0 Where Science Means Business An Introduction to Yissum November 2007 Tami Kfir, VP Licensing Healthcare.

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Where Science Means Business An Introduction to Yissum

November 2007

Tami Kfir, VP Licensing Healthcare

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The Hebrew University Of Jerusalem

Over 1/3 of all academic scientific research In Israel

43% of Israel’s biotechnology research

>1/3 of PhD students in Israel

4 Campuses

5 Affiliated Hospitals

24,000 Students

1,200 Researchers (Staff Members)

1,600 Post-Graduate Students in Biotechnology

320 Researchers in Applied Sciences

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The Hebrew University of JerusalemMount Scopus Campus, Jerusalem

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The Hebrew University of Jerusalem

Edmond J. Safra Campus, Jerusalem

Agriculture & Environmental Sciences Campus, Rehovot

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The Hebrew University of JerusalemEin Kerem Campus, Jerusalem

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Israel’s Top University

U of Texas for Institute of Higher Education, Shanghai Jiaotong University Israel 12th worldwide in academic

research Hebrew University no. 1 in Israel 60th worldwide Only Israeli university in top 100

Times Higher Education 2006 HU 63rd worldwide in biomedicine HU 52nd worldwide in science 29th worldwide ex-US, UK

Newsweek Hebrew University 82nd worldwide Only Israeli university in top 100

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A Nobel Heritage

2002 Nobel Prize in Economics Daniel Kahneman, Princeton

2004 Nobel Prize in Physics David J. Gross, UC Santa Barbara

2004 Nobel Prize in Chemistry Avram Hershko, Technion Aaron Ciechanover, Technion

2005 Nobel Prize in Economics Robert J. Aumann, Hebrew University

2006 Nobel Prize in Chemistry Roger Kornberg, Stanford

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Top 20 Most Frequently Cited PapersStem Cells 1998-2004

10http://www.milkeninstitute.org/pdf/m2m2006_uni_bio.pdf

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Biotech

Nano-science

Materials

ComputerSciences

Medicine

EnvironmentHomelandSecurity

Agriculture

A Broad Range of Technologies

ComputerEngineering

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Yissum’s Mission

To promote the transfer of Hebrew University technology for the benefit of society, while maximizing returns to support research, education and scientific excellence

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Current Snapshot

$1 Billion annual sales of Hebrew University- based products

5,000 patents 1,400 inventions 400 licenses 60 spin-offs

Raised $150 mil in past year from leading VCs

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A Record of Achievement

2006 revenues $40mil, up from $34mil in 2005 $29mil royalties $11mil sponsored research & services

HU research budget $100mil

Ranked in top 15 worldwide (AUTM) Leading US university royalties

MIT $35-40mil / year Research budget: $1 Billion

Stanford $50-60 / year Research budget: $900 Million

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Board of Directors Business leaders

Yissum Business-oriented organization

Founded 1964

The Hebrew University Non-profit organization

Where Science Means Business

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Board of Directors

Giora Yaron, PhD – ChairmanUri Banin, PhDReuven BeharHervé Bercovier, PhDS. Morry Blumenfeld, PhDMartin GerstelElhanan HacohenAlex Keynan, PhDAmos Mar-HaimHadar Ron, MDMoshe Vigdor

Chairman, Mercury; founder, P-Cube, ExanetHebrew University, Director Nanoscience CentreManaging Partner, FBC&Co.; chairman, NetafimHebrew University, VP R&DVC, ex-CEO GE Medical, IsraelEx-CEO Alza; chairman, CompugenHebrew University, VP & Director GeneralHebrew University, Prof. EmeritusDirector, JDA; Ex-CEO Clal IndustriesManaging Director, Israel Healthcare VenturesDirector General, Jewish Agency

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Product-based

Business-oriented

Mission/project focused

Confidentiality essential

Timeframes & milestones

Economic role

Knowledge-based

Curiosity-driven

Broad scope

Publications

No time limits

Educational role

Industry vs. Academia

The Challenge

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Intellectual Property

2006 Snapshot 100 new inventions 72 new patent applications 58 new patents granted

Intellectual Property at HU Yissum owns all IP

developed at HU Researchers receive

40-60% of revenues

Computer Science & Engeneering

13%

Applied Physics2%

Business Models1%

Agriculture6%

Materials13%

Life Science and Biotechnology

61%

Food and Nutrition2%

Environment2%

2006 New Inventions

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Global Reach

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Yissum’s Spin-offs

Rav-Galai

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Long Shelf Life & CherryTomatoes

The world’s most popularcocktail hybrids for greenhouse production

Prof. Nachum KedarProf. Haim Rabinowich Department of Field Crops,Vegetables and Genetics:Faculty of Agriculture, FoodAnd Environmental Sciences The Hebrew UniversityRehovot Campus 2006 sales $70 million

Success Stories - Tomatoes

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DOXIL®Doxorubicin HCI liposome injection Alza’s Lead Product for Oncology Prof. Yechezkel Barenholz Department of BiochemistryFaculty of Medicine The Hebrew UniversityOf Jerusalem 2006 sales $375 million

Success Stories - Doxil

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For Treatment of Alzheimer’sDisease and Dementia Prof. MartaWeinstock-Rosin Department of PharmacologyFaculty of Medicine The Hebrew UniversityOf Jerusalem 2006 sales $525 million

Success Stories - Exelon

Healthcare - Source of Innovations

• Faculty of Medicine

• School of Pharmacy

• School of Dental Medicine

• Faculty of Science

• Faculty of Agriculture

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Healthcare Technologies Scope

NCEs New Uses Drug Delivery Medical devices Diagnostics Research tools

Markets

• CNS • Dermatology • Oncology • Infectious Diseases • Cardiovascular • Respiratory diseases • Metabolic• Dianostic (biomarkers; Imaging,

Bioinformatics)• Devices mainly Therapeutics

World Wide Leaders in Drug Delivery

Main Expertise:

• Liposomes

• Sustained release

• Transdermal

• Nasal

• Colonic Delivery

• Biodegradable - Polymer encapsulates

• microparticulate and nanoparticulate targetable drug delivery systems

World Wide Leaders in Drug Delivery

Yechezkel Barenholz Simon Benita Daniel Cohen Abraham Domb Michael Friedman Nissim Garti Chaim Gilon Gershon Golomb Avraham Hochberg Amnon Hoffman Philip Lazarovici Shlomo Magdassi Abraham Rubinstein Elka Touitou Itamar Wilner

Bio Park

• First in Israel• Service & support from near by university and

hospitals• 10,000m2 of research laboratories

Commercial Efforts

Friendly WebSite Use of web – tools such as Pharma –

Licensing MiniPlans Israeli Opportunities: Incubators; BioLine;

Teva Active marketing worldwide including Bio-

Conferences Networking

The TTM can help you manage your entire technology transfer or licensing office. It can help increase the effectiveness of your office without increasing size. Some of the benefits using the TTM include:

The TTM can help you manage your entire technology transfer or licensing office. It can help increase the effectiveness of your office without increasing size. Some of the benefits using the TTM include:

Increase the quality of your invention disclosure Improve the financial management of your technology portfolio including connection to an external financial system (SAP) Maximize license revenues through effective contract management Improve contact with researchers in your organization allowing them external access to the system. Expand marketing reach of your organization for your technologies by allowing easy export of the technologies to external databases including the website Make powerful reports on the data for effective business management and follow up Integrated with Office environment Built with the most up to date technology

TTM (Technology Transfer Management)

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Thank you for your attention

[email protected]