02.03.2017 Kit components Product code Description · 02.03.2017 Kit components Product code Description NEL810001KT Opal 4-Color Manual IHC Kit 50 slides Components: FP1498 1X Plus

Kit components02.03.2017

Product code Description

NEL810001KT Opal 4-Color Manual IHC Kit 50 slides

Components:FP1498 1X Plus Amplification DiluentFP1487A Opal 520 ReagentFP1488A Opal 570 ReagentFP1497A Opal 690 ReagentFP1490A Spectral DAPIARD1001EA Antibody Diluent, 1X, 100mLARH1001EA PolyHRP Broad SpectrumDMSO0500UL DMSOAR600125ML AR6 Buffer

Page 1/6

Safety data sheetaccording to 1907/2006/EC, Article 31

Printing date 02.03.2017 Revision: 02.03.2017

44.1.4

SECTION 1: Identification of the substance/mixture and of the company/undertaking

· 1.1 Product identifier

· Trade name: 1X Plus Amplification Diluent

· Product number: FP1498· 1.2 Relevant identified uses of the substance or mixture and uses advised against

No further relevant information available.· Application of the substance / the mixture

Laboratory chemicalsPreparation

· 1.3 Details of the supplier of the safety data sheet· Manufacturer/Supplier:

PerkinElmer Inc549 Albany stBoston, MA 02118

· Further information obtainable from:US Technical Support800-762-4000

· 1.4 Emergency telephone number:If inside USA, call CHEMTREC at 1-800-424-9300If outside USA, call CHEMTREC at 1-703-527-3887

SECTION 2: Hazards identification

· 2.1 Classification of the substance or mixture· 2.1.1 Classification according to Regulation (EC) No 1272/2008

The product is not classified according to the CLP regulation.

· 2.2 Label elements· Labelling according to Regulation (EC) No 1272/2008 Void· Hazard pictograms Void· Signal word Void· Hazard statements Void· Additional information:

Safety data sheet available on request.· 2.3 Other hazards· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.

SECTION 3: Composition/information on ingredients

· 3.2 Chemical characterisation: Mixtures· Description: Mixture of substances listed below with nonhazardous additions.

· Dangerous components:

CAS: 1330-43-4EINECS: 215-540-4

disodium tetraborate, anhydrous Repr. 1B, H360FD <1.0%

CAS: 10043-35-3EINECS: 233-139-2

boric acid Repr. 1B, H360FD <1.0%

(Contd. on page 2) GB

Page 2/6



Trade name: 1X Plus Amplification Diluent

(Contd. of page 1)

44.1.4

· Additional Components

CAS: 7647-14-5EINECS: 231-598-3

sodium chloride 10-25%

CAS: 7722-84-1EINECS: 231-765-0

hydrogen peroxide solution Ox. Liq. 1, H271; Skin Corr. 1A, H314; Acute Tox. 4, H302; Acute Tox.

4, H332

<0.1%

CAS: 7732-18-5EINECS: 231-791-2

Water 75-100%

· SVHC

1330-43-4 disodium tetraborate, anhydrous

10043-35-3 boric acid

· Additional information: For the wording of the relevant risk phrases refer to section 16.

SECTION 4: First aid measures

· 4.1 Description of first aid measures· General information: No special measures required.· After inhalation: Supply fresh air; consult doctor in case of complaints.· After skin contact: If skin irritation continues, consult a doctor.· After eye contact: Rinse opened eye for several minutes under running water.· After swallowing: If symptoms persist consult doctor.· 4.2 Most important symptoms and effects, both acute and delayed No further relevant information available.· 4.3 Indication of any immediate medical attention and special treatment needed

No further relevant information available.

SECTION 5: Firefighting measures

· 5.1 Extinguishing media· Suitable extinguishing agents: Use fire extinguishing methods suitable to surrounding conditions.· 5.2 Special hazards arising from the substance or mixture No further relevant information available.· 5.3 Advice for firefighters· Protective equipment: Wear self-contained respiratory protective device.

SECTION 6: Accidental release measures

· 6.1 Personal precautions, protective equipment and emergency procedures Not required.· 6.2 Environmental precautions: Do not allow to enter sewers/ surface or ground water.· 6.3 Methods and material for containment and cleaning up:

Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).· 6.4 Reference to other sections

See Section 7 for information on safe handling.See Section 8 for information on personal protection equipment.See Section 13 for disposal information.

SECTION 7: Handling and storage

· 7.1 Precautions for safe handling No special measures required.· Information about fire - and explosion protection: No special measures required.


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(Contd. of page 2)

44.1.4

· 7.2 Conditions for safe storage, including any incompatibilities· Storage:· Requirements to be met by storerooms and containers: No special requirements.· Information about storage in one common storage facility: Not required.· Further information about storage conditions: None.· 7.3 Specific end use(s) For research use only.

SECTION 8: Exposure controls/personal protection

· Additional information about design of technical facilities: No further data; see item 7.

· 8.1 Control parameters

· Ingredients with limit values that require monitoring at the workplace:

1330-43-4 disodium tetraborate, anhydrous (<1.0%)

WEL Long-term value: 1 mg/m³

· 8.2 Exposure controls· Personal protective equipment:· General protective and hygienic measures:

The usual precautionary measures are to be adhered to when handling chemicals.· Respiratory protection: Not required.· Protection of hands:

The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation

· Material of glovesThe selection of the suitable gloves does not only depend on the material, but also on further marks of quality andvaries from manufacturer to manufacturer. As the product is a preparation of several substances, the resistanceof the glove material can not be calculated in advance and has therefore to be checked prior to the application.

· Penetration time of glove materialThe exact break through time has to be found out by the manufacturer of the protective gloves and has to beobserved.

· Eye protection: Goggles recommended during refilling· Environmental Exposure Controls N/A

SECTION 9: Physical and chemical properties

· 9.1 Information on basic physical and chemical properties· General Information· Appearance:

Form: FluidColour: According to product specification

· Odour: Characteristic· Odour threshold: Not determined.

· pH-value: N/A

· Change in conditionMelting point/freezing point: Undetermined.Initial boiling point and boiling range: 100 °C

· Flash point: Not applicable.


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(Contd. of page 3)

44.1.4

· Flammability (solid, gas): Not applicable.

· Ignition temperature:

Decomposition temperature: Not determined.

· Auto-ignition temperature: Product is not selfigniting.

· Explosive properties: Product does not present an explosion hazard.

· Explosion limits:Lower: Not determined.Upper: Not determined.

· Vapour pressure at 20 °C: 23 hPa

· Density: Not determined.· Relative density Not determined.· Vapour density Not determined.· Evaporation rate Not determined.

· Solubility in / Miscibility withwater: Not miscible or difficult to mix.

· Partition coefficient: n-octanol/water: Not determined.

· Viscosity:Dynamic: Not determined.Kinematic: Not determined.

· Solvent content:Organic solvents: 0.0 %Water: 84.5 %

Solids content: 14.8 %· 9.2 Other information No further relevant information available.

· Additional information N/A

SECTION 10: Stability and reactivity

· 10.1 Reactivity No further relevant information available.· 10.2 Chemical stability· Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.· 10.3 Possibility of hazardous reactions No dangerous reactions known.· 10.4 Conditions to avoid No further relevant information available.· 10.5 Incompatible materials: No further relevant information available.· 10.6 Hazardous decomposition products: No dangerous decomposition products known.

SECTION 11: Toxicological information

· 11.1 Information on toxicological effects· Acute toxicity Based on available data, the classification criteria are not met.· Primary irritant effect:· Skin corrosion/irritation Based on available data, the classification criteria are not met.· Serious eye damage/irritation Based on available data, the classification criteria are not met.· Respiratory or skin sensitisation Based on available data, the classification criteria are not met.


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(Contd. of page 4)

44.1.4

· CMR effects (carcinogenity, mutagenicity and toxicity for reproduction)· Germ cell mutagenicity Based on available data, the classification criteria are not met.· Carcinogenicity Based on available data, the classification criteria are not met.· Reproductive toxicity Based on available data, the classification criteria are not met.· STOT-single exposure Based on available data, the classification criteria are not met.· STOT-repeated exposure Based on available data, the classification criteria are not met.· Aspiration hazard Based on available data, the classification criteria are not met.

SECTION 12: Ecological information

· 12.1 Toxicity· Aquatic toxicity: No further relevant information available.· 12.2 Persistence and degradability N/A· 12.3 Bioaccumulative potential N/A· Behaviour in environmental systems: N/A· 12.4 Mobility in soil No further relevant information available.· Ecotoxicity: N/A· Ecotoxical effects: N/A· Additional ecological information:· Other adverse effects:

Water hazard class 1 (German Regulation) (Self-assessment): slightly hazardous for waterDo not allow undiluted product or large quantities of it to reach ground water, water course or sewage system.

· 12.5 Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.· 12.6 Other adverse effects No further relevant information available.

SECTION 13: Disposal considerations

· 13.1 Waste treatment methods· Recommendation Must be specially treated adhering to official regulations.

· Uncleaned packaging:· Recommendation: Disposal must be made according to official regulations.

SECTION 14: Transport information

· 14.1 UN-Number· ADR, ADN, IMDG, IATA Void

· 14.2 UN proper shipping name· ADR, ADN, IMDG, IATA Void

· 14.3 Transport hazard class(es)

· ADR, ADN, IMDG, IATA· Class Void

· 14.4 Packing group· ADR, IMDG, IATA Void

· 14.5 Environmental hazards: Not applicable.


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(Contd. of page 5)

44.1.4

· 14.6 Special precautions for user Not applicable.

· 14.7 Transport in bulk according to Annex II ofMarpol and the IBC Code Not applicable.

· UN "Model Regulation": Void

SECTION 15: Regulatory information

· 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

· Directive 2012/18/EU· Named dangerous substances - ANNEX I None of the ingredients is listed.· REGULATION (EC) No 1907/2006 ANNEX XVII Conditions of restriction: 30

· National regulations:

· Other regulations, limitations and prohibitive regulations

· Substances of very high concern (SVHC) according to REACH, Article 57

1330-43-4 disodium tetraborate, anhydrous

10043-35-3 boric acid

· 15.2 Chemical safety assessment: A Chemical Safety Assessment has not been carried out.

SECTION 16: Other informationThe information provided in this Material Safety Data Sheet is based on our present knowledge,and believed to be correct at the date of publication. However, no representation is madeconcerning its accuracy and completeness. It is intended as guidance only, and is not to beconsidered a warranty or quality specification. All materials may present unknown hazards, andshould be used with caution. Although certain hazards are described, we cannot guarantee thatthese are the only hazards which exist. PerkinElmer, Inc. shall not be heldliable for any damage resulting from handling or from contact with the product.

· Relevant phrasesH360FD May damage fertility. May damage the unborn child.

· Abbreviations and acronyms:ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationGHS: Globally Harmonised System of Classification and Labelling of ChemicalsEINECS: European Inventory of Existing Commercial Chemical SubstancesELINCS: European List of Notified Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)PBT: Persistent, Bioaccumulative and ToxicSVHC: Substances of Very High ConcernvPvB: very Persistent and very BioaccumulativeRepr. 1B: Reproductive toxicity – Category 1B

GB

Page 1/7



44.1.4



· Trade name: Opal 520 Reagent

· Product number: FP1487A· 1.2 Relevant identified uses of the substance or mixture and uses advised against









Acute Tox. 4 H302 Harmful if swallowed.

Skin Irrit. 2 H315 Causes skin irritation.

Eye Irrit. 2 H319 Causes serious eye irritation.

STOT SE 3 H335 May cause respiratory irritation.· 2.1.3 Additional information: For the wording of the relevant risk phrases refer to section 16.

· 2.2 Label elements· Labelling according to Regulation (EC) No 1272/2008

The product is classified and labelled according to the CLP regulation.· Hazard pictograms

GHS07

· Signal word Warning

· Hazard-determining components of labelling:4-IODOPHENYLBORONIC ACID

· Hazard statementsH302 Harmful if swallowed.H315 Causes skin irritation.H319 Causes serious eye irritation.H335 May cause respiratory irritation.

· Precautionary statementsP261 Avoid breathing dust/fume/gas/mist/vapours/spray.P280 Wear protective gloves / eye protection / face protection.


Page 2/7



Trade name: Opal 520 Reagent

(Contd. of page 1)

44.1.4

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, ifpresent and easy to do. Continue rinsing.

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.P501 Dispose of contents/container in accordance with local/regional/national/international

regulations.· 2.3 Other hazards· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.




5122-99-6 4-IODOPHENYLBORONIC ACID Acute Tox. 4, H302; Skin Irrit. 2, H315; Eye Irrit. 2, H319; STOT SE 3, H335

75-100%


Fluorescein Tyramide 2.5-10%



· 4.1 Description of first aid measures· General information:

Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hoursafter the accident.

· After inhalation: In case of unconsciousness place patient stably in side position for transportation.· After eye contact:

Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.· After swallowing: Call for a doctor immediately.· 4.2 Most important symptoms and effects, both acute and delayed No further relevant information available.· 4.3 Indication of any immediate medical attention and special treatment needed



· 5.1 Extinguishing media· Suitable extinguishing agents:

CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.· 5.2 Special hazards arising from the substance or mixture No further relevant information available.· 5.3 Advice for firefighters· Protective equipment: Wear self-contained respiratory protective device.


· 6.1 Personal precautions, protective equipment and emergency procedures Not required.· 6.2 Environmental precautions: Do not allow to enter sewers/ surface or ground water.


Page 3/7




(Contd. of page 2)

44.1.4

· 6.3 Methods and material for containment and cleaning up:Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).Dispose contaminated material as waste according to item 13.Ensure adequate ventilation.

· 6.4 Reference to other sectionsSee Section 7 for information on safe handling.See Section 8 for information on personal protection equipment.See Section 13 for disposal information.


· 7.1 Precautions for safe handlingEnsure good ventilation/exhaustion at the workplace.Prevent formation of aerosols.

· Information about fire - and explosion protection: No special measures required.

· 7.2 Conditions for safe storage, including any incompatibilities· Storage:· Requirements to be met by storerooms and containers: No special requirements.· Information about storage in one common storage facility: Not required.· Further information about storage conditions: Keep container tightly sealed.· 7.3 Specific end use(s) For research use only.



· 8.1 Control parameters· Ingredients with limit values that require monitoring at the workplace:

The product does not contain any relevant quantities of materials with critical values that have to be monitored atthe workplace.


Keep away from foodstuffs, beverages and feed.Immediately remove all soiled and contaminated clothingWash hands before breaks and at the end of work.Avoid contact with the eyes and skin.

· Respiratory protection:In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure useself-contained respiratory protective device.Suitable respiratory protective device recommended.

· Protection of hands:

Protective gloves



Page 4/7




(Contd. of page 3)

44.1.4



· Eye protection:

Tightly sealed goggles

· Environmental Exposure Controls N/A





· pH-value: N/A


· Flash point: 95 °C







· Vapour pressure: Not determined.





Page 5/7




(Contd. of page 4)

44.1.4


· Solvent content:Organic solvents: 0.0 %






· 11.1 Information on toxicological effects· Acute toxicity

Harmful if swallowed.· Primary irritant effect:· Skin corrosion/irritation

Causes skin irritation.· Serious eye damage/irritation

Causes serious eye irritation.· Respiratory or skin sensitisation Based on available data, the classification criteria are not met.· CMR effects (carcinogenity, mutagenicity and toxicity for reproduction)· Germ cell mutagenicity Based on available data, the classification criteria are not met.· Carcinogenicity Based on available data, the classification criteria are not met.· Reproductive toxicity Based on available data, the classification criteria are not met.· STOT-single exposure

May cause respiratory irritation.· STOT-repeated exposure Based on available data, the classification criteria are not met.· Aspiration hazard Based on available data, the classification criteria are not met.


· 12.1 Toxicity· Aquatic toxicity: No further relevant information available.· 12.2 Persistence and degradability N/A· 12.3 Bioaccumulative potential N/A· Behaviour in environmental systems: N/A· 12.4 Mobility in soil No further relevant information available.· Ecotoxicity: N/A


Page 6/7




(Contd. of page 5)

44.1.4

· Ecotoxical effects: N/A· Additional ecological information:· Other adverse effects:







· 14.1 UN-Number· ADR, IMDG, IATA UN2810

· 14.2 UN proper shipping name· ADR 2 8 1 0 T O X I C L I Q U I D , O R G A N I C , N . O . S . ( 4 -

IODOPHENYLBORONIC ACID)· IMDG, IATA T O X I C L I Q U I D , O R G A N I C , N . O . S . ( 4 -

IODOPHENYLBORONIC ACID)


· ADR, IMDG, IATA

· Class 6.1 Toxic substances.· Label 6.1

· 14.4 Packing group· ADR, IMDG, IATA III


· 14.6 Special precautions for user Warning: Toxic substances.· Danger code (Kemler): 60· EMS Number: F-A,S-A· Stowage Category A · Stowage Code SW2 Clear of living quarters.



Page 7/7




(Contd. of page 6)

44.1.4

· Transport/Additional information:

· ADR· Limited quantities (LQ) 5L· Excepted quantities (EQ) Code: E1

Maximum net quantity per inner packaging: 30 mlMaximum net quantity per outer packaging: 1000 ml

· Transport category 2 · Tunnel restriction code E

· IMDG· Limited quantities (LQ) 5L· Excepted quantities (EQ) Code: E1


· UN "Model Regulation": UN 2810 TOXIC LIQUID, ORGANIC, N.O.S . (4-IODOPHENYLBORONIC ACID), 6.1, III



· Directive 2012/18/EU· Named dangerous substances - ANNEX I None of the ingredients is listed.· REGULATION (EC) No 1907/2006 ANNEX XVII Conditions of restriction: 3· 15.2 Chemical safety assessment: A Chemical Safety Assessment has not been carried out.


· Relevant phrasesH302 Harmful if swallowed.H315 Causes skin irritation.H319 Causes serious eye irritation.H335 May cause respiratory irritation.

· Abbreviations and acronyms:ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationGHS: Globally Harmonised System of Classification and Labelling of ChemicalsEINECS: European Inventory of Existing Commercial Chemical SubstancesELINCS: European List of Notified Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)PBT: Persistent, Bioaccumulative and ToxicvPvB: very Persistent and very BioaccumulativeAcute Tox. 4: Acute toxicity – Category 4Skin Irrit. 2: Skin corrosion/irritation – Category 2Eye Irrit. 2: Serious eye damage/eye irritation – Category 2STOT SE 3: Specific target organ toxicity (single exposure) – Category 3

GB

Page 1/7



44.1.4



















GHS07






Page 2/7




(Contd. of page 1)

44.1.4








75-100%


Cyanine-3-Tyramide 2.5-10%












· 6.1 Personal precautions, protective equipment and emergency procedures Not required.(Contd. on page 3)

GB

Page 3/7




(Contd. of page 2)

44.1.4

· 6.2 Environmental precautions:Dilute with plenty of water.Do not allow to enter sewers/ surface or ground water.















Protective gloves



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(Contd. of page 3)

44.1.4



· Eye protection:







· pH-value: N/A











· Solubility in / Miscibility withwater: Fully miscible.



Page 5/7




(Contd. of page 4)

44.1.4



· 9.2 Other information No further relevant information available.











· 12.1 Toxicity· Aquatic toxicity: No further relevant information available.· 12.2 Persistence and degradability N/A· 12.3 Bioaccumulative potential N/A· Behaviour in environmental systems: N/A· 12.4 Mobility in soil No further relevant information available.· Ecotoxicity: N/A· Ecotoxical effects: N/A


Page 6/7




(Contd. of page 5)

44.1.4

· Additional ecological information:· Other adverse effects:





· Uncleaned packaging:· Recommendation: Disposal must be made according to official regulations.· Recommended cleansing agents: Water, if necessary together with cleansing agents.







· ADR, IMDG, IATA







Page 7/7




(Contd. of page 6)

44.1.4














GB

Page 1/7



44.1.4



















GHS07






Page 2/7




(Contd. of page 1)

44.1.4








75-100%


Cyanine 5.5-HCA 2.5-10%












· 6.1 Personal precautions, protective equipment and emergency procedures Not required.· 6.2 Environmental precautions: Do not allow to enter sewers/ surface or ground water.


Page 3/7




(Contd. of page 2)

44.1.4















Protective gloves



Page 4/7




(Contd. of page 3)

44.1.4



· Eye protection:







· pH-value: N/A














Page 5/7




(Contd. of page 4)

44.1.4














· 12.1 Toxicity· Aquatic toxicity: No further relevant information available.· 12.2 Persistence and degradability N/A· 12.3 Bioaccumulative potential N/A· Behaviour in environmental systems: N/A· 12.4 Mobility in soil No further relevant information available.· Ecotoxicity: N/A· Ecotoxical effects: N/A


Page 6/7




(Contd. of page 5)

44.1.4

· Additional ecological information:· Other adverse effects:












· ADR, IMDG, IATA







Page 7/7




(Contd. of page 6)

44.1.4














GB

Page 1/6



44.1.4



· Trade name: Spectral DAPI










The product is not classified according to the CLP regulation.

· 2.2 Label elements· Labelling according to Regulation (EC) No 1272/2008 Void· Hazard pictograms Void· Signal word Void· Hazard statements Void· 2.3 Other hazards· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.



· Dangerous components: Void


CAS: 28718-90-3EINECS: 249-186-7

2-phenylindole-4',6-dicarboxamidinedihydrohydrochloride (hydrate) 1-2.5%

CAS: 7732-18-5EINECS: 231-791-2

Water 75-100%

· Additional information: For the wording of the relevant risk phrases refer to section 16. GB

(Contd. on page 2)

Page 2/6



Trade name: Spectral DAPI

(Contd. of page 1)

44.1.4


· 4.1 Description of first aid measures· General information: No special measures required.· After inhalation: Supply fresh air; consult doctor in case of complaints.· After skin contact: If skin irritation continues, consult a doctor.· After eye contact: Rinse opened eye for several minutes under running water.· After swallowing: If symptoms persist consult doctor.· 4.2 Most important symptoms and effects, both acute and delayed No further relevant information available.· 4.3 Indication of any immediate medical attention and special treatment needed






Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).· 6.4 Reference to other sections



· 7.1 Precautions for safe handling No special measures required.· Information about fire - and explosion protection: No special measures required.



· Additional information about design of technical facilities: No further data; see item 7.(Contd. on page 3)

GB

Page 3/6




(Contd. of page 2)

44.1.4




The usual precautionary measures are to be adhered to when handling chemicals.· Respiratory protection: Not required.· Protection of hands:




· Eye protection: Goggles recommended during refilling· Environmental Exposure Controls N/A





· pH-value: N/A










· Density: Not determined.


Page 4/6




(Contd. of page 3)

44.1.4

· Relative density Not determined.· Vapour density Not determined.· Evaporation rate Not determined.










· 11.1 Information on toxicological effects· Acute toxicity Based on available data, the classification criteria are not met.· Primary irritant effect:· Skin corrosion/irritation Based on available data, the classification criteria are not met.· Serious eye damage/irritation Based on available data, the classification criteria are not met.· Respiratory or skin sensitisation Based on available data, the classification criteria are not met.· CMR effects (carcinogenity, mutagenicity and toxicity for reproduction)· Germ cell mutagenicity Based on available data, the classification criteria are not met.· Carcinogenicity Based on available data, the classification criteria are not met.· Reproductive toxicity Based on available data, the classification criteria are not met.· STOT-single exposure Based on available data, the classification criteria are not met.· STOT-repeated exposure Based on available data, the classification criteria are not met.· Aspiration hazard Based on available data, the classification criteria are not met.


· 12.1 Toxicity· Aquatic toxicity: No further relevant information available.· 12.2 Persistence and degradability N/A· 12.3 Bioaccumulative potential N/A· Behaviour in environmental systems: N/A


Page 5/6




(Contd. of page 4)

44.1.4

· 12.4 Mobility in soil No further relevant information available.· Ecotoxicity: N/A· Ecotoxical effects: N/A· Additional ecological information:· Other adverse effects:


















· Directive 2012/18/EU· Named dangerous substances - ANNEX I None of the ingredients is listed.· 15.2 Chemical safety assessment: A Chemical Safety Assessment has not been carried out.

GB

(Contd. on page 6)

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(Contd. of page 5)

44.1.4


· Abbreviations and acronyms:ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationGHS: Globally Harmonised System of Classification and Labelling of ChemicalsEINECS: European Inventory of Existing Commercial Chemical SubstancesELINCS: European List of Notified Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)PBT: Persistent, Bioaccumulative and ToxicvPvB: very Persistent and very Bioaccumulative

GB

Page 1/7



44.1.4



· Trade name: Antibody Diluent, 1X, 100mL

· Product number: ARD1001EA· 1.2 Relevant identified uses of the substance or mixture and uses advised against









Skin Sens. 1 H317 May cause an allergic skin reaction.· 2.1.3 Additional information: For the wording of the relevant risk phrases refer to section 16.



GHS07


· Hazard-determining components of labelling:Proclin-300

· Hazard statementsH317 May cause an allergic skin reaction.

· Precautionary statementsP261 Avoid breathing dust/fume/gas/mist/vapours/spray.P280 Wear protective gloves.P272 Contaminated work clothing should not be allowed out of the workplace.P333+P313 If skin irritation or rash occurs: Get medical advice/attention.P302+P352 IF ON SKIN: Wash with plenty of water.P501 Dispose of contents/container in accordance with local/regional/national/international regulations.

· 2.3 Other hazards· Results of PBT and vPvB assessment· PBT: Not applicable.


Page 2/7



Trade name: Antibody Diluent, 1X, 100mL

(Contd. of page 1)

44.1.4

· vPvB: Not applicable.




CAS: 1185-53-1EINECS: 214-684-5

2-amino-2-(hydroxymethyl)propane-1,3-diolhydrochloride Skin Irrit. 2, H315; Eye Irrit. 2, H319; STOT SE 3, H335

1-2.5%

CAS: 55965-84-9 Proclin-300 Acute Tox. 3, H301; Acute Tox. 3, H311; Acute Tox. 3, H331; Skin Corr. 1B,

H314; Aquatic Acute 1, H400; Aquatic Chronic 1, H410; Skin Sens. 1, H317

<0.1%


CAS: 7647-14-5EINECS: 231-598-3

sodium chloride <1.0%

CAS: 9000-71-9 casein <1.0%

CAS: 7732-18-5EINECS: 231-791-2

Water 75-100%



· 4.1 Description of first aid measures· After inhalation:

Supply fresh air and to be sure call for a doctor.In case of unconsciousness place patient stably in side position for transportation.

· After eye contact: Rinse opened eye for several minutes under running water.· After swallowing: If symptoms persist consult doctor.· 4.2 Most important symptoms and effects, both acute and delayed No further relevant information available.· 4.3 Indication of any immediate medical attention and special treatment needed






Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).Ensure adequate ventilation.


Page 3/7




(Contd. of page 2)

44.1.4











Immediately remove all soiled and contaminated clothingWash hands before breaks and at the end of work.



Protective gloves




· Eye protection: Goggles recommended during refilling(Contd. on page 4)

GB

Page 4/7




(Contd. of page 3)

44.1.4






· pH-value: N/A

















GB

(Contd. on page 5)

Page 5/7




(Contd. of page 4)

44.1.4




· 11.1 Information on toxicological effects· Acute toxicity Based on available data, the classification criteria are not met.· Primary irritant effect:· Skin corrosion/irritation Based on available data, the classification criteria are not met.· Serious eye damage/irritation Based on available data, the classification criteria are not met.· Respiratory or skin sensitisation

May cause an allergic skin reaction.· CMR effects (carcinogenity, mutagenicity and toxicity for reproduction)· Germ cell mutagenicity Based on available data, the classification criteria are not met.· Carcinogenicity Based on available data, the classification criteria are not met.· Reproductive toxicity Based on available data, the classification criteria are not met.· STOT-single exposure Based on available data, the classification criteria are not met.· STOT-repeated exposure Based on available data, the classification criteria are not met.· Aspiration hazard Based on available data, the classification criteria are not met.








Page 6/7




(Contd. of page 5)

44.1.4
















· Relevant phrasesH301 Toxic if swallowed.H311 Toxic in contact with skin.H314 Causes severe skin burns and eye damage.H315 Causes skin irritation.H317 May cause an allergic skin reaction.H319 Causes serious eye irritation.H331 Toxic if inhaled.


Page 7/7




(Contd. of page 6)

44.1.4

H335 May cause respiratory irritation.H400 Very toxic to aquatic life.H410 Very toxic to aquatic life with long lasting effects.

· Abbreviations and acronyms:ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationGHS: Globally Harmonised System of Classification and Labelling of ChemicalsEINECS: European Inventory of Existing Commercial Chemical SubstancesELINCS: European List of Notified Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)PBT: Persistent, Bioaccumulative and ToxicvPvB: very Persistent and very BioaccumulativeAcute Tox. 3: Acute toxicity – Category 3Skin Corr. 1B: Skin corrosion/irritation – Category 1BSkin Irrit. 2: Skin corrosion/irritation – Category 2Eye Irrit. 2: Serious eye damage/eye irritation – Category 2Skin Sens. 1: Skin sensitisation – Category 1STOT SE 3: Specific target organ toxicity (single exposure) – Category 3Aquatic Acute 1: Hazardous to the aquatic environment - acute aquatic hazard – Category 1Aquatic Chronic 1: Hazardous to the aquatic environment - long-term aquatic hazard – Category 1

GB

Page 1/7



44.1.4



· Trade name: PolyHRP Broad Spectrum

· Product number: ARH1001EA, ARH1A01EA· 1.2 Relevant identified uses of the substance or mixture and uses advised against












GHS07



· Hazard statementsH317 May cause an allergic skin reaction.

· Precautionary statementsP261 Avoid breathing dust/fume/gas/mist/vapours/spray.P280 Wear protective gloves.P272 Contaminated work clothing should not be allowed out of the workplace.P333+P313 If skin irritation or rash occurs: Get medical advice/attention.P302+P352 IF ON SKIN: Wash with plenty of water.P501 Dispose of contents/container in accordance with local/regional/national/international regulations.

· 2.3 Other hazards· Results of PBT and vPvB assessment· PBT: Not applicable.


Page 2/7



Trade name: PolyHRP Broad Spectrum

(Contd. of page 1)

44.1.4

· vPvB: Not applicable.




55965-84-9 Proclin-300 Acute Tox. 3, H301; Acute Tox. 3, H311; Acute Tox. 3, H331; Skin Corr. 1B, H314; Aquatic Acute 1, H400; Aquatic Chronic 1, H410; Skin Sens. 1, H317

<0.1%


Polink-1 HRP Broad 10-25%

CAS: 1185-53-1EINECS: 214-684-5

2-amino-2-(hydroxymethyl)propane-1,3-diolhydrochloride Skin Irrit. 2, H315; Eye Irrit. 2, H319; STOT SE 3, H335

<1.0%

CAS: 7647-14-5EINECS: 231-598-3

sodium chloride <1.0%

CAS: 9000-71-9 casein <1.0%

CAS: 7732-18-5EINECS: 231-791-2

Water 75-100%





· After eye contact: Rinse opened eye for several minutes under running water.· After swallowing: If symptoms persist consult doctor.· 4.2 Most important symptoms and effects, both acute and delayed No further relevant information available.· 4.3 Indication of any immediate medical attention and special treatment needed






Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).Ensure adequate ventilation.


Page 3/7




(Contd. of page 2)

44.1.4











Immediately remove all soiled and contaminated clothingWash hands before breaks and at the end of work.



Protective gloves




· Eye protection: Goggles recommended during refilling(Contd. on page 4)

GB

Page 4/7




(Contd. of page 3)

44.1.4






· pH-value: N/A

















GB

(Contd. on page 5)

Page 5/7




(Contd. of page 4)

44.1.4




· 11.1 Information on toxicological effects· Acute toxicity Based on available data, the classification criteria are not met.· Primary irritant effect:· Skin corrosion/irritation Based on available data, the classification criteria are not met.· Serious eye damage/irritation Based on available data, the classification criteria are not met.· Respiratory or skin sensitisation









Page 6/7




(Contd. of page 5)

44.1.4
















· Relevant phrasesH301 Toxic if swallowed.H311 Toxic in contact with skin.H314 Causes severe skin burns and eye damage.H317 May cause an allergic skin reaction.H331 Toxic if inhaled.H400 Very toxic to aquatic life.H410 Very toxic to aquatic life with long lasting effects.


Page 7/7




(Contd. of page 6)

44.1.4

· Abbreviations and acronyms:ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationGHS: Globally Harmonised System of Classification and Labelling of ChemicalsEINECS: European Inventory of Existing Commercial Chemical SubstancesELINCS: European List of Notified Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)PBT: Persistent, Bioaccumulative and ToxicvPvB: very Persistent and very BioaccumulativeAcute Tox. 3: Acute toxicity – Category 3Skin Corr. 1B: Skin corrosion/irritation – Category 1BSkin Sens. 1: Skin sensitisation – Category 1Aquatic Acute 1: Hazardous to the aquatic environment - acute aquatic hazard – Category 1Aquatic Chronic 1: Hazardous to the aquatic environment - long-term aquatic hazard – Category 1

GB

Page 1/7



44.1.4



· Trade name: DMSO

· Product number: DMSO0500UL· CAS Number:

67-68-5· EC number:

200-664-3· 1.2 Relevant identified uses of the substance or mixture and uses advised against










Eye Irrit. 2 H319 Causes serious eye irritation.· 2.1.3 Additional information: For the wording of the relevant risk phrases refer to section 16.


The substance is classified and labelled according to the CLP regulation.· Hazard pictograms

GHS07

· Signal word Warning· Hazard statements

H315 Causes skin irritation.H319 Causes serious eye irritation.

· Precautionary statementsP280 Wear protective gloves / eye protection / face protection.P264 Wash thoroughly after handling.P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if

present and easy to do. Continue rinsing.P332+P313 If skin irritation occurs: Get medical advice/attention.P337+P313 If eye irritation persists: Get medical advice/attention.


Page 2/7



Trade name: DMSO

(Contd. of page 1)

44.1.4

P302+P352 IF ON SKIN: Wash with plenty of water.· 2.3 Other hazards· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.


· 3.1 Chemical characterisation: Substances· CAS No. Description

67-68-5 dimethyl sulfoxide· Identification number(s)· EC number: 200-664-3


· 4.1 Description of first aid measures· After inhalation: In case of unconsciousness place patient stably in side position for transportation.· After eye contact:

Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.· After swallowing: If symptoms persist consult doctor.· 4.2 Most important symptoms and effects, both acute and delayed No further relevant information available.· 4.3 Indication of any immediate medical attention and special treatment needed






· 6.1 Personal precautions, protective equipment and emergency procedures Not required.· 6.2 Environmental precautions:

Dilute with plenty of water.Do not allow to enter sewers/ surface or ground water.

· 6.3 Methods and material for containment and cleaning up:Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).


GB

(Contd. on page 3)

Page 3/7



Trade name: DMSO

(Contd. of page 2)

44.1.4


· 7.1 Precautions for safe handling Store in cool, dry place in tightly closed receptacles.· Information about fire - and explosion protection: No special measures required.




· 8.1 Control parameters· Ingredients with limit values that require monitoring at the workplace: Not required.



· Respiratory protection: Suitable respiratory protective device recommended.· Protection of hands:

Protective gloves


· Material of glovesThe selection of the suitable gloves does not only depend on the material, but also on further marks of quality andvaries from manufacturer to manufacturer.


· Eye protection:


· Environmental Exposure Controls N/A GB

(Contd. on page 4)

Page 4/7



Trade name: DMSO

(Contd. of page 3)

44.1.4



Form: FluidColour: Colourless

· Odour: Odourless· Odour threshold: Not determined.

· pH-value: N/A

· Change in conditionMelting point/freezing point: 18.45 °CInitial boiling point and boiling range: 189 °C



· Ignition temperature: 270 °C

· Decomposition temperature: Not determined.

· Auto-ignition temperature: Not determined.


· Explosion limits:Lower: 1.8 Vol %Upper: 63 Vol %

· Vapour pressure at 20 °C: 2.5 hPa

· Density at 20 °C: 1.1 g/cm³· Relative density Not determined.· Vapour density Not determined.· Evaporation rate Not determined.

· Solubility in / Miscibility withwater: Fully miscible.


· Viscosity:Dynamic at 20 °C: 198 mPasKinematic: Not determined.Organic solvents: 100.0 %




· 10.1 Reactivity No further relevant information available.· 10.2 Chemical stability· Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.· 10.3 Possibility of hazardous reactions No dangerous reactions known.· 10.4 Conditions to avoid No further relevant information available.· 10.5 Incompatible materials: No further relevant information available.


Page 5/7



Trade name: DMSO

(Contd. of page 4)

44.1.4

· 10.6 Hazardous decomposition products: No dangerous decomposition products known.


· 11.1 Information on toxicological effects· Acute toxicity Based on available data, the classification criteria are not met.

· LD/LC50 values relevant for classification:

67-68-5 dimethyl sulfoxide

Oral LD50 14500 mg/kg (rat)

· Primary irritant effect:· Skin corrosion/irritation


Causes serious eye irritation.· Respiratory or skin sensitisation Based on available data, the classification criteria are not met.· CMR effects (carcinogenity, mutagenicity and toxicity for reproduction)· Germ cell mutagenicity Based on available data, the classification criteria are not met.· Carcinogenicity Based on available data, the classification criteria are not met.· Reproductive toxicity Based on available data, the classification criteria are not met.· STOT-single exposure Based on available data, the classification criteria are not met.· STOT-repeated exposure Based on available data, the classification criteria are not met.· Aspiration hazard Based on available data, the classification criteria are not met.









Page 6/7



Trade name: DMSO

(Contd. of page 5)

44.1.4

· Recommended cleansing agents: Water, if necessary together with cleansing agents.













· Directive 2012/18/EU· Named dangerous substances - ANNEX I Substance is not listed.· REGULATION (EC) No 1907/2006 ANNEX XVII Conditions of restriction: 3· 15.2 Chemical safety assessment: A Chemical Safety Assessment has not been carried out.


· Abbreviations and acronyms:ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationGHS: Globally Harmonised System of Classification and Labelling of ChemicalsEINECS: European Inventory of Existing Commercial Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)LC50: Lethal concentration, 50 percentLD50: Lethal dose, 50 percentPBT: Persistent, Bioaccumulative and ToxicvPvB: very Persistent and very Bioaccumulative


Page 7/7



Trade name: DMSO

(Contd. of page 6)

44.1.4

Skin Irrit. 2: Skin corrosion/irritation – Category 2Eye Irrit. 2: Serious eye damage/eye irritation – Category 2

GB

Page 1/7



44.1.4



· Trade name: AR6 Buffer

· Product number: AR600125ML, AR600250ML, AR6001KT· 1.2 Relevant identified uses of the substance or mixture and uses advised against














GHS07



· Hazard statementsH315 Causes skin irritation.H319 Causes serious eye irritation.H317 May cause an allergic skin reaction.

· Precautionary statementsP261 Avoid breathing dust/fume/gas/mist/vapours/spray.P280 Wear protective gloves / eye protection / face protection.P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if

present and easy to do. Continue rinsing.P333+P313 If skin irritation or rash occurs: Get medical advice/attention.


Page 2/7



Trade name: AR6 Buffer

(Contd. of page 1)

44.1.4

P337+P313 If eye irritation persists: Get medical advice/attention.P501 Dispose of contents/container in accordance with local/regional/national/international





55965-84-9 Proclin-300 Acute Tox. 3, H301; Acute Tox. 3, H311; Acute Tox. 3, H331; Skin Corr. 1B, H314; Aquatic Acute 1, H400; Aquatic Chronic 1, H410; Skin Sens. 1, H317

<1.0%


CAS: 6132-04-3 Sodium citrate 2.5-10%

CAS: 7732-18-5EINECS: 231-791-2

Water 75-100%





· After eye contact:Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.

· After swallowing: If symptoms persist consult doctor.· 4.2 Most important symptoms and effects, both acute and delayed No further relevant information available.· 4.3 Indication of any immediate medical attention and special treatment needed





· 6.1 Personal precautions, protective equipment and emergency procedures Not required.· 6.2 Environmental precautions: No special measures required.· 6.3 Methods and material for containment and cleaning up:

Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).(Contd. on page 3)

GB

Page 3/7




(Contd. of page 2)

44.1.4

Ensure adequate ventilation.· 6.4 Reference to other sections














Protective gloves




Page 4/7




(Contd. of page 3)

44.1.4


· Eye protection:







· pH-value: N/A















Page 5/7




(Contd. of page 4)

44.1.4







· 11.1 Information on toxicological effects· Acute toxicity Based on available data, the classification criteria are not met.· Primary irritant effect:· Skin corrosion/irritation


Causes serious eye irritation.· Respiratory or skin sensitisation



· 12.1 Toxicity· Aquatic toxicity: No further relevant information available.· 12.2 Persistence and degradability N/A· 12.3 Bioaccumulative potential N/A· Behaviour in environmental systems: N/A· 12.4 Mobility in soil No further relevant information available.· Ecotoxicity: N/A· Ecotoxical effects: N/A· Additional ecological information:· Other adverse effects: Generally not hazardous for water· 12.5 Results of PBT and vPvB assessment· PBT: Not applicable.


Page 6/7




(Contd. of page 5)

44.1.4

· vPvB: Not applicable.· 12.6 Other adverse effects No further relevant information available.






· 14.2 UN proper shipping name· ADR 1760 CORROSIVE LIQUID, N.O.S. (Proclin-300)· IMDG, IATA CORROSIVE LIQUID, N.O.S. (Proclin-300)


· ADR, IMDG, IATA

· Class 8 Corrosive substances.· Label 8


· 14.5 Environmental hazards:· Marine pollutant: No

· 14.6 Special precautions for user Warning: Corrosive substances.· Danger code (Kemler): 80· EMS Number: F-A,S-B· Stowage Category A · Stowage Code SW2 Clear of living quarters.







Page 7/7




(Contd. of page 6)

44.1.4



· UN "Model Regulation": UN 1760 CORROSIVE LIQUID, N.O.S. (PROCLIN-300), 8, III





· Relevant phrasesH301 Toxic if swallowed.H311 Toxic in contact with skin.H314 Causes severe skin burns and eye damage.H317 May cause an allergic skin reaction.H331 Toxic if inhaled.H400 Very toxic to aquatic life.H410 Very toxic to aquatic life with long lasting effects.

· Abbreviations and acronyms:ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationGHS: Globally Harmonised System of Classification and Labelling of ChemicalsEINECS: European Inventory of Existing Commercial Chemical SubstancesELINCS: European List of Notified Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)PBT: Persistent, Bioaccumulative and ToxicvPvB: very Persistent and very BioaccumulativeAcute Tox. 3: Acute toxicity – Category 3Skin Corr. 1B: Skin corrosion/irritation – Category 1BSkin Irrit. 2: Skin corrosion/irritation – Category 2Eye Irrit. 2: Serious eye damage/eye irritation – Category 2Skin Sens. 1: Skin sensitisation – Category 1Aquatic Acute 1: Hazardous to the aquatic environment - acute aquatic hazard – Category 1Aquatic Chronic 1: Hazardous to the aquatic environment - long-term aquatic hazard – Category 1

GB

02.03.2017 Kit components Product code Description · 02.03.2017 Kit components Product code Description NEL810001KT Opal 4-Color Manual IHC Kit 50 slides Components: FP1498 1X Plus

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