley V, Ryan R, Jackson D, van Zundert A, Roberts J. Funder: ANZCA

Does Cefazolin Prophylaxis During Bariatric Surgery Achieve Therapeutic Concentration in Plasma & Interstitial Fluid. Ryan R, Christensen R, Jackson D, Roberts J. Funder: RBWH Foundation DeCIPhER (DiffiCult Intubation PrEdictive Radiology) - defining upper airway radiological parameters to predict difficult intubation. Lee J, Fripp J, Blanco M, Town C, van Zundert A, Cervin A, Groundwater A. Intraoperative cuff pressure measurements of supraglottic airway devices and endotracheal tubes in the operating theatres of an Australian quaternary hospital. Lee J, van Zundert A, Reynolds H, Khatun M. A series of studies on ROTEM® in obstetrics to optimise the management of postpartum haemorrhage. Lee J. Funder: National Blood Authority (NBA), RBWH Foundation Rates of Venous Thromboembolism among orthopaedic surgical patients: A single site retrospective audit. Keys M, Dalgleish L, Legg A. A pilot study on the pharmacokinetics of oxytocin in pregnant women with a body mass index > 40 and a comparison of two measurement techniques for serum oxytocin. Eley V, Ungerer J, Roberts J, Christensen R, Ryan R, Jackson D, van Zundert A, Lipman J. What are the blood and tissue levels of antibiotics and the blood levels of oxytocin, in overweight women having elective caesarean section. Christensen R. Funder: ANZCA.

5. Emergency Medicine The Department of Emergency Medicine's (DEM) research focus centres around improving outcomes and evaluating new processes for treating patients in the Emergency Department. Projects include: Accelerated pathway in the assessment of acute coronary syndrome in the DEM. Cullen L, Brown A, Than M, Greenslade J, Hammett C, Hou X-Y, Ungerer J, Chu K, Parsonage W. Funder: QEMRF, RBWH Foundation Evaluation of a new massive transfusion protocol for exsanguinating trauma patients. Hurn C, Muller M, Cook S, Chu K, Greenslade J, Hou X-Y, Campbell D, Holley A, Rowell J. Funder: Statewide Trauma Clinical Network Medication and fluid orders in the Emergency Department: Examining the incidence of error and adverse events. Richardson P, Greenslade J, Doran E, Chu K Funder: QEMRF Post Concussion Syndrome: A longitudinal investigation of patient outcomes following mild traumatic brain injury. Greenslade J, Sullivan K, Edmed S.

Funder: RBWH Rapid assessment of cardiac chest pain: The Australia and New Zealand Assessment of chest Pain Rule (ANZAP rule): A prospective validation study. Cullen L, Brown AT, Greenslade J, Chu K, Hou J, Parsonage W, Graves N, Than M, Tate J. Funder: QEMRF Diagnostic workup for suspected subarachnoid haemorrhage. Chu K. Funder: QEMRF Prevalence and risk factors associated with CA-MRSA in Queensland Urban Emergency Departments: A prospective study. Williams J, Paterson D, Nimmo G, Greenslade J, Doucet K, Chu K. Funder: QEMRF Checking radiology reports and reviewing patient records: an IT solution for preventing missed limb fractures. Chu K, Lind J, Walholikar A, Crilly J, O’Dwyer J, Philips N, Greenslade J, Keijzers G. Funder: QEMRF Drugs for the treatment of nausea and vomiting in adult patients in the Emergency Department setting. Furyk J, Egerton-Warburton D, Meek R. Funder: QEMRF A RCT of conservative versus interventional treatment of primary spontaneous pneumothorax (PSP). McAuley D, Brown S. End of Life Decision making. Richardson P. Relationship between patient delay distribution and 12-month health outcomes. Cullen L. A decision analytic cost-effectiveness model for chest pain pathways. Cullen L. Loss of Consciousness Study: Basel Syncope Evaluation Study. Cullen L, Parsonage W, Greenslade, J, Mueller C. Funder: QEMRF Relationship between patient delay distribution and 12-month health outcomes. Cullen L, Parsonage W, Than M, Pemberton C. Funder: National Heart Foundation of Australia. A comprehensive evaluation of a hospital in nursing home program in three Queensland hospitals. Lukin W, Hou X-Y et al Funder: QEMRF Management of Back Pain in DEM: a RCT. Samtani M, Paratz J, O’Leary S. Comparison of two approaches to acute mechanical back pain in the emergency setting: a randomized controlled trial Kramer D, Samtani M, Paratz J, O'Leary S, Suna J

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6. Military Medicine Head injury and trauma are the leading causes of death and disability amongst the young, active population in Australia. Our trauma teams are engaged in research investigating all aspects of trauma care from pre-hospital care to longitudinal health outcomes. With the Australian Defence Force joining our centre, research in military trauma medicine has expanded, particularly in the treatment of traumatic coagulopathy, traumatic brain injury, pulmonary contusion and trauma systems design. Much of this work will also benefit civilian patients, particularly those in rural hospitals. Projects include: The tyranny of distance: exploring contributory factors for delays in transfer and intervention in multi-trauma patients. Wullschleger M, Pollard C, Dulhunty J, Paratz J, Hosein S, Bandeshe H, Elcock M, Rashford S. Investigation of the Cerebral Microcirculation after Head Injury. Bellapart J, Boots R, Fraser J, Maybauer M, Helps S. Funder: Brain Foundation, Defence Health Foundation, RBWH

Micro-environment analysis of traumatic wounds using microdialysis to determine molecular and biochemical markers and antibiotic concentrations. Wullschleger M, Roberts J, Pollard C, Lipman J, Tetsworth K, Upton Z Funder: RBWH The Australasian Sedation Practice in Intensive Care Evaluation (SPICE) RCT. Shehabi, Y, Bellomo R, Reade M, Bailey M, Bass F, Howe B, MacArthur C, Seppelt I, Webb S, Weisbrodt L. Funder: NHMRC, Hospira, Orion Corporation Post Concussion Syndrome: A longitudinal investigation of patient outcomes following mild traumatic brain injury. Greenslade J, Sullivan K, Edmed S. Funder: RBWH Towards optimisation of tissue oxygenation in the critically ill. The effect of fresh and aged blood in infection and trauma. Fraser J, Chew M, Fung L, Reade M, Shekar K, Molenaar P, Tung JP, Dunster K, Moore J , Edelman J, Thom O. Funder: QEMRF, TPCH Foundation Evaluation of cryopreserved platelets for the treatment of perioperative haemorrhage. Reade M, Holley A, Irving D, Marks D, Johnson L, Fraser J, Bellomo R, Gattas D. Funder: ANZCA, Australian Red Cross Blood Service (ARCBS) Tranexamic acid blood levels in patients achieved using CRASH-2 dosing: the PATCH-LEVELS study. Reade M, Lipman J, Wallis S,

Gruen R. Funder: ICF Diggers to Veterans: risk, resilience and recovery in the First AIF. McCalman J, Kippen R, Reade M, Shanks D, Hopper D. Funder: Australian Research Council (ARC) Prehospital Antifibrinolytics for Traumatic Coagulopathy associated with Haemorrhage (The PATCH Study). Gruen R, Mitra B, Bernard S, Jacobs I, Medcalf R, Reade M, Tran H. Funder: NHMRC Epidemiology of pyroglutamic acid concentrations in the blood of critically ill patients. Reade M, Ungerer J. Funder: RBWH Foundation

CRE REDUCE Specific Projects Project 1: In vitro effect of antimicrobial exposure on the emergence of resistance for S. aureus, S. pneumoniae, P. aeruginosa, K. pneumoniae, E. coli and A. baumannii. Led by Dr C Landersdorfer and Prof J Roberts Project 2: Intensive-sampled infection site PK of antibiotics in mechanically ventilated patients with ventilator-associated or community-acquired pneumonia. Led by Dr O Cotta, Prof J Roberts, Dr D Koulenti Project 3a: Sampling Antibiotics in Renal Replacement Therapy (SMARRT). Led by Prof J Roberts and Prof Jeff Lipman Project 4: Antimicrobial PK in lung transplant, bone marrow transplant and cystic fibrosis patients. Led by Dr Hafiz Abdul-Aziz and Prof J Roberts Project 5: Flucloxacillin and lincomycin PK in burns patients. Led by Prof J Roberts Project 6: SAFE ICU (Sampling AntiFungal Exposure in ICU)- Multinational study of antifungal PK in ICU. Led by Dr F Sime, Dr Claire Roger (France) and Prof J Roberts Project 7: Antimicrobial PK in critically ill paediatric patients. Led by Dr S Parker Project 8: Multi-centre study of antimicrobial PK in obese critically ill patients. Led by Prof J Roberts and Dr A Alobaid Project 9: Combining in vitro resistance data with in vivo clinical PK data into robust pharmacostatistical models for innovative antimicrobial doses. Led by Prof J Roberts Project 10: Multi-centre study of feasibility of therapeutic drug monitoring (TDM) optimisation of β-lactams for critically ill, burns and transplant patients. Led by Dr O Cotta and Prof J Roberts Project 11: Multinational study of clinical outcomes of continuous infusion vs intermittent β-lactam antibiotic administration in critically ill patients with severe sepsis and not receiving RRT. Led by Prof J Lipman, Dr J Dulhunty, Prof J Roberts and Dr Os Cotta

RESEARCH PROJECTS

Multi-centre trials ADRENAL: A RCT of the effect of hydrocortisone on mortality in critically ill patients with septic shock. Principal Investigator: J Cohen ASAP-ECMO: Extracorporeal Membrane Oxygenation: A study evaluating the pharmacokinetics of various antibiotics, antifungals, sedatives and analgesics in critically ill patients receiving ECMO. Principal Site Investigator: J Roberts DahLIA: A randomised, double-blind, placebo controlled trial of dexmedetomidine for patients with agitation and delirium in the ICU. Principal Investigator: M. Reade. Principal Site Investigators: M Reade, S O’Donoghue SMARRT: Sampling Antibiotics in Renal Replacement Therapy. Principal Investigator: J Roberts RSVP: A Multi-centred trial to examine implications of a routine versus clinically indicated need to change giving sets for iv infusions. Principal Site Investigator: J Gowardman CLIP (Cryopreserved vs LIquid Platelet study): Evaluation of cryopreserved platelets for the treatment of perioperative haemorrhage. Principal Investigator: M Reade MicroSOAP: Microcirculatory Shock Occurrence in Acutely ill Patients—microcirculatory alterations in ICU patients with tachycardia are associated with a substantially increased risk of in-hospital death. Principal Investigator: A Holley TRANSFUSE: STandaRd Issue TrANsfusion versuS Fresher red blood cell Use in intenSive care. A multi-centre randomised double blinded phase III trial of the effect of standard issue red blood cell blood units on mortality compared to freshest available red blood cell units. Principal Investigator: M Reade; Principal Site Investigator: A Holley A RCT of interventional versus conservative treatment of primary spontaneous pneumothorax'. Principal Site Investigator: D McAuley T3 Trial: Triage, Treatment and Transfer of patients with stroke in emergency departments. Principal Site Investigator: J Williams Testing the effectiveness of a targeted implementation intervention compared with passive dissemination on the uptake of key evidence-based recommended practices in the emergency department management of mild head injury in Australia: A cluster randomised trial. Principal Site Investigator: F Williamson Pregabalin for the management of post-dural puncture headache after unintentional dural puncture in obstetric patients: a randomised, double-blind, placebo-controlled trial. Site Investigator: V Eley PneumoINSPIRE (endorsed by ESICM): an international

multicentre prospective observational cohort study of nosocomial pneumonia in intensive care units. Principal Investigator: D Koulenti Estim cycle early rehabilitation in ICU: a RCT. Principal Site Investigator: J Paratz Improving the outcome of sepsis: a RCT. Principal Investigator: J Paratz SAFE-ICU: Screening Anti-Fungal Exposure in Intensive Care Units. An international, multi -centre prospective pharmacokinetic evaluation of antifungal drug exposure in intensive care unit patients receiving conventional dosing regimens. Principal Investigator: J Roberts DIANA: DetermInants of Antimicrobial use aNd de-escalAtion in critical care. A multicentre, international, prospective, observational cohort study of critically ill patients receiving empirical antibiotic therapy for suspected or confirmed infections at ICU (endorsed by the ESICM). Principal Site Investigator: O Cotta AMINO III— An international survey on aminoglycoside practices in critically ill patients: AMINO Critically III survey. Principal Investigators: J Roberts, C Roger

OACES—A prospective two-centre observational pharmacokinetic study evaluating and Optimizing Antibiotic CSF ExposureS in critically ill patients with in situ external ventricular drains (EVD) for the treatment and prevention of nosocomial central nervous system infections associated with ventriculostomy. Principal Investigator: J Lipman DecubICUs - A global point-prevalence study on pressure ulcers in ICUs. Trials Group project of the ESICM. Principal Investigator: S Blot AbSeS - The Abdominal Sepsis Study: Epidemiology and Outcome. Trials Group project of the ESICM. Principal Investigator: S Blot

RESEARCH PROJECTS

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New to BTCCRC — Clinical Microsampling Group The newly formed Clinical Microsampling Group aims to replace traditional, highly invasive blood-taking techniques with an innovative, microsampling approach that enables measuring drug concentrations in a drop of blood. The microsampling devices used for this purpose require only 10—20 microlitres instead of millilitres of sample which is easily processed. Studies which characterise drug concentrations in children with severe infection, or ‘pharmacokinetic’ studies, are lacking and consequently, clinicians do not know which doses should be used in these patients. In part, the lack of pharmacokinetic studies is

due to the onerous blood sampling required: frequent sampling (5-8 times) of up to 5 mL per sample. However, there are psychological and physiological burdens and risks associated with taking blood from babies, infants and children. Blood sampling is highly concerning to these vulnerable patients and their parents; it is frequently a factor of discussion for research ethics committees when considering whether a research project is acceptable. Recent advances in the sensitivity of the instruments that measure drugs now provide the opportunity to reduce blood sampling volumes. The research undertaken by the Clinical Microsampling Group for a new approach to sampling can be applied to strategic pharmacokinetic studies to establish evidence-based, effective drug dosing regimens. For babies, infants and children treated with our novel dosing regimens, they will have an easier fight and a better chance at getting home sooner, where they belong.

This research is an interdisciplinary collaboration between the staff at Lady Cilento Children’s Hospital (LCCH), South Brisbane and the BTCCRC and is headed by Dr Suzanne Parker. The chief investigators are Dr Suzanne Parker, Post-Doctoral Research Fellow, BTCCRC and Dr Tavey Dorofaeff, Paediatric Intensivist, LCCH. Other investigators include Prof Jason Roberts, Professor of Medicine and Pharmacy, BTCCRC UQ, Prof Jeffrey Lipman, Professor of Medicine, BTCCRC, Ms Yarmarly Guerra Valero, PhD student and research assistant, BTCCRC and Dr Steve Wallis, Lab Manager, BTCCRC. Funding has been received from the RBWH Foundation and the Australian Hellenic Education Progressive Association (AHEPA).

Researcher

Showcase

L to R: Jason Roberts, Suzanne Parker, Yarmarly Guerra Valero, Tavey Dorofaeff, Steve Wallis

Neoteryx Mitra Microsampling Devices

Grant Title Granting Body Investigators Amount

BLING III: A phase III randomised controlled trial of continuous β-lactam infusion compared with

intermittent β-lactam dosing in critically ill patients

NHMRC Project Grant APP1121481 Lipman J, Roberts J, Myburgh J, Peake S, Dulhunty J, Paterson D, McGuiness S, Rhodes

A, de Waele J, Finfer S

$3,269,942.70

Redefining antibiotic dosing to reduce bacterial resistance

NHMRC Practitioner Fellowship Roberts J $474,512

Improving rapid decision-making in the face of uncertainty: a randomised trial of a 1-hour troponin protocol in suspected acute coronary syndromes.

NHMRC Project Grant APP1124471 Chew D, Briffa T, Cullen L, Quinn S, Karnon J. $1,095,320.

Is highly-sensitive troponin testing advancing clinical practice, improving outcomes and cost-effective in the investigation and management of chest pain in

the Emergency Department?

NHMRC Project Grant APP1122792 Briffa T, Cullen L, Chew D, Knuiman M, Fatovich D, Hickman P, et al.

$1,193,966

Does Cefazolin Prophylaxis During Elective Bariatric Caesarean Section Achieve Therapeutic

Concentration in Plasma & Interstitial Fluid

ANZCA Project Grant Christensen R, Eley V, Ryan R, Jackson D, van Zundert A, Roberts J.

$34,059

Does Cefazolin Prophylaxis During Bariatric Surgery Achieve Therapeutic Concentration in Plasma &

Interstitial Fluid

ANZCA Project Grant Ryan R, Christensen R, Jackson D, Roberts J

$34,059

Using a drop of blood to optimise antibiotic dosing in infants and children

Ian Potter Medical Research grant Parker S, Roberts J $39,500

A series of studies on a new clotting test in pregnant women to optimise the management of bleeding

National Blood Authority Early career Funding

Lee J $30,000

Describing the experiences of social workers in a tertiary ED

Emergency Medicine Foundation Markwell L, Howell T, Windsor C, Bell A, Chu K, O'Malia A.

$14,735

Whole genome sequencing to track, treat and prevent nosocomial infections

QLD Genomic Health Alliance Paterson D, Harris P, Nimmo G, Allworth A, Hadjkowicz K, Jennison, Lipman J…..Roberts J,

Schembri M, Beatson S…….Schlebusch S

$600,000

Building PK and clinical trial capacity at the Herston Campus

UQ Strategic Funding Lipman J $1,584,005

Screening Anti-Fungal Exposure in Intensive Care Units: the SAFE_ICU study

RBWH & RBWH Foundation Roberts J, Roger C $40,000

‘Implementing microsampling into clinical pharmacokinetic research studies - it only takes a

drop of blood!

RBWH & RBWH Foundation Lipman J, Parker S, Dorofaeff T $40,000

PK/PD substudy of patients randomised to receive β-lactam antibiotics by either intermittent or

continuous infusion

RBWH & RBWH Foundation Cotta M, Roberts J, Dulhunty J, Lipman J $40,000

Does Routine Antibiotic Administration in Overweight Women Having Elective Caesarean Section Achieve

Therapeutic Levels?

RBWH & RBWH Foundation Christensen R, Eley V, Ryan R, Jackson D, van Zundert A, Roberts J, Lipman J

$40,000

A pilot randomized cross-over placebo control trial of metformin for reducing weight gain and metabolic

syndrome among people initiated on clozapine

RBWH & RBWH Foundation Flaws D, Siskind D, Patterson S $40,000

Quality of Life outcomes post-major burn injuries in adults - a longitudinal exploratory study

RBWH & RBWH Foundation Druery M, Rudd M, Newcombe P, Cameron C

$40,000

Raised Intracranial Pressure and its relationship with Optic Nerve Sheath Diameter PONS Study

RBWH & RBWH Foundation Collins G, Dalgleish L $40,000

Antibiotic Resistance and the Development of a Bedside Antibiotic Commencement Tool

QLD Health Junior Research Fellowship

Denny K $250,000

Predicting delirium at the time of hospital admission QLD Health Junior Research Fellowship

Flaws D, Mudge A, Byrne G

$500,000

Personalisation of antimicrobial therapy in critically ill patients: meeting a global challenge!

UQ Health Outcomes ProgramS Roberts J $300,000

Small equipment grant. The Prince Charles Foundation Dalgleish L $5,000

Improving the outcome in burns RBWH & RBWH Foundation Paratz J, Muller M, Plaza A $40,000

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Grant Title Granting Body Investigators Amount

Psychosocial outcomes post-major burn injuries in adults - a longitudinal exploratory study

Professor Stuart Pegg Adult Burns Centre, RBWH Scholarship

Druery M $20,000

Psychosocial outcomes post-major burn injuries in adults - a longitudinal exploratory study

RBWH Foundation – Red Blanket Funding

Druery M $15,000

Auditory display of respiratory status of anaesthetised patients: Longitudinal study of varied cases

RBWH & RBWH Foundation Taraporewalla K, Sanderson P, Watson M, Reynolds H, van Zundert A.

$40,000

Single dose population PKs of intravenous Posaconazole in critically ill patients.

Merck, Sharpe & Dohme Roberts J $77,752

An observational PK study of Ceftolozane-Tazobactam in intensive care unit patients with and without

continuous renal replacement therapy.

Merck, Sharpe & Dohme Roberts J $225,009

A prospective observational PK evaluation of the plasma and CSF concentrations of a single dose

ceftolozane/tazobactam in infected critically ill patients with an indwelling external ventricular drain

Merck, Sharpe & Dohme Roberts J $110,215

Association for Vascular Access ASM 2016, Orlando Ian Potter Foundation Travel Grant Reynolds H $2,600

A series of studies on ROTEM® in obstetrics to optimise the management of postpartum haemorrhage

ASA scholarship Lee J $10,000

A series of studies on ROTEM® in obstetrics to optimise the management of postpartum haemorrhage

RBWH Foundation Scholarship Lee J $39,142

DecubICUs– a point-prevalence study on pressure ulcers in ICUs

Flemish Society for Critical Care Nurses Blot S €10.000

Emergency Department Opioid Prescribing Intervention: Optimising Discharge (ED OPIOID) Study

Emergency Medicine Foundation Savage R, Bell A, Kline T, Lock C, Pattullo C, Grayson V

$34,955

Too much of a good thing; Does fluid resuscitation worsen septic shock?

Emergency Medicine Foundation Cullen L, Fraser J, Shekar K, Byrne L, Nchfatso O…...Passmore M, Maitland K

$77,233

Redesigning systems of care for heart failure patients to improve outcomes

National Heart Foundation Partnership Engagement Grant

Driscoll A, Tonkin A, Hare D, Prior D, Cullen L…...Mohebbi M, Patsamanis H

$150,000

Impact of fluid volume resuscitation on nitric oxide-induced oxidative stress and cardiac dysfunction in an

ovine septic shock model

Prince Charles Hospital Foundation New Investigator Grant

Crawford W, Cullen L $9,994

Diagnosis of Acute Coronary Occlusion in patients with a Ventricular Paced Rhythm

Emergency Medicine Foundation Mitchell G, Cullen L, Greenslade J $16,842

Emergency Department Opioid Prescribing Intervention: Optimising Discharge (ED OPIOID)

Study. Department of Emergency Medicine, RBWH

RBWH & RBWH Foundation Bell A, Savage R, Kline T, Lock C, Pattullo C

$12,500

Atrial fibrillation in the emergency chest pain presentation Royal Brisbane and Women's Hospital

RBWH and RBWH Foundation Lancini D, Cullen L, Martin P, Prasad S, Greenslade J

$15,335

The impact of ImpACT: a protocol to improve emergency chest pain assessment.

AusHSI Partnership Grant Cullen L, Graves N $110,000

PneumoINSPIRE Rebecca Cooper Medical Research Foundation

Koulenti D $25,000

Advancing infectious diseases research in critical care UQ Research Fellowship Koulenti D $197,818

A translational approach to optimisation of antimicrobial therapy for critically ill patients that

prevents the emergence of ‘Superbugs’

UQ Research Fellowship Sime F $197,818

RBWH Foundation Donations

$153,687 $10,100

Sponsorship and Donations

RESEARCH FUNDING

Julian Williams Emergency Physician PhD Student

Infection costs the Australian healthcare system millions of dollars every year and imposes a significant burden of illness on the Australian community. Serious infections can cause tragedy at a much more personal level, with lethal outcomes possible even in young previously healthy individuals. Despite the significant consequences of these illnesses, clinicians have very limited information about the best way to identify and treat infection in Australian ED. Julian is completing a PhD thesis focusing on patients who present to the ED with community acquired infection. This research aims to identify the factors that are apparent early during the course of infection that may predict a poor outcome. In addition, he also aims to improve the immediate treatment of sepsis syndromes by determining and optimising various aspects of care, including antibiotic administration and fluid resuscitation. This ground breaking body of research is likely to have a significant impact on the way that sepsis is identified and managed in the emergency setting in Australia.

Jayesh Dhanani Intensivist PhD Student Pneumonia occurs commonly in the community but despite antibiotic therapy, patient outcomes remain poor. One of the reasons for this could be insufficient antibiotic concentrations at the site of infection, the interstitial space of the lungs. Administering higher doses of antibiotics systemically could cause severe adverse effects whilst sub-therapeutic antibiotic exposure could lead to emergence of drug resistant organisms and poor health outcomes. Due to the drying up of the antibiotic pipeline, there is renewed interest in alternative modalit ies of drug administration. Aerosolized antibiotic therapy for lung infections whilst not novel, is being used increasingly worldwide to improve patient outcomes particularly in the context of drug resistant pathogens. Understanding and applying key PK principles is important for effective antibiotic therapy. P. aeruginosa is a common cause of hospital and ventilator acquired pneumonia. Tobramycin is an effective antibiotic for this pathogen. High-dose systemic tobramycin therapy is not suitable to treat P. aeruginosa due to the likelihood of severe side effects. Aerosolized tobramycin might be a valid application for critically ill patients with pneumonia given the supportive data from cystic fibrosis patients, although the dose and frequency for optimal therapy in this population is unclear. Jayesh’s PhD aims to investigate the disposition of aerosolized tobramycin for use in mechanically ventilated patients with pneumonia.

Caleb Economou Pharmacist PhD Student The PK of antibiotics in critically ill patients undergoing extended daily diafiltration is Caleb’s area of research interest. During 2014, Caleb completed recruiting patients at the Gold Coast Hospital ICU who were prescribed the antibiotic ticarcillin/clavulanate whilst undergoing extended daily diafiltration (EDDf). Concurrently, he completed ex vivo simulations of vancomycin, meropenem, ticarcillin/clavulanate and piperacillin/tazobactam in a renal replacement therapy circuit to determine the amount of antibiotic that adsorbs to the filter membrane of dialysis machines. Currently, Caleb is working on an ex vivo haemodiafiltration circuit in which the study antibiotics are added to diluted blood and recycled around the circuit. He is able to calculate the amount of antibiotic removed from the circuit during this process and thus determine the sieving coefficient or likelihood an antibiotic will leave the blood and move into the dialysis fluid. The purpose of this research is to provide information to prescribers on improving antibiotic dosing in critically ill patients undergoing haemodiafiltration.

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Gloria Wong MBBS/PhD Student Gloria’s main interest is in the use of TDM to optimize β-lactam dosing in ICUs. Despite increasing utility of β-lactam TDM in ICUs, data on this subject remains limited albeit urgently needed to optimize patient outcomes. The existing reports for β-lactam TDM have all used total antibiotic concentrations and published protein binding values for determining the need for dose adjustment, which is problematic given that the unbound concentration of antibiotic is responsible for bacterial killing and protein binding changes in the critically ill is uncertain. Accuracy of such an approach was evaluated in a recent publication as part of my project, utilizing a new unbound drug assay developed by our colleagues in Chemical Pathology. Another aim of Gloria’s project is to document the pharmacokinetic/pharmacodynamic parameters of measured unbound β-lactams in ICU patients. Data collection is completed and we hope this information will provide a more comprehensive view of the effectiveness of present dosing regimen and the value of TDM in this setting. Furthermore, in her latest publication, she addressed various practical approaches to implement β-lactam TDM in selected experienced centres in Australia, Belgium, France, Germany, Italy, Switzerland and USA. Among numerous variations in β-lactam TDM clinical practice, the use of heterogeneous clinical targets has been one of the major issues. In collaboration with the same group of researchers, a retrospective study is underway with the aim to address this gap in daily ICU practice and robustly define targets for β-lactam TDM.

Dylan Flaws MBBS/PhD Student Dylan’s research investigates which statistical method is best used to produce risk scores in the setting of the 2 hour chest pain pathway by deriving various decision tools from a single population, and then validate on diverse populations. Since 2013, Dylan has validated the cardiac risk scores in Vancouver, Canada as well as Manchester, UK and Stockport, UK. In Vancouver the score derived from Multiple Regression outperformed other scores, and the performance of each score was comparable to our local findings. The performance of the Multiple regression score (EDACS) has been submitted for publication in Academic Emergency Medicine. The findings from Manchester and Stockport have not been published due to missing an important blood test result in the data. However, the rules appear to have comparable performance in Stockport, but not in Manchester. In total, the performance of each rule has now been tested within-subjects on over 4,000 patients from 3 separate health systems.

Yarmarly Guerra Valero Bioanalytical Scientist PhD Student

The title of Yarmarly’s thesis is “Translating microsampling techniques into better antibiotic dosing for critically ill children”. This project is focused on evaluating a range of microsamples (small volumes of liquid blood collected into glass capillary, blood spots collected onto Guthrie Cards as well as new sampling products such as Mitra® and Noviplex® devices, as well as plasma equivalents) for their suitability as accurate and reliable sampling techniques to perform studies in antibiotics in the paediatric critical care environment. I’m also working on the development of novel methods for measuring different antibiotics in microsamples using UHPLC-MS/MS techniques. The aim of this research project is to measure antibiotic concentrations using microsamples to perform pharmacokinetic studies in critically ill paediatric patients. This will provide suitable antibiotic dosing strategies that may lead to improved clinical outcomes in this paediatric population.

STUDENT

SHOWCASE

Julie Lee Anaesthetist PhD Student Rotational thromboelastometry (ROTEM®) measures the viscoelastic properties on multiple aspects of coagulation. The use of ROTEM® is well established in hepatic and cardiac surgery, but not as yet in the obstetric setting. Recruitment for two ROTEM® studies has been completed on labour ward and on elective Caesarean patients. These studies aim to provide data on reference ranges in normal pregnancies in order to develop an obstetric algorithm as well as to further the understanding of the effects of antenatal complications on ROTEM® interpretation. A third study will analyse the severity of platelet dysfunction in pre-eclampsia using ROTEM® Platelet. These prospective studies aim to enable improved haemostasis management in the parturient by examining the correlation between ROTEM® parameters, transfusion requirements and the probability of postpartum haemorrhage. The relationship between FIBTEM and fibrinogen will also be examined in patients with abnormal coagulation or a history of exposure to anticoagulant therapy.

Judith Bellapart Intensivist PhD Student Victims of traumatic brain injury (TBI) often lose much blood resulting in dangerously low levels of oxygen reaching the brain. Optimal transfusion and subsequent oxygenation of the brain are therefore essential to both survival and successful recovery in these patients. Studies have shown that blood transfusion benefits brain oxygenation and that the more anemic the patient, the greater the benefit of a blood transfusion. Therefore, TBI patients who are at high risk of brain death due to loss of blood would benefit the most from a blood transfusion. Although this is known, an understanding of how the small blood vessels circulate blood during injury and the best procedure for transfusion in TBI has not yet been determined. After the successful completion of our pilot study in a sheep model, in which the use of colour coded microspheres injected via the heart proved to be a feasible method to analyse cerebral blood flow, a series of studies based on the effect of normovolemic anemia in the injured brain in ovine models, have been designed to establish a transfusion threshold based on quantification of cerebral microcirculation (CM). These studies comparing CM between injured and non-injured hemispheres during different degrees of anemia are underway. Before, and at various times after induced head injury and varying degrees of anemia, microspheres of different colours are injected to assess CM over time. The various colours help to distinguish changes in CM at different times post injury.

Danny Tsai Pharmacist PhD Student Danny’s thesis has described the pharmacokinetics of meropenem, ceftriaxone, vancomycin and piperacillin in critically ill Australian Indigenous patients with severe sepsis and has provided dose recommendations for different parameters such as creatinine clearance and MIC of the target pathogen. Overall, the study showed a high interindividual variability in the pharmacokinetics of these antibiotics, but it is adequately described by the patient’s measured creatinine clearance and body weight except for ceftriaxone. Thee was no difference in the pharmacokinetics of vancomycin and meropenem when compared with critically ill patients of other populations. A slightly lower drug clearance was observed in the Indigenous patients for ceftriaxone and piperacillin, however the clinical relevance is likely to be insignificant. Furthermore, 32% of critically ill Indigenous patients manifested augmented renal clearance and all calculated creatinine clearance equations have limited utility in comparison with measured creatinine clearance. Dose individualisation is important to optimise pharmacokinetic/pharmacodynamics target attainment.

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Orlando Flores Physiotherapist PhD Student Orlando’s project “Reversing Metabolic Changes post Burn Injury” is investigating whether an interventional program of exercise and/or adrenergic blockade will improve outcomes related with Physical health, Psychological health and Health Realted Quality of Life (HRQoL) in patients suffering severe burn injuries. During this PhD project, two systematic reviews and meta-analysis had been conducted. The first one assessed the efficacy and safety of beta-blockers in burn population. The second one analysed the effectiveness of exercise on improving physical, physiological and psychological outcomes after burn injuries. We have commenced the design of a survey of practice aiming to investigate the extent and characteristics of the use of exercise in burn specialized and non-specialized centers across the world in the treatment of subjects affected by burns. Additionally, a further study on measurement of body composition by dual energy x-ray absorptiometry in burns patients had commenced this year. The two interventional trials (effects of beta-blockers and effects of exercise on reversing metabolic changes post burn injury) had begun and there is steady recruitment occurring.

Victoria Eley Anaesthetist PhD Student Victoria’s thesis is titled “Clinical Guidelines relating to the Anaesthetic Management of Obese Parturients: An Evaluation of their Utility in Clinical Practice and the Evidence Supporting the Recommendations”. Three papers included in the thesis have been successfully published in 2016. Obesity in pregnancy is increasing in prevalence and managing the technical difficulties presented by these patients is an increasingly common clinical scenario for anaesthetists. One element of interest to practicing anaesthetists, (and closely examined in the thesis), is the concept of “early epidural analgesia” for obese parturients, which is practiced locally and overseas, despite a limited evidence-base. This thesis examines the role of practice guidelines in the management of obese parturients, using qualitative and quantitative methodology.

Martha Druery Social Worker PhD Student The aim of Martha’s proposed prospective longitudinal exploratory research is to investigate how adult survivors of burn injuries recover in relation to their Quality of Life and psychological well-being, as well as examining the societal burden of their injuries. It seeks to research the influence of pre-existing social factors on these outcomes over time, in the first year after the initial injury. Although treatment of burns has seen vast improvements in recen t d ecades an d med ica l advancements have led to declining mortality rates, it remains a devastating injury for many survivors due to the pain, disfigurement, disability and trauma incurred. The epidemiological and predisposing factors reported for adult burns consistently highlight the significant role of socio-economic indices for increased risk. However, there has been a paucity of research investigating the relationship between these social factors and post-injury outcomes for adult burns survivors. It is envisaged that the financial and social costs of surviving a burn injury are inequitably distributed and are not only borne by the survivors themselves but by society as a whole. It is argued that these costs, individually and societally, need to be quantified and better understood in order to plan cost-effective and efficient health care services that can be measured against the baseline data generated by the proposed research.

STUDENT

SHOWCASE

Tavey Dorofaeff Paediatric Intensivist PhD Student Critical illness alters the effectiveness of antibiotics in fighting sepsis. Augmented clearance and altered pharmacokinetics have been proven in adults with critical illness. Very little is known about the effect of critical illness in the paediatric patient. There is early evidence to suggest that antibiotics need to be dosed differently. The age range of a patient in the paediatric intensive care varies from newborn to 16yrs of age. In some cases up to 21yrs. Weights vary from 3kg to 140kg. In addition to this there are developmental changes in the body’s enzyme systems and organ functioning that make the study of the pharmacology in these patients very challenging. The prescribing of antibiotics is one of the most common therapies used in the Paediatric Intensive Care. In this PhD study Tavey hopes to understand how we can effectively dose antibiotics in critically unwell children and in doing so dose more efficiently to guard against the threat of antibiotic resistance.

Elissa Milford PhD Student Elissa’s thesis is investigating the role of the endothelial glycocalyx (EG) in severe trauma The EG is a microscopically thin layer of g l y c o p r o t e i n s , p r o t e o g l y c a n s , glycosoaminoglycans and plasma proteins that lines all the blood vessels in the body. Damage to the EG (termed shedding) occurs early following severe traumatic injury, and the degree of EG shedding has been associated with poor outcomes in trauma. However, it is unclear if EG shedding is simply a marker of disease severity or if it directly contributes to poor outcomes. If a causal link is established, then there is great potential for the EG to be a therapeutic target in the treatment not only of trauma patients, but also in other illnesses such as severe sepsis. Alternatively, EG shedding may still prove to be a useful marker of microcirculation hypoperfusion. This project aims to determine the significance of EG shedding in severe trauma, and to investigate potential therapies.

Rochelle Ryan Anaesthetist MPhil

Rochelle’s research describes Cefazolin PK in bariatric surgery. Cefazolin, a β-lactam antibiotic, is the recommended antibiotic for surgical prophylaxis in many surgeries. The efficacy of cefazolin relies upon the time above the minimal inhibitory concentration of potential pathogens in susceptible tissues, in particular the subcutaneous interstitial fluid (ISF). Pharmacokinetic data of cefazolin in the perioperative period is sparse and confl icting and inadequate ISF concentrations may predispose to surgical site infections. Microdialysis is an in vivo sampling technique to measure subcutaneous ISF drug concentrations. This project will use microdialysis ISF and serum concentrations to evaluate the pharmacokinetic-pharmacodynamics of cefazolin in the perioperative period and examine optimal dosing regimens.

STUDENT

SHOWCASE

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Lisa Wang Medical Resident MPhil Student Infection in burns patients can lead to serious consequences if not treated appropriately. One of the main sources of infection in these patients is from the burn wound. Previous studies have shown that the antibiotic concentrations in blood and tissue do not necessarily run parallel. To ensure optimal antibiotic treatment to the burn wound infection, our project aims to assess the relationship of antibiotic concentrations in blood and tissue. This will allow us to determine the dosing required for antibiotics in this group of patients to ensure effective antibiotic therapy. The aim of the project is to describe the plasma and tissue concentrations of the antibiotic lincomycin in burns patients with burn wound infection. We aim to use this data to develop robust dosing recommendations for effective lincomycin therapy.

Kevin Chia MBBS/Hons A retrospective cohort analysis was performed comparing length of stay (LOS) outcomes of patients admitted to an intensive care unit after inter-hospital transfer (IHT) with similar patients who did not undergo transfer, and to assess the impact of geographical and service availability factors on LOS in these patients. Critically ill patients who underwent IHT have longer LOS than patients that did not, even after adjustment for their greater severity of illness and other significant characteristics. Clinical service availabilities of discharge destinations were significant predictors of LOS, but distance travelled, patient remoteness, and severity of illness were not. Our findings potentially identify targets to which tailored interventions could reduce the increased LOS associated with IHT, improving efficiency in critical care delivery.

Nilesh Kumta MBBS/MPhil Student Nilesh’s project is a two-centre observational pharmacokinetic study (conducted jointly with the Prince of Wales Hospital, Hong Kong SAR) aiming to determine optimised dosing regimens for four antibiotics routinely used in the treatment and prevention of central nervous system infections in critically ill patients. Three groups of patients will have antibiotic concentrations measured over a dosing interval in serial blood, cerebrospinal fluid and urine samples. These data will be subjected to sophisticated pharmacokinetic modelling for each of the four antibiotics, which include ceftriaxone, meropenem, piperacillin-tazobactam and vancomycin. The model can then be used to perform dosing simulations in order to design more effective antibiotic dosing strategies, so as to optimise patient outcomes by ensuring effective concentrations in the CSF of relevant critically ill patients. This study has received HREC and site specific approval, and sample collection is expected to commence in November 2016.

Title Name Degree BTCCRC Supervisor Ms Bernie Bissett PhD DA/Prof J Paratz/A/Prof R Boots

Dr Judith Bellapart PhD A/Prof R Boots/A/Prof J Paratz

Dr Julian Williams PhD Prof J Lipman/Prof A Brown

Mr Caleb Economou PhD Prof J Roberts/Prof J Lipman

Mr Mohd Hafiz Abdul Aziz PhD Prof J Roberts/Prof J Lipman

Mr Danny Tsai PhD Prof J Roberts/Prof J Lipman

Mr Orlando Flores PhD A/Prof J Paratz

Ms Gloria Wong MBBS/PhD Prof J Roberts/Prof J Lipman

Dr Victoria Eley PhD Prof A van Zundert/Prof J Lipman

Dr Jayesh Dhanani PhD Prof J Roberts/A/Prof J Cohen

Dr Julie Lee PhD Prof A van Zundert/A/Prof J Cohen/A/Prof K Wyssusek

Dr Tavey Dorofaeff PhD Dr S Parker/Prof J Lipman/Prof J Roberts

Mr Dylan Flaws MBBS/PhD Prof L Cullen

Ms Martha Druery PhD Prof J Lipman

Dr Lisa Wang MPhil Prof J Roberts/Prof J Lipman/Prof M Muller

Mr Nilesh Kumta MBBS/MPhil Prof /J Lipman

Dr Rochelle Ryan MPhil Prof J Roberts/Prof J Lipman/Prof A van Zundert/A/Prof K Wyssusek

Mr Kevin Chia MBBS/Hons Prof M Reade/A/Prof R Boots

Dr Elissa Milford PhD Prof M Reade

Ms Yarmarly Guerra Valero PhD Prof J Roberts

BTCCRC Research Supervision

Supervision of Research for UQ Medical Student Observerships, Junior Doctors and Volunteers

Prof Louise Cullen—Robert Nayer, Alessandro Iliceto, Mallory Emig, Ariel Ho Dr Susannah Sherlock—Ohmar Aung for Diploma in Hyperbaric Medicine Dr Julie Lee—Alana Pinheiro, Ellen Coonan, Shaiyla Sivakumar, Tory Lingard, Joel Thomas, Margo Blanco, Ly Zhang and Surya Bhamidipaty-Pelosi Prof Michael Reade—Dr George Evetts, Ms Meng Mei Phua Dr Despoina Koulenti— David Thompson, Kimberly Tu, Vipin Varghese, Graham Unis, Ashley Antovich, Mathew Robin Judd, Noori Dhaliwal, Amy-Lou Richter, Ethel Soh, AnXuan Ang, Amarjargal Byambatsogt, Harman Khaira, Waseem Gazale, Dan Pasternak, Estefania Torrivilla

Completion of Higher Degree Congratulations to the following on completion of their degree this year. Dr Hafiz Abdul-Aziz PhD Dr Victoria Eley PhD Dr Aziz Alobaid PhD Dr Bernie Bissett PhD Dr Natasha van Zyl MPhil Mr Andrew Flint MBBS/Hons Dr Marco Haanschoten PhD Dr Evelien Verstraete PhD Ms Michelle Donovan MPhil

RESEARCH

SUPERVISION

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Students Enrolled in Other Schools/Institutes who are supervised/co-supervised by our staff

Mahipal Sinnollareddy (University of South Australia) PhD. Supervisor — Prof J Roberts

Kiran Shekar (UQ) PhD. Co-supervisor — Prof J Roberts

Sonali Coulter (QUT) PhD. Assoc supervisor — Prof J Roberts

Kelly Mulvogue (UQ) MPhil. Co-supervisor — Prof J Roberts

Annie Sultana (UQ) MPhil. Investigating underlying mechanisms of transfusion-related acute lung injury. Supervisor — Prof M Reade

Natasha van Zyl (UQ) MPhil. Development of an ovine model of trauma-induced coagulopathy. Supervisor — Prof M Reade

Paul Jarrett (QUT) MPhil. Nursing interventions for acute confusion in critical illness. Supervisor — Prof M Reade

Andrew Flint (Monash University) MBBS/Hons. Retrospective analysis of the effect of duration of platelet storage on outcome of trauma and critical illness. Supervisor — Prof M Reade

Courtney Clark (Griffith University) PhD. Supervisor — A/Prof J Paratz.

Julie Adsett (Griffith University) PhD. Hydrotherapy in heart failure. Supervisor — A/Prof J Paratz

Lauren O’Connor (Griffith University) PhD. The effect of the Passy Muir valve on postural retraining. Supervisor — A/Prof J Paratz

Maureen Peasey (Griffith University) MPhil. Physical activity in COPD. Supervisor — A/Prof J Paratz

Jemima Boyd (Griffith University) MPhil. Haemodynamic measurement in mobility post cardiac surgery. Supervisor — A/Prof J Paratz

Rofhiwa Mathiba (University of the Witwatersrand, South Africa) MMed. Malaria at Chris Hani Baragwanath Intensive Care Unit: Comparing outcomes between Quinine and Artesunate therapy. Supervisor — Dr G Nethathe

David De Wandel (Ghent University, Belgium) PhD. The impact of hand hygiene education in long term care facilities. Supervisor — Prof S Blot

Evelien Verstraete (Ghent University, Belgium) PhD. Epidemiology of hospital-acquired bloodstream infection in neonatal ICU. Supervisor — Prof S Blot

Andy Lo (UQ) MPhil. Use of an electronic app to collect and analyse pharmacist interventions in a hospital ward environment. Supervisor — Prof J Roberts

Chandra Sumi (UQ) PhD. Optimization of alternative antibiotic dosing regimens for maximal antibacterial activity and suppression of emergence of resistance. Supervisor — Prof J Roberts

Marco Haanschoten (University of Maastricht, Netherlands) PhD. Towards efficient cardiac surgery – the integrating role of anaesthesiology and intensive care. Supervisor — Prof A van Zundert

Gladness Nethathe (University of Witswatersrand, South Africa) PhD. Aspects of the Neuroendocrine Stress Response in Patients with Severe Sepsis or Multi-Trauma. Supervisor —A /Prof J Cohen

Aaron Heffernan (Griffith University) MD/PhD. ntravenous and nebulised dose optimisation of fosfomycin and amikacin in the treatment of multi-drug resistant gram-negative pneumonia. Supervisor — Prof J Roberts

Kirsten Strudwick (UQ) PhD. Supervisor — Dr A Bell

Daniel Lancini (UQ) PhD. Supervisor — Prof L Cullen and A/Prof R Boots

Thushani Adikari (UQ) MD/Hons. Supervisor — Prof L Cullen

William Crawford (UQ) MD. New Investigator. Mentor — Prof L Cullen

Gabriella Simonov (UQ) PhD. Development of sheep laboratory models to investigate the effects of transfusion with stored and cryo preserved blood products. Assoc. Supervisor—Prof M Reade

Timothy Sladden (UQ) PhD. Assoc. Supervisor—Prof J Lipman

Bernie Bissett In 2016 the randomised trial of inspiratory muscle training for ICU patients was published in the journal Thorax, accompanied by an editorial by Professor Rik Gosselink which highlighted the importance of our research findings for ICU clinicians. I also presented these results at the American Thoracic Society conference in San Francisco in May, as well as the Canberra Health Annual Research Meeting in August, where the presentation won "Best Allied Health Oral Presentation". With the PhD submitted and accepted in 2016, I would like to thank the BTCCRC for their ongoing support of my research across the life of my candidature from 2010 - 2016. I look forward to continuing to collaborate with my supervisors Jenny Paratz, Rob Boots and Anne Leditschke and maintaining the Brisbane-Canberra ICU connection in the coming years.

Mohd Hafiz Aziz Critically ill patients are markedly different from those in general ward settings as they are associated with higher morbidity and mortality rates. These patients commonly demonstrate a high level of illness severity which causes profound physiological changes that can alter the pharmacokinetics of antibiotics. Antibiotic dosing that does not account for these changes may lead to therapeutic failure and the emergence of antibiotic resistance. My thesis aimed to better characterize the PK/PD of β-lactam antibiotics to determine whether there is any therapeutic advantage associated with prolonged dosing (continuous infusion and/or extended infusion) as compared to intermittent bolus dosing. The findings of my thesis suggest that conventional β-lactam dosing does not address the physiological changes and as such, increases the likelihood of therapeutic failure and the emergence of resistance in critically ill patients. Altered dosing approaches may be needed to ensure optimal β-lactam exposure and may produce better therapeutic outcomes than intermittent bolus

administration, particularly in critically ill patients with severe sepsis. Eleven research articles have been published from my PhD projects. Abdulaziz Alobaid The increasing numbers of critically ill obese patients in the intensive care unit and the high frequency of antimicrobial prescription in these patients present a challenge for prescribing effective antimicrobial doses. My thesis addresses the limitations of current knowledge by describing the plasma pharmacokinetics of piperacillin, meropenem and fluconazole in critically ill non-obese, obese and morbidly obese patients. The overall results of my thesis suggest that the BMI does not have a profound effect on antimicrobial dosing requirements for critically ill obese patients. Renal function, which was best described by creatinine clearance, was the major determinant of dosing requirements in individual patients. It can be concluded that although a higher than standard dose may be appropriate for the first 24-h of treatment, on subsequent days, dosing need only be based on robust estimates of renal function. My thesis contains five publications: one overview article, one retrospective study, and three original research articles.

Michelle Donovan My research focused on a unique area of burns donor site scar management. The overarching aim of the research undertaken was to test a low pressure tubular support garment (IPGT) as a potential intervention to firstly, support the healing of donor wounds of burn patients, and secondly, to improve the overall appearance of the donor site scar. The preliminary results indicated a trend towards a decrease in donor site scar thickness over time for the IPGT group, compared to the control group. This supports the hypothesis that the application of IPGT as a treatment for burns donor sites may support healing and consequently reduce scar thickness. Continuation of this research will be required to consolidate this evidence.

Suzanne Parker Critically ill patients experience illness-related physiological changes; a pharmacokinetic study describing these changes is required to optimise dosing for effective antibiotic treatment. My thesis described a method for the quantitative analysis of the antibiotic fosfomycin, suitable for a pharmacokinetic study. This included the validation of two innovative blood-sampling strategies using very small volumes of dried blood. The pharmacokinetics of fosfomycin in critically ill patients was characterised in my thesis and I identified highly variable clearance and volumes of distribution. Contemporary dosing of fosfomycin was found to be inadequate for many pathogens in patients with augmented renal clearance.

GRADUATIONS

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Critical Care Research within the RBWH ICU continued to thrive yet again in 2016 and we continued to produce meaningful and practical research. Our publications are impressive improving on last year’s numbers. We published in prestigious medical journals such as New England Journal of Medicine, Lancet Infectious Diseases, Clinical Diseases, Intensive Care Medicine and Critical Care Medicine to name a few. This year, in a Critical Care research first, our researchers published with a relative of one of our patients. Julie Vermeir wrote a brilliant, thought-provoking article on how the bedside communication that occurs amongst health professionals can be quite daunting from a wife’s (or family’s) perspective. This followed on an article last year by the patient himself describing his experiences from the other side of the bed. Consumer engagement was the emphasis of both articles. As the result of our national and international clinical trials and multi-centre studies, our collaborations grew with an increasing number of overseas collaborators, particularly European, but also colleagues from UK, Asia, South Africa, Middle East and USA. With the commencement of Dr Koulenti’s international PneumoINSPIRE study which is investigating pneumonia in the ICU setting, our collaborating ICUs have grown from 200 to over 350, including increasing collaboration across Asia, obviously an important part of our region. Our research projects investigating the management and outcome of critically ill patients with or without sepsis and those with head injury, will continue to provide evidence based treatments that improve health outcomes and quality of life. Prof Jeff Lipman

Drug Dosing and Pharmacokinetics

2016 has been another stellar year for the PK/PD group within BTCCRC. The research metrics remain strong with quality being very strong. We are also delighted with the progression of our numerous research higher degree (RHD) students through the milestones of their study. We also welcome Ms Yarmarly Guerra Valero and Dr Tavey Dorofaeff who commenced their PhD study in 2016 and Mr Nilesh Kumta who commenced the MPhil component of his MBBS/MPhil degree. However, we are particularly excited with the RHD graduations! Specifically, we congratulate Dr Suzanne Parker, Dr Mohd Hafiz Abdul-Aziz, Dr Kiran Shekar, Dr Abdulaziz Alobaid who all had their PhDs conferred in 2016. Suzie and Hafiz will continue to work at BTCCRC as Post-doctoral Fellows which is exciting to have that expertise and continuity. We also congratulate Dr Os Cotta for his 3-year UQ Fellowship which will allow him to play a major role on the 7000 patient BLING-3 Study which has been funded in the 2016 NHMRC Project Grant round. Os’ role will be based in School of Pharmacy, UQ which remains a very strong collaborator of BTCCRC. Sadly, we farewell Dr Claire Roger from CHU Nimes in France who spent a year at BTCCRC performing pharmacometric analyses and coordinating clinical trials like the SAFE-ICU Study. Her visit continued the very strong collaboration the PK/PD Group enjoys with CHU Nimes. From a funding and publication perspective, the PK/PD Group had another excellent year with very good outputs. We are particularly proud of our increasing linkages with Pharmaceutical Industry where we are able to make earlier impacts on optimising dosing for difficult to treat patient groups. BTCCRC have enjoyed a successful first year of the NHMRC CRE REDUCE, which is very well managed by Mr Nermin Karamujic. This centre provides funding support to increase capacity in the research areas of antimicrobial dosing in difficult to treat patient groups. One of the laboratories that we are fostering relationships with is the Centre for Translational Anti-infective Pharmacodynamics at School of Pharmacy, UQ which has a state-of-the-art in vitro PK/PD system to better inform antibiotic dosing that not only maximises bacterial killing, but also suppresses the emergence of antibiotic resistance. Importantly, we would like to thank each of the funding bodies that have supported our work this year, as without them, our meaningful contributions to patient care may not have been possible. We also acknowledge all our collaborators for the research opportunities provided again this year and look forward to future excellent achievements together. Finally, we thank the tireless efforts of the research staff at BTCCRC and the RBWH ICU who allow our research to be of the highest integrity and clinical relevance. Prof Jason Roberts

RESEARCH THEME

REPORTS

Anaesthesia 2016, has been another big year in research and education for the Department of Anaesthesia. The research team continues to grow and expand through collaborations at state, national and international level. This is set to continue through 2017 as the department carries on its participation in local investigator driven and global multi-centre trials. Research in the department has matured as we see our researcher’s progress through their higher degrees. Victoria Eley submitted her PhD thesis, and carries on her research in analgesia use in obese parturients; while Julie Lee continues to advance through her PhD studies on ROTEM® thromboelastometry in obstetric anaesthesia. Rochelle Ryan has recently commenced her MPhil researching the impact obesity has on antibiotic dosing. The department has been awarded 5 scholarships and over $200,000 worth of grant funding this year. The ANZCA CTG BALANCED study is currently progressing successfully under the guidance of Michael Edwards, as site coordinator, and the department’s research nurse Cienwen Town. This study looks at the depth of anaesthesia in elderly surgical patients and associated outcomes. We are continuing to collaborate with the ANZCA CTG, commencing the international, multi-centre trial PADDI in January 2017 to assess the perioperative administration of dexamethasone and infection rates. Julie Lee is the site coordinator with support from research nurse Lizanne Dalgleish. Professor Van Zundert continues to investigating best airway management practices, looking at both patients and manikins to improve intubation practice. Professor’s research is supported by research nurse Heather Reynolds. Other ongoing collaborative research with ICU and burns includes studies investigating: antibiotic prophylaxis in bariatric Caesarean and surgical patients (Rebecca Christensen, Victoria Eley, Mathew Smith, Dwane Jackson, Rochelle Ryan, Andre Van Zundert, Jason Roberts and Jeffrey Lipman); Optic nerve sheath measurement of intracranial pressure (Gareth Collins, Lizanne Dalgleish and Cienwen Town); and dermal matrix for deep burns. From an educational perspective, the renovations for the state-of-the-art teaching and research centre, the ‘Centre for Excellence and Innovation in Anaesthesia’ (CEIA), reached completion in late 2016. The centre has allowed the department to facilitate the expansion of the Big 5: teaching, training, equipment, quality and research. With thanks to Dr Nathan Peters the department is already reaping its rewards as it becomes the first QLD based, accredited, simulation based, focused transthoracic echocardiography workshop facility. This workshop reduces the need for physicians to travel interstate to acquire the necessary skills for college qualifications. Lizanne Dalgleish has been appointed Nurse Manager for the CEIA, Katherine Hames continues as the lead for departmental educational activities, and Kersi Taraporewalla directs simulation for the university and medical training. Linda Beckmann, carries on as Airway Management Workshops lead, which is set to grow with the CEIAs expansion. Michelle Roets has been instrumental in facilitating the equipment evaluation for the Systematic analysis of basic equipment in Anaesthesia (SABEA project). Geoffrey Messer and Anthony Hade continue their great work in Quality and Safely management. By the end of 2016, our Department has published 6 book chapters, 32 journal articles and made 24 conference presentations by Professor Van Zundert, Associate Professor Kerstin Wyssusek, Associate Professor Kersi Taraporewalla, Dr Victoria Eley, Dr Julie Lee, Dr Ben Snow, Dr Heather Reynolds and Ms Lizanne Dalgleish. Prof Andre van Zundert

Emergency Medicine

Throughout 2016 the Department of Emergency Medicine at RBWH engaged in a broad spectrum of research activities. Collectively, our researchers realised their most productive year to date; having authored or co-authored more than 50 peer-reviewed publications. This achievement is the culmination of ever-increasing research efforts over many years that have been driven by our talented senior researchers and leaders and well-supported by enthusiastic research staff and students. It also reflects our focus on high quality research questions and our engagement in successful collaborative partnerships. These collaborative partnerships extended locally across RBWH departments, and nationally and internationally across hospitals and universities. Our research work was presented throughout the year at conferences and symposia in Brisbane, Melbourne, Adelaide, New Zealand, Fiji, Spain, Italy and USA. Our researchers were recognised with several awards: Dan Bodnar was awarded “Best Paper” at the 12th Annual Queensland Emergency Medicine Autumn Symposium in Brisbane; Tracey Hawkins and the CREDIT study team were awarded “Best Poster” presentation at the 33rd Annual Scientific Meeting of the Australasian College of Emergency Medicine in Queenstown, New Zealand; Louise Cullen and co-researchers won the prestigious Ko Awatea International Excellence in Health Improvement Award at the APAC Forum in Sydney for their work on the Accelerated Chest Pain Risk Evaluation (ACRE) project; Louise Cullen also received the Metro North Hospital and Health Service Research Excellence Award, the Clinical Researcher Award from the Australian Society for Medical Research, and was part of the research team that received an “Honourable Mention” at the UQ-Ochsner Clinical School Annual Research Day. As always, we greatly appreciate the financial support of our research funding partners. In 2016 we were very fortunate to be working on projects that were supported by the Emergency Medicine Foundation, RBWH Foundation and Queensland Health. New funding was awarded by the Emergency Medicine Foundation, RBWH Foundation, The Prince Charles Hospital Foundation and the National Heart Foundation. A/Prof Kevin Chu

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Military Medicine 2016 saw both Professor Reade and Dr Anthony Holley deployed to Iraq for several months. Operational experience continues to shape the research priorities of the BTCCRC Military Theme. In March 2016 in Brussels, Professor Reade presented the Dexmedetomidine to Lessen ICU Agitation (DahLIA) trial, simultaneously published in JAMA, demonstrating the effectiveness of dexmedetomidine treating agitated delirium associated with critical illness. Preliminary work building on these results includes trials in traumatic brain injury and delirium prophylaxis. In 2017-2018 this will be led by Dr David Liu, undertaking his postdoctoral research fellowship supported by a prestigious Queensland Health fellowship, under the supervision of Professor Reade and Professor Charles Gilks of the UQ School of Public Health. Professor Reade also commenced supervision, with Dr Deb Long, of Dr Paul Lee-Archer’s PhD trial of dexmedetomidine as a component of paediatric anaesthesia. The BTCCRC collaboration with the Australian Red Cross Blood Service continues to flourish, with Professor Reade co-supervising two PhD students with Drs John-Paul Tung and Melinda Dean. These involve whole-animal and cell monolayer models in which cryopreserved blood products can be assessed, and is an extension of research undertaken by Dr Natasha van Zyl, who in 2016 graduated as the first MPhil student in the BTCCRC Military Theme. Dr van Zyl’s work, performed under the co-supervision of Prof John Fraser, developed the first ovine model of acute traumatic coagulopathy. CAPT Elissa Milford has built on her early PhD laboratory work on this model by commencing a clinical observational study, to be followed by human volunteer studies of glycocalyx degradation at the UK’s Defence Science and Technology Laboratory at Porton Down. Clinical trials related to military trauma progressed, with the 5000-patient TRANSFUSE trial of age of blood storage, led by the ANZIC-RC, completing recruitment in late 2016. The CLIP (Cryopreserved vs. Liquid Platelets) at last solved considerable logistical problems, and is now 1/3 the way to its 90-patient target. In the process Renae Deans, the CLIP project manager, has developed a uniquely detailed knowledge of ultra-low temperature monitoring and remote alarm systems! The PATCH-Trauma trial of prehospital tranexamic acid is now recruiting well in Queensland, with the addition of partner sites in New Zealand and the United States planned in 2017. The proposal to fund a Queensland Comprehensive Trauma Institute at RBWH, led by A/Prof Cliff Pollard and Dr Amanda Dines with input from Prof Reade and A/Prof Kirsten Vallmuur, gained momentum at the end of 2016. Promising a single data repository integrating all trauma data from prehospital to rehabilitation, the Institute will offer a globally unique opportunity to study trauma systems design in a region with highly dispersed population and trauma management assets – analogous to that found on military operations. At the end of 2016 the military trauma and critical care section of the BTCCRC includes 4 ADF officers amongst 4 PhD, 2 Masters, and 2 MBBS students, with one MPhil student and 3 MBBS / MBBS(Hons) students completing their projects this year. In 2016, 15 manuscripts were published or accepted for publication, including contributions to JAMA, the Journal of Trauma and Acute Care Surgery, and Transfusion, and 32 conference presentations were made. Prof Michael Reade

Burns 2016 has been a successful year for the Burns research team. Michelle Donovan was awarded a Masters of Philosophy on the topic “Interim compression garments in donor sites” through the University of Queensland. The International Society Burn Injuries meeting was held in Miami and Anita Plaza presented an invited paper . Publications in 2016 in the burns area included one in the Journal of Trauma (Flores, Paratz, Stockton, Muller), and Trials (Donovan, Simpson, Muller, Rudd, Paratz). Anita Plaza and Jennifer Paratz published a chapter on Burn Management in a leading textbook. Two PhD students (Martha Druery and Orlando Flores) are continuing their studies in the burns area. Orlando Flores, from Chile, is researching Metabolism in burns, whilst Martha Druery is investigating factors associated with psychosocial outcomes in burns. Lisa Wang, a resident medical officer is completing the Masters of Philosophy on her topic “Pharmacodynamics of Lyncmycin in Burn Patients”. A/Prof Jenny Paratz

RESEARCH THEME

REPORTS

Journal Articles Abdul-Aziz M, Lipman J, Akova M, Bassetti M, De Waele J, Dimopoulos G, et al. Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort. J Antimicrob Chemother 2016;71:196-207 Abdul-Aziz M, Sulaiman H, Mat-Nor M, Rai V, Wong K, Hasan M, et al. Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intens Care Med 2016;42:1535-45 Adsett J, Morris N, Kuys S, Hwang R, Mullins R, Khatun M, Paratz J, Mudge A. Aquatic Exercise Training is Effective in Maintaining Exercise Performance in Trained Heart Failure Patients: A Randomised Crossover Pilot Trial. Heart Lung Circ. 2016;S1443-9506:31691-2 Afonso E, Blot K, Blot S. Prevention of primary and central line-associated bloodstream infection through chlorhexidine-gluconate impregnated washcloth bathing in intensive care units: a systematic review and meta-analysis of randomized crossover trials. Euro Surveill 2016;21:pii: 30400 Aldous S, Richards A, Cullen L, Pickering J, Than M. The incremental value of stress testing in patients with acute chest pain beyond serial cardiac troponin testing. Emerg Med J 2016;33:319-24 Alobaid A, Wallis S, Jarrett P, Starr T, Stuart J, Lassig-Smith M, Ordóñez Mejia J, Roberts M, Sinnollareddy M, Roger C, Lipman J, Roberts J. Effect of Obesity on the Population Pharmacokinetics of Fluconazole in Critically Ill Patients. Antimicro Agents Chemother 2016;60:6550-57 Alobaid A, Wallis S, Jarrett P, Starr T, Stuart J, Lassig-Smith M, Ordóñez Mejia J, Roberts M, Lipman J, Roberts J. Effect of Obesity on the Population Pharmacokinetics of Meropenem in Critically Ill Patients. Antimicro Agents Chemother 2016;60:4577-84 Alobaid A, Brinkmann A, Frey O, Roehr A, Luque S, Grau S, et al. What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients? J Antimicrob Chemother 2016;71:696-702 Alobaid A, Hites M, Lipman J, Taccone F, Roberts J. Effect of obesity on the pharmacokinetics of antimicrobials in critically ill patients: A structured review. Intl J Antimicrob Agents 2016;47:259-68 Aroney C, Cullen L. Appropriate use of serum troponin testing in general practice: a narrative review. Med J Aust. 2016;205:91-4 Arvaniti K, Lathyris D, Blot S, Apostolidou-Kiouti F, Koulenti D, Haidich A-B. Cumulative evidence of randomized controlled and

observational studies on catheter-related infection risk of central-venous catheter insertion site in ICU patients: a pairwise and network meta-analysis. Crit Care Med 2016; Epub ahead of print. Balit CR, Horan R, Dorofaeff T, et al. Pediatric Hematopoietic Stem Cell Transplant and Intensive Care: Have Things Changed? Ped Crit Care Med 2016;17:e109-e16 Bandeshe H, Boots R, Dulhunty J, Dunlop R, Holley A, Jarrett P, et al. Is inhaled prophylactic heparin useful for prevention and Management of Pneumonia in ventilated ICU patients?: The IPHIVAP investigators of the Australian and New Zealand Intensive Care Society Clinical Trials Group. J Crit Care 2016;34:95-102 Barbier F, Lipman J, Bonten M. In 2035, will all bacteria be multidrug-resistant? No. Intensive Care Med 2016;42:2017-20 Bell A, McDonald F, Hobson T. The Ethical Imperative to Move to a Seven-Day Care Model. J Bioeth Inq 2016;13:251-60 Bellapart J, Abi-Fares C, Cuthbertson K, Dunster K, Diab S, Platts DG, Raffel C, Gabrielian L, Barnett A, Paratz J, Boots R, Fraser J. Cerebral microcirculation during mild head injury after a contusion and acceleration experimental model in sheep. Brain Inj. 2016;26:1-10 Bellapart J, Cuthbertson K, Dunster K, Diab S, Platts DG, Raffel O, Gabrielian L, Barnett A, Paratz J, Boots R, Fraser J. Cerebral Microcirculation during Experimental Normovolaemic Anemia. Front Neurol 2016;2;7:6 Bellapart J, Roberts J, Appadurai V, Wallis S, Nuñez-Nuñez M, Boots R. Pharmacokinetics of a novel dosing regimen of oral melatonin in critically ill patients. Clin Chem Lab Med 2016;54:467-72 Bergen P, Bulitta J, Kirkpatrick C, Rogers K, McGregor M, Wallis S, et al. Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling. J Antimicrob Chemother 2016;71:2509-20 Bissett B, Green M, Marzano V, Byrne S, Leditschke I, Neeman T, Boots R, Paratz J. Reliability and utility of the Acute Care Index of Function in intensive care patients: An observational study. Heart Lung 2016;45:10-4 Bissett B, Leditschke I, Neeman T, Boots R, Paratz J. Inspiratory muscle training to enhance recovery from mechanical ventilation: a randomised trial. Thorax 2016;71:812-9 Blot S, Koulenti D, Labeau S. Optimizing educational initiatives to prevent ventilator-associated complications. Am J Infect Control 2016; Blot S, Koulenti D. Factors influencing outcomes in intensive care unit patients with nosocomial infections. Arch Iran Med 2016;19:677-8

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Journal Articles (cont’d) Blot S, Rello J, Koulenti D. The value of polyurethane-cuffed endotracheal tubes to reduce microaspiration and intubation-related pneumonia: a systematic review of laboratory and clinical studies. Crit Care 2016;20:203 Blot S, Torres A, Francois B. Evidence in the eye of the beholder: about probiotics and VAP prevention. Intens Care Med 2016;42:1182-4 Boeddinghaus J, Reichlin T, Cullen L, Greenslade J, Parsonage W, Hammett C, et al. Two-Hour Algorithm for Triage toward Rule-Out and Rule-In of Acute Myocardial Infarction by Use of High-Sensitivity Cardiac Troponin I. Clin Chem 2016;62:494-504 Bos M, van Loon R, Heywood L, Morse M, van Zundert A. Comparison of the diameter, cross-sectional area and position of the left and right internal jugular vein and carotid artery in adults using ultrasound. J Clin Anaesth 2016;32:65-9 Bos M, van Mook W, van Zundert A. Asymmetric Jugular Veins: Implication for Central Venous Access in the ICU. Crit Care Med 2016;44:e778-9 Boyle R, van Zundert A. Professor Tess Cramond (1926-2015) – An appreciation of her contributions to anaesthesia and pain Medicine. Anaesth Intens Care 2016 Brown A, Nandurkar H. Idarucizumab. An intravenous bolus reversal agent for dabigatran. Med Today 2016;17:63-5. Brown A, Zia M, Symons P, Moore N. You two - there must be some mistake! Emerg Med Australas 2016;28: 758-60

Calandra T, Roberts J, Antonelli M, Bassetti M, Vincent J. Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy. Crit Care 2016;20:125 Caragata R, Wyssusek K, Kruger P. Acute Kidney injury following liver transplantation: a systematic review of published predictive models. Anaesth Intens Care 2016;44:251-61 Carlton E, Greenslade J, Cullen L, Body R, Than M, Pickering J, et al. Evaluation of High-Sensitivity Cardiac Troponin I Levels in Patients With Suspected Acute Coronary Syndrome. JAMA Cardiol 2016;1:405-12 Cheng Q, Greenslade J, Parsonage W, Barnett A, Merollini K, Graves N, et al. Change to costs and lengths of stay in the emergency department and the Brisbane protocol: an observational study. BMJ open 2016;6:e009746

Chetty S, Sng BL, Sia A, Gatt S, van Zundert A. Alternatives to Epidural Analgesia for Labor and Delivery. RAPM 2016;41:5-S1:e13-e16, ESRA 6-0521. Chew D, Scott I, Cullen L, French J, Briffa T, Tideman P, et al. National Heart Foundation of Australia & Cardiac Society of Australia and New Zealand: Australian Clinical Guidelines for the Management of Acute Coronary Syndromes 2016. Heart Lung Circ 2016;25:895-951 Chew D, Scott I, Cullen L, French J, Briffa T, Tideman P, et al. National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand: Australian clinical guidelines for the management of acute coronary syndromes 2016. Med J Aust 2016;205:128-33 Chu K, Howell T, Keijzers G, Furyk J, Eley R, Kinnear F, et al. Acute headache presentations to the emergency department: A state-wide cross-sectional study. Acad Emerg Med 2016; DOI: 10.1111/acem.13062 Chu K, Mahmoud I, Brown A. What is the chance all your trainees will pass the next Fellowship exam: A statistician's view. Emerg Med Australas 2016;29:113–15 Chuang A, Hancock D, Horsfall M, Alhammad N, Zhou J, Cullen L, et al. The predictive value of high sensitivity-troponin velocity within the first 6h of presentation for cardiac outcomes regardless of acute coronary syndrome diagnosis. Int J Cardiol 2016;204:106-11 Cohen J, Pretorius C, Ungerer J…..Jarrett P, Lassig-Smith M, Stuart J, Dunlop R, Starr T, Venkatesh B. Glucocorticoid sensitivity is highly variable in critically ill patients with septic shock and is associated with disease severity. Crit Care Med 2016;44:1034-41 Cotta M, Dulhunty J, Roberts J, Myburgh J, Lipman J. Should β-lactam antibiotics be administered by continuous infusion in critically ill patients? A survey of Australia and New Zealand intensive care unit doctors and pharmacists. Int J Antimicrob Agents 2016;47:436-8 Cotta M, Roberts J, Lipman J. We need to optimize piperacillin-tazobactam dosing in critically ill patients-but how? Crit Care 2016;20:163 Crilly J, Greenslade J, Lincoln C, Timms J, Fisher A. Measuring the impact of the working environment on emergency department nurses: A cross-sectional pilot study. Int Emerg Nurs 2016; https://doi.org/10.1016/j.ienj.2016.04.005 Cristallini S, Hites M, Kabtouri H, Roberts J, et al. New Regimen for Continuous Infusion of Vancomycin in Critically Ill Patients. Antimicrob Agents Chemother 2016;60:4750-6

PUBLICATIONS

Journal Articles (cont’d) Cullen L, Greenslade J, Carlton E, Than M et al. Sex-specific versus overall cut points for a high sensitivity troponin I assay in predicting 1-year outcomes in emergency patients presenting with chest pain. Heart 2016;102:120-6 Cullen L, Greenslade J, Menzies L, Leong A et al. Time to presentation and 12-month health outcomes in patients presenting to the emergency department with symptoms of possible acute coronary syndrome. Emerg Med J 2016;33:390-5 Culwick M, Merry A, Clarke D, Taraporewalla K, Gibbs N. Bow-tie diagrams for risk management in anaesthesia. Anaesth Intens Care 2016;44:712-18 Delgado-Valverde M, Torres E……..Gutiérrez-Gutiérrez B, Roberts J, Farkas A, Pascual Á, Rodríguez-Baño J; REIPI/GEIH-SEIMC BACTERAEMIA-MIC group. Impact of the MIC of piperacillin/tazobactam on the outcome for patients with bacteraemia due to Enterobacteriaceae: the Bacteraemia-MIC project. J Antimicrob Chemother 2016;71:521-30 Denning D, Cadranel J, Beigelman-Aubry C, Ader F, Chakrabarti A, Blot S et al on behalf of the European Society for Clinical Microbiology and Infectious Diseases and the European Respiratory Society. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management. Eur Respir J 2016;47:45-68 Denny K, Cotta M, Parker S, Roberts J, Lipman J. The use and risks of antibiotics in critically ill patients. Expert Opin Drug Saf 2016;15:667-78 Denny K, Lipman J. Bugs, genes, and the intensive care unit. J Thorac Dis 2016;8:E788-90 Dhanani J, Fraser J, Chan H, Rello J, Cohen J, Roberts J. Fundamentals of aerosol therapy in critical care. Crit Care 2016;20:269 Dimopoulos G, Koulenti D, Tabah A, Poulakou G et al ESKA Bloodstream infections in ICU with increased resistance: epidemiology and outcomes. Minerva Anestesiologica 2016;81:405-18 Dodds M, Frazer C, Lipman J, Reade M. Use of neostigmine for acute colonic pseudo-obstruction in a patient receiving dexmedetomidine. Crit Care Resusc 2016;18:59-61 Donovan M, Muller M, Simpson C, Rudd M, Paratz J. Interim pressure garment therapy (4–6 mmHg) and its effect on donor site healing in burn patients: study protocol for a randomised controlled trial. Trial 2016;17:214 Dorofaeff T, Bandini R, Lipman J, et al. Uncertainty in Antibiotic Dosing in Critically Ill Neonate and Pediatric Patients: Can Microsampling Provide the Answers? Clin Ther 2016;38:1961-75

Eley V, Callaway L, van Zundert A, Lipman J, Gallois C. Interpretation of Care Guidelines for Obese Women in Labour: Intergroup Language and Social Identity. J Lang Psychol 2016;1-27 Eley V, Callaway L, van Zundert A, Lipman J, Gallois C. Anaesthetists’ experiences with the early labour epidural recommendation for obese parturients: a qualitative study. Anaesth Intens Care 2016;44:620-27 Eley V, van Zundert A, Lipman J, Callaway L. Anaesthetic management of obese parturients: what is the evidence supporting practice guidelines? Anaes Intens Care 2016;44:552-59 Evans O, Gowardman J, Rabbolini D, McGrail M, Rickard C. In situ diagnostic methods for catheter related bloodstream infection in burns patients: A pilot study. Burns 2016;42:434-40 Fan L, Hou X, Zhao J, Sun J, Dingle K, Purtill R, et al. Hospital in the Nursing Home program reduces emergency department presentations and hospital admissions from residential aged care facilities in Queensland, Australia: a quasi-experimental study. BMC Health Serv Res 2016;16:46 Farkas A, Daroczi G, Villasurda P, Dolton M, Nakagaki M, Roberts J. Comparative Evaluation of the Predictive Performances of Three Different Structural Population Pharmacokinetic Models To Predict Future Voriconazole Concentrations. Antimicrob Agents Chemother 2016;60:6806-12 Ferguson I, Bell A, Treston G, New L, Ding M, Holdgate A. Propofol or Ketofol for Procedural Sedation and Analgesia in Emergency Medicine-The POKER Study: A Randomized Double-Blind Clinical Trial. Ann Emerg Med 2016;68:574-82 Flaws D, Than M, Scheuermeyer F, Christenson J, Boychuk B, Greenslade J et al. External validation of the emergency department assessment of chest pain score accelerated diagnostic pathway (EDACS-ADP). Emerg Med J 2016;33:618-25 Flores O, Stockton K, Roberts J, Muller M, Paratz J. The efficacy and safety of adrenergic blockade after burn injury: A systematic review and meta-analysis. J Trauma Acute Care Surg 2016;80:146-55 Furyk J, Chu K, Banks C, Greenslade J et al. Distal Ureteric Stones and Tamsulosin: A Double-Blind, Placebo-Controlled, Randomized, Multicenter Trial. Ann Emerg Med 2016;67:86-95 Garcia-de-Lorenzo A, Luque S, Grau S, Agrifoglio A et al. Comparative Population Plasma and Tissue Pharmacokinetics of Micafungin in Critically Ill Patients with Severe Burn Injuries and Patients with Complicated Intra-Abdominal Infection. Antimicrob Agents Chemother 2016;60:5914-21

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Journal Articles (cont’d) Garrouste-Orgeas M, Vinatier I, Tabah A, Misset B, Timsit J. Reappraisal of visiting policies and procedures of patient’s family information in 188 French ICUs: a report of the Outcomerea Research Group. Ann Intens Care 2016;6:82 Gibbs, N, Shanmugam S, Goulding G, Taraporewalla K, Culwick M. Chewing gum in the preoperative fasting period: an analysis of de-identified incidents reported to webAIRS. Anaesth Intens Care 2016;44:282-84 Giuliano J, Markovitz B, Brierley J, Levin R, Williams G, Lum L, Dorofaeff T et al; Sepsis PRevalence, OUtcomes, and Therapies Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Network. Comparison of Pediatric Severe Sepsis Managed in US and European ICUs. Ped Crit Care Med 2016;17:522-30 Greenslade J, Beamish D, Parsonage W, Hawkins T et al. Relationship Between Physiological Parameters and Acute Coronary Syndrome in Patients Presenting to the Emergency Department With Undifferentiated Chest Pain. J Cardiovasc Nurs 2016;31:267-73 Greenslade J, Parsonage W, Than M, Scott A et al. A Clinical Decision Rule to Identify Emergency Department Patients at Low Risk for Acute Coronary Syndrome Who Do Not Need Objective Coronary Artery Disease Testing: The No Objective Testing Rule. Ann Emerg Med 2016;67:478-89 Hann A, Osenda E, Reade J, Economides D, Sharma D. Case Report: Successful open resection of a symptomatic giant liver haemangioma during the second trimester of pregnancy. J Surg Case Reports 2016;2016(11) pii: rjw185 Hanrahan T, Lipman J, Roberts J. Antibiotic dosing in obesity: a BIG challenge. Crit Care 2016;20:240 Harris P, McNamara J, Lye D, Davis J et al. Proposed primary endpoints for use in clinical trials that compare treatment options for bloodstream infection in adults: a consensus definition. Clin Microbiol Infect 2016;S1198-743X(16)30512-2 Hockey C, van Zundert A, Paratz J. Does objective measurement of tracheal tube cuff pressures minimise adverse effects and maintain accurate cuff pressures? A systematic review and meta-analysis. Anaesth Intens Care 2016;44:560-70 Hoste P, Vanhaecht K, Ferdinande P, Rogiers X, Eeckloo K, Blot S et al Care pathways for organ donation after brain death: a guidance from available literature? J Adv Nurs 2016;722369-80 Iliceto A, Berndt S, Greenslade J, Parsonage W et al. Agreement Between Patient-reported and Cardiology-adjudicated Medical History in Patients With Possible Ischemic Chest Pain: An Observational Study. Crit Path Cardiol 2016;15:121-5 Ingram P, Rawlins M, Murray R, Roberts J, Manning L. Tigecycline use in the outpatient parenteral antibiotic therapy setting. Eur J Clin Microbiol Infect Dis 2016;35:1673-7

Jager N, van Hest R, Lipman J, Taccone F, Roberts J. Therapeutic drug monitoring of anti-infective agents in critically ill patients. Expert Rev Clinic Pharmacol 2016;9:961-79 Jin H, Greenslade J, Parsonage W, Hawkins T, Than M, Cullen L. Does a uric acid level provide additional risk stratification information in emergency patients with symptoms of possible acute coronary syndrome? Crit Path Cardiol 2016;15:169-73 Johnston A, Abraham L, Greenslade J, Thom O et al. Review article: Staff perception of the emergency department working environment: Integrative review of the literature. Emerg Med Australas 2016;28:7-26 Kalil A, Metersky M, Klompas M, Muscedere J et al. Executive Summary: Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clinic Infect Dis 2016;63:575-82 Karam O, Demaret P, Duhamel A, Shefler A et al and PlasmaTV investigators. Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions. Ann Intens Care 2016;6:98 Koulenti D, Tsigou E, Rello J. Nosocomial pneumonia in 27 ICUs in Europe: perspectives from the EU-VAP/CAP study. Eur J Clin Microbiol Infect Dis 2016; Jun 10 ePub DOI 10.1007/s10096-016-2703-z Labeau S, Rello S, Dimopoulos G, Lipman J……..Blot S. The value of E-learning in the prevention of E-learning to support evidence-based guidelines for the prevention of healthcare-associated infections. Infect Control Hosp Epidemiol 2016;37:1052-9 Lukin B, Fan , Zhao J, Sun J et al. Emergency department use among patients from residential aged care facilities under a Hospital in the Nursing Home scheme in public hospitals in Queensland Australia. World J Emerg Med 2016;7:183-90 Mark D, Sonne D, Jun P, Schwartz D et al. False-negative Interpretations of Cranial Computed Tomography in Aneurysmal Subarachnoid Hemorrhage. Acad Emerg Med 2016;23:591-8 Martin S, Chu K, Mahmoud I, Greenslade J, Brown A. Double-dorsal versus single-volar digital subcutaneous anaesthetic injection for finger injuries in the emergency department: A randomised controlled trial. Emerg Med Australas 2016;28:193-8 Martin-Sanchez F, Christ M, Miro O, Peacock F et al. Practical approach on frail older patients attended for acute heart failure. Int J Cardiol 2016;222:62-71 McDonald C, Cotta M, Little P, McWhinney B, Ungerer J, Lipman J, et al. Is high-dose β-lactam therapy associated with excessive drug toxicity in critically ill patients? Minerva Anestesiologica 2016;82:957-65

Journal Articles (cont’d) Meek R, Braitberg G, Cullen L, Than M, Graudins A, Glynn D. Outcome at 30 days for low-risk chest pain patients assessed using an accelerated diagnostic pathway in the emergency department. Emerg Med Australas 2016;28:279-86 Milford E, Reade C. Comprehensive Review of Platelet Storage Methods for Use in the Treatment of Traumatic Hemorrhage. Transfusion 201656:S140-S148 Miro O, Peacock F, McMurray J, Bueno H et al. European Society of Cardiology - Acute Cardiovascular Care Association position paper on safe discharge of acute heart failure patients from the emergency department. Eur Heart J Acute Cardiovasc Care 2016;Epub ahead of print. Miro O, Burbano P, Graham C..… Brown AFT, Martin-Sanchez F. Analysis of h-index and other bibliometric markers of productivity and repercussion of a selected sample of worldwide emergency medicine researchers. Emerg Med J 2016; doi:10.1136/emermed-2016-205893 Mitrić G, Udy A, Bandeshe H, Clement P, Boots R. Variable use of amiodarone is associated with a greater risk of recurrence of atrial fibrillation in the critically ill. Crit Care 2016;20:90 Montravers P, Blot S, Dimopoulos G, Eckman C……de Waele J. Therapeutic management of peritonitis: a comprehensive guide for intensivists. Intens Care Med 2016;42:1234-47 Mulvogue K, Roberts J, Coombes I, Cottrell N, Kanagarajah S, Smith A. The effect of pharmacists on ward rounds measured by the STOPP/START tool in a specialized geriatric unit. J Clin Pharm Therap 2016; Nelson P, Bell A, Nathanson L, Sanchez L, Fisher J, Anderson P. Ethnographic analysis on the use of the electronic medical record for clinical handoff. Intern Emerg Med 2016; Nethathe G, Matamba T, Malumalu J, Dladla N et al. Traditional Medicine use in surgical patients in a South African tertiary hospital. South African J Anaesth Analges 2016;22:89-92 Nethathe G, Mbeki M. Heparin flush vs saline flush for use in the maintenance of adult central venous and intra-arterial catheters: potential harm, too little gain? South African J Anaesth Analges 2016;22:70-1 Nethathe G, Patel N. Survival after Pneumocystis jirovecii pneumonia requiring ventilation: A case report. Southern African J HIV Med 2016;17:1-4 Neumann J, Sorensen N, Ojeda F, Schwemer T et al. Immediate Rule-out of Acute Myocardial Infarction Using Electrocardiogram and Baseline High-sensitivity Troponin I. Clin Chem 2016(in press). Neumann J, Sorensen N, Schwemer T, Ojeda F et al. Diagnosis of Myocardial Infarction Using a High-Sensitivity Troponin I 1-

Hour Algorithm. JAMA Cardiol 2016;1:397-404 Osthoff M, Siegemund M, Balestra G, Abdul-Aziz M, Roberts J. Prolonged administration of βlactam antibiotics - a comprehensive review and critical appraisal. Swiss Med Week 2016;146:w14368 Paiva J, Pereira J, Tabah A……Koulenti D…..Rello J, Ma X, Tamowicz B, Timsit J. Characteristics and risk factors for 28-day mortality of hospital acquired fungemias in ICUs: data from the EUROBACT study. Crit Care 2016;20:53 Paratz J, Boots R. Dealing with the critical care aftermath: where to from here? J Thorac Dis 2016;8:2400-02 Parker S, Dorofaeff T, Lipman J…..Wallis S, et al. Is there a role for microsampling in antibiotic pharmacokinetic studies? Exp Opin Drug Metabol Toxic 2016;12:601-14 Parker S, Guerra Valero Y, Lipman J, Roberts J, Wallis S. Effect of time on recovery of plasma microsamples for the quantitative determination of vancomycin. Bioanal 2016;8:2235-42 Parker S, Guerra Valero Y, Roberts D, Lipman J, Roberts J, Wallis S. Determination of Cefalothin and Cefazolin in Human Plasma, Urine and Peritoneal Dialysate by UHPLC-MS/MS: application to a pilot pharmacokinetic study in humans. Biomed Chroma 2016;30:872-9 Parsonage W, Mueller C, Greenslade J, Wildi K et al. Validation of NICE diagnostic guidance for rule out of myocardial infarction using high-sensitivity troponin tests. Heart 2016;102:1279-86 Perner A, Gordon A, De Backer D….Lipman J, et al. Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy. Intens Care Med 2016;42:1958-69 Pickering J, Greenslade J, Cullen L, Flaws D et al. Assessment of the European Society of Cardiology 0 Hour/1 Hour Algorithm to Rule Out and Rule In Acute Myocardial Infarction. Circulation 2016;134:1532-41 Pickering J, Greenslade J, Cullen L, Flaws D et al. Validation of presentation and 3 h high-sensitivity troponin to rule-in and rule-out acute myocardial infarction. Heart 2016;102:1270-8

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Journal Articles (cont’d) Pieters B, van Zundert A. Videolaryngoscopes differ substantially in illumination of the oral cavity: A manikin study. Indian J Anaesth 2016;60:325-9 Pieters B, Wilbers N, Huijzer M, Winkens B, van Zundert A. Comparison of seven videolaryngoscopes with the Macintosh laryngoscope in manikins by experienced and novice personnel. Anaesth 2016;71:556-64 Playford E, Lipman J, Jones M, Lau A et al. Problematic Dichotomization of Risk for ICU-Acquired Invasive Candidiasis: Results Using a Risk-Predictive Model to Categorize 3 Levels of Risk From a Multicenter Prospective Cohort of Australian ICU Patients. Clin Infect Dis 2016;63:1463-9 Ranganathan D, Naicker S, Wallis S, Lipman J, Ratanjee S, Roberts J. Stability of Antibiotics for Intraperitoneal Administration in Extraneal 7.5% Icodextrin Peritoneal Dialysis Bags (STAB Study). Periton Dial Intl 2016;36:421-6 Reade M, Eastwood G, Bellomo R, Bailey M et al for the DahLIA Investigators and the ANZICS Clinical Trials Group. Effect of dexmedetomidine added to standard care on ventilator-free time in patients with agitated delirium. A randomized controlled trial. J Amer Med Assoc 2016;315:1460-68 Reade M. A military-specific injury scoring system to aid in understanding the Golden Hour. JAMA Surg, 2016, 13. doi: 10.1001/jamasurg.2015.4915. [Epub ahead of print] Reade M. Dexmedetomidine: what next? AnnTransl Med 2016;4:247

Reynolds H, Chalk T, Van Zundert A, Rickard C. A way to go to meet guidelines for prevention of intravenous catheter infection and complications: Audit of perioperative peripheral venous catheter care. Vasc Acc 2016;2:2-9 Reynolds H, Ullman A, Culwick M, Mihala G, Alexandrou E, Rickard C. Dressings, securements and integrated dressings to prevent complications in peripheral arterial catheters. Cochrane Database of Systematic Reviews 2016, Issue 11. DOI: 10.1002/14651858. Accepted. Richardson P, Greenslade J, Isoardi J, Davey M, Gillett M, Tucker A, et al. End-of-life issues: Withdrawal and withholding of life-sustaining healthcare in the emergency department: A comparison between emergency physicians and emergency registrars: A sub-study. Emerg Med Australas 2016;28:684-90

Richardson P, Widdecombe N, Mahmoud I. End-of-Life-Issues: Withdrawal and/or Withholding of Life Sustaining Health Care: A Comparison between Emergency Physicians and Intensive Care Specialists. J Emerg Med Int Care 2016;2:111 Ridgeon E, Bellomo R, Myburgh J…...Cohen J et al. Validation of a classification system for causes of death in critical care: an assessment of inter-rater reliability. Crit Care Resusc 2016;18:50-54 Roberts D, Ranganathan D, Wallis S, Varghese J, Kark A, Lipman J, et al. Pharmacokinetics of Intraperitoneal Cefalothin and Cefazolin in Patients Being Treated for Peritoneal Dialysis-Associated Peritonitis. Perit Dial Intnl 2016;36:415-20. Roberts J….Deans R, Peake S…..Bellomo R, Turnidge J, Wallis S, Roberts M, Roberts D, Lassig-Smith M, Starr T, Lipman J. SaMpling Antibiotics in Renal Replacement Therapy (SMARRT): an observational pharmacokinetic study in critically ill patients. BMC Infect Dis 2016;16:103 Roberts J, Abdul-Aziz M, Davis J, Dulhunty J, Cotta M et al. Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials. Amer J Respir Crit Care Med 2016;194:681-91 Roberts J, Cotta M, Cojutti P, Lugano M, Della Rocca G, Pea F. Does critical illness change levofloxacin pharmacokinetics? Antimicrob Agents Chemother 2016;60:1459-63 Roberts J, Taccone F, Lipman J. Understanding PK/PD. Intens Care Med 2016;42:1797-800 Roger C, Muller L, Wallis S, Louart B, Saissi G, Lipman L, Lefrant J, Roberts J. Population pharmacokinetics of linezolid in critically ill patients on renal replacement therapy: comparison of equal doses in continuous venovenous haemofiltration and continuous venovenous haemodiafiltration. J Antimicrob Chemother 2016;71:464–70 Roger C, Nucci B, Louart B, Friggeri A, Knani H, Evrard A, et al. Impact of 30 mg/kg amikacin and 8 mg/kg gentamicin on serum concentrations in critically ill patients with severe sepsis. J Antimicrob Chemother 2016;71:208-12 Roger C, Wallis S, Louart B, Lefrant J, Lipman J et al. Comparison of equal doses of continuous venovenous haemofiltration and haemodiafiltration on ciprofloxacin population pharmacokinetics in critically ill patients. J Antimicrob Chemother 2016;71:1643-50

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Journal Articles (cont’d)

Roger C, Wallis S, Muller L, Saissi G, Lipman J, Bruggemann R, et al. Caspofungin Population Pharmacokinetics in Critically Ill Patients Undergoing Continuous Veno-Venous Haemofiltration or Haemodiafiltration. Clin Pharmaco 2016; Roger C, Wallis S, Muller L, Saissi G, Lipman J, Lefrant J, et al. Influence of Renal Replacement Modalities on Amikacin Population Pharmacokinetics in Critically Ill Patients on Continuous Renal Replacement Therapy. Antimicrob Agents Chemother 2016;60:4901-9 Ryan K, Greenslade J, Dalton E, Chu K, Brown A, Cullen L. Factors associated with triage assignment of emergency department patients ultimately diagnosed with acute myocardial infarction. Aust Crit Care 2016;29:23-6 Sanders S, Flaws D, Than M, Pickering J, Doust J, Glasziou P. Simplification of a scoring system maintained overall accuracy but decreased the proportion classified as low risk. J Clin Epidemiol. 2016;69:32-9 Sartelli M, Weber D, Ruppe E, Bassetti M et al. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA). World J Emerg Surg 2016;11:33 Sekandarzad M, van Zundert A, Lirk P, Doornebal C, Hollmann M. Perioperative Anesthesia Care and Tumor Progression. Anesth Analg 2016 Nov 8. [Epub ahead of print] Sekandarzad M, van Zundert A. Effect of volatile anaesthetics on cancer recurrence. Time will tell. Anaesth 2016;71:2120 Shanmugam S, Goulding G, Gibbs N, Taraporewalla K, Culwick M. Chewing gum in the preoperative fasting period: an analysis of de-identified incidents reported to webAIRS. Anaesth Intens Care 2016;44:281-4 Sherlock S, Thistlethwaite K, Rubini A, Khatun M, Perry C, Tabah A. Hyperbaric oxygen therapy in the treatment of sudden sensorineural hearing loss: a retrospective analysis of outcomes. Diving Hyperb Med 2016;46:160-5 Sherlock S. Inappropriate care in medicine. Med J Aust. 2016;204:70-70e1 Silbert B, Ho K, Lipman J, Roberts J et al. Determinants of Urinary Output Response to IV Furosemide in Acute Kidney Injury: A Pharmacokinetic/Pharmacodynamic Study. Crit Care Med 2016;44:e923-9 Silbert B, Ho K, Lipman J, Roberts J, Corcoran T, Morgan D, et al. Does Furosemide Increase Oxidative Stress in Acute Kidney Injury? Antioxid Redox Signal 2016;26:221-26 Sime F, Roberts J. Antibiotic Dosing In Critically Ill Patients Receiving Renal Replacement Therapy. Exp Rev Clin Pharmacol 2016:1-3

Sinnollareddy M, Roberts S, Lipman J, Lassig-Smith M, Starr T et al. In Vivo Microdialysis To Determine Subcutaneous Interstitial Fluid Penetration and Pharmacokinetics of Fluconazole in Intensive Care Unit Patients with Sepsis. Antimicrob Agents Chemother 2016;60:827-32 Skoien W, Page K, Parsonage W, Ashover S, Milburn T, Cullen L. Use of the Theoretical Domains Framework to evaluate factors driving successful implementation of the Accelerated Chest pain Risk Evaluation (ACRE) project. Implement Sci 2016;11:136 Sng B, Sia A, Chetty S, Gatt S, van Zundert A. Modern Labor Epidural Analgesia. RAPM 2016;41:5-S1:e16-e19, ESRA 6-0522 Sole-LLeonart C, Roberts J, Bassetti M, Blot S et al. Global Survey on nebulization of antimicrobial agents in mechanically ventilated patients: a call for international guidelines. Clin Microbiol Infect 2016; 22:359-64 Sole-LLeonart C, Roberts J, Bassetti M, Blot S et al. Intratracheal administration of antimicrobial agents in mechanically ventilated adults: an international survey on delivery practices and safety. Respir Care 2016;61:1008-14 Staib A, Sullivan C, Griffin B, Bell A, Scott I. Report on the 4-h rule and National Emergency Access Target (NEAT) in Australia: time to review. Aust Health Rev 2016;40:319-23 Staib A, Sullivan C, Jones M, Griffin B, Bell A, Scott I. The ED-inpatient dashboard: Uniting emergency and inpatient clinicians to improve the efficiency and quality of care for patients requiring emergency admission to hospital. Emerg Med Australas 2016;doi: 10.1111/1742-6723.12661 Sturgess D, Greenland K, Senthuran S, Ajvadi F, van Zundert A, Irwin M. Tracheal extubation of the adult intensive care patient with a predicted difficult airway - a narrative review. Anaesth 2016; Nov 2. doi: 10.1111/anae.13668 Sullivan C, Staib A, Khanna S, Good N, Boyle J, Cattell R, et al. The National Emergency Access Target (NEAT) and the 4-hour rule: time to review the target. Med J Aust. 2016;204:354 Tabah A, Cotta M, Garnacho-Montero J, Schouten J, Roberts J, Lipman J, et al. A Systematic Review of the Definitions, Determinants, and Clinical Outcomes of Antimicrobial De-escalation in the Intensive Care Unit. Clin Inf Dis 2016;62:1009-17

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44

Journal Articles (cont’d)

Tabah A, Lipman J, Roberts J. Are new gentamicin dosing guidelines suitable for achieving target concentrations in patients with sepsis and septic shock? Anaesth Crit Care Pain Med 2016;35:311-2 Than M, Pickering J, Aldous S, Cullen L et al. Effectiveness of EDACS Versus ADAPT Accelerated Diagnostic Pathways for Chest Pain: A Pragmatic Randomized Controlled Trial Embedded Within Practice. Ann Emerg Med 2016;68:93-102.e1 Tong S, Nelson J, Paterson D, Fowler V et al. CAMERA2 - combination antibiotic therapy for methicillin-resistant Staphylococcus aureus infection: study protocol for a randomised controlled trial. Trials 2016;17:170 Tsai D, Stewart P…….Wallis S, Lipman J, Roberts J. Optimising meropenem dosing in critically ill Australian Indigenous patients with severe sepsis. Int J Antimicrob Agents 2016;48:542-46 Tsai D, Stewart P…...Wallis S, Lipman J, Roberts J. Piperacillin pharmacokinetics in critically ill Australian Indigenous patients with severe sepsis. Antimicrob Agents Chemother 2016;60:7402-6 Tsai D, Stewart P…..Wallis S, Lipman J, Roberts J. Pharmacokinetics of total and unbound ceftriaxone in critically ill Australian Indigenous patients with severe sepsis. Int J Antimicrob Agents 2016;48:748-52 Udy A, Jarrett P, Lassig-Smith M, Stuart J, Starr T, Dunlop R, Deans R, Roberts J…..Lipman J. Augmented renal clearance (ARC) in traumatic brain injury (TBI): A single-centre observational study of atrial natriuretic peptide, cardiac output, and creatinine clearance. J Neurotrauma 2016;34:137-44 van Zundert A. Double gloves: a randomized trial to evaluate a simple strategy to reduce contamination in the operating room. ESRA Academy 2016; van Zundert A. Hand hygiene knowledge and perceptions among anesthesia providers. ESRA Academy 2016; van Zundert A, Kumar C, Van Zundert T. Malpositioning of supraglottic airway devices: preventive and corrective strategies. Br J Anaesth 2016;116:579-82 van Zundert A, Kumar C, van Zundert T. Measures to prevent malpositioning of supraglottic airway devices. Br J Anaesth 2016;117 van Zundert A, Gatt S, Kumar C, van Zundert T, Pandit J. Gradings of malpositioned supraglottic airway devices and practical corrective solutions. Br J Anaesth 2016;117: van Zundert A, Gatt S, Mahajan R. Continuing to Excel in Anaesthesia through the ‘Big Five’: Teaching, Training, Testing, Quality and Research. Br J Anaesth 2016;117:276-9 van Zundert A, Skinner M, Van Zundert T, Luney S, Pandit J.

Value of knowing physical characteristics of the airway device before using it. Br J Anaesth 2016;117:12-6 van Zundert A, Town C, Dalgleish L, Reynolds H. Which airway should we use in airway management? J Anaesth Periop Med 2016;3: 247- 57 van Zundert A, Wyssusek K. Postoperative sore throat - know where your airway is positioned. Anaesth 2016;71:1241-2. van Zundert A, Wyssusek K, Vivian V. Verification of Nasopharyngeal Temperature Probes – They are not always were you think they are! Anesth Analg 2016;123:1338-9 van Zundert A, Wyssusek K. Review of videolaryngoscopy pharyngeal wall injuries. Laryngosc 2016 Oct 31. van Zyl N, Milford E, Diab S…..Reade M, Fraser J, Staib A. Activation of the protein C pathway and endothelial glycocalyx shedding is associated with coagulopathy in an ovine model of trauma and hemorrhage. J Trauma Acute Care Surg 2016;81:674-84 Vermeir J, Holley A, Lipman J. "Not out of the woods"-a wife's perspective: bedside communication. Intens Care Med 2016;42:446-7 Verstraete E, Mahieu L, De Coen K, Vogelaers D, Blot S. Impact of healthcare-associated sepsis on mortality in critically ill infants. Eur J Ped 2016;175:943-52 Vincent J, Bassetti M, Francois B, Karam G et al. Advances in antibiotic therapy in the critically ill. Crit Care 2016;20:133 Vivian V, van Zundert A. Nasotracheal intubation and epistaxis. Anaesth 2016;71:722-3 Williams J, Greenslade J, Chu K, Brown A, Lipman J. Severity Scores in Emergency Department Patients With Presumed Infection: A Prospective Validation Study. Crit Care Med 2016;44:539-47 Williams J, Greenslade J, Dymond C, Chu K, Brown A, Lipman J. Characteristics, treatment and outcomes for all emergency department patients fulfilling criteria for septic shock: a prospective observational study. Eur J Emerg Med 2016;DOI:10.1097/MEJ.0000000000000419 Winearls J, Reade M, Miles H, Bulmer A et al. Targeted Coagulation Management in Severe Trauma: The Controversies and the Evidence. Anesth Analg 2016;123:910-24 Woodruff T, Wu M, Morgan M, Bain N, Jeanes A, Lipman J, et al. Epha4-Fc Treatment Reduces Ischemia/Reperfusion-Induced Intestinal Injury by Inhibiting Vascular Permeability. Shock 2016;45:184-91

Journal Articles (cont’d)

Wyssusek K, Foong W-M, Steel C, Gillespie B. The gold in garbage: implementing a waste segregation and recycling initiative. AORN Journal 2016;103:316.e1-316.e8 Wyssusek K, Keys A, Young J, Sivalingam P, Paul S, Moloney E. Evaluation of preoperative predictors of acute kidney injury post orthotropic liver transplantation. Anaesth Intens Care 2016; 44:641-42 Young J, Pickering J, George P, Aldous S et al. Heart Fatty Acid Binding Protein and cardiac troponin: development of an optimal rule-out strategy for acute myocardial infarction. BMC Emerg Med. 2016;16:34 Zahar J-R, Weiss E, Tabah A. Quelle définition et quelle stratification de la désescalade antibiotique ? How Can Antibiotic De-Escalation Be Defined and Stratified? Réanimation 2016;25:263-65 Zelenitsky S, Lawson C, Calic D, Ariano R, Roberts J, Lipman J, et al. Integrated pharmacokinetic-pharmacodynamic modelling to evaluate antimicrobial prophylaxis in abdominal surgery. J Antimicrob Chemother 2016;71:2902-8 Zhang L, Gowardman J, Morrison M, Runnegar N, Rickard C. Microbial biofilms associated with intravascular catheter-related bloodstream infections in adult intensive care patients. Eur J Clin Microbiol Infect Dis 2016;35:201-5

Book Chapters Cotta M, Roberts J. Pharmacokinetic and pharmacodynamic principles of antimicrobials. In: Laundy M GM, Whitney L editor. Antimicrobial Stewardship - A practical guide to the introduction, maintenance and development of an effective program. Oxford, UK: Oxford University Press; 2016. Finn P, Reade M. Bleeding Emergencies. In: Rapid Response Systems: A Practical Guide. New York, Oxford University Press USA, 2016, in press, accepted Jun 2016. Guffey PJ, Culwick M. Quality and Safety in Anesthesia and Perioperative Care Edited by Keith J. Ruskin, Marjorie P. Stiegler, and Stanley H. Rosenbaum. Chapter - Adverse Event Prevention and Management. Sept 2016. Jamal J, Roberts J. Polyene antifungals. In: Zaidi ST, Roberts JA, editors. Drug Dosing in Obesity, Volume 1: Antimicrobials. Switzerland, Springer, 2016. Jamal J, Roberts J. Aminoglycoside dosing in obesity. In: Zaidi ST, Roberts JA, editors. Drug Dosing in Obesity, Volume 1: Antimicrobials. Switzerland, Springer, 2016. Paratz J, Ntoumenopoulos G Jones A, , Management of the Critically Ill Patient In Denehy L, Main E Cardiopulmonary Physical Therapy, Churchill Livingstone Elsevier, London 2016

Philippart F, Tabah A , Carlet J. Chapter 32: Evaluation of the Febrile Patient in the Intensive Care Unit , In: Surgical Intensive Care Medicine, J.M. O’Donnell, F.E. Nácul (eds.), Springer International Publishing Switzerland 2016 Plaza A, Paratz J, , Management Acute Burn Patient In Denehy L, Main E Cardiopulmonary Physical Therapy, Churchill Livingstone Elsevier, 2016 Sinnollareddy M, Roberts J. Pharmacodynamic considerations in critically ill patients. In: Rotschafer JC AD, Rodvold KA, editor. Antibiotic Pharmacodynamics. New York,: Springer; 2016.

Books Brown AFT, Cadogan MD. “Emergency Medicine Diagnosis and Management”. 7th Edition. CRC Press, Taylor & Francis Group, Boca Raton 2016.

Published Conference Proceedings Shehabi Y, Bellomo R, Bailey M, Kadiman S, Ti LK, Reade M et al. Early pain, agitation, depth of sedation and mobilization as predictors of 180-day mortality: A multinational prospective longitudinal cohort study (The SPICE-PAD Study). Intens Care Med in press, accepted 8/8/16 Reade M. A bibliometric analysis of military trauma registry publications. J Milit Veter Health 2016 in press, accepted 12/10/16 Reade M. New ANZCOR guidelines for traumatic cardiac arrest: building on military experience. J Milit Veter Health 2016 in press, accepted 12/10/16 Hann A, Presneill J, Wall D, Reade M. Utility of digital rectal examination following trauma: a retrospective study. ANZ J Surg 2016 in press, accepted 7/3/16 Van Zyl N, Milford E, Diab S, Dunster K, McGiffen P, Rayner S, Reade M, Fraser J, Staib A. Activation of the protein C pathway and endothelial glycocalyx shedding is associated with coagulopathy in an ovine model of trauma and haemorrhage. ANZ J Surg 2016 in press, accepted 7/3/16

46

Invited Presentations Michael Reade

The new Australian Defence Force Blood Transfusion policy. Australasian Association of Clinical Biochemists/Australian Institute of Medical Scientists Combined Scientific Meeting, Brisbane, 2016

Dexmedetomidine in agitated delirium: the DahLIA trial results. ANZICS Annual Scientific Meeting (ASM), Perth, 2016

Recent clinical trials of dexmedetomidine. Asia-Pacific Sedation Conference, Seoul, 2016

Blast injury in civilian practice. 5th Annual Best of Brussels Meeting, Indian Society of Intensive Care Medicine (ISICM) , Pune, 2016

Are non-arterial blood gases any use? 5th Annual Best of Brussels Meeting, ISICM, Pune, 2016

Why I would, and why I would not, use whole blood transfusions in civilian practice. 5th Annual Best of Brussels Meeting, ISICM, Pune, 2016

How I manage agitated delirium in the ICU after the DahLIA trial. 5th Annual Best of Brussels Meeting, ISICM, Pune, 2016

Penetrating thoraco-abdominal trauma in an austere Role 2 hospital. Remote Damage Control Resuscitation Conference, Bergen, 2016

Treatment of agitated delirium: new aspects. 36th International Symposium on Intensive Care and Emergency Medicine (ISICEM), Brussels, 2016

Can we measure blood gases and lactate from venous or capillary blood? 36th ISICEM, Brussels, 2016

Fibrinogen concentrate: is there really equipoise for a clinical trial? 36th ISICEM, Brussels, 2016

Treatment of agitated delirium: new aspects. 36th ISICEM, Brussels, 2016

When to shift from pro- to anti-coagulant therapy after trauma? 36th ISICEM, Brussels, 2016

Will whole blood transfusion ever be viable in civilian practice? 36th ISICEM, Brussels, 2016

Agitated delirium: can dexmedetomidine help? 36th ISICEM, Brussels, 2016

Blast injury: myths and facts. 36th ISICEM, Brussels, 2016 Holley A, Seppelt I, Reade M. Fluid resuscitation. ANZICS

ASM, Perth, 2016 Holley A, Reade M, Robertson A, New C, Lumsden J,

Sharpe S, Weber D, Rogerson T, Mackie B, Herron R. Military critical care. ANZICS ASM, Perth, 2016

Hann A, Presneill J, Reade M. Hollow viscus injury following blunt abdominal trauma: A case series. General Surgeons Australia ASM, Melbourne, 2016

Andre van Zundert

Combined spinal epidural anaesthesia – tips for successful & safe blocks, Indo-Anaesthesia International Meeting, Jakarta, Indonesia, Feb 2016

Why go blind if you can see the airway? Indo-Anaesthesia International Meeting, Jakarta, Indonesia, Feb 2016

Postdural puncture headache – what’s old – what’s new?

Indo-Anaesthesia International Meeting, Jakarta, Indonesia, Feb 2016

The future of airway management, Udayna University, Sangladesh, Indonesia , Feb 2016

The history of IV cannulation, Australian Vascular Access Society's ASM (AVATAR), Brisbane, Apr 2016

Premetrics of difficult airways, Anaesthesia Update Meeting, alembang, Indonesia, Aug 2016

The future of anaesthesia, Anaesthesia Update Meeting, Palembang, Indonesia, Aug 2016

Videolaryngoscopy – the standard of airway management, Anaesthesia Update Meeting, Palembang, Indonesia, Aug 2016

Modern strategies of airway management, Anaesthesia Group, Toowoomba, Australia, Aug 2016.

The LMA-Protector – a new 2nd generation supraglottic airway devices (SAD), Royal Hospital Hobart, Tasmania, Aug 2016

Malpositioning and SADs, Royal Hospital Hobart, Tasmania, Aug 2016.

Alternatives to neuraxial labour analgesia, Annual Congress European Society of Regional Anaesthesia and Pain Therapy (ACESRAPT), Maastricht, The Netherlands, Sept 2016

Modern labour analgesia, ACESRAPT, Maastricht, The Netherlands, Sept 2016.

Videolaryngoscopy – the standard for airway management, ACPAN National Conference, Melbourne, Nov 2016 (Keynote)

Airway Management, 48th Annual Convention of the Philippine Society of Anesthesiologists (PSA), Manila, Philippines, Nov 2016

Benigno Sulit Jr Memorial Lecture: How to bring anaesthesia to the next level – the Big Five in Anaesthesia: Teaching, Simulation, Testing Equipment, Quality Care and Research, 48th Annual Convention of the PSA, Manila, Philippines, Nov 2016

How IV catheters revolutionized medicine, 48th Annual Convention of the PSA, Manila, Philippines, Nov 2016

Videolaryngoscopy – a masterpiece in airway management, 48th Annual Convention of the PSA, Manila, Philippines, Nov 2016

CONFERENCE PRESENTATIONS

Invited Presentations (cont’d)

Martin Culwick

National registries, big data resources - how to do it, what's their value? The World Congress of Anaesthesiologists Meeting, Hong Kong, Aug 2016

Show us the evidence – an analysis of the webAIRS data. The Australian Society of Anaesthetists (ASA), National Scientific Congress, Melbourne, Sept 2016

Culwick M, Reynolds H, Kamp R. WebAIRS: strategies to analyse and manage anaesthetic crises. ANZCA ASM Auckland, May 2016

Susannah Sherlock

Hyperbaric therapy for idiopathic sudden sensorineural hearing loss, ANZCA ASM Hyperbaric Special Interest, Auckland, May 2016

Idiopathic Sudden Sensorineural Hearing Loss, SPUMS conference, Fiji, May 2016

Gratton Institute Report, Australian Orthopaedic Society Meeting, Gold Coast, Jun 2016

Stijn Blot

Antibiotics in the ICU – Basic issues and pitfalls for optimal dosing. Critical Care Society of South Africa Egoli Branch Minisymposium, Egoli, Sandton, 12 Mar 2016 (e-lecture)

Antibiotic therapy: do not forget the practical organization. 36th International Symposium on Intensive Care and Emergency Medicine (ISICEM), Brussels, Mar 2016

Asperillus in endotracheal aspirates – What does it mean? 36th ISICEM, Brussels, Mar 2016

Multiresistant organisms – Do we need surveillance cultures? 36th ISICEM, Brussels, Mar 2016

Ventilator-associated pneumonia – Is oral care harmful? 36th ISICEM, Brussels, Mar 2016

Antibiotica op kritieke diensten: tips voor verpleegkundigen. Symposium voor hulpverleners op spoedgevallen en intensieve zorgen. Thomas More Hogeschool, Mechelen, Campus de Vest, May 2016

Limiting the attributable mortality of healthcare-associated infections and antibiotic resistance. Sigma Theta Tau International, European Conference, Utrecht, Jun 2016

Quality improvement initiatives to reduce CLABSI rates in ICUs. 3M Masterclass: Reducing infection risk at all access points. Brussels, Jun 2016

Health economic benefits of CHG dressing. 3M Masterclass: Reducing infection risk at all access points. Brussels, Jun 2016

Quality improvement initiatives to reduce CLABSI rates in ICUs. 3M Masterclass: Reducing infection risk at all access points. Delft, Jun 2016

Health economic benefits of CHG dressing. 3M Masterclass: Reducing infection risk at all access points. Delft, Jun 2016

Postgraduate course: Fungal lung infections in critically ill patients. European Respiratory Society (ERS) Congress, London, Sept 2016

Value-based caring: What’s in a name. 29th Annual congress of the European Society of Intensive Care

Medicine (ESICM), Milan, Oct 2016 Hemodynamics explained: a framework on determinants

of arterial blood pressure. 29th Annual congress of the ESICM, Milan, Oct 2016

Review of N&AHPs activites at the ESICM. 29th Annual congress of the ESICM, Milan, Oct 2016

Controversies in oral care for intubated patients. Australian Intensive Care Foundation, Clinical Trials Group/Foundation Masterclass, Perth, Oct 2016

Routine surveillance cultures to guide empiric antibiotic therapy. 41st ANZICS/ACCCN Intensive Care ASM, Perth, Oct 2016

Avoiding micro-aspiration – a key element in the prevention of ventilator-associated pneumonia. 41st ANZICS/ACCCN Intensive Care ASM, Perth, Oct 2016

Antibiotics in the ICU: what nurses should know. 41st ANZICS/ACCCN ASM, Perth, Oct 2016

How to avoid micro-aspiration? A key element in the prevention of ventilator-associated pneumonia. 6th Scientific-Practical Conference on Healthcare-Associated Infections. Actual and Discussion Questions in Nursing Practice. Pigorov National Medical & Surgical Centre, Moscow, Russian Federation, Oct 2016

Basics of optimizing antibiotic therapy in the ICU. 6th Scientific-Practical Conference on Healthcare-Associated Infections. Actual and Discussion Questions in Nursing Practice. Pigorov National Medical & Surgical Centre, Moscow, Russian Federation, Oct 2016

Adrian Chin

A randomised controlled trial comparing ultrasound and palpation assisted combined spinal-epidural anaesthesia for elective Caesarean section (Gilbert Brown session), ANZCA ASM Auckland, May 2016

Block rooms - is it worth it? Newcastle Anaesthesia Conference, Newcastle, Jul 2016

Neuraxial Ultrasound - a needed skill? ASA Conference, Melbourne, Sept 2016

Anthony Brown

Research tips and getting published. Mater RMO Society Research Conference; Mater Hospital, Brisbane, Jul 2016

Kerstin Wyssusek

Implementing a waste segregation & recycling initiative. In: Operating Theatre Management Conference ACORN, RBWH Education Centre, Herston, Brisbane, Aug 2016

Jennifer Paratz

Facilitating clinicians to implement evidence into practice. RBWH Healthcare Symposium, Brisbane, Sept 2016

Paratz J, Kayambu G, Boots R. Early exercise and the effect on the microcirculation in sepsis. ESICM, Milan, Oct 2016

Paratz J, Boots R. Follow up clinic for sepsis survivors, preliminary results & feasibility ESICM, Milan, Oct 2016

48

Invited Presentations (cont’d) Bill Lukin

End of life care conversations. Nurses in Management - Aged Care (NIMAC) Conference; Benowa, Queensland, Jun 2016

Advance care planning. Advance Care Planning National Forum; Auckland, Nov 2016

Aged care to ED: what are we missing? End Of Life Care Improvement Group Workshop The Health Roundtable; Sydney, Apr 2016

Communication and palliation in the ED. Integrated Emergency Care for Older Persons Summit; Melbourne, Oct 2016

Palliative Care in the ED. 12th Annual Queensland Emergency Medicine Autumn Symposium; Brisbane, May 2016

Despoina Koulenti

Ventilator-Associated Tracheobronchitis, ESICM 29th Annual Congress, Milan, Oct 2016

Current Evidence in VAP Prevention, ESICM 29th Annual Congress, Milan, Oct 2016

Louise Cullen National Heart Foundation of Australia (NHFA) and Cardiac

Society of Australia and New Zealand (CSANZ): Australian clinical guidelines for the management of acute coronary syndromes. 33rd Australasian College for Emergency Medicine (ACEM) ASM, Queenstown, New Zealand, Nov 2016

Troponins and rule out in 2016 (Masterclass). Emergency Medicine Core Knowledge (EMCORE) conference; Fiji, Sept 2016

Troponins and rapid rule out. EMCORE conference; Melbourne, Jun 2016

One arrhythmia you must know. EMCORE conference; Melbourne, Jun 2016

Heather Reynolds

Clinical studies, an evidence-based educational approach and web-based strategies provide a clear path for practice improvement, AVA ASM 2016. Orlando, USA.

Jason Roberts

Under Dosing of Antibiotics in the ICU - A PK/PD Approach. IDWeek, Infectious Diseases Society of America (IDSA) ASM, New Orleans USA, Oct 2016

Antibiotic use in extracorporeal techniques. ESICM Annual Congress, Milan, Italy, Oct 2016

Dosing antifungals in the critically ill. ESICM Annual Congress, Milan, Italy, Oct 2016

Antibiotic PK/PD for treatment of MDR infections. ESICM Annual Congress, Milan, Italy, Oct 2016

Optimized PK/PD: Can It Reduce Resistance? ASM Microbe, Boston, USA, Jun 2016

Fitting data to models. ESCMID Postgraduate Technical Workshop Population Modelling and Dose Optimization with Pmetrics and BestDose: Antimicrobial Applications. Lyon, France, Apr 2016

The importance of antibiotic dosing as part of AMS. 2nd Annual Targeting and Evaluating Antimicrobial Stewardship Forum, Melbourne, Jun 2016,

Renal Replacement Therapy, Critical Care Seminar, Society of Hospital Pharmacists of Australia (SHPA) Brisbane, May 2016

Is there a role for TDM in infective endocarditis? Australian Society for Antimicrobials ASM, Melbourne, Feb 2016

Using MIC in Predicting Clinical Outcomes of Antibiotic Treatment. Australian Society for Antimicrobials ASM, Melbourne, Feb 2016

Approaches to funding the response to antimicrobial resistance. 3rd Queensland Forum on Antimicrobial Resistance, Brisbane, Nov 2016

Getting Systemic Therapy Right! Orthopaedic Infections – State of the Art. Wesley Hospital, Brisbane, Nov 2016

Individualised antibiotic dosing and TDM. Royal North Shore Hospital, Sydney, Sept 2016

Drug dosing in obesity. SHPA, Queensland Branch Continuing Education Series, Jun 2016

CONFERENCE PRESENTATIONS

Presentations Louise Cullen

Are we overdiagnosing myocardial infarction? Preventing Overdiagnosis; Barcelona, Spain, Sept 2016

Milburn T, Ashover S, Skoien W et al. Economic Impact of the Accelerated Chest Pain Risk Evaluation (ACRE) Project - A Large Scale Implementation of the ADAPT Accelerated Diagnostic Protocol into Clinical Practice. 64th CSANZ ASM and the International Society for Heart Research Australasian Section ASM, Adelaide, Aug 2016

Neumann J, Sorensen N, Schwemer T et al. Rapid measurement of a single troponin I combined with negative ECG allow accurate ruleout of NSTEMI in patients with suspected AMI. European Society of Cardiology Congress; Rome, Italy, Aug 2016 (Poster)

Skoien W, Ashover S, Milburn T, Page K, Cullen L, Parsonage W. Research Translation: Implementation Evaluation of the Queensland Accelerated Chest Pain Risk Evaluation (ACRE) Project. 64th CSANZ ASM and the International Society for Heart Research Australasian Section Annual Scientific Meeting; Adelaide, Aug 2016 (Poster)

Anthony Brown

Anaphylaxis and angioedema: An update. 12th Annual Queensland Emergency Medicine (AQEM) Autumn Symposium; Brisbane, May 2016

Brown A, Burkett E, Tilleard J et al. Evidence and Eminence: Panel Discussion of the latest literature. 12th AQEM Autumn Symposium; Brisbane, May 2016

How to get published. Building your medical career through research: doctors in training, AMA Queensland; Brisbane, Mar 2016 (Poster)

Unexpected alternate emergency department diagnoses in two patients with HAE with normal C1INH (HAE type III). 2016 Global Forum for Hereditary Angiodema; Warsaw, Poland, Nov 2016 (Poster)

Holley A, Brown A. Trauma Scenarios - Small group, all-day workshop. Current Concepts in Critical Care Course; RBWH Brisbane, Dec 2016 (Poster)

Michael Reade

Phua M-M, Pretorius C, McWhinney B et al. Confirming Hypothesised Associations Of Increased Pyroglutamic Acid In A Mixed Sample Of Critically Ill Patients: An Observational Cohort Study. ANZICS ASM, Perth, 2016 (Poster)

Martha Druery

Maskell J, De Young A, Druery M et al Current Psychosocial Care of Burn Patients: Screening and Support Provision across ANZBA burn centres. Australia and New Zealand Burn Association (ANZBA) ASM, Auckland, 2016

Small Burns, Big Issues: preliminary results from a Quality of Life outcomes study post-burns. Australian Association of Social Workers (AASW) North and South Queensland Branches Social Work Conference, Brisbane, 2016

Quality self-care in social work practice: The art and the

science of building your own trauma resilience. AASW North and South Queensland Branches Social Work Conference, Brisbane, 2016

From Fate to Good Fortune; One Social Worker’s journey through redundancy, research and private practice. AASW North and South Queensland Branches Social Work Conference, Brisbane, 2016

Druery M, Heyes L. Navigating your personal journey in the age of media technology. Julian Burton Burns Trust (JBBT) Burn Survivor & Family Education & Support Forum, Adelaide, Jun 2016

Heyes L, Druery M. Lost and Found: Reconnecting with who you really are. JBBT Burn Survivor & Family Education & Support Forum, Adelaide, Jun 2016

Heyes L, Druery M. Managing difficult emotions. JBBT Burn Survivor & Family Education & Support Forum, Adelaide, Jun 2016

Working through the pain of loss – applying theory and evidence to grief and loss work across the lifespan. Standby (Suicide Postvention) National Coordinators’ Forum Noosa, May 2016

Becoming Grief Competent: Understanding the trauma of suicide bereavement. Mental Health Professionals’ Brisbane Suicide Bereavement Network Meeting, Oct 2016

Julie Lee Intraoperative cuff pressure measurements of endotracheal

tubes in the operating theatres of an Australian quaternary hospital. ANZCA ASM, Auckland, May 2016; RBWH Health Symposium, Brisbane, Oct 2016 (Poster)

Intraoperative cuff pressure measurements of supraglottic airway devices in the operating theatres of an Australian quaternary hospital. ASA National Scientific Congress, Melbourne, Sept 2016

An audit of intraoperative blood product usage pre- and post- implementation of ROTEM® thromboelastometry in a quaternary referral hospital. ANZCA ASM, Auckland, May 2016

ROTEM® thromboelastometry – A survey of anaesthetists’ experiences. ANZCA ASM, Auckland, May 2016

Tavey Dorofaeff

MRI findings in Paediatric Delerium – Case Series, 8th World Congress of Paediatric Intensive Care, Toronto, Canada

Tracey Hawkins

Hawkins T, Greenslade J, Van Hise C et al. Cannulation rates in the emergency department intervention trial (CREDIT). 33rd ACEM ASM Queenstown, New Zealand, Nov 2016 (Poster)

CONFERENCE PRESENTATIONS

50

Presentations (cont’d) Jaimi Greenslade

Lancini D, Martin P, Cullen L, Greenslade J et al. Prognostic impact of atrial fibrillation in the emergency chest pain presentation. CSANZ ASM; Adelaide, Aug 2016

Milburn T, Ashover S, Skoien W, Cullen L, Greenslade J, Parsonage W. A large scale implementation of the ADAPT Accelerated Diagnostic Protocol into clinical practice in Queensland: Impact on hospital length of stay and admission rates for possible cardiac chest pain. 64th CSANZ ASM and the International Society for Heart Research Australasian Section ASM, Adelaide, Aug 2016

Neumann J, Sorensen N, Ojeda F et al. Immediate Rule-out of Acute Myocardial Infarction Using Electrocardiogram and Baseline High-sensitivity Troponin I. European Society of Cardiology Congress; Rome, Aug 2016

liceto A, Berndt S, Greenslade J et al. Agreement Between Patient-reported and Cardiology-adjudicated Medical History in Patients With Possible Ischemic Chest Pain: An Observational Study. Ochsner Clinical School 13th Annual Research Day; New Orleans, USA, May 2016 (Poster)

Kevin Chu

Chu K, Howell T, Keijzers G et al. Characteristics and diagnosis of patients representing to the emergency department with a headache. 33rd ACEM ASM, Queenstown, New Zealand, Nov 2016

Dan Bodnar

Bodnar D, Bosley E, Rashford S. The introduction of a pre-hospital intranasal fentanyl drug therapy protocol increases the proportion of children receiving opiod analgesia for traumatic injuries. 12th AQEM Autumn Symposium; Brisbane, May 2016 (Poster)

Bodnar D, Rashford S, Handy M, Bosley E. Trauma ultrasound in the pre-hospital environment (TUPHEn Study). 12th AQEM Autumn Symposium; Brisbane, May 2016 (Poster)

Trent Lipp

Coulthard L, Hewson A, Symons P et al. Identifying Trauma Patients at Risk of Missed Injury in the Emergency Department. 33rd ACEM ASM Queenstown, New Zealand, Nov 2016 (Poster)

Hewson A, Coulthard L, Symons P et al. Emergency Trauma Clinical Decisions in Imaging Pathways. 33rd ACEM ASM, Queenstown, New Zealand, Nov 2016

Danny Tsai

Tsai D, Stewart P, Goud R, Gourley S, Hewagama S, Krishnaswamy S, Wallis S, Lipman J, Roberts JA. Optimising Meropenem dosing in critically ill Australian Indigenous patients with severe sepsis. European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 25th International Conference, Amsterdam, Apr 2016

Adrian Chin

Technology Bias may shape patient perceptions, ANZCA ASM Auckland, May 2016 (Poster)

Angus Hann Hann A, Presneill J, Reade M. Hollow viscus injury following

blunt abdominal trauma: A case series. General Surgeons Australia ASM 2016

Hann A, Presneill J, Wall D, Reade M. Utility of the digital rectal examination following trauma in the era of the “pan scan”. Royal Australian College of Surgeons Annual Scientific Congress 2016

Heather Reynolds

Bundled interventions for safe care of peripheral arterial catheters in adult patients: the ALICE (Arterial Line Insertion and CarE) protocol, World Congress on Vascular Access (WoCoVA), Lisbon, 2016

Intraoperative cuff pressure measurements of endotracheal tubes, Australian College of Perianaesthesia Nurses (ACPAN) ASM, Melbourne, 2016

Reynolds H, Gowardman JR, Van Zundert A, Rickard CM. Bundled Interventions for safe care of peripheral arterial catheters in adult patients: The ALICE (Arterial Line Insertion and Care) Protocol. Royal Brisbane and Women’s Hospital Symposium, Brisbane, 2016 (Poster)

Reynolds H, Gowardman JR, Van Zundert A, Rickard CM. Bundled Interventions for safe care of peripheral arterial catheters in adult patients: The ALICE (Arterial Line Insertion and Care) Protocol. ACPAN ASM, Melbourne, 2016 (Poster)

Victoria Eley

Eley V, Callaway L, van Zundert A, Lipman J, Gallois C. Early epidural analgesia: Practice guidelines are interpreted variably by specialist anaesthetists caring for obese parturients, ANZCA Clinical Trials Network Annual Strategic Research Workshop, Coogee, Aug 2016

Jason Roberts

Byrne C, Roberts J, McWhinney B, Fennell J, O’Byrne P, Deasy E, Egan S…..McHugh J. The impact of serum albumin concentrations on the pharmacokinetics of unbound teicoplanin in patients with haematological malignancy. ECCMID, Amsterdam, Denmark, Apr 2016

Lopez M, Grau S, Moreno I, Rubio M, Luque S, Roberts J. Pharmacokinetics of micafungin in patients receiving ECMO. ECCMID, Amsterdam, Denmark, Apr 2016

Farkas A, Luque S, Frey O, Roehr A, Grau S, Roberts J. Population pharmacokinetics of linezolid as it applies to therapeutic drug monitoring: a comparison of ten approaches. ECCMID, Amsterdam, Denmark, Apr 2016

Roberts J, Roger C, Wallis S, Muller L, Lipman J, Lefrant JY. Comparative effect of equal dose of continuous veno-venous haemofiltration and continuous veno-venous haemodiafiltration on ciprofloxacin population pharmacokinetics in critically ill patients. ECCMID, Amsterdam, Denmark, Apr 2016

Alobaid A, Roberts M, Wallis S, Lipman J, Roberts J. What is the effect of obesity on the population pharmacokinetics of meropenem in critically ill patients? ECCMID, Amsterdam, Denmark, Apr 2016

Workshops/Courses Presented Michael Reade

EMST, BASIC Dylan Flaws

Metro North Research Interactive Workshop Brisbane Diamantina Health Partners – Brain and Mental

Health Workshop Susannah Sherlock

EMAC instructor for crisis management at Herston Skills Centre May, Jun, Oct 2016

Martha Druery

Working through the pain of loss – applying theory and evidence to grief and loss work across the lifespan. AASW Brisbane, Feb 2016

Andre van Zundert

Airway management, Indo-anaesthesia International Meeting, Jakarta, Indonesia, Feb 2016.

Airway management, Udayna University, Sangladesh, Indonesia, Feb 2016

Videolaryngoscopy – a masterpiece in airway management, 48th Annual Convention of the PSA, Manila, Philippines, Nov 2016

Benjamin Snow

Anaesthesia and analgesia for blunt thoracic trauma, Queensland ANZCA/ASA Conference 2016

Adrian Chin

Regional anaesthesia workshop, Queensland ANZCA/ASA combined meeting,

Regional anaesthesia workshop, Newcastle Anaesthesia Conference,

Regional anaesthesia workshop, Melbourne ASA Conference

Julie Lee

Small group discussion (SGD) on Rotational Thromboelastometry (ROTEM®) in Obstetric Patients. ASA National Scientific Congress, Melbourne, Sept 2016

Helmet Shoengen

Presentation to the Anaesthetic Department, University Hospital of the RWTH University Aachen, Germany: “Working with MSF in Jahun, Nigeria”, Jan 2016

Multiple presentations of “Working with MSF in Aden, Yemen” for RBWH recovery nursing staff, the RWBH anaesthetic department, medical students and others, Jun 2016

Presentation to the Newcastle Real World Anaesthesia Special Interest Group: “MSF mission in Aden, Yemen 2016” , Jul 2016

Danny Tsai Antibiotic use in the remote setting—given to remote area

nurses in a pharmacotherapeutic course (Centre for Remote Health, a joint centre of Flinders University and Charles Darwin University), Apr 2016

Jason Roberts

TDM for β-lactams, sharing of centres experience, expert’s vision for the future. Singapore TDM Workshop. Singapore, Apr 2016

Fitting data to models. NHMRC Centre of Research Excellence REDUCE Workshop on Population Modelling and Dose Optimization, Brisbane, Oct 2016

WORKSHOPS/ COURSES

52

Achievements and Awards

Michael Reade

Fellowship of the American College of Critical Care Medicine (FCCM)

Associate Fellowship of the Royal Australasian College of Medical Administrators

Dylan Flaws

Awarded Queensland Health Junior Doctor Research Fellowship

Metro North “Rising Star” Early Career Researcher of the Year

Adrian Chin

ANZCA Meeting Auckland – Gilbert Troup Award 2016, “A randomized controlled trial comparing ultrasound and palpation assisted combined spinal-epidural anaesthesia for elective Caesarean section”

Andre van Zundert

Professorship—University of Udayana, Indonesia Professorship—Queensland University of Technology Professorship—Victoria University, Melbourne (Faculty of

Engineering & Science) Angus Hann

2016 John Ham Medal. Awarded for the best paper presented by a trainee involved in research at the General Surgeons Australia annual meeting

Despoina Koulenti

UQ Development Fellowship Julie Lee

NBA Early Career Researcher Award ASA PhD Award RBWH Foundation Scholarship award ANZCA Meeting Auckland – Finalist: Trainee Academic

Poster Prize Jennifer Paratz

Outstanding leadership in Allied Health research, Learning & Innovation, Metro North Symposium 2016

Dan Bodnar Best Paper—”The introduction of a pre-hospital intranasal

fentanyl drug therapy protocol increases the proportion of children receiving opiod analgesia for traumatic injuries.” 12th Annual Queensland Emergency Medicine Autumn Symposium, Brisbane.

Louise Cullen

Ko Awatea Award (APAC Forum 2016) Research Excellence Award (Metro North) Clinical Researcher Award (Australian Society for Medical

Research) Honorable Mention, Student Category (University of

Queensland-Ochsner Clinical School Annual Research Day)

Victoria Eley

Submitted PhD thesis for examination Jason Roberts

Six PhD students completed Fekade Sime

UQ Development Fellowship Gladness Nethathe

The South African Society of Anaesthesiologists Perioperative Medicine Grant.

ACHIEVEMENTS/ AWARDS

Teaching Jeffrey Lipman

Specialties II, Critical Care Course, MBBS Year 4 Sepsis Symposium, MBBS Year 2

Michael Reade

UQ Year 2 and Year 4 examiner UQ Higher degree examiner

Dylan Flaws

Teaching medical students as part of registrar role Co-supervising other registrars’ scholarly projects

Susannah Sherlock

ANZCA primary short course and regular weekly tutorial programme

Adrian Chin

Provisional Fellow Professional Development lecture Gareth Collins

Formal teaching to Anaesthesia Part 1 candidates, Viva practise and marking of practise written exam

answers to Part 2 candidates Kirsten Wyssusek

Final Examination ANZCA UQ MBBS Year 2 & Year 4 UQ MD year 2 Supervisor - UQ Summer School Scholarship

Despoina Koulenti

UQ MBBS Year 4 [MEDI 4019] UQ MBBS Year 3 [MEDI 3013/7305] Supervision of Research Observerships of UQ-Ochsner

Year1 medical students Julie Lee

Supervision of medical students for the UQ Summer School Student Research Program

Examiner for practice anaesthetic vivas for final exam candidates at RBWH

Educator for the RBWH primary exam tutorial program Jennifer Paratz

Lectures in Cardiology & Intensive Care to University of Queensland and Australian Catholic University undergraduates

Helmet Shoengen

Bedside teaching of UQ Medical Students, Interns, Junior Health Officers, Senior Health Officers, registrars

Tavey Dorofaeff

Clinical Bedside teaching of Paediatric Intensive Care registrars

Cienwen Town Summer Research Programme supervisor

Lizanne Dalgleish

Summer Research Programme supervisor Elizabeth McLellan

Facilitator Primary Exam teaching session: Physiology and Pharmacology of Neuromuscular blockers

Mock examiner QARTS Primary Exam Viva Practice Mock examiner RBWH Final Exam Viva Practice Facilitator Registrar teaching session: A Practical

Approach to Regional Anaesthesia In-theatre teaching medical students and anaesthetic

residents Heather Reynolds

Mentor for Griffith University Mentoring Program Victoria Eley

Special Study Unit Supervisor, ANZCA Obstetric Anaesthesia

Scholar role tutor (ANZCA training program), RBWH Stream Lead: Research. Department of Anaesthesia and

Perioperative Medicine, RBWH Alexandra Markwell

Registrar/Intern and medical student teaching/training, RBWH and Greenslopes Private Hospital

TEACHING

54

Professional Organisation Activities

Michael Reade Editorial Board: Anaesthesia and Intensive Care;

Disaster and Military Medicine Organising committee ANZICS 2017 conference

Dylan Flaws

Metro North Women in Health Science Committee MNHHS Research Committee Queensland Trainee Psychiatrists Association Psychiatry Trainee Academic Committee Reviewer: Circulation; Academic Emergency Medicine

Susannah Sherlock

Organiser of Workshop for 2017 ANZCA ASM Co-Organiser of ANZCA ASM SIG for Hyperbaric

Medicine and Diving Orlando Flores

Lead—financial committee of 4th Chilean Graduate Conference, UQ, Oct 2016

Andre van Zundert

Representative for Australia and New Zealand of the Obstetric Anaesthesia Society of Asia & Oceania

Martha Druery

Trauma-Informed Psychosocial Care e-learning Package for Allied Health Professionals Expert Reference Panel Member

Committee Chair – Burnslife Community Program in partnership with RBWH Foundation

Member: Psychosocial Expert Reference Group for the Quality Indicator Working Party (ANZBA); Member of the Corresponding Reference Group for the Burns Node of Johanna Briggs Institute COnNECT

Stijn Blot

Chair, Nurses & Allied Healthcare Professionals, ESICM Research officer, ESICM Research officer, ESCMID (working group on infections

in critically ill patients) Executive board, Flemish Society Critical Care Nurses Editorial board: Am J Crit Care, Austral Crit Care,

Intensive Crit Care Nurs Despoina Koulenti

Chair: Working Group on Pneumonia of ESICM Member: International Advisory board of Journal of

Medical and Surgical Intensive Care Medicine; Journal Review Club of ESICM; Delphi Panel & Consensus meeting of the COVent study

NHMRC and ESCMID research grant reviewer ESCMID and ESICM Annual Congress abstract reviewer NHMRC Research Grants External assessor Reviewer: Intensive Care Medicine, Clinical Microbiology

and Infection, International Journal of Antimicrobial

Agents and Chemotherapy, Respiratory Care, Minerva Anestesiologiica, European Journal of Clinical Microbiology and Infectious Diseases, Intensive and Critical Care Nursing

Invited Session Chair: Oral Presentations—Respiratory Infections, ESICM 29th Annual Congress, Milan, Oct 2016

Invited Session Chair: Thematic Session—Hospital-Acquired & Ventilator-Associated Pneumonia, ESICM 29th Annual Congress, Milan, Oct 2016

Julie Lee

Queensland Representative for the Public Practice Advisory Committee (PPAC) ASA

Facilitator of a small group discussion on ROTEM® in Obstetrics at the ASA National Scientific Congress, Sept 2016

Jennifer Paratz

Acting Chair, UQ Research Ethics Committee 2016 Faculty member, Queensland Skills centre Reviewer: American J Resp & Critical Care Medicine,

Intensive Care Medicine, BMJ, Critical Care Medicine, NHMRC grants

Helmet Shoengen

Video assisted Specialist Examination preparation for ANZCA trainees

RBWH Clinical supervisor of anaesthetic Interns, Junior Health Officers, Senior Health Officers, registrars

ANZCA Specialised Study Unit Ophthalmic Procedures Supervisor

Heather Reynolds

Reviewer: Critical Care Medicine, BMJ Innovations, Journal of Anesthesia & Clinical Care, Medical Research Archives

Member: Australian Vascular Access Society, Alliance for Vascular Access Teaching and Research Group, Association for Vascular Access, Australian College of Nursing, Honor Society of Nursing, Sigma Theta Tau International, ACPAN, Australian College of Operating Room Nurses, Australian College of Critical Care Nurses

Appointed Chair, Professional Standards Council/Chief Standards Editor 2016-2019, ACPAN

Cienwen Town

Research Interest Group of Anaesthesia (RIGA) Lizanne Dalgleish

RIGA

PROFESSIONAL ACTIVITIES

Professional Organisation Activities (cont’d) Victoria Eley

Facilitator, small group discussion: Obesity in obstetric anaesthesia, ASA National Scientific Congress Melbourne, 2016

Facilitator, small group discussion: Preeclampsia in Obstetric Anaesthesia. Regional Organising Committee Member, ANZCA ASM, Brisbane 2016

Current Chair, ANZCA Obstetric Anaesthesia Special Interest Group

Executive Member of ANZCA Obstetric Anaesthesia Special Interest Group

David Rosengren

Chair Queensland Faculty, ACEM Jason Roberts

Panel member: Health Practitioner Scheme Queensland Health

Project Grant External Reviewer: Austrian Science Fund, Research Council KU Leuven, Belgium

Reviewer: SHPA, Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT), American Society for Microbiology (ASM), Australian Society for Antimicrobials (ASA),

ESICM, Australian Society of Infectious Diseases (ASID), ESCMID, International Society of Anti-Infective Pharmacology (ISAP, International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT), Population Approach Group of Australia and New Zealand (PAGANZ)

Journal Reviewer: Blood Purification, Antimicrobial Agents and Chemotherapy, British Journal of Clinical Pharmacology, Burns, Clinical Microbiology and Infection, Clinical Pharmacokinetics, Critical Care , D i a g n o s t i c Microbiology and Infectious Disease, Drugs, Infectious Diseases and Therapy, Intensive Care Medicine, International Journal of Antimicrobial Agents, Pharmacotherapy, PLOS ONE, Journal of Antimicrobial Chemotherapy, Journal of Clinical Pharmacology, Journal of Clinical Pharmacy and Therapeutics

Alexandra Markwell

Deputy Chair ACEM Continuing Professional Development Sub-Committee

Reviewer: ACEM Best of Web, MJA and Medical Education Member: AMA Board Remuneration Committee; AMA

Ethics and Medicolegal Committee

2016 has been an enterprising first year for CRE REDUCE. In July, the Centre was officially launched and presented as a strategic collaboration between the Federal and State governments, various domestic and international universities and consumers of healthcare. The launch attracted a significant amount of local and state media attention and was publicised as a major international collaboration to re-evaluate the dosing and preserve the long term effectiveness of our existing antimicrobials. You are able to view many of the excellent presentations from the launch at our website or on YouTube - https://cre-reduce.centre.uq.edu.au The Centre also kicked off its ambitious education program with the first Pharmacokinetic workshop held over three days in October at Union College, St Lucia. The workshop was aimed at clinicians and researchers interested in improving PK analysis using Pmetrics and BestDose software. The favourably reviewed workshop was fully accredited by SHPA under the auspices of the Australian Pharmacy Council (APC) and attracted significant sponsorship from MSD Australia. CRE REDUCE was pleased to host 32 participants from 10 countries. Speakers included Prof Michael Neely from the University of Southern California, Prof William Hope from the University of Liverpool and Prof Jason Roberts. In November, the Centre organised the Antibiotic Awareness Week Symposium in order to mark the WHO and the ACSQH endorsed Antibiotic Awareness Week. The presentations delivered by Prof Jeffrey Lipman and Prof Mark Schembri, offered academic and clinical perspectives on bacterial biofilms and their implications for treatment and emergence of antimicrobial resistance. The successful talks were telecast to 15 ICUs across Queensland and promoted on ABC Local Radio, Brisbane.

I n

late 2016, over 3 days, the Centre hosted two distinguished visitors from Singapore – Dr Andrea Kwa and Dr Lawrence Lee, both international leaders in Antimicrobial Stewardship, infectious diseases and antimicrobial resistance. Their visit culminated in a delivery of a seminar on prospective antibiotic combination testing for guiding treatment of drug-resistant gram-negative bacteria infections and on improving antimicrobial use and dosing in difficult to treat patients in Singapore.

Early in 2017, CRE REDUCE is looking forward to finalising its multi

-institutional agreements with the national and international

collaborators and proceeding with the research that will describe

antimicrobial behaviour across key patient populations and tackle

ineffective dosing and unrestrained prescribing of antimicrobials.

CRE REDUCE UPDATE

56

BTCCRC heARTfelt Dinner Fundraiser Now in its 3rd year, the heARTfelt Dinner has proven to be a very popular event with 150 guests attending the art-themed fundraiser, making it our biggest yet! The Royal on the Park Ball Room was transformed into a work of art itself with splashes of bright colours strewn across the room resembling a Pro Hart masterpiece. Guests filled the Royal on the Park Ball Room for an incredible and colourful night of fine wine, entertainment and an amazing three-course meal. In keeping with previous years, the highlight of the Dinner was the exciting art exhibition featuring generously donated artwork by Cheryl Slater, Wayne Singleton, Amanda Brooks, Jan James, Aliki Rathgeber, Barbara Fletcher, Janice Pungutji Murray, Di Cox, Margot Warre, Julie Crane, Pauline Napangardi Gallagher, Robert Brownhall, Tony Walker, Eliza Rose, Millie Dent Design, Andrew Costi , A l a n Fletcher and David Hinchliffe. There was an abundance of auctions and prizes, all with a backdrop of raising

money to fund life-saving medical research and patient care initiatives in the Intensive Care and Burns Units at RBWH. We thank our MC for the evening, Matthew Hickey, who kept everyone entertained and a big thank you to Phill Broom who did a fantastic job as our auctioneer for the evening. We must also thank our guest speakers Jennifer Tucker, one of our patients who was treated for trauma in our ICU after a car hit her whilst cycling and Prof Jason Roberts, one of our leading researchers. The evening could not have been the success it was without the generosity of our event partners, A Noble Event, AshMed, Black Arts, Royal on the Park and Eckersley’s and prize sponsors The Ginger Factory, Betty

Yanardasis, Victoria Park, Elisa Rose, Sand Dunes Resort, Ken and Donaugh Jones, Art By Brooks, Nerece Mahon, Planet Cycles, Rupert McCall, Birdsnest, David Pugh, Milly Dent Design, Urban Art Projects, Hummingbird The Shop, Margot Warren Design, South Family Jewellers, Stafford Physiotherapy, Purple Daze Hair Studio, Wayne Singleton Relief Block Printmaker, In Therapy Skin & Body,

Brisbane BMW, Newstead Brewing Co., Brisbane International Hotel Windsor, Dello Mano, Crown Family Jewellers, Rode Meats, Kafeneio, Oxlades, Lefkas Taverna, The Greek Club, Aliki's Art in Mind, Aromas Head Office, Hub Café Kitchen, SportFirst, Petrol Boutique, Brisbane International, Ribs and Rumps Milton, The Coffee Club / Minor DKL Food Group, Panda Pearls, Designs by Sparrow, Blake and Taylor, Fireworks Gallery, T2, LaDiDa Beauty Co, One Wybelenna, PCYC, Healthyworld Pharmacy, Norwex, Hoopoe Home, QMFT and Nic's Beauty Haven.

We thank them and the wonderful volunteers who supported our fundraiser. We also thank the Lions Herston Club for their generous

donation on the evening.

HEARTFELT FUNDRAISER

Name Institution Reason for Visit

Dr Claire Roger Centre Hospitalier-Universitaire Nimes, France

Collaborative activities for PK/PD studies including NHMRC funded SMARRT Study

Prof Jean-Yves Lefrant Intensivist/Director ICU

Centre Hospitalier-Universitaire Nimes, France

Discussion of PK of caspofungin and micafungin in a piglet model of septic shock

Ms Jiao Xie The First Affiliated Hospital of Xi’an Jiaotong University, China

Develop population PK of tigecycline in critically ill patients with multidrug-resistant Acinetobacter baumannii pneumonia. Develop the in vitro model to simulate PK of tigecycline in humans

Dr Haiyan Dong The First Affiliated Hospital of Xi’an Jiaotong University, China

Anti-infective therapy and individualized dosing regimen development

Dr Thomas Taengden Uppsala University, Sweden Collaborative activities for PK/PD of common anti-infectives against multi-drug resistant bacteria

Ms Iris Minichmayr Freie Universität, Germany TDM of anti-infectives

Dr Andrea Kwa Singapore General Hospital Deliver seminar to pharmacy and medical clinicians and academics from RBWH, PAH and UQ CCR

Dr Lawrence Lee National University of Singapore. Deliver a seminar to pharmacy and medical clinicians and academics from RBWH, PAH and UQ CCR

Prof Michael Neely University of Southern California, USA

Presentation-CRE REDUCE “Population PK Modelling & Dose Optimisation of Antimicrobials” Workshop

Prof William Hope University of Liverpool, UK Presentation-CRE REDUCE “Population PK Modelling & Dose Optimisation of Antimicrobials” Workshop

A/Prof Bernd Froessler Lyell McEwin Hospital, Adelaide Presentation-“Peri-operative blood management” to the RBWH Department of Anaesthesia

Visitors to the BTCCRC

NEWS & EVENTS CRE REDUCE official launch Fri 29 July by Honourable Dr Anthony Lynham MP, Minister

for State Development and Minister for Natural Resources and Mines. hosted the Population Pharmacokinetic Modelling and Dose Optimisation

of Antimicrobials Workshop (13-15 Oct). hosted two distinguished visitors (7-9 Nov) – Dr Andrea Kwa from

Singapore General Hospital and Dr Lawrence Lee from the National University of Singapore.

held a symposium at the RBWH Education Centre (16 Nov) to mark the WHO endorsed Antibiotic Awareness Week. The ESICM endorsed PneumoINSPIRE study coordinated by BTCCRC has had a very successful site recruitment with more than 200 participating sites worldwide.

Michael Reade—Deployed to Iraq for three months, the second time in two years.

Dylan Flaws—preparing his PhD thesis for a May 2017 submission.

Tavey Dorofaeff and Yarmarly Guerra Valero—commenced their PhD projects in January.

Helmet Shoengen—2 months humanitarian mission with MSF (Doctors without Borders), working as Medical Anaesthetist in the MSF Emergency Trauma Centre in Aden, Yemen; RBWH Anaesthetic Intern Training re-accredited by Queensland Prevocational Medical Accreditation

NEWS & EVENTS

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QUEENSLAND Prof David Paterson, Casey Pfluger, Hosam Zowawi, University of Queensland Centre for Clinical Research A/Prof S Brauer, School of Health & Rehabilitation Sciences A/Prof Paul Mills, Vet Pathology & Anatomy Prof Paul Colditz, Dr Barbara Lingwood, Perinatal Research Centre Prof Alastair McEwan, Prof Michael Jennings, A/Prof Mark Schembri , A/Prof Scott Beatson, Molecular & Microbial Sciences Dr Ian Shiels, Prof Stephen Taylor, Dr Trent Woodruff, Department of Physiology & Pharmacology Dr David Liu, A/Prof Xiu Li, A/Prof Michael QZ Sheng, School of Information Technology and Electrical Engineering Prof April Wright, School of Business Dr Zephanie Tyack, Dr Kellie Stockton, UQ-Child Health Research Centre Prof David Reutens, Dr Hana Burianová, Centre for Advanced Imaging Dr Nana Sunn, Dr Antje Blumenthal, Prof David Evans, Diamantina Institute Dr Andreas Obermair, Queensland Centre for Gynaecological Cancer Prof Michael Roberts, Dr Greg Medley, Dr Sheree Cross, Dr Thomas Robertson, Therapeutics Research Unit The University of Queensland A/Prof Graham Nimmo Queensland Health Pathology Service Prof Claire Rickard, Dr Li Zhang, School of Nursing & Midwifery Prof Paul Scuffham, Centre for Applied Health Economics Alliance for Vascular Access Teaching and Research (AVATAR) Griffith University Dr Peter Kruger, Prof Bala Venkatesh, Dr Geoff Playford, Dr Rob Eley, ICU Princess Alexandra Hospital Prof John Fraser, A/Prof Kiran Shekar, Dr Fran Kinnear The Prince Charles Hospital Dr James Lind, Dr Jonathan Field, A/Prof Gerben Keijzers Gold Coast Hospital Dr Phillip Cowlishaw Mater Hospital Dr Christopher Hammet, Cardiology Dr William Parsonage, Cardiology Dr Jonny Younger, Cardiology Dr Jacobus Ungerer, Chemical Pathology Dr John Cardinal, Chemical Pathology Dr Carel Pretorius, Chemical Pathology Dr Brett McWhinney, Chemical Pathology Ms Jill Tate, Pathology Queensland A/Prof Mark Coulthard, Paediatrics and Child Health Dr Helen Healy, Renal Medicine Dr Adrian Kark, Renal Medicine Dr Dwarka Ranganathan, Renal Medicine

Prof Rob Fassett, Renal Medicine Dr Vincent D'Intini, Renal Medicine Dr Queenie Lau, Pathology Dr Thomas Robertson, Pathology Dr Merrilyn Banks, Nutrition and Dietetics Dr Lynda Gillen, Nutrition and Dietetics Dr Lynda Ross, Nutrition and Dietetics A/Prof Cliff Pollard, Queensland Trauma Registry Dr R Webb, Hyperbaric Medicine Dr A Bourke, Hyperbaric Medicine Dr P Atkinson, Hyperbaric Medicine Dr D King , Hyperbaric Medicine Dr Alison Mudge, Internal Medicine and Aged Care Dr Peter Donovan, Ms Prue McCrae, Aged Care Dr Caroline Acton, Oral and Maxillofacial Surgery Prof Graeme Dickie, Radiation Oncology Dr Craig Readdy, Medical Imaging Dr Tracey Comans, Physiotherapy Dr Renuka Sekar Dr Tim Donovan Royal Brisbane and Women’s Hospital Prof Gerry FitzGerald, Dr Jannah Baker, Dr Monika Janda, School of Public Health Prof Zee Upton, School of Life Sciences Prof Kerrie Mengersen, Mathematical Sciences Prof Fiona Coyer, School of Nursing A/Prof Carol Windsor, Dr Karen Sullivan Queensland University of Technology Dr Jurgen Fripp CSIRO Image Analysis Team The Australian eHealth Research Centre Dr Jee Poh, Dr Isabelle Tham Logan Hospital Dr Matthew Howes Mater Mother’s Hospital Dr Steve Rashford Queensland Ambulance Service

COLLABORATORS

Dr David McMillan, Bacterial Pathogenesis Laboratory A/Prof David Whiteman, Cancer Control Group Prof Grant Montgomery, Molecular Epidemiology Laboratory Dr D Reid, Respiratory Physician Lutz Krause, Bioinformatics QIMR Berghofer Medical Research Institute Dr Mark Elcock Retrieval Services Queensland Dr David Cooksley Royal Brisbane and Women’s Hospital Squadron Leader Australian Defence Force Dr Tim Warhurst Redcliffe Hospital Dr Nai An Lai QEII Jubilee Hospital Dr Indranil Chatterjee Toowoomba Hospital Dr Kylie Baker Ipswich Hospital Prof Dennis Shanks Australian Army Malaria Research Institute, Gallipoli Barracks, Enogerra

NATIONAL A/Prof Jon Iredell, Prof Tania Sorrell, Dr Heather Giddings Dr Catriona Halliday, Dr John Gallagher, Dr Vineet Nayyar Westmead Hospital, Sydney A/Prof David Tuxen, A/Prof Carlos Scheinkestel, Dr Andrew Davies, A/Prof Denis Spelman, Dr Alex Padiglione, A/Prof Anne Holland, Dr Carol Hodgson Prof Russell Gruen, National Trauma Research Institute The Alfred Hospital, Melbourne Prof Rinaldo Bellomo, Dr Sue Berney, Prof Lindsay Grayson Dr Barrie Mayall, Dr Glenn Eastwood Austin & Repatriation Hospital, Melbourne Prof John Myburgh, Prof Simon Finfer, Dr Manoj Saxena The George Institute for International Health, Sydney Dr Joshua Davis Menzies School of Health Research, Darwin Prof Steve Webb, Dr Geoff Dobb, Dr Paul Ingram, Dr KM Ho, Dr Andrew Heard, Dr Richard Riley, Dr Matt Rawlins Royal Perth Hospital A/Prof Debbie Marriott, Dr Sam Rudham St Vincent’s Hospital, Sydney

Dr Shane Patman Notre Dame University, Perth Dr Dianne Stephens Royal Darwin Hospital, NT Dr David Cooper Royal Hobart Hospital, TAS Dr Frank van Haren, Ms Margot Green, Dr Marta Kot Canberra Hospital, ACT Elizabeth Skinner Monash Medical Centre, Melbourne Dr Reny Segal Royal Melbourne Hospital Prof Carl Kirkpatrick, Pharmacy & Pharmaceutical Sciences Dr Carol Hodgson, Public Health & Preventive Medicine Dr Cornelia Landersdorfer, Centre for Medicine Use & Safety Dr Philip Bergen, Centre for Medicine Use & Safety Prof Jamie Cooper, Prof Rinaldo Bellomo, Ms Lynne Murray Prof Steve Webb, Dr Carol Hodgson, Ms Lorraine Little, Prof Alistair Nichol, Mr Tony Trapani, ANZIC Research Centre Prof Kim Bennell, Prof Janet McCalman, Prof Linda Denehy, A/Prof Sue Berney, Prof S Paul Monash University Dr Chris Acott Royal Adelaide Hospital Prof Nick Taylor La Trobe University, Melbourne Dr George Kotsiou Royal North Shore Hospital, Sydney Dr David Noble Biodevices International Pty Ltd., Victoria Dr David Irving, Dr Denese Marks, Research and Development Australian Red Cross Blood Service, NSW Dr Barry Dixon St Vincent’s Hospital, Melbourne Dr Charudatt Shirwadkar Blacktown Hospital, NSW Dr Milind Sanap, Dr Peter Thomas Lyell McEwin Hospital, Adelaide Dr David Durham Flinders Medical Centre, Adelaide Dr Stuart Baker, A/Prof David Mountain Sir Charles Gairdner Hospital, Perth

60

Dr Jason Fletcher Bendigo Hospital Bendigo, Victoria

Dr Neil Orford, Dr Claire Cattigan Geelong Hospital, Victoria Dr Rob Cameron Gosford Hospital Dr David Gattas Royal Prince Alfred Hospital Dr Andrew Cheung St George Hospital, Sydney Dr Martin Sterba Wollongong Hospital A/Prof Sandra Peake ANZICS Clinical Trials Group Prof Antonio Celenza, A/Prof Tim Inglis, Prof Simon Brown, Prof Michael Paech The University of Western Australia Dr Anne Leditschke Australian National University & Canberra Hospital Prof Michael Paech King Edward Memorial Hospital

INTERNATIONAL

Prof Charles Gomersall, Prof Gavin Joynt, Dr Gordon Choi Anaesthesia & Intensive Care Chinese University of Hong Kong Prof Michael Irwin Department of Anaesthesiology The University of Hong Kong Prof Mervyn Singer, Dr Alberto Corona Bloomsbury Institute of Intensive Care Medicine University College London, UK Prof Wolfgang Krueger

Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Germany Dr Noelle Lim

Dept of Anaesthesia & Surgical Intensive Care, Changi General Hospital, Singapore Prof Jordi Rello, Dr Elsa Afonso, Dr Laura Ruano Critical Care Department Hospital Vall d'Hebron, Spain Prof Satish Bhagwanjee, Ms Juan Scribante Dept of Anaesthesia University of Witwatersrand, South Africa Dr Guido Bertolini Laboratory of Clinical Epidemiology, Institute of Pharmacological Research, Italy Dr A Peter Wilson Department of Microbiology, University College London, UK Dr Martin Than Department of Emergency Medicine University of Otago, New Zealand Prof Tony Whitehouse Queen Elizabeth Hospital, Birmingham, United Kingdom Prof Jesus Rodriguez-Bano Hospital Macarena Seville, Spain Prof Dale Needham John Hopkins University, USA Dr Jürgen Bulitta College of Pharmacy University of Florida Prof Jack Iwashyna University of Michigan, USA Prof Ignacio Martin-Loaches University of Dublin, Ireland Prof Alistair Nichol National University of Ireland Prof M Kollef Washington University, Missouri, USA Prof George Drusano Ordway Research Institute, New York, USA Dr Shahed Omar Baragwanath Hospital, South Africa Dr Dick Dinsdale, Dr Paul Young Wellington Regional Hospital Wellington, New Zealand

COLLABORATORS

Dr Colin McArthur, Dr Shay McGuinness Auckland City Hospital, New Zealand Dr Seton Henderson Canterbury District Health Board, New Zealand Dr Alex Kazemi Middlemore Hospital, New Zealand Dr Ross Freebairn Hawkes Bay Hospital, New Zealand Prof Alan Merry University of Auckland, New Zealand Prof Jamie Sleigh, Dr Rob Frengley Waikato Clinical School of Medicine, New Zealand Prof Andries Gous School of Pharmacy University of Limpopo, South Africa Dr Paul Young Wellington Regional Hospital Medical Research Institute of New Zealand, Wellington A/Prof Andrew Shorr Washington Hospital Center, USA Dr Joao Pedro Baptista Coimbra University Hospitals, Portugal Prof Paul Marik Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, USA

Dr Andrew Rhodes St George’s Healthcare NHS Trust and St George’s University of London, London, England Dr Suresh Kumar, Dr Shanthi Ratnam, Dr Zubaidah Abd Wahab Hospital Sungai Buloh, Malaysia Prof George Dimopoulos, Aglaia Xristodoulou Attikon University Hospital, Athens, Greece Dr Murat Akova, Dr Arife Özveren Hacettepe University Hospital, Turkey Prof Matteo Bassetti Ospedale, San Martino, Genova, Italy

Prof Philippe Montravers Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, Université Paris VII, Paris, France Dr Claude Martin Hospital Nord, Marseille; AzuRea Group, France Prof Jan de Waele, Prof Stijn Blot, Dr Luc De Crop Ghent University Hospital, Ghent, Belgium Colonel Rob Russell Royal Centre for Defence Medicine, Birmingham, UK. Prof Derek Angus University of Pittsburgh, USA Prof Kathy Rowan UK Intensive Care National Audit and Research Centre London, England Colonel Jeff Bailey, Colonel Todd Rasmussen US Army Institute of Surgical Research Lieutenant Commander Travis Polk US Navy NATO Role 3 Hospital, Kandahar, Afghanistan Dr Christopher McCoy, Dr John Marshall, Dr Daniel Dalmor Beth Israel Deaconess Medical Centre Boston, USA Dr Fabio Taccone Erasme Hospital, Free University of Brussels Dr Antonio Margarit Ribas Hospital Nostra Senyora de Meritxell, Escaldes-Engordany, Andorra Prof Ioannis Pneumatikos, Dr Vassiliki Theodorou, Dr Georgios Kouliatsis, Dr Stylianos Fotakis, Dr Elias Christoforidis University Hospital of Alexandroupolis, Greece Prof Otto Frey Heidenheim Hospital, Heidenheim, Germany Nicole Salazar, Jana Stojanova, Leslie Escobar, Marcial Cariqueo Santiago, Chile Ramona Hopkins Brigham University USA Dr Geetha Kayambu National University Hospital, Singapore Prof Alice Jones Hong Kong Polytechnic University Dr Georgios Anthopoulos, Dr George Choutas, Dr Thanos Rantis 251 Air Force General Hospital of Athens, Greece

COLLABORATORS

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Dr Stylianos Karatzas, Dr Margarita Balla, Dr Metaxia Papanikolaou, Dr Efstratios Mainas General Hospital of Athens ‘Hippokrateion’, Greece Prof Pavlos Myrianthefs, Dr Alexandra Gavala, Prof Georgios Fildisis Aghioi Anargyroi Hospital, Athens, Greece Prof Antonia Koutsoukou, Dr Magdalini Kyriakopoulou, Dr Kalomoira Petrochilou Sotiria General Hospital, Athens, Greece Dr Maria Kompoti, Dr Martha Michalia, Dr Fillis-Maria Clouva-Molyvdas Thriassio General Hospital of Eleusis, Athens, Greece Dr Georgios Gkiokas, Dr Fotios Nikolakopoulos, Dr Vasiliki Psychogiou Aretaieion University Hospital, Athens, Greece Prof Dimitrios Georgopoulos, Dr Polychronis Malliotakis, Dr Evangelia Akoumianaki, Dr Emmanouil Lilitsis, Dr Charalampos Psarologakis University Hospital Herakleion, Crete, Greece Prof Vassilios Koulouras, Prof George Nakos, Dr Mihalis Kalogirou, Dr Athanasios Papathanasiou University Hospital of Ioannina, Ioannina, Greece Dr Apostolos Komnos, Dr Tilemachos Zafeiridis, Dr Achilleas Chovas, Dr Panagiotis Papamichalis General Hospital of Larissa, Larissa, Greece Dr Kostoula Arvaniti, Dr Dimitrios Matamis, Dr Christos Chaintoutis General Hospital of Thessaloniki ‘G. Papageorgiou’, Greece Dr Christina Kydona, Dr Nikoleta Gritsi-Gerogianni, Dr Tatiana Giasnetsova General Hospital of Thessaloniki ‘Hippokrateion’, Greece Dr Maria Giannakou-Peftoulidou, Dr Ioanna Soultati, Dr Ilias Chytas, Dr Eleni Anastasiou, Dr Aikaterini Efthymoiu AHEPA University Hospital, Thessaloniki, Greece Dr Eleni Antoniadou, Dr Elli Antipa, Dr Dimitrios Lathyris General Hospital ‘G. Gennimatas’, Thessaloniki, Greece Dr Triantafyllia Koukoubani, Dr Theoniki Paraforou, Dr Kyriaki Spiropoulou General Hospital of Trikala, Greece Dr Vasileios Bekos, Anna Spring RN, Theodora Kalatzi RN, Georgia-Laura Panagou RN Naval Hospital of Athens, Greece Dr Hara Nikolaou, Dr Maria Laskou, Dr Ioannis Strouvalis Aghia Olga-Konstantopouleion General Hospital, Athens, Greece Dr Stavros Aloizos, Dr Spyridon Kapogiannis, Dr Ourania

Soldatou General Hospital of Athens ‘NIMITS’, Greece Dr Herbert Spapen Universitair Ziekenhuis Brussels, Belgium Dr Joost Wauters Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium Dr Thierry Dugernier Clinique Saint Pierre, Ottignies, Belgium Dr Philippe Jorens Universitair Ziekenhuis Antwerpen, Edegem, Belgium Dr Ilse Dapper Algemeen Ziekenhuis Monica, Deurne, Belgium Dr Francisco Alvarez-Lerma, Dr Maria Pilar Gracia-Arnillas, Dr Sonia Luque Hospital Del Mar, Barcelona, Spain Dr Francisco Fernández Centro Médico Delfos, Barcelona, Spain Dr Neus Feijoo, Dr Neus Bardolet, Dr Assumpta Rovira Hospital General de L’Hospitalet, Barcelona, Spain Dr Pau Garro, Dr Diana Colon Hospital General de Granollers, Barcelona, Spain Dr Carlos Castillo, Dr Juan Fernado Hospital Txagorritxu, Vitoria, Spain Dr Maria Jesus Lopez, Dr Jose Luis Fernandez, Dr Ana Maria Arribas Hospital Universitario de Burgos, Spain Dr Jose Luis Teja, Dr Elsa Ots Hospital Universitario Marques de Valdecilla, Santander, Spain Dr Juan Carlos Montejo, Dr Mercedes Catalan Hospital Universitario 12 de Octubre, Madrid, Spain Dr Isidro Prieto, Dr Gloria Gonzalo Hospital Ramon y Cajal, Madrid, Spain Dr Beatriz Galvan Hospital Universitario La Paz, Madrid, Spain Dr Miguel Angel Blasco, Dr Estibaliz Meyer, Dr Frutos Del Nogal Hospital Universitario Severo Ochoa, Madrid, Spain Dr Loreto Vidaur, Dr Rosa Sebastian, Dr Pila Marco Garde Hospital Universitario de Donostia, Donostia, Spain Dr Maria del Mar Martin Velasco Hospital Universitario Nuestra Señora de Candelaria, Spain

Dr Rafael Zaragoza Crespo Hospital Universitario Dr. Peset, Spain Prof Mariano Esperatti, Prof Antoni Torres Institut Clínic del Tòrax, Hospital Clinic, Barcelona, Spain; Centro de Investigación Biomedica En Red- Enfermedades Respiratorias (CibeRes). Prof Stephan Harbarth, Prof Angela Hunter University Hospital of Geneva, Switzerland Prof Rishi Dhillon University Hospital of Wales , Wales Prof Olivier Baldesi Centre Hospitalier Pays D Aix, Aix en Provence; AzuRea Group, France Prof Herve Dupont Centre Hospitalier Universitaire d'Amiens, Amiens, France Prof Yazine Mahjoub Centre Hospitalier-Universitaire d'Amiens; AzuRea Group, France Prof Sigismond Lasocki Centre Hospitalier-Universitaire d'Angers, France Prof Jean Michel Constantin Centre Hospitalier Universitaire de Clermont-Ferrand; AzuRea Group, France Prof Jean François Payen Centre Hospitalier-Universitaire Grenoble; AzuRea Group, France Prof Jacques Albanese Hopital Nord, Marseille; AzuRea Group, France Prof Yannick Malledant Hôpital Pontchaillou, Rennes, France Prof Julien Pottecher University Hospital, Strasbourg; AzuRea Group, France Prof Jean-Yves Lefrant , Dr Claire Roger Centre Hospitalier-Universitaire Nimes; AzuRea Group, France Prof Samir Jaber Hospitalier-Universitaire Montpellier; AzuRea GroupFrance Prof Olivier Joannes-Boyau Centre Hospitalier-Universitaire Bordeaux; AzuRea Group, France Prof Christophe Orban Centre Hospitalier-Universitaire Nice; AzuRea Group, France Prof Francesca Rubulotta, Prof Anthony Gordon Charing Cross Hospital, London, United Kingdom

Dr George Ntoumenopolous, Dr Marlies Ostermann, Prof Catherine McKenzie, Prof William Berry, Prof John Smith, Prof Katie Lei St Thomas' Hospital, London, United Kingdom Prof Stephen Brett Hammersmith Hospital, Imperial Healthcare NHS Trust, London, United Kingdom Prof Martin Stotz, Prof Maie Templeton St Mary's Hospital, Imperial Healthcare NHS Trust, London, United Kingdom Prof Claudia Ebm, Prof Carl Moran St George's Hospital, St George's Healthcare NHS Trust, London, United Kingdom Dr Kirsi-Maija Kaukonen, Dr Ville Pettilä Helsinki University Central Hospital, Helsinki, Finland

Prof Chiara Adembri, Prof Gianluca Villa Azienda Ospedaliero Universitaria Careggi, Florence, Italy Prof Antonio Giarratano, Prof Santi Maurizio Raineri, Prof Andrea Cortegiani, Prof Francesca Montalto, Prof Maria Strano Università degli Studi di Palermo, Palermo, Italy Prof V. Marco Ranieri, Prof Rosario, Prof Urbino Ilaria Mastromauro, Prof Francesco G. De Rosa Universitaria San Giovanni-Battista Molinette, Turin, Italy Prof Claudio Sandroni, Prof Gennaro De Pascale Catholic University School of Medicine, Rome, Italy Prof Alexandre Molin, Prof Paolo Pelosi University of Genoa, Genoa, Italy Prof Luca Montagnani Universitaria San Martino, Genova, Italy Prof Federico Pea University of Udine, Udine, Italy Prof Teresa Cardoso Hospital de Santo António, Porto, Portugal Prof Susana Afonso Hospital de St António dos Capuchos, Lisbon, Portgual Prof João Gonçalves-Pereira Hospital de São Francisco Xavier, Lisbon, Portugal

COLLABORATORS

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Projects for Honours, postgraduate (Masters and PhD) and postdoctoral researchers are possible through the Burns, Trauma & Critical Care Research Centre. There is high expertise in postgraduate supervision within our research centre. The centre is also keen to support clinical staff who wish to undertake research projects. Prospective candidates can obtain further information about postgraduate study from the UQ Graduate School at https://graduate-school.uq.edu.au/home This page contains information on the various postgraduate degrees available and how to apply for each.

Postgraduate Enquiries A/Prof Jenny Paratz Honorary Research Fellow, Burns Trauma & Critical Care Research Centre Email [email protected] Dr Sia Athanasas Research Manager, Burns Trauma & Critical Care Research Centre Email [email protected] Phone 61 7 3346 5020 Fax 61 7 3346 5598

General Enquiries Dr Sia Athanasas Research Manager, Burns Trauma & Critical Care Research Centre Email [email protected] Phone 61 7 3346 5020 Fax 61 7 3346 5598 Postal Address Burns Trauma & Critical Care Research Centre Level 8, UQ Centre for Clinical Research (UQCCR) Royal Brisbane and Women’s Hospital QLD, Australia, 4029 www.btccrc.centre.uq.edu.au

ENQUIRIES

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