S1 SUPPORTING INFORMATION. Supporting Information: An Aromatic Region to Induce a Switch between Agonism and Inverse Agonism at the Ghrelin Receptor Sylvia Els, Enrico Schild, Pia Steen Petersen, Tom-Marten Kilian, Jacek Mokrosinski, Thomas M. Frimurer, Constance Chollet, Thue W. Schwartz, Birgitte Holst, Annette G. Beck-Sickinger SYNOPSIS TOC: Supporting Information (SI) containing the analytical data of the synthesized peptides and pair wise alignment for computational modeling is available online (Table S1 and Figure S1). Table S1. Analytical data of synthesized peptides. No Peptide mass calc (Da) mass exp (Da) [M+H] + %B a %B b purity 1 Ghrelin 3368.9 3369.8 37.4 41.0 > 95% 2 KwFwLL-NH 2 890.5 891.6 52.0 55.5 > 95% 3 K-(D-1-Nal)-FwLL-NH 2 901.7 902.5 54.1 57.5 > 95% 4 K-(D-Bth)-FwLL-NH 2 907.7 908.4 53.8 57.3 > 95% 5 K-(D-Dip)-FwLL-NH 2 927.7 928.5 55.3 59.1 > 95% 6 K-(D-2-Nal)-FwLL-NH 2 901.7 902.6 54.0 57.4 > 95% 7 K-(D-Bpa)-FwLL-NH 2 955.7 956.6 54.6 58.0 > 95% 8 K-(D-Bip)-FwLL-NH 2 927.7 928.6 56.1 59.6 > 95% 9 K-(D-Phe)-FwLL-NH 2 851.5 852.5 51.1 54.9 > 95% 10 K-(D-tBf)-FwLL-NH 2 907.7 908.6 55.9 60.6 > 95% 11 K-(D-Trp(Me))-FwLL-NH 2 904.7 905.5 53.1 56.6 > 95% 12 K-(D-1-Nal)-(Cha)-wLL-NH 2 907.9 908.6 56.3 60.9 > 95% 13 K-(D-1-Nal)-(D-Phe)-wLL-NH 2 901.7 902.6 49.1 52.9 > 95% 14 K-(D-1-Nal)-(L-tBf)-wLL-NH 2 957.9 958.7 58.9 63.1 > 95% 15 K-(D-1-Nal)-(L-Nva)-wLL-NH 2 853.8 854.7 51.4 55.5 > 95% 16 K-(D-1-Nal)-(L-Phg)-wLL-NH 2 887.8 888.6 53.0 56.6 > 95% 17 KwF-(D-2-Nal)-LL-NH 2 901.7 902.5 54.9 58.4 95% 18 KwF-(D-1-Nal)-LL-NH 2 901.7 902.7 54.9 58.3 > 95% 19 KwF-(D-Bip)-LL-NH 2 927.7 928.5 56.9 60.2 95% 20 KwF-(D-Bpa)-LL-NH 2 955.7 956.5 54.6 57.8 > 95% 21 KwF-(D-Dip)-LL-NH 2 927.7 928.7 55.6 59.4 > 95%