2. CND

Compounding Capsules

Richie A. I. Chandra, S.Farm., M.Sc., Apt

Introduction

Capsule (USP) :

A solid dosage form some which the dragees enclosed withan either hard or soft soluble container or shell.

Contemporary Physician Group Practice20 S Park Street Triturate, WI 53706Tel : (608) 555 1333 Fax : 555-1335

Name : Jacob Date : 12-01-2011Addres : P02 Alba Street Age : 17

R/ Theophylline 118mgEphedrine Sulfate 24mgPhenobarbital 8mgDisperse capsulae #6

Sig 1 – 2 q4 has pain breathing

E. S Clyde, MDRefill 4 times

Contemporary Physician Group Practice20 S Park Street Triturate, WI 53706Tel : (608) 555 1333 Fax : 555-1335

Name : Jacob Date : 12-01-2011Addres : P02 Alba Street Age : 17

R/ Theophylline 118mgEphedrine Sulfate 24mgPhenobarbital 8mgDisperse capsulae #6

Sig 1 – 2 q4 has pain breathing

E. S Clyde, MDRefill 4 times

Richie A. I. Chandra

Calculation

Theophyllin ???

Ephedrine ???

Phenobarbital ???

Please note the minimal of weight in compounding process.Which used the best for calculation on the preparation of oneadditional capsules

Phenobarbital ???

Additional ??? Capsules size

Richie A. I. Chandra

Mixing

Theophyllin

Ephedrine

PhenobarbitalGeometrically mix and triturate

Additional

Punch Capsules

Richie A. I. Chandra

Weigh Capsule on Torsion balance

If you using a torsion balance part the weigh ensure that thebalance is clean, level on zero

Then place an empty capsule shell of the same size you areusing to punch the capsule on the left hand pan of thebalance, and dial in the selected weight for the content ofyour capsule.

Richie A. I. Chandra

Should the weight for the content of your capsule be lessthan the selected target weight, as indicate in this slide, thenlock the torsion balance and remove the capsule from theweighing pan

Should the weight for the content of your capsule be lessthan the selected target weight, as indicate in this slide, thenlock the torsion balance and remove the capsule from theweighing pan

Then separate cap from the body oh this capsule, punch amore powder into the body of the capsule slightly recaps thenreweight

Richie A. I. Chandra

Should the weight for the content of your capsule be morethan the selected target weight, as indicate in this slide, thenlock the torsion balance and remove the capsule from theweighing pan

Once again separate cap from the body oh this capsule, thistime empty a small amount of the powder from the body ofthe capsule slightly recaps then reweight

Once again separate cap from the body oh this capsule, thistime empty a small amount of the powder from the body ofthe capsule slightly recaps then reweight

Continue this process of adding and removing powder fromeach capsule into the pointer align with the sign of markingon the scale as indicated here, indicating that the targetweight has been attained

Richie A. I. Chandra

Weigh Capsule on Digital balance

If you using a electronic balance part the weight as with thetorsion balance ensure that the balance is clean and level

Then place a small weighboard and the single gelatincapsule of the same size you are using to punch the capsuleon the weighing surface

Then tare the balance

Remove the empty gelatin capsule from the weighboard andreplace with the punch capsule

Richie A. I. Chandra

Should the content of the capsule weight less than desiretarget weight, then remove the capsule from the scale.

Remove the caps of the capsule from the body, punch inmore powder, gently recap then reweight

Richie A. I. Chandra

Should the content of the capsule weight more than desiretarget weight, again remove the capsule from the scale.

Remove the caps of the capsule from the body, empty outsome of the powder from body of the capsule, gently recapthen reweight

Continue this process of adding and removing powder fromthe capsule until the desired weight is attained

Richie A. I. Chandra

Continue punching all capsules

Continue punching and weighing each individual capsule untilall of the capsule have been prepared

Inspect the final capsule for esthetic appearance and polishthem using a clean wipe if necessaryInspect the final capsule for esthetic appearance and polishthem using a clean wipe if necessary

Finally packed the capsule into properly size prescriptioncontainer to be labeled an dispensed

Richie A. I. Chandra

Prescription LabelsPractical Pharmacy

314 N Park Street Triturate, WI 53706Tel : (608) 555 1200 Fax : 555-1210

RX : 836 Pharmacist : Claire Date : 13-01-2011Jacob Doctor : Clyde

Take one or two capsules by mouth every four hours asneeded for breathing

Theophylline …mg, Ephedrine ….mg, and Phenobarbital …mgCapsule

Quantity :6 (discard after 6 month)Refill 4 times

Practical Pharmacy314 N Park Street Triturate, WI 53706Tel : (608) 555 1200 Fax : 555-1210

RX : 836 Pharmacist : Claire Date : 13-01-2011Jacob Doctor : Clyde

Take one or two capsules by mouth every four hours asneeded for breathing

Theophylline …mg, Ephedrine ….mg, and Phenobarbital …mgCapsule

Quantity :6 (discard after 6 month)Refill 4 times

Richie A. I. Chandra

Prescription documentation

Please make note the following items documented by thepharmacist on the prescription hardcopy

Write amount lactose that incorporated into each capsuleWrite amount lactose that incorporated into each capsule

Write Rx number, pharmacist name, the day date fill and thesize and colour of capsule used in the compound have beenrecord

Richie A. I. Chandra

Patient consultation

??????????????????

Richie A. I. Chandra

Compounding Suspension

Richie A. I. Chandra, S.Farm., M.Sc., Apt

Introduction

Suspension (USP) :

Liquid preparation consist of solid particle disperse to liquidphase in which the particles are not soluble.

Contemporary Physician Group Practice20 S Park Street Triturate, WI 53706Tel : (608) 555 1333 Fax : 555-1335

Name : Jacob Date : 19-03-2012Addres : P02 Alba Street Age : 17

R/ HCT 25mg/5mLMethylcellulose q.s

m.f suspension 60 mLSig 5 mL per NG tube b I d

E. S Clyde, MDRefill 11 times

Contemporary Physician Group Practice20 S Park Street Triturate, WI 53706Tel : (608) 555 1333 Fax : 555-1335

Name : Jacob Date : 19-03-2012Addres : P02 Alba Street Age : 17

R/ HCT 25mg/5mLMethylcellulose q.s

m.f suspension 60 mLSig 5 mL per NG tube b I d

E. S Clyde, MDRefill 11 times

Richie A. I. Chandra

Calculation

Since the prescription instruct to prepare 60mL of suspensionat concentration of 25mg/5mL, we can easily calculate theamount of HCT required for the prescription to be 300mg

Weigh the recommended suspending agent, 1,5 – 2%Weigh the recommended suspending agent, 1,5 – 2%

Finnaly, by selecting sodium benzoate as a preservative atconcentration 0,2%, we can calculate 1,2 g of sodiumbenzoate would be needed

Richie A. I. Chandra

Mixing

Selecting to use comercially available 50 mg HCT, we canagain easily determine that 6 of 50 mg tablet would benecessary to prepare the prescription

Combine the sodium benzoate and methylcellulose with HCTpowder residing in the mortarCombine the sodium benzoate and methylcellulose with HCTpowder residing in the mortar

Richie A. I. Chandra

1. Obtain HCT Tablet

a. The first step in the procedure is to obtain six 50 mg HCTtablet

b. These tablet would then added to mortarb. These tablet would then added to mortar

2. Crush tablet using trituration

The tablet then crush using trituration until a very fine powder

Richie A. I. Chandra

3. Weighing suspending agent

a. The next step is to accurately weigh 120 mg ofpreservative, sodium benzoate

b. Then we must weigh the recommended suspending agent,Citrucel in this example is 2g for 60 mL of suspensionb. Then we must weigh the recommended suspending agent,Citrucel in this example is 2g for 60 mL of suspension

4. Geomtrically mix powder ingredients

Next combine the sodium benzoat and citrucel with the crushHCT powder residing the mortar, mix until uniform,homogenous.

Richie A. I. Chandra

5. Form primary suspension

In this point, gradually add approximately 40 mL of purifiedwater to the mixture

6. Transfer the suspension to the bottle

Now transfer these primary suspension into 60mLprescription bottle

Richie A. I. Chandra

7, Rinse mortar with purified water

a. Using a small amount of purified water, rinse the mortarthroughly with channel trituration in order to retrieve anyresidue product remaining in the mortar

a. Using a small amount of purified water, rinse the mortarthroughly with channel trituration in order to retrieve anyresidue product remaining in the mortar

b. Then transfer the rinsing to the prescription bottle

c. Use purified water to qs the product to the 60 mL mark onthe prescription bottle

Richie A. I. Chandra

8. Cap bottle and shake vigorously

a. Cap the prescription bottle seecurely

b. Shake vigorously to ensure that the suspension iscompletely mixedb. Shake vigorously to ensure that the suspension iscompletely mixed

c. The prescription is now ready to be labeled and dispensed

Richie A. I. Chandra

Prescription LabelsPractical Pharmacy

314 N Park Street Triturate, WI 53706Tel : (608) 555 1200 Fax : 555-1210

RX : 836 Pharmacist : Claire Date : 19-03-2012Jacob Doctor : Clyde

Give five mL of syrup through the NGT twice daily, then rinsetube with water

Hidroclorthiazid 25 mg/ 5 mL

Quantity :6o mL (discard after 14 days)Refill 11 times

Practical Pharmacy314 N Park Street Triturate, WI 53706Tel : (608) 555 1200 Fax : 555-1210

RX : 836 Pharmacist : Claire Date : 19-03-2012Jacob Doctor : Clyde

Give five mL of syrup through the NGT twice daily, then rinsetube with water

Hidroclorthiazid 25 mg/ 5 mL

Quantity :6o mL (discard after 14 days)Refill 11 times

Richie A. I. Chandra

Prescription documentation

Please make noted the following items documented by thepharmacist on the prescription hardcopy

Write amount lactose that incorporated into each capsuleWrite amount lactose that incorporated into each capsule

Write Rx number, pharmacist name, the day date fill and thesize and colour of capsule used in the compound have beenrecord

Richie A. I. Chandra

Patient consultation

??????????????????

Richie A. I. Chandra