1 Blank to maintain numbering. 2 Midterm There will be one Periodic Table, Hemoglobin, DNA, Anfinsen, Tamiflu will feature Study TOPIC guide will appear.

1Blank to maintain numbering

2Midterm• There will be one

• Periodic Table, Hemoglobin, DNA, Anfinsen, Tamiflu will feature

• Study TOPIC guide will appear

• Syllabus says Oct. 18; I’m thinking 25 may be more likely. Will inform next week or by e-mail

3Anfinsen

A1) each molecule more or less instantly goes to fully correct form. It’s a ‘snowball rolling down hill’ model, where each correct association greatly enhances the subsequent. So my 2nd bond is quicker than your 1st. Predicts precise tracking of disulfides formed vs. achieved activity

4Anfinsen A1

A1) each molecule more or less instantly goes to fully correct form. It’s a ‘snowball rolling down hill’ model, where each correct association greatly enhances the subsequent. So my 2nd bond is quicker than your 1st. Predicts precise tracking of disulfides formed vs. achieved activity

5Anfinsen A2

A2) Only correct bonds form, but with different rates for different bonds--so there is an order and timing of bond formation that is the same for all molecules. So A-A’ might form quickly; B-B’ slowly, etc.

6Deadline = line + dead

deadline |ˈdedˌlīn|noun1 this definition not relevant2 historical a line drawn around a prison beyond which prisoners were liable to be shot.

think about it

Does it really make sense to designate that period at the end as the target as opposed to that at the

beginning?

Is it really the case that your schedule is such that all available times just happen to fall at the last minute?

77

Beating TamifluBeating TamifluThemes:

Evolution: then and nowamino acids, mutations, folding: they

matter

Themes: Evolution: then and now

amino acids, mutations, folding: they matter

8How evolution happens

• Good ideas are rewarded not sought/planned

• There’s no mechanism for foresight, so it cannot be that way

9How the flu happens

http://www.ch.ic.ac.uk/local/projects/sanderson/images/lifecyc.gif


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Just passin’ through



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12




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Tamiflu: you shall not pass!

http://en.wikipedia.org/wiki/File:Oseltamivir-3D-balls.png

a.k.a. oseltamivir

http://en.wikipedia.org/wiki/File:Oseltamivir-3D-balls.png

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And it goes like this...

http://www.ks.uiuc.edu/Research/influenza/

Note: this is modeled, not a crystal structure

1 Blank to maintain numbering. 2 Midterm There will be one Periodic Table, Hemoglobin, DNA, Anfinsen, Tamiflu will feature Study TOPIC guide will appear.

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