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Successful 19th Annual Academic Evening Held Tuesday, May 17, 2011

The 19th Annual Academic Evening, held on Tuesday May 17 at the Millennium Hotel, was a wonderful success! Junior level investigators performing research in our department presented eighty-eight posters. As in past years, the size of the event continues to increase breaking records from all previous years. Even more important, the surge in academic activity

remained widely disbursed through all training levels and divisions of the department.

The prize winners are listed below and congratulations to each of those individuals and teams. However, it was a very tough year for defining those that stood out and many presentations that did not achieve a prize presented amazing research, fully consistent with the overall goal of advancing anesthesia/critical care and pain management through discovery. Who knows what next leap forward in anesthesiology research and care will look back and find it’s seed in one of the case reports, retrospective reviews, prospective trials, or basic science discoveries reported at this year’s event!

Roderic Eckenhoff, MD served as our guest judge and speaker. His presentation was focused on the study of anesthetic interactions with the pathogenesis of Alzheimer’s disease. He portrayed a wide and rapidly evolving arena of both preclinical and clinical studies that leave open major questions for ongoing work to identify potential molecular mechanisms

of anesthetic neurotoxicity, definition of windows of vulnerability, and clinical research studies necessary to determine the extent to which this is a clinical problem.

Thanks to everyone who participated, especially those who served as abstract judges, moderators, mentors, program directors, support staff, and those who made it possible for the clinical mission to proceed despite the heavy attendance at the event. It was a day to remember for us all!

http://anesthesiology.duke.edu 1

NewsMonday, May 23, 2011 • Volume 13, Issue 21

Additional pictures on page 3.

And now, the 2011 Academic Evening Award Winners!

Post Doc – Clinical (Dick Smith Award)1st Place: Heather Frederick – “A Randomized Controlled Trial in Children Having Ophthalmic Surgery”

Runner Ups:Grace McCarthy – “Impact of Uncorrected Mitral Regurgitation on Long-Term Outcomes”Michael Shaughnessy – “Time of Day of Surgery in not a Risk factor for early PONV”Andy Vimuktanandana – “Diastolic Dysfunction and Cardiac Surgery-Associated Acute Kidney”

Post Doc – Basic Science1st Place: Sukhpal Brar – “Susceptibility to Global Myocardial Ischemia”

Runner Ups:Liangli Wang – “Deep Hypothermia”Rafael Chaparro – “Refanalin, a Hepatocyte Growth Factor Mimetic”Ken Honjo – “Screen to Identify Novel Genes Required for Nociception”

Resident 1st Place: Anne Cherry – “PGC-1a and the Mitochondrial Antioxidant Response During Sepsis”Runner Up: Dionne Peacher – “Pulmonary Hemodynamics During Cold Water Exercise”

Medical Student1st Place: Nathan Waldron – “Dexamethasone for Postoperative Pain Relief”Runner Up: Shannon Klebe – “Predictors of Postoperative Renal Dysfunction in Elective Colon Resection”

Predoc, Non-Medical1st Place: Michael Smith – “MicroRNA Expression Signatures Following Surgical”1st Place: Kristine Brown – “Constitutive Activity of Neurokinin”

Case Reports1st Place: Collin Clarke – “The Successful Management of a Pediatric Patient with Neuropathic Pain”1st Place: Jason Guercio – “Physostigmine for Emergence Delirium During Awake Craniotomy”

Department of Anesthesiology Research ConferenceMonday, June 13, 2011 | 5-6 pm | 5685-HAFS

May cancelled for Academic Evening. Next conference is on June 13, 2011.

ThIs Month In the DepartMent of anesthesIology


May 2011MonDay tUesDay WeDnesDay thUrsDay frIDay23 24 25 26 27

7:15-8:00 a.m., RM203-Pain ClinicMRC Pain Conference

2:30-3:30 p.m., VAMCVA EchocardiographyConference

4-7 p.m.Resident Practice Oral Exams

5-6 p.m., 5685-HAFSCT Conference

5-6 p.m. 6686-HAFSGVTCCM Conference: “Anesthet-ic Implications of Carcinoid Tumor Resection” - Ifey Ifeanyi, MD

IrB Deadline: submit 1 original and 3 copies to Dr. gan’soffice by 5 p.m.

6:30 a.m., 2001DNResident Conference Lecture: “Anesthesia for Aortic Aneurysm Repair” - Catherine Kuhn, MD

7:15 a.m., 2001DNGrand Rounds: “Perioperative-Psychological Trauma” - Christopher Merritt, MD

7:15-8:00 a.m., RM203-PainClinicMRC Pain Journal Club

12:00-12:45 p.m., 2003DNCritical Care Grand Rounds: “Lec-ture TBA” - Dr. David Joseph

4-5 p.m., 5680A-HAFSPediatric Conference: “Hypoxic Bradycardia and the Mammalian Diving Reflex” - Dr. Anne Cherry

5-6 p.m., 2002DNResident Education Session: “LVAD Management for Non-Car-diac Surgery” - Ian Welsby, MD

30 - Memorial Day 31 June 1, 2011 2 3




5-6 p.m. 6686-HAFSGVTCCM Conference: “Topic TBA” - John Lemm, MD

6:30 a.m., 2001DNResident Conference Lecture

7:15 a.m., 2001DNGrand Rounds


12:00-12:45 p.m., 2003DNCritical Care Grand Rounds

4-5 p.m., 5680A-HAFSPediatric Conference

6 7 8 9 10



5-6 p.m., 5685-HAFS Faculty Meeting

6-7:30 p.m., 5685-HAFS Executive Team Meeting (Dinner Provided)


5-6 p.m. 6686-HAFSGVTCCM Conference







5-6 p.m., 5685-HAFSResident Education Session: “M&M” - Dr. Habib

13 14 15 16 17



5:30 p.m., 5680A-HAFSPerioperative Leadership Group Meeting


5-6 p.m. 6686-HAFSGVTCCM Conference







5-6 p.m., 5685-HAFSEducation Committee Meeting

Upcoming:Nineteenth Annual Academic Evening: Tue., May 17, 2011 | Millennium Center, Durham, NCresident graduation awards Banquet & subspecialty recognition Ceremony: Sat., June 11, 2011 | Hope Valley Country Club, Durham, NC2011 Duke Anesthesiology Alumni Reception: Sun., October 16, 2011, The Field Museum Chicago, IL2011 ASA: October 15-19, 2011 | McCormick Place Convention Complex, Chicago, IL 2011 Duke Anesthesiology Holiday Party: Sat., December 3, 2011 | The Cotton Room at Golden Belt, Downtown Durham, NC

2011 aCaDeMIC eVenIng pICtUres

2011 aCaDeMIC eVenIng pICtUres


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new Departmental research grant awardsRichard Moon, MD, Medical Director of the Center for Hyperbaric Medicine and Environmental Physiology, and Dawn Kernagis, received a two-year $254,897 grant from the Office of Naval Research entitled “Identification of Blood Biomarkers of Decompression Stress (DCS) through Genome-Wide Expression Profiling”. Dawn is currently a graduate student at Duke University working with Dr. Moon on her Ph.D. thesis work focused on identifying blood biomarkers of decompression stress in divers and investigating how genetics

may influence individual susceptibility to decompression sickness.

Decompression sickness (DCS) is a physical manifestation of decompression stress (DS), defined as the physiologic response to dissolved gas coming out of solution into the venous circulation as a body moves from a high pressure to low pressure environment, such as surfacing from a dive. At present, the only measure of DS is the direct manifestation of symptoms (DCS). Biochemical measures of an individual’s response to venous bubbling could provide a mechanism to monitor subclinical DS and lead to safer and more time effective decompression profiles. Identifying blood biochemical markers for DS could also provide insight into the molecular interactions with gas emboli, allowing for the development of preventive, adjunctive or non-recompressive therapies for DCS. However, no specific biomarkers of DS or specific biochemical predictors of DCS have been described. Additionally, there are no data available describing interaction of physiological pathways in the pathology of DS or DCS. Genome-wide expression profiling allows for comprehensive exploration of gene patterns or aberrant gene expression associated with disease and biological processes. The goals of this project are to identify and validate global gene expression patterns characteristic of DS, evaluate potential blood biomarkers of DS, and determine the role of genetic variation in differential DS response and susceptibility to DCS.

Zhiquan Zhang, phD, Assistant Professor in the Division of Basic Sciences and member of the Systems Modeling of Perioperative Organ Injury Laboratory, was awarded a two-year $154,000 MAA Spring 2011 Beginning Grant-in-Aid from the American Heart Association (AHA) entitled “A Novel Annexin-A1 Tripeptide, Perioperative Myocardial Injury and NF-kappaB”.

Perioperative myocardial injury (PMI) due to ischemia/reperfusion (I/R) remains a major cause of cardiovascular

morbidity and mortality following cardiac surgery. The molecular and cellular mechanisms associated with PMI have not yet been satisfactorily clarified and need further investigation. NF-kB mediated pro-inflammatory responses triggered by cardiopulmonary bypass (CPB), myocardial I/R, and neutrophil transmigration during cardiac surgery play key roles in PMI. Therefore, inhibition of myocardial inflammation in general, and NF-kB activation in particular, could be beneficial for patients undergoing cardiac surgery. This study will assess important parameters of the pharmacological action of ANXA1sp; explore its mechanism of action; and set the stage for its thorough preclinical evaluation that is required for first-in-man cardioprotective applications.

The Future is HereBrandon Winchester, MD

At Academic Evening last Tuesday, I was unable to come because I was landing in Denver to teach a course. However, I was still able to present my poster, thanks to Skype and Verizon 4G LTE. In my taxi ride from the airport to the hotel, I connected to the internet on my laptop using a webcam and the new Verizon 4G LTE technology, and within two minutes I was video-conferencing live with the Academic Evening judges from the back seat of the taxi to present our poster. One of the posters we presented at Academic Evening can be viewed by clicking the link below, which demonstrated that using Skype video-conferencing between a patient and physician was able to nearly double the enrollment in a research study.

http://anesthesiology.duke.edu/wysiwyg/downloads/AcaEve11/videoconferencing-poster.pdf

Dr. James Accepted to the 4th Annual national Institute of neurological Disorders and stroke (nInDs)

The Program Committee for the Clinical Trial Methods Course (CTMC) in Neurology has completed its review of all the applicants for the course that will be held August 15-21, 2011 at the Vail Marriott Mountain Resort located in Vail, Colorado. Dr. Luke James has been accepted to the fourth annual NINDS sponsored Clinical Trial Methods Course and will receive one of the fellowships awarded. Congratulations on your fine application and acceptance to this course.

Va Division end of year accomplishmentsTalia Schwartz is a Duke 2010 graduate, a Research assistant in the VA division, and will be attending medical school at UNC Chapel Hill in August.

Andrew Kuo, Son of Becky Schroeder & Paul Kuo will be graduating from Durham Academy and attending US Naval Academy in June. He has also been invited to the US Navy Lacrosse Team Try-outs.

raquel Bartz, MD will be attending Duke University Fuqua School of Business in August and has a Masters in Clinical Informatics. Zach Wiener, Son of Dana & David Wiener will be graduating East CHHS, one of several straight A valedictorians. He will be attending Duke University, Pratt School of Engineering in August.

atilio Barbeito, MD will be attending UNC Gillings School of Global Public Health, Masters in Public Health, expected Spring 2012.

Srini Pyati, MD passed all 3 levels of the USMLE recently.

Becky Schroeder, MD, was awarded an AHA-National Patient Safety Foundation Leadership Fellowship for year 2010-11.

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Bragging Rights! Accomplishments of Anesthesia Faculty and Staff

Lisa Mangum’s youngest daughter, Jana Mangum, will be graduating from Riverside High School on June 9th, 2011. Jana will be attending East Carolina University in the fall.

4th Annual UNC-Duke Pediatric Anesthesiology Conference “Best Practices in Pediatric Anesthesia Care”

Saturday August 27, 2011 The William & Ida Friday Center for Continuing Education | Chapel Hill, UNC

Due to their many anatomic, physiologic, and developmental differences, infants and young children constitute a high-risk population for undergoing anesthesia and surgery. A collaborative approach requires that all team members function with the most up-to-date information on providing safe pediatric anesthesia care. This one-day conference provides lectures, pro-con debates, and panels discussing a variety of common and challenging pediatric anesthesia problems. Participants can earn up to 7 hours of continuing education credits.

Register online at: http://cmetracker.net/DUKE/login?FormName=RegLoginLive&Eventid=40615

Join us for the 2011 susan g. Komen race for the Cure 5K Walk/Run

Join us for the 2011 Susan G. Komen Race for the Cure 5K Walk/Run in Raleigh on June 11th. The Susan G. Komen NC Triangle Race for the Cure raises funds and awareness for

the fight against breast cancer, celebrates breast cancer survivorship, and honors those who have lost their battle with the disease. Sign up at www.komennctriangle.org and join the Duke Medicine: PeriOperative Services team. Plastic and Reconstructive Surgery is taking the lead and Anesthesia should represent. It’s a race for a cause that affects 1 in 8 women and countless families, friends and loved ones.

If you are unable to join us, please donate to our team. Seventy-five percent of the funds raised through events like the Race for the Cure go to funding grants in our 20 county service area at local hospitals and community organizations that provide breast health education, and breast cancer screening and treatment programs for medically underserved

women in our community. The remaining 25% supports the Susan G. Komen for the Cure Award and Research Grant Program, which funds ground-breaking breast cancer research at the national level. Contact Tina Stark, Plastics RN or Kali Schwindt, CRNA with questions.

May 22-28 Birthday Wishes

Naraida Balajonda Jacquelane Libed Dr. Jeffrey TaekmanPatricia Fletcher Karen Rattini Dr. Ian WelsbyBonita Funk Dr. Michael Stella Tianshi Wu

Note: If you do not want your name listed here, please send a removal notice to [email protected]. See errors? Please report them to the business office.

ClassifiedsReal Estate/Rentals

For Sale: House on Quiet Cul-de-Sac 5 minutes to Duke. 10 DuBarry Court, Durham, NC 27705 *$224,900* 3 bed-room, 2 bath in Westwood Estates on quiet cul-de-sac. Approx. 1940 sq. ft. on approx. .42 acres. Berini Built home. 3 large bedrooms, 2 bathrooms, large eat-in kitch-en, formal dining room, formal living room, entrance foyer, family room/den, fireplace with gas logs, laundry closet off

of kitchen, deck, storage shed in backyard, carport with storage room, hardwood floors throughout except kitchen and family room. Call 919-475-1780 or 919-724-0924 if you would like more information or see the house.

For Rent: THE SANDPIPER, Kure Beach, North Carolina. Six bedrooms. Four bathrooms. Tastefully furnished. Wonderful kitch-en. Ocean views. An elevator. One car garage. Walking distance to the pier and Kure Beach restaurants. Visit www.bradandneil.com for details and availability or e-mail [email protected].

For Rent: Our 4 BR, 4 BA OCEANFRONT Beach Cottage at Carolina Beach is available for rent until June 17th. If you are in-terested, please send me an email and I will send you more infor-mation on the specifics. Spring rental for the week will be $1500 or $500 for a weekend. Allison Ross at [email protected].

For Sale: 7 Preakness Drive. Beautiful end unit brick town-home. $183,000. 3 Bedrooms, 2.5 Baths, 1819 Sq Ft, spa-cious floor plan, Great neighborhood, Excellent location, Close to UNC, Duke, I-40 to Raleigh, Beautiful natural light, Wooded yard for Privacy, Spacious backyard deck, Up-graded bathrooms with Tile flooring Professionally Painted,

Large master bedroom with Vaulted ceilings, Brand New stainless steel Kitchen Appliances. Contacts (owners): Neda Esmaili at 919-672-0114, [email protected] or Michael Stadler at 919-358-9263, [email protected].

Wanted

I am looking for a car to buy by the last week of June. Sedan or hatchback, auto-matic or manual. Model year 2008 onwards, mileage preferably less than 70,000 miles. Toyota/Honda/Nissan preferable. The max price I am looking for is $10,000 +/- 100. If you are selling or know someone who is, please contact Srinivasan Karthikeyan at [email protected].

Services


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Upcoming CME Activities

4th annual emerging technologies in the or& great fluid DebateJune 12-17, 2011 | Disney’s grand floridian resort & Spa lake Buena Vista, floridaFor more information, email Katherine Siler: [email protected] course will enable the participant to make evidence-based intravenous fluid management decisions in the clini-cal environments of the operating room, critical care and the emergency room. In addition, it is designed to focus on awareness among anesthesia providers concerning the function, use and limitations of new technology currently being used in the operating suites.

14th Annual Duke Cardiothoracic Update and TEE Board ReviewJointly presented by Departments of Anesthesiology at Duke University and Beth Israel Deaconess Medical Center, Harvard Medical School June 23-26, 2011 | hilton head Marriott resort & spa | hilton head Island, sCFor more information, email: [email protected] your calendars for another year of cutting-edge re-search and updated information designed for medical per-sonnel of all skill levels. neW for 2011: focused course for the TEE Board Exam in June 2011.

Ultrasound for Every Anesthesiologist Pre-ASA Workshopoctober 14, 2011 | the W hotel, lakeshore | Chicago, IlFor more information, email Katherine Siler: [email protected] is a one-day intensive hands-on workshop specifically designed to teach ultrasound to Anesthesiologists of all skill levels ensuring that ultrasound is being used correctly and to its full potential. The use of ultrasound guided re-gional anesthesia could increase patient cases and suc-cess in patient outcome.

Collaborative anesthesia and obstetric Care of the High-risk Delivery: What’s new in patient safety?november 12, 2011 | rizzo Conference Center | Kenan-Flagler Business School, Chapel Hill, NCFor more information, email Bridget White: [email protected] one-day course will focus on the obstetric and anes-thetic considerations and preparations for the management of high-risk parturients.

Ultrasound guided regional anesthesia Preceptorship Course2011 Dates available | Duke University Medical Center, Durham, NCFor more information, email Katherine Siler: [email protected] in the Duke Preceptorship will spend three days in the regional block area, operating rooms and on the floor with post surgery patients observing ultrasound guided single shot nerve blocks and catheter techniques in a wide variety of clinical scenarios. They will learn how to set up the block area for maximum efficiency in the OR environment, improve their decision making ability and make choices in the performance of regional anesthesia. A one-on-one discussion with the Duke Faculty member re-viewing cases, scanning techniques and the image library as well as covering handout materials will augment the preceptorship experience.

Visiting preceptorship in Intraoperative Transesophageal Echocardiography2011 Dates available | Duke University Medical Center, Durham, NCFor more information, email Jaime C. Cooke: [email protected] in the Duke Intraoperative TEE Preceptor-ship spend one three-day session in the cardiac operat-ing suites, observing techniques of intraoperative TEE and interpretation of images. Preceptors will participate in active discussions with cardiothoracic anesthesia faculty and fellows, and learn the basic TEE exam. They will also learn how to troubleshoot difficult cases and enhance their decision-making skills in the operating room. Cases will be reviewed with fellows and faculty and images from pathol-ogy libraries will be used to augment the preceptorship experience.

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