11/09 NUR240 Urinary Tract Stressors: UTI Cystitis Urolithiasis Bladder Ca PKD ARF/CRF Joy Borrero, RN, MSN.

11/09

NUR240Urinary Tract Stressors:

UTICystitis

UrolithiasisBladder Ca

PKDARF/CRF

Joy Borrero, RN, MSN

Kidney Physiology

Primary role of kidney is regulation of fluid and electrolyte balance, additional life preserving functions include:

• Excretion of metabolic wastes-micturition• Water and salt regulation• Maintenance of acid – base balance.

http://www.kidney.org/• Regulation of BP• Stimulation of RBC production• Regulation of calcium – phosphate metabolism.

Urinary Tract

• Upper urinary tract:• Kidneys – 2 bean shaped organs,

composed of nephrons. A complex vascular system. Each weighs about 8oz.

• Ureters – extensions of the renal pelvis and empty into the bladder.

• Lower urinary tract:• Bladder, urethra and prostate gland

(males).

Renal and Urinary Terms

Azotem ia Uremia Dysuria Frequency

Hesitency Micturation Nocturia Oliguria

Polyuria Uremia Urgency Anuria

Serum creatinine

Blood urea nitrogen

BUN/Creatinine Ratio

Glomerular FiltrationRate

Assessment of Renal and Urinary Tract Systems

• History of disease or trauma• Urinary patterns• Relevant meds• Allergies• Fluid status-edema• Pruritis• BP• LOC, level of alertness• Pain assessment• Numbness and tingling of extremities• GI symptoms- anorexia, N&V, diarrhea

Urinary Tract Pain

• Kidney- dull ache in costovertebral angle and radiates to umbilicus

• Ureteral – pain in back that radiates to abdomen, upper thigh, testes and labia

• Bladder- low abdominal or over suprapubic area

• Renal Colic- flank pain radiating to lower abdomen or epigastric area, N&V

Diagnostic Tests

• IVP• CAT Scans• Renal angiography• Ultrasounds• Cystoscopy- Dx and

Tx• Renal Bx-

Open/Closed

• UA, urine electrolytes, osmolality

• C&S• Serum creatinine and

BUN• Hgb and Hct• Creatinine clearance- 24h

collection• KUB

Cystoscopy

Pre procedure: bowel prep, NPO if general anesthesia, IVF for adequate urine flow

Post procedure: BR for short period Pink tinged urine is comon, retention may

occur Pain in back, bladder spasms and a feeling

of fullnessEncourage large amts of fluids

Urinary tract infections-described by location in the tract

• UTI – dysuria, frequency, urgency• Assessment – flank pain, cloudy urine, possible

fever. WBC’s in urine.• Treatment with antibiotics:

Fluoroquinolones(Cipro), nitrofurantoin(Macrobid), Sulfonamides (Septra, Bactrim)• Prevention: void before and after sex.• Wipe front to back, showers better than baths.• No perfumes to perineal area.• Avoid sitting in wet bathing suits• Avoid pantyhose with slacks or tight clothing

UTI-Lower and Upper

• Risk Factors:• Aging • Increased incidence with DM• Increased risk of urinary stasis• Impaired immune response• Females: short urethra, cystocele, rectocele• Males: BPH• Obstructions: tumor, calculi, strictures

EBP- UTI Bundles

• Assess daily for need for catheter

• Foley bag below level of bladder

• Closed system

• Secure cath to prevent movement, tugging

• Use of smallest size catheter possible

Cystitis

• Most common UTI (superficial, bladder mucosa)

• Manifestations:dysuria, frequency, urgency, nocturia, foul odor urine, hematuria

• Older patients:nocturia, incontinence, confusion, behavioral changes, lethargy, anorexia, fever or hypothermia

Dx for cystitis

• UA

• Urine for Gram Stain

• Urine for C & S

• Evaluation of urinary tract

Interventions

Uncomplicated:1. Single dose regimen2. AntispasmodicsRecurrent or chronic1. Sulfonamides2. Antiseptics3. Analgesics4. Surgical Management

Management of Cystitis

• Increase fluid intake

• Acidify urine

• Ascorbic acid

• Avoid bladder irritants

• Antibiotics based on C&S

• Patient teaching

Upper Urinary Tract Infections

• Pyelonephritis: inflammation of kidney caused by bacterial infection following a bladder infection

• Infection begins in lower urinary tract with organisms ascending into renal pelvis

• E coli causes most cases of pyelonephritis

• Affects filtration,reabsorption and secretion = decrease in renal function

Risk Factors

• Women over age 65• Older men with prostate problems• Chronic urinary stone disorder• Spinal cord injury• Pregnancy• Congenital malformations• Bladder tumors• Chronic illness: HTN, DM, chronic cystitis• Recurrence is common

Physical Assessment

• Patient presents with acute distress

• Hx of dysuria, frequency, urgency and other signs of cystitis

• Costovertebral tenderness

• Fever, chills, nausea and flank pain

• N & V, malaise, fatigue

• Cloudy urine or hematuria

Diagnostic Assessment

• UA and C&S

• WBC with diff

• Blood Cultures

• Serum creatinine and BUN

• CRP-C-reactive protein

• ESR

• KUB, IVP

Nursing Interventions

• Pain management

• Antibiotic therapy

• Increase fluid intake

• Monitor temperature

• Provide emotional support

• Assist with personal hygiene

• Follow-up urine cultures

Assess for Complications

• Septic shock

• Renal Failure

• Hypertension

Urolithiasis

• Etiology- presence of calculi (stones) in the urinary tract, by an unknown cause

• Recurrence is increased 35-50% in pt with + family hx or if first stone occurs <25 yrs of age

• Increased incidence in males• Majority of stones (75%) are composed of Ca

oxalate or Ca phosphate• Hi doses of Vitamin C• Conditions causing urinary stasis, dehydration,

urinary retention

Physical Assessment

• Pain, obstruction, tissue trauma with secondary hemorrhage and infection

• Sharp, severe pain (renal colic) with sudden onset deep in lumbar region around to side

• N & V• Urinary frequency or dysuria• Pallor, diaphoresis• VS:• Oliguria, anuria, hematuria

Diagnostic Assessment

• UA- RBCs, WBCs, bacteria, turbidity,odor

• Serum Ca, PO4, Uric Acid levels

• Elevated serum WBC if infection is present

• KUB, IVP, Xrays, Ultrasound

Non-surgical Management

• Pain management- MSO4, NSAIDS• Antispasmotics-Ditropan, Pro-Banthine• Antiemetics- Zofran• Strain all urine- send stones for analysis• Increase fluid intake to 3000mL/day• Client education re: meds/diet

Methods of Stone Removal

• Stenting

• ESWL- Extracorporeal Shock Wave Lithotripsy

• Retrograde ureteroscopy/cystoscopy

• Percutaneous or open ureterolithotomy/pyelolithotomy/nephrolithotomy

Urinary Drainage Tubes

Ureteral Stents

• Maintain ureteral flow in pts with ureteral obstruction

• Divert urine

• Promote healing of ureter

• Maintain patency of ureter after sugery

• Temporary or permanent-inserted via nephrostomy tube, cystoscopy or open sx.

Nephrostomy Tubes

• Catheter is placed into renal pelvis for urine drainage (placed in flank area)

• Relieve obstruction, route for insertion of ureteral stent

• Drainage for when ureter doesn’t drain• Administer meds, biopsy• Never clamp a nephrostomy tube-can lead to

pyelonephritis• Never irrigate without specific order• Monitor urine output

Nursing Interventions in client education

• Restrictions based on stone analysis• Ca Phosphate- Limit foods high in animal

protein, limit Na and Ca intake• HCTZ- to increase Ca reabsorption• Ca Oxalate- Limit oxalate sources: spinach,

black tea, cocoa, beets, pecans, limit Na intake• Uric Acid: Limit foods high in purines: organ

meats, poultry, fish, gravies, red wine and sardines. Allopurinol (Zyloprim)

Assess for Complications

• Hydronephrosis

• Infection

• Ureteral obstruction

Bladder Cancer

• Etiology: about 54,000 new cases yearly, more common in >age 60

• Industrial exposure

• Long term use of Cyclophosphamide (Cytoxan) and Aziothioprine (Imuran)

• Tobacco use

• Secondary to mets

Diagnostic Assessment

• Urinalysis-presence of gross or microscopic hematuria

• Cystoscopy-Bladder-wash specimens and bladder biopsy

• CT scans and MRI –to assess for mets

Physical Assessment

• Painless hematuria- major sign

• Assess general health, exposure to cigarette smoke, harmful environmental agents

• Changes is urinary habits

Nonsurgical Interventions

• Intravesical immunotherapy- instillation into the bladder

Bacille Calmette-Guerin (BCG)

• Intravesical chemotherapy-mitomycin (Mutamycin), Doxorubicin (Adriamycin)

• Complications: bladder irritation, frequency, dysuria, contact dermatitis

• Systemic chemotherapy

Surgical Interventions

• Radiation used to reduce tumor size preop

• Cystoscopic tumor resection by excision, fulguration, laser photocoagulation

• TURBT- Transuretheral Resection of Bladder Tumor

• Simple or radical cystectomy-urinary diversion necessary (ileal conduit)

Methods of Urinary Diversion After Cystectomy

Urinary Diversion- divert urine away from kidney and leaves body via another route

1.Continent urinary diversion- ureters implanted into portion( pouch) of ileum (reservoir) for urine, stoma to abdomen

2.Incontinent diversions: ileal conduit

3.Uretersigmoidostomy

4. Bladder reconstruction, neobladder

Post-op Care

• Routine post op care including pain management

• Disturbed body image• Risk for impaired skin integrity• Assess urinary drainage• Sexual dysfunction• Pt and family education re: meds, fluids, care of

urinary diversion system• Referral to www.acs.org and local support

groups

PKDPolycystic Kidney Disease

• Congenital disorder-grapelike clusters of cysts in the nephrons, progressive

• Affects 250,00-500,000 people in the US• Men=Women• S&S: abdominal or flank pain, HTN,

nocturia, Increased abdominal girth, constipation, bloody or cloudy urine, kidney stones

• Renal insufficiency and CRF by age 50-60

Diagnostic Assessment

• UA-proteinuria, hematuria

• Urine C&S

• Rising BUN and Creatinine levels

• Decreased creatinine clearance

• Renal sonograms,CT and MRI

Interventions

• Mainly supportive- prevent renal damage from HTN, UTI, obstruction

• Pain management-caution with NSAIDS and ASA

• Antibiotic tx for UTIs• Constipation prevention• HTN control- ACE inhibitors• Diet management- Low NA, protein• Emotional support

Acute and Chronic Renal Failure

Acute renal failure (ARF)

Three causes of ARF:

• 1. Prerenal

• 2. Intrarenal (intrinsic)

• 3. Postrenal

1.Prerenal- conditions that cause decreased cardiac output: shock, CHF, pulmonary embolism, sepsis, anaphylaxis,hypotension

ARF

2. Intrarenal - caused by damage to renal tissue.

• Causes – glomeruonephritis,infection,drugs pyelonephritis, vasculitis, acute tubular necrosis (ATN), tumors

3. Postrenal- obstructions of outflow of urine: calculi, tumors, atony of bladder, urethral stricture, trauma

4 Phases of ARF

• Onset

• Oliguric

• Diuretic

• Recovery

1.Onset

ARF

Oliguric phase – urinary output decreased. Renal insult,gradual accumulation of

nitrogenous wastes (BUN and creatinine), can last hrs to 3 weeks.

• Increasing BUN, hyperkalemia, metabolic acidosis, hypocalcemia, hypermagnesemia, hyperphosphatemia.

• As plasma levels of nitrogenous wastes increase changes in:

• Oxygenation, metabolism, immune response, perception and coordination result.

ARF

3.Diuretic phase – high output phase, up to 10L/day. This phases lasts 1 – 2 weeks.

4.Recovery phase – begins when BUN stabilizes at normal, client begins to return to normal activities.

• The mortality rate for ARF- greater than 50% and for those requiring dialysis, between 60 -90%

• Prerenal is the most common cause and is usually reversible with prompt interventions

ARF

• Lab findings• Drug therapy –

prerenal – fluid challenges and diuretics used to promote perfusion.

• Oliguric phase – dopamine- small dose, continuous renal perfusion.

Test Normal Range

Serum Creatinine

0.6-1.2mg/dL

Serum BUN

10-20mg/dL

24hr Urine

Creatinine

Clearance

80-140mL/min

ARF

• Diet – high calorie diet needed for catabolic state, if client cannot eat enough, then TPN is considered.

• During the oliguric phase of ARF, the following diagnoses may apply :

• High risk for fluid volume excess

• High risk for injury

• High risk for altered nutrition.

ARF- Physical Assessment

1.Prerenal – hypotension, tachycardia, decreased cardiac output and CVP, decreased urine output and lethargy.

2. Intrarenal and postrenal-:

• Renal – oliguria or anuria

• Cardiac- hypertension, tachycardia, JVD, increased CVP, peripheral edema, efffusions,

ARF- Assessment

• Respiratory – SOB, orthopnea, crackles, pulmonary edema.

• GI – anorexia, nausea, vomiting, flank pain,metallic taste, gastritis

• Neuro- lethargy, headache, tremors, confusion, insomnia, seizures

• Hematology-anemia, bruising• Weight gain. 1kg=approx 1L fluid retained

Management and Prognosis of ARF

• Tx precipitating cause• Fluid restriction (500-600mL) plus fluid

loss• Nutritional management• Measures to lower serum K• Phosphate binding agents• TPN or enteral nutrition• Initiation of dialysis is necessary

Nursing Management & Interventions

1. Fluid volume deficit r/t…2. Fluid volume excess r/t…3. Nutrition: Less than body requirements r/t4, Impaired gas exchange r/t…5. PC: Hyperkalemia r/t….6. PC Metabolic acidosis r/t…7. PC Decreased Calcium r/t…

• The patient is a 64-year-old man. He visits the primary care provider because of mild lower abdominal pain, decreased urine output, and increased shortness of breath. He is 5 feet, 8 inches tall and weighs 246 pounds. The only drugs he takes include a daily multivitamin, a beta blocker, and occasionally acetaminophen for headache. His past medical history includes kidney stones 1 year ago and mild hypertension over the past 5 years. Physical assessment reveals bilateral crackles in the lung bases. Vital signs are T, 98.8 F; P, 96/min, R, 28/min, and BP, 148/92.

• 1. For which type(s) of acute renal failure is he at risk? Why?• 2. Do any of his usual drugs increase his risk for ARF? Which one(s) and

why?• 3. Is there any specific assessment data you could obtain without a

prescription to evaluate his risk for acute renal failure? If so, which ones and why?

•  • The physician prescribes these interventions:• IV placement with a 20-gauge cannula, NS at 20 mL/hr• Accurate intake and output• Ibuprofen 600 mg orally• Furosemide 40 mg IV

Chronic renal failure (CRF)

• CRF is a chronic,progressive, irreversible disease, leading to end stage renal disease

• Five stages:• Stage 1- diminished renal reserve, increased

BP, increased pressure on glomerular apparatus, decreased ability to concentrate urine- nocturia and polyuria.

• Stage 2 – Renal Insufficiency- metabolic wastes begin to accumulate

CRF

• Stage 3- End stage renal disease, excessive amounts urea and creatinine in blood.

• Treatment by dialysis is necessary.• Sodium: • Early in CRF – hyponatremia, polyuria

causes sodium depletion. • Later, ESRD – sodium retention – but

dilutional hyponatremia (masked by fluid volume excess).

CRF

• Potassium – hyperkalemia – 7 -8 meq/L, ECG changes and fatal dysrhythmias.

• Acid – base balance: Acid excretion (H ions)- restricted results in metabolic acidosis. Kussmaul respirations.

• Calcium and phosphate – demineralization.

• Uremic pruritis- toxic accumulation of nitrogenous wastes.

CRF- Affects all body systems

• Cardiac Alterations• Hypertension • CHF and LV hypertrophy• Uremic Pericarditis• Hematologic Alterations• GI alterations• MS• Neuro• Dermatological• Endocrine

Goals of Therapy

• Retain kidney function and maintain homeostasis as long as possible

• Improve nutrition• Monitor electrolytes• Manage anemia• Control HTN• Maintain glycemic control• Emotional support

ESKD Concept Map

CRF

• Common Nursing diagnoses:

• 1. Altered nutrition less than body requirements r/t nausea, vomiting, decreased appetite, effects of catabolic state, decreased LOC, altered taste, or dietary restrictions.

CRF- Interventions

• Dietary restrictions: limit protein intake• Limitation of fluid intake• Restriction of K, NA, phosphorous• Administration of Vitamins and minerals• Adequate calories to meet metabolic

demands• Collaborate with MD and dietician

CRF

• Fluid volume excess r/t inability of kidney to maintain body fluid balance.

• Interventions: Fluid restriction depends on-– Urinary output– Based on fluid wt. gain– With hemodialysis, 500 -700 ml/day plus

amount of urinary output.

Nursing Diagnoses

• Impaired skin integrity

• Risk for injury

• Activity intolerance

• Constipation

• Diarrhea

• Anticipatory Grieving

CRF- Drug Therapy

Cardiac glycosides: digoxin• Monitor for signs and symptoms of toxicity

and hypokalemiaVitamins and minerals- FeSo4 and Folic

AcidErythropoietin- Epogen, ProcritPhosphate Binders- Renagel, TumsStool Softeners- Colace

Assessment for patients with CRF

• Assess CV and respiratory systems:• VS, especially BP, heart sounds• Chest pain?, Edema?, JVD?• Dyspnea?, Crackles?• Assess nutritional status- Protein, fluid, K,

Na, P restrictions• Weight gain or loss• Anorexia, nausea, vomiting

Assessment

• Assess renal status-

• Amount, frequency and appearance urine

• Bone Pain?

• Hyperglycemia-stress need for control

• Assess hematologic status, including_

• Petichiae, purpura, ecchymosis?

• Fatigue?, SOB?

Assessment

• Assess GI status-

• Stomatitis

• Melena

• Assess neurological status-

• Change in mental status?

• Seizure activity?

• Sensory changes?, Lower ext. weakness?

Assessment

• Assess Integumentary system-

• Skin integrity

• Discoloration?

• Pruritis?

• Assess lab data, including:

• BUN, creatinine, creatinine clearance, CBC, electrolytes.

Assessment

• Assess psychosocial status, including-

• Anxiety?

• Maladaptive behavior

• Refer to a community resource group

Interventions to Manage ESRDPeritoneal Dialysis and Hemodialysis

Functions:

1. Rid the body of excess fluids and electrolytes

2. Achieve acid-base balance

3. Eliminate waste products, toxins

4. Restore internal fluid balance through osmosis, diffusion and ultrafiltration

Concepts of Dialysis

• Dialysate: solution of electrolytes,modified salt, acetate, glucose and heparin

• Dialyzer- Artificial kidney with a semipermeable membrane (Hemodialysis) or the peritoneum as a semipermeable membrane (Peritoneal Dialysis)

• Diffusion-

• Osmosis-

Peritoneal Dialysis

• May be hemodynamically unstable, can’t tolerate anticoagulation.

• Peritonitis is a major complication.• Procedure- surgically inserted tube into abdominal

cavity- infusion of dialysate.ONE EXCHANGE:Fill time: Infuse 1-2 liters by gravity over 20 min.Dwell time: Dialysate dwells in abdomen over

specified period of time.Drain Time- 10-15 min. Output usually 100-200mL.

input

PD

• Fluid then drains out by gravity.• This effluent contains dialysate, excess

water, electrolytes and nitrogenous wastes.

• The number and frequency of exchanges depend on client’s condition and lab data.

• Types of PD – Continuous ambulatory PD (CAPD), multiple bag CAPD, automated or continuous cycle.

PD- Complications

Peritonitis, manifested by:• Cloudy outflow (effluent)• Rebound abdominal tenderness• Abdominal pain• General malaise• Nausea, vomiting• Intervention – send C and S, Tx. with

appropriate Antibiotic.

PD- Complications

• Pain – pain initially

• Exit site and tunnel infection

• Insufficient flow of dialysate

• Dialysate leakage.Dyspnea

• Formation of fibrin clots

• Altered body image

Care of the Tenckhoff Catheter

• Mask for yourself and client• Put on clean gloves. Remove the old dressing,

remove contaminated gloves.• Assess area for signs of infection, swelling,

redness, or discharge around catheter site.• Use aseptic technique:• Sterile field, 2 4x4”s, cotton swabs soaked in

providone iodine, put on sterile gloves.• Use cotton swabs to clean around catheter site,

in a circular motion. • Apply pre-cut gauze pads over catheter site.• Tape edges of gauze pads.

Care of patient during PD

• Before treatment – monitor vitals, weight, lab values.

• During dialysis – continually monitor pt., VS taken regularly, assess for pain, assess catheter site for leaking.. Monitor dwell time, and document.

• Record amount outflow, note clarity of effluent, I and O.

Hemodialysis

http://kidney.niddk.nih.gov/kudiseases/pub/• Vascular access – AV fistula,anastomosis of an

artery and a vein or AV shunt• Temporary double lumen catheter in subclavian,

IJ or femoral vein• Pre-dialysis Interventions-• Assess patency – bruit, thrill,distal pulses• Common complications of access- • Thrombosis or stenosis, infection, aneurysm

formation, ischemia, bleeding• Determime if meds should be held

Post Dialysis Nursing Care

Assess for Complications:• Hypotension• Headache• Nausea, vomiting• Malaise• Dizziness• Muscle cramps• Monitor BUN/Creat/Lytes/Hct• LOC• Bleeding

HD

• Heparinization – used for dialysis:

• All invasive procedure avoided 4-6 hrs. after dialysis.

• Nurse monitors for signs of hemorrhage during dialysis and 1 hr. after.

• Complications – Disequilibrium syndrome

• Infectious diseases – can be transmitted, hepatitis and HIV

HD

• Nursing Care- Get report.

• Weigh client before and after dialysis

• Know the client’s dry weight

• Measure vitals, observe for bleeding

• Assess LOC, HA?, nausea? Vomiting?

Renal Transplantation

• Candidates must be:• Free from medical problems• Usually age 40 – 70 years old.• Candidates excluded:

– Active infection– IV drug abuse– Malignant neoplasm– Severe obesity– Acute vascultitis– Severe psych problems– Long standing pulmonary disease– Advanced cardiac disease

Renal Transplantation

Donors- Absence of systemic disease/ infectionNo history of cancerAbsence hypertension and renal diseaseAdequate renal function – diagnostic tests.

Renal Transplantation

• Complications-

• Rejection- immunosuppressive drug therapy, corticosteroids.

• Renal artery stenosis – HTN, bruit, decreased renal function.

• Post – op care- Monitor vitals, renal function, I and O, urine output, color.

• Diuretics may be ordered.

Renal Transplantation

• Daily weights

• Carefully monitor I and O.

• Monitor for electrolyte imbalances.

• Patient teaching for discharge regarding: meds, diet, wound care,signs of infection and rejection, and follow up care with PMD.

Review of Terminology

Acute Renal Failure• Usually temporary

and may be reversed, leaving no permanent or serious damage to kidneys

• Sudden loss of the ability of the kidneys to excrete wastes, concentrate urine and conserve electrolytes

Chronic Renal Failure• Long term and

irreversible• Usually occurs over a

number of years as the internal structures of the kidney are slowly damaged