1 Complement Pathways Complement Activation Proteins are normally inactive - need to be activated (or transient) Activation - sequential proteolysis Covalent Attachment - become stably active after attaching to microbe (ab complexes) Regulation! - important to minimize complement mediated damage to host cells
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1
Complement Pathways
Complement Activation
Proteins are normally inactive -need to be activated (or transient)
Activation - sequential proteolysis
Covalent Attachment - becomestably active after attaching tomicrobe (ab complexes)
Regulation! - important tominimize complement mediateddamage to host cells
2
C1 Inhibitor Regulation
3
Inhibition of C3 Convertase Formation
4
Factor I mediated cleavage of C3b
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