Who appreciates ART is NO LESS than who creates it 1/12 Connective tissue neoplasms Connective tissue neoplasms: Clinically, most of the benign connective tissue tumors present as swellings which maybe indistinguishable from hyperplastic lesions Histologically, oral connective tissue tumors resemble their counterparts occurring at other sites in the body Classification of connective tissue neoplasms according to the tissue of origin : 1. Tumors of fibrous tissue 2. Tumors of adipose tissue 3. Tumors of vascular tissue 4. Tumors of peripheral nerves 5. Granular cell tumor 6. Tumors of muscles 7. Malignant lymphoma Tumors of fibrous tissue True benign neoplastic overgrowths of fibrous tissue (true fibroma) in the oral cavity are rare since clinically and histologically they can't reliably be distinguished from hyperplasias ** The term fibroma has been used inappropriately to describe reactive lesions (such as fibrous epulis and Fibroepithelial polyp) but to avoid confusion the term is best avoided except for specific entities such as the peripheral odontogenic fibroma (which is a true benign tumor) Malignant tumors (fibrosarcoma) are also rare in the oral cavity and they have a relatively good prognosis {5 year survival rate is 70%} ** Sarcoma = cancer of bone, cartilage, fat, muscles or blood vessels ** Sarcomas show the cytological malignant features of cellular and nuclear pleomorphism, mitotic figures and Hyperchromatism Other lesions of fibrous tissue: Fibrous histiocytoma There is disagreement amongst pathologists as to whether this benign soft tissue lesion represents a true neoplasm, a developmental defect, or a reactive process. Cells in here show fibroblastic and histiocytic differentiation. These tumors have unpredictable behavior from locally aggressive to malignant. They are rare in the oral cavity and if they occur, they arise on the buccal mucosa and vestibule
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Who appreciates ART is NO LESS than who creates it
1/12
Connective tissue neoplasms
Connective tissue neoplasms:
Clinically, most of the benign connective tissue tumors present as swellings which maybe
indistinguishable from hyperplastic lesions
Histologically, oral connective tissue tumors resemble their counterparts occurring at other sites in the body
Classification of connective tissue neoplasms according to the tissue of origin:
1. Tumors of fibrous tissue
2. Tumors of adipose tissue
3. Tumors of vascular tissue
4. Tumors of peripheral nerves
5. Granular cell tumor
6. Tumors of muscles
7. Malignant lymphoma
Tumors of fibrous tissue
True benign neoplastic overgrowths of fibrous tissue (true fibroma) in the oral cavity are rare since
clinically and histologically they can't reliably be distinguished from hyperplasias
** The term fibroma has been used inappropriately to describe reactive lesions (such as fibrous epulis
and Fibroepithelial polyp) but to avoid confusion the term is best avoided except for specific entities
such as the peripheral odontogenic fibroma (which is a true benign tumor)
Malignant tumors (fibrosarcoma) are also rare in the oral cavity and they have a relatively good
prognosis {5 year survival rate is 70%}
** Sarcoma = cancer of bone, cartilage, fat, muscles or blood vessels
** Sarcomas show the cytological malignant features of cellular and nuclear pleomorphism,
mitotic figures and Hyperchromatism
Other lesions of fibrous tissue:
Fibrous histiocytoma There is disagreement amongst pathologists as to whether this benign soft
tissue lesion represents a true neoplasm, a developmental defect, or a reactive process. Cells in
here show fibroblastic and histiocytic differentiation. These tumors have unpredictable behavior
from locally aggressive to malignant. They are rare in the oral cavity and if they occur, they arise
on the buccal mucosa and vestibule
Who appreciates ART is NO LESS than who creates it
2/12
Nodular fasciitis This benign soft tissue lesion represents a reactive non-neoplastic process
BUT the cause is still unknown. It is rapidly-growing but self-limiting and it may be mistaken
for a fibrosarcoma histologically. It is rare in the oral cavity
Peripheral odontogenic fibroma It is an uncommon gingival mass. It can be confused
with peripheral ossifying fibroma (fibrous epulis). In contrast to the peripheral ossifying
fibroma, the peripheral odontogenic fibroma is a rare lesion. It present clinically as slowly
growing, solid, firmly attached gingival mass sometimes arising between teeth and sometimes
displacing teeth. It consists of cellular fibrous connective tissue with non-neoplastic islands of
odontogenic epithelium
Fibromatosis This term refers to a group of non-neoplastic infiltrating fibrous proliferations
with a biologic behavior and microscopic appearance intermediate between those of true
fibromas and fibrosarcomas. They have certain characteristics in common, including: absence of
cytological & clinical malignant features, histological proliferation of well-
differentiated fibroblasts, an infiltrative growth pattern, and aggressive clinical behavior with
frequent local recurrence
** Aggressive fibromatosis: it is a rare slowly growing proliferation that is locally aggressive and
doesn't show any metastatic potential. It can damage nearby structures causing organ dysfunction.
Approximately 10% of individuals with Gardner's syndrome have such tumors. Histologically it
resembles low-grade fibrosarcomas but it is very locally aggressive and tends to recur even after