| Jade (with her mother) Fabry disease USA Welcome Doherty Memorial High School Genzyme Center November 1, 2012.

|www.genzyme.com

Jade (with her mother) Fabry disease USA

Welcome Doherty Memorial High School

Genzyme Center

November 1, 2012

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Jannan Multiple Sclerosis USA

Our mission is to discover

and deliver transformative

therapies for patients with

rare and special unmet

medical needs, providing

hope where there was

none before.

Focused on rare diseases andmultiple sclerosis (MS)

6 major marketed products

10,000 employees worldwide

Founded in 1981 and pioneered treatments for rare diseases

David Meeker, MD, CEO

About Genzyme

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Our Global Commitment

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Headquarteredin the U.S.

with global locationsin over 40 countries

Expanding manufacturing

capabilities in the U.S. and E.U.

Collaborating with patient communities, physicians, universities, hospitals,

charitable organizations, companies globally

Serving patients in over 100 countries

Genzyme, a Sanofi company

• In April 2011, Genzyme became a wholly owned subsidiary of Sanofi

• We benefit from the reach and resources of one of the world’s largest pharmaceutical companies

• Sanofi’s portfolio of products includes: prescription medicines, vaccines, generics, consumer health care, and animal health

• 110,000 employees worldwide

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Patients are at the heart of what we do

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Science

Manufacturing & Distribution

Government Affairs

RegulatoryAdvocacy & Access

Legal, HR, Communications

Sales & marketing

AnisaMPS I disease

AveryFabry disease

Eulacio Children Gaucher disease

MelanieMultiple Sclerosis

FidaPompe disease

ThomasFH

JoanThyroid Cancer

A lifetime commitment

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“My mom was just tremendous and an

amazing role model for me. I know the

doctors told her that I was going to die

but her perseverance, dedication and

ability to work closely with Genzyme

and search around the world to develop

a treatment was amazing.”

– Brian Berman, Gaucher disease type 1

1983 1991 2001 2011

Cardiovascular

Late-stage treatment for Familial Hypercholesterolemia (FH)

Genzyme’s Business Units

Rare Diseases Multiple Sclerosis

Genetic Diseases

One oral marketed product and

One late-stage infusion treatment

Endocrinology

Gaucher disease type 1, Fabry disease, Pompe disease, MPS I disease

Facilitating thyroid cancertreatment and testing

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Driven by Science• Genzyme R&D Center

• Broad range of technology platforms• Closely integrated with clinical, commercial, regulatory, patient advocacy• Dedicated to pursuing unmet medical needs

• Highlights• Research in Parkinson’s, Niemann-Pick, Lupus, and Cystic Fibrosis• Next-generation therapies for Gaucher, Pompe, and Fabry diseases

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School Science Program Waterford, Ireland

Community Involvement: Employee volunteerism, support for science education and health initiatives

Humanitarian Programs: Free drug programs

Environmental Initiatives: Green buildings and greenhouse gas reduction efforts

Our Responsibility

Genzyme Center - Today

How did we get here and why?

Genzyme: The Beginning - 1981

Kneeland Street, Boston

A company that cares about

• Patients

• Employees

Genzyme’s Headquarters 1990-2003

One Kendall Square

Cambridge, MA

Brownfield Site - Cambridge, MA

• A Brownfield site is an industrial site that has ground contamination

− plant that turned coal into gas (a coal gasification plant)

• Developer bought 10 acre site for $21 million

• Cost to remediate site from contaminants - $198 million

Remediation of Brownfield Site

Committed to the Community

1925 2000 2003

Principal architect Behnisch Architects, Germany

Construction managers Turner Construction

Developers Lyme Properties

Square footage 350,000 sq. ft.

Occupancy November 2003; ~950 employees

Anchor of Mixed Use Development

Considerations for New World Headquarters

• Location

• Size

• Cost

• Comfort of Employees

• Recruitment & Retention

• The Environment

− Building Materials

• Company Culture

Reflecting Corporate Values in the Building

Drive

Innovation

Integrity

Collaboration

Entrepreneurialism

Compassion

Core Values -

INNOVATION

COLLABORATION

TRANSPARENCY

The Concept of Genzyme Center

• Reflective of Genzyme’s core values

• Designed from the inside out

• Productive and collaborative workspace

• Environmentally responsible and energy-efficient

United States Green Building Council

• Genzyme Center received Platinum LEED rating

− Leadership in Energy & Environmental Design

− The highest rating of the United States Green Building Council

− Rating is based on:

− Sustainable site design

− Materials selection

− Energy use

− Water conservation

− Indoor environmental quality

Site Selection, Design & Indoor Environmental Quality

• Restored Brownfield site

• Living roof: heat reduction, rainwater run-off reduction

• White roof to reduce “heat island effect”

• Direct view of the outdoors from 90% of work spaces

• 18 themed interior gardens

Material Selection

• Recycled 93% of construction waste

• 23% of materials used in building are recycled material (concrete, steel, aluminum, tile, drywall, ceilings, carpets)

• More than 60% materials from local sources

• Wood materials from managed forests

• Recycled content carpet squares

• Concrete filigree slab construction

Energy-Efficient Features

• Concrete slab construction

• Insulating “loggia”

• 800+ operable windows

• Solar panels

− Produce 1% of Genzyme Center’s electricity

• Waste steam used for heating and cooling, efficient systems, building control, use of natural ventilation

• Use of “green” power from renewable source

Water Conservation

• High efficiency irrigation using soil sensors

• Rainwater run-off collection systems

• Low flow fixtures – waterless urinals, dual flush toilets

• 525,000 gallons per year saved

• Lobby floor water feature / reflecting pool

Natural Light Enhancement Systems

Natural Light Enhancement Systems

• Soaring 12-story atrium

Natural Light Enhancement Systems

• All glass exterior

• Heliostats on roof

Natural Light Enhancement Systems

• Skylight and louvered sunshades

Natural Light Enhancement Systems

• Chandelier− Prismatic tiles

Natural Light Enhancement Systems

• “Light wall” of polished aluminum strips

• Reflecting pool

Natural Light Enhancement Systems

• Computer controlled blinds

• Reflective Ceiling Panels

Ceiling Design

• Inspired by Matisse’s Blue Nude

Ceiling Design

Genzyme Green Buildings - LEED Registered and Certified

2005: Genzyme Center: NC: Platinum

2007: 675 West Kendall: CI: Silver

2008: Framingham Science Center: NC: Gold

2009: Ridgefield: NC: Gold

2010: Lyon: HQE Certified (and LEED)

2010: Phoenix: CI: Silver

2010: Allston: NC Gold

2010: Waterford: NC Gold

2010: San Antonio: EB Silver

2011: Ridgefield: CI: Platinum

31 New York Avenue

68 New York Avenue

Northborough Distribution Center

Geel, Belgium

Framingham Science Center, 49 New York Avenue

Lyon, France Manufacturing Plant

LEED NC: new constructionCI: commercial interiorEB: existing buildingHQE: High Environmental Quality (French Standard)

Questions?

Thank You