1 Longevity and Tea. 2 Tegreen 97 n Second most popular beverage n Tremendous positive press n Top 20 in health food sales n Thousands of studies worldwide.

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Longevity and Tea Longevity and Tea

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Tegreen 97Tegreen 97

Second most popular beverage

Tremendous positive press Top 20 in health food sales Thousands of studies

worldwide Including National Cancer

Institute Dose: 250 mg capsule; 1

capsule/day with food

Tea is HOT!

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Proprietary processingProprietary processing

Only finest leaf buds and young leaves used

Cultivated in Zhejiang province (number one tea-producing region in China)

Proprietary extraction process Achieves 97% polyphenols

65% Catechins• 38% EGCg

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Green tea vs. Black teaGreen tea vs. Black tea

Green tea Camellia sinensis Non-fermented

Lightly steamed and dried

Benefit of process Preservation

polyphenols (similar to fresh leaves)

Black tea Camellia sinensis Fermented and

dried. Benefit of process

Flavor enhancing Disadvantage

Destroys polyphenols

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Green tea researchGreen tea research

Epidemiological studies on green tea drinkers

Polyphenol Research Proven antioxidants Cell protection Inhibition of abnormal cell proliferation

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What are Polyphenols?What are Polyphenols?

Powerful antioxidants High concentrations in green tea Tegreen enriched for polyphenol anti-

oxidants, particularly Epigallocatechin gallate (EGCg)

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TeGreen

0

20

40

60

80

10 20 30 400

Dose (µM)

Vitamin C

Vitamin E

Antioxidant potency

Example of Pharmanex research Example of Pharmanex research on Tegreen on Tegreen

EGCG

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3 glasses ofred wine

4 cups ofgreen tea

4 glasses oficed tea

Based on EGCg levels

Anti-oxidant equivalency to Anti-oxidant equivalency to other beverages without caffeine other beverages without caffeine or alcoholor alcohol

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New Research by Pharmanex New Research by Pharmanex collaboratorscollaborators

Abnormal cells proliferate and live longer than normal cells

The life of a normal cell is regulated by a natural regulatory mechanism called programmed cell death (apoptosis)

Apoptosis is severely limited in abnormal cells Pharmanex collaborators discovered unique

enzyme (tNOX) in abnormal cells associated with this defect

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Inhibition of enzyme (tNOX) Inhibition of enzyme (tNOX) activity in cancer cells activity in cancer cells

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0.5

1

1.5

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2.5

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3.5

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Control 10 nM 1000nM

100000nM

EGCg

Tegreen

Cancer cell enzyme activity

Source: Morre et al.

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Tegreen Vs EGCg in promoting Tegreen Vs EGCg in promoting cancer drug activitycancer drug activity

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1

2

3

4

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0 1 10 100 1000 10000

Anti-cancer drugalone

Tegreen+ Anti-cancer drug

Anti-cancer drug, glaucarubolone, nM

Cancer cell killing

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Tegreen 97 AttributesTegreen 97 Attributes

Highest levels of polyphenols in industry 97% polyphenols Most competitors: 50-65% polyphenols

Once per day dose Equivalent to 4 cups of green tea beverage

Caffeine free