26-06-2013 1 phase III combined oral contraceptive trials (1950s) experience with depot medroxy-progesterone acetate (Depo-Provera ® ; Upjohn) and norethisterone enanthate (Schering, 1960s) WHO evaluation and research program (1970s) Expert WHO/NIH/Population Council consultations (from 1979) 90 days reference period Definitions Collabora’ve Study Group. Eur J Contracept Reprod Health Care 1998 90 days reference period Definitions Collabora’ve Study Group. Eur J Contracept Reprod Health Care 1998
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26-06-2013
1
phase III combined oral contraceptive trials (1950s)
experience with depot medroxy-progesterone acetate (Depo-Provera®; Upjohn) and norethisterone enanthate (Schering, 1960s)
WHO evaluation and research program (1970s)
Expert WHO/NIH/Population Council consultations (from 1979)
90 days reference period Definitions
Collabora've Study Group. Eur J Contracept Reprod Health Care 1998
90 days reference period Definitions
.
.
Collabora've Study Group. Eur J Contracept Reprod Health Care 1998
26-06-2013
2
Bleeding Patterns Shifted reference period 1
0 10 20 30 40 50 60 70 80
amenorrhoea 1-2 B/S episodes
3-5 B/S episodes
6 or more B/S episodes
prolonged
Desogestrel POP starters/switchers
30 µg LNG starters/switchers
%
Collabora've Study Group. Eur J Contracept Reprod Health Care 1998