Figure (1): NO production by Dextran coated vs. Lipid coated SPIO particles in Macrophages-24 h SPIO-4 SPIO-2 SPIO-3 Control 0.0 0.1 0.2 0.3 SPIO-4 SPIO-2 SPIO-3 Control OD550 (Nitrite level)
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Figure (1): NO production by Dextran coated vs. Lipid coatedSPIO particles in Macrophages-24 h
SPIO-4SPIO-2 SPIO-3 Control0.0
0.1
0.2
0.3
SPIO-4
SPIO-2SPIO-3
Control
OD
550
(Nitr
ite le
vel)
10.0 5.0 2.5 1.3 0.6 0.00
1
2
3
4
ug/mL FITC SPIO
AFU
/wel
l S
D
Figure (3) A: macrophages harvested from mice injected with FITC-SPIO show intracellular fluorescence. The same panel stained with DAPI to show nuclear stain and viability. B: Circulating monocyte, shows iron particles (arrow), after the injection of SPIO.
A B
Dark (negatively enhanced) aortic wall, full of iron particles
Bright aortic lumen and wall without negative enhancement and no significant number of iron particles in pathology
Before Injection After Injection (5 Days )
Apo E Deficient mouse
C57B1 (control) mouse
Figure 7:
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