Pathology 1 pidemiology and Disease Processes apter 17, amples from Chapter 19 elds of Microbiology idemiology -- Population focus -- disease spread & containment crobial pathology -- Disease focus -- ‘etiology’ of disease -- Biology of pathogen & effects on host inical Microbiology -- Patient focus -- ID of pathogen and treatment Germs John Snow’s classic search for source of cholera – London, 1854
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Pathology 1
Epidemiology and Disease Processes
Chapter 17, examples from Chapter 19
Fields of Microbiology
Epidemiology-- Population focus
-- disease spread & containment
Microbial pathology-- Disease focus
-- ‘etiology’ of disease-- Biology of pathogen & effects on host
Clinical Microbiology-- Patient focus
-- ID of pathogen and treatment
Germs
John Snow’s classic search for source of cholera – London, 1854
Damage to cells, tissues and organse.g., respiratory infections, syphilis, etc
Damaging immune responsese.g., many diseases; tuberculosis, leprosy
rheumatic fever, etcToxins
exotoxinsGram-Positive sp.proteinsSecreted from cellsHighly toxic, specific effects
endotoxinsGram-negative LipopolysacchraridesLess toxic, more general effects
pyrogenic hypotension
Syphilis lesions in liver
Pathology 16
What causes the symptoms of Syphilis?
AgentTreponema pallidumspirochete
Stages of the infectionIncubation
Primary (1O) syphilischancre
(clinical latency)
Secondary (2O) syphilis
immune hypersensitivity
(clinical latency/ recurrent 2O)
Tertiary syphilisgumma lesions
Pathology 17
Syphilis, con’t.
Tertiary syphilisgumma lesions
autoimmunity?
Treatment
Congenital syphilis
Saddle nose
Notched teeth
Saber shin nose
Pathology 18
A Souvenir of London
Bought a souvenir in Londongot to hide it from my mum.
Can't declare it at the customs,but I'll have to take it home.Tried to keep it confidential,but the news is leaking out.Got a souvenir of London.There's a lot of it about.
Yes I've found a bit of London,and I'd like to lose it quick.Got to show it to my doctor,'cos it isn't going to shrink.
Want to keep it confidential,but the truth is leaking out.Got a souvenir of London.There's a lot of it about.