16.05.2013 Nancy B Hopf, Aurelie Berthet, David Vernez, Emilie Langard, Philipp Spring, René Gaudin Skin permeation and metabolism of di(2-ethylhexyl) phthalate (DEHP) Institut universitaire romand de Santé au Travail Institut für Arbeit und Gesundheit Institute for Work and Health
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16.05.2013
Nancy B Hopf, Aurelie Berthet, David Vernez, Emilie Langard,
Philipp Spring, René Gaudin
Skin permeation and metabolism of
di(2-ethylhexyl) phthalate (DEHP)
Institut universitaire romand de Santé au Travail
Institut für Arbeit und Gesundheit
Institute for Work and Health
Background
• High-molecular-weight phthalates (HMWP) are used in plastic tubing, food packaging and processing materials, containers, vinyl toys, vinyl floor coverings, and building products
• Phthalate exposures have produced a variety of male reproductive effects
• Phthalates are assumed to have low dermal absorption however this is based on a few dermal absorption studies excluding the skin’s possibility to metabolize phthalates
• Skin permeation rates used in dermal exposure assessments might therefore underestimate the absorbed dose in health risk assessments.
2
Biological monitoring
• Urinary metabolites MEHP, 5OH-MEHP, 5oxo-
MEHP, 5cx-MEPP, and 2cx-MMHP are collected
post shift
• 5cx-MEPP is the primary metabolite in humans1
• Half lives 2 - 24 hours2
1 Wittassek and Angerer, 2008
2 Koch and Angerer, 2007; Koch et al., 2005
3
Workers’ exposures
• High exposures during manufacturing of products
containing phthalates1
• Urinary metabolite concentrations often exceed the 95th
percentile of the general population2.
• HMWPs are not very volatile, but readily form airborne
aerosols possibly inhaled by workers during work with
heated processes3
• Urinary HMWP metabolites are present after non-heated
processes. Can dermal exposures potentially play a role
in non-heated processes?
• 1 Gaudin et al., 2011; Gaudin et al., 2008; Hines et al., 2008; Hines et al., 2009; Koch et al., 2012
• 2 NRC 2008
• 3 Smith et al., 1980
4
Dermal exposure during non-heated
processes
• workers preparing DEHP-containing plastisol at room
temperature and supervising the plastisol coating of glass
flasks automatically dipped into vats filled with the