1 NIH Clinical Center,CTSAs NIH Molecular Libraries Initiative Disease Targe t ID Assa y Dev. HTS Prob e to Lead Pre- Clini cal FDA IND Ph. I Ph. II Ph. III FDA Review NIH RAID NIH TRND New NIH FDA Partnerships CAN Provides a Framework for Integration And for Process Engineering Cures Acceleration Network
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1 NIH Clinical Center,CTSAs NIH Molecular Libraries Initiative Disease Target ID Assay Dev. HTS Probe to Lead Pre- Clinical FDA IND Ph. IPh. IIPh. III.
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NIH Clinical Center,CTSAsNIH Molecular
Libraries Initiative
Disease Target
IDAssay Dev.
HTSProbe
to Lead
Pre-Clinical
FDA IND
Ph. I Ph. II Ph. IIIFDA
Review
NIH
RA
ID
NIH
T
RN
D
New NIH FDA Partnerships
CAN Provides a Framework for IntegrationAnd for Process Engineering
Approx. Stage of ResearchTraining and Development Mechanism of Support
GRADUATE/MEDICALSTUDENT
POSTDOCTORAL
EARLY
MIDDLE
SENIOR
CA
RE
ER
Predoctoral Institutional Training Grant (T32)
NIH Pathway to Independence (PI) Award (K99/R00)Mentored Research Scientist Development Award (K01)Mentored Clinical Scientist Development Award (K08)Mentored Patient-Oriented RCDA (K23)Mentored Quantitative RCDA (K25)
Midcareer Investigator Award in Patient-Oriented Research (K24) Exploratory/
Development Grant (R21)
NIH Offers Funding Programs to Support Scientists at Every Stage of Their Career
*Graph represents a small sample of NIH funding mechanisms available.
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• NIH Director’s ARRA Funded Pathfinder Award to Promote Diversity – Supports investigators who intend to pursue new research directions
related to workforce diversity– Total funding ~ Up to $2M total costs over 3 year period
• New Innovator Award– Supports small number of exceptionally creative new investigators– Provides up to $300,000 in direct costs
• Transformative R01– Common Fund initiative for exceptionally innovative, high risk, original
and/or unconventional research projects– Supports both individuals and collaborative investigative teams– Total funding ~ Up to $25 million total costs for 5 year period
• NIH Director’s Pioneer Award– Supports exceptionally creative individual scientists– Total funding ~ $5 million for 5 year period
Opportunities for Tomorrow:Investing in Innovative Researchers
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EARLY STAGE & NEW INVESTIGATORS
NIH fosters research independence of early career investigators.
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NEW DIRECTIONS IN PEER REVIEW
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Enhancing Peer Review
A Self-Study by the NIH in Partnership with the Scientific Community to Strengthen Peer Review in Changing Times
Keeping the Goal in Mind:
“Fund the Best Science, by the Best Scientists, with the Least Administrative Burden.”
(NIH)• Public Notice• Scope • Investigator Training
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Future Challenges for NIH
• Translation of Basic Science• Scientific Workforce• Emerging Technologies and Data Needs• Ethical and Social Implications of Research • Economic Impact of Research• Academic/Biomedical Industry Relationships• Post-ARRA Funding Issues• Accountability and Transparency – making the case
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NIH encourages applicants to describe their research in terms that are easily understood by:
u Congress u Public u Scientists u Administrators u Peer Reviewers ____________________________________
Titles, abstracts and statements of public health relevance should:
• Convey the value of the research in plain language – clear, succinct, and professional
• Be comprehensible to both scientists and the public• Relay the potential impact of the research on health
This information on funded grant applications is publicly available on NIH’s RePORTER Web Site at http://ProjectRePORTER.NIH.gov.