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Vol.49 No.5 339
舌 に 発 生 し た 紡 錘 細 胞 癌 の1例
大 竹 史 浩 ・小 谷 勇 ・土井理恵子
音 田 貢 ・須 藤 昌 紀 ・領 家 和 男
A case of spindle cell carcinoma of the tongue
OHTAKE Fumihiro•EKODANI Isamu•EDOI Rieko
ONDA Mitugi•ESUDOH Masaki•ERYOKE Kazuo
Abstract: Spindle cell carcinoma (SpCC) is a biphasic tumor consisting of a squamous cell carcinoma com-
ponent and a sarcomatoid component of spindle cells. Without immunohistochemical or ultrastructuralstudy, it is difficult to differentiate the sarcomatoid component of SpCC from sarcoma.
We describe a case of spindle cell carcinoma arising as a polypoid mass in the tongue of a 74-year-old
woman. The mass was successfully differentially diagnosed on immunohistochemical analysis. Pathologi-
cal analysis of the tumor revealed three components of squamous cells, histiocyte-like cells, and spindlecells. Immunohistochemical characterization of tumor cells was done with antibodies to keratin, vimentin,
smooth muscle actin, desmin, and 5-100 protein to differentiate SpCC from melanoma and leiomyo-
sarcoma. The histiocyte-like cells and spindle cells were positive for keratin and vimentin, and negative for
smooth muscle actin, desmin, and 5-100 protein. Given these findings, we diagnosed SpCC. In the 7 months
following surgery, there has been no local recurrence or metastasis.
(主任:領 家和男教授)Division of Oral and Maxillofacial BiopathologicalSurgery, Department of Medicine of Sensory andMotor Organs, School of Medicine, Tottori UniversityFaculty of Medicine (Chief: Prof. RYOKE Kazuo)受付 日:2002年10月21日
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