1 A Meta-analysis on the A Meta-analysis on the Sensitivity and Specificity Sensitivity and Specificity of Exhaled Nitric Oxide and of Exhaled Nitric Oxide and Induced Sputum Eosinophilia Induced Sputum Eosinophilia for the Diagnosis of Asthma for the Diagnosis of Asthma Introdução à Medicina 2006/2007 Class 3, First Year João Almeida Lopes Fonseca Altamiro Manuel Rodrigues da Costa Pereira
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1 A Meta-analysis on the Sensitivity and Specificity of Exhaled Nitric Oxide and Induced Sputum Eosinophilia for the Diagnosis of Asthma Introdução à Medicina.
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A Meta-analysis on the A Meta-analysis on the
Sensitivity and Specificity of Sensitivity and Specificity of
2nd stage: full text (non-agreement solved by consensus or a third reviewer)
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A Meta-analysis on the Sensitivity and Specificity of Exhaled Nitric Oxide and Induced Sputum Eosinophilia for the Diagnosis of Asthma
Class 3; 2006-7
Methods Methods Study Selection
Inclusion criteria
1. Studies the use of exhaled nitric oxide or eosinophil levels in induced sputum for the diagnosis of asthma in humans
2. Reports original data on the sensitivity and specificity of the application of inflammatory biomarkers
Exclusion criteria
3. Not written in English, Portuguese, French or Spanish4. Full text not available via Medline, Scopus, FMUP library or
through contact with authors5. Does not describe the criteria used for the diagnosis of asthma
After the 2nd stage of selection, the articles repeated in both data bases were excluded
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A Meta-analysis on the Sensitivity and Specificity of Exhaled Nitric Oxide and Induced Sputum Eosinophilia for the Diagnosis of Asthma
Class 3; 2006-7
MethodsMethodsWhy Were Articles Not Included?
Criteria
1. Does not study the use of exhaled nitric oxide or eosinophil levels in induced sputum for the diagnosis of asthma in humans
2. Does not report original data on the sensitivity and specificity of the application of inflammatory biomarkers
3. Not written in English, Portuguese, French or Spanish
4. Full text not available via Medline, Scopus, FMUP library or through contact with authors
5. Does not describe the criteria used for the diagnosis of asthma
6. Article repeated in both data bases
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A Meta-analysis on the Sensitivity and Specificity of Exhaled Nitric Oxide and Induced Sputum Eosinophilia for the Diagnosis of Asthma
Class 3; 2006-7
MEDLINE SCOPUS
1671 articles 732 articles
1st stage: 284 articles included
2nd stage: 18 articles included
MethodsMethodsSearch Results
After applying inclusion and exclusion criteria, 9 articles from Medline and 9 from Scopus were included. However, 5 articles were repeated
5 44
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A Meta-analysis on the Sensitivity and Specificity of Exhaled Nitric Oxide and Induced Sputum Eosinophilia for the Diagnosis of Asthma
Class 3; 2006-7
Methods Methods Included Articles: : Quality Criteria and Statistical Analysis
STARD Checklist(1) to evaluate the articles regarding their methodological quality – mean of two reviewers
Meta-Disc 1.4 and SPSS 14.0 to extract relevant information
(1) BOSSYUT, PM, et al; The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. The Standards for Reporting of Diagnostic Accuracy Group;
Croat Med J.; 2003; 44(5):639-50
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A Meta-analysis on the Sensitivity and Specificity of Exhaled Nitric Oxide and Induced Sputum Eosinophilia for the Diagnosis of Asthma
Class 3; 2006-7
MethodsMethodsAgreement Between Reviewers
Kappa = 0,899
Agreement Between Reviewers
2382 3 2385
1 18 19
2383 21 2404
Excluded
Included1st Reviewer
Total
Excluded Included
2nd Reviewer Total
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A Meta-analysis on the Sensitivity and Specificity of Exhaled Nitric Oxide and Induced Sputum Eosinophilia for the Diagnosis of Asthma
Class 3; 2006-7
ResultsResultsDescription of Included Studies
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A Meta-analysis on the Sensitivity and Specificity of Exhaled Nitric Oxide and Induced Sputum Eosinophilia for the Diagnosis of Asthma
Class 3; 2006-7
ResultsResultsQuality Assessment
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A Meta-analysis on the Sensitivity and Specificity of Exhaled Nitric Oxide and Induced Sputum Eosinophilia for the Diagnosis of Asthma
Class 3; 2006-7
ResultsResultsData Analysis – Fe(NO)
Summary sensitivity
There is no evidence of heterogeneity
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A Meta-analysis on the Sensitivity and Specificity of Exhaled Nitric Oxide and Induced Sputum Eosinophilia for the Diagnosis of Asthma
Class 3; 2006-7
Summary specificity
There is evidence of heterogeneity
ResultsResultsData Analysis – Fe(NO)
2020
A Meta-analysis on the Sensitivity and Specificity of Exhaled Nitric Oxide and Induced Sputum Eosinophilia for the Diagnosis of Asthma