制作人 张晓东 张晗晖 韩思奇 尹利国 梁婷婷 张莹 徐芳 Source Mechanism Function Diseases ( IDDM ) Therapy prospect catalogue.

制作人• 张晓东• 张晗晖• 韩思奇• 尹利国• 梁婷婷• 张莹• 徐芳

• Source• Mechanism• Function• Diseases (IDDM)• Therapy• prospect

catalogue

Source

• Helper T cells are found in two distinct cell types,Th1 and Th2,distinguished by the cytokines they produce and the immune responses they are involved in

Mechanism

CKs secreted by Th1

• IFN-γ

• TNF- β

• IL-8

• other Chemokines

Function

• CKs secreted by Th1 can activate and attract macrophage to the inflammatory location.

• IFN-γ inhibits the proliferation of Th2

CKs secreted by Th2

• IL-4

• IL-5

• IL-6

• IL-10

• IL-13

• IL-12

Function

• CKs secreted by Th2 play an important role in activation,differentiation,proliferation of B lymphocyte.

• IL-12 promoting activation of Th1.

• IL-10 inhibites Th1 secreting IFN-γ.

DiseasesAutoimmune Diseases

Th1 predominant response diseases

Insulin dependent diabetes mellitus(IDDM)

Theumatoid arthritis

Helicobacter pylori(HP) infection

Th2 predominant response diseases

• Systemic lupus eryhematosus

• Metal ion induced autoimmune diseases

Rheumatoid arthritis

Systemic lupus eryhematosus(SLE)

Therapy

• Anti-Th1 type cytokine therapy

• Anti-Th2 type cytokine therapy

• Other therapy for Th1/Th2 cytokine balance

Anti-Th1 type cytokines therapy and mechanism

Mechanism of insulin dependent diabetes mellitus

• Pancreatic islet βcell destroy insulin produced decrease

• DDM is mediated by Th1cell ,which produce large amount of IFN-γ.it is imoportant in leading to diabetes

therapy

• Inject IFN-γ monoclonal antibody can turn Th1 to Th2,then cytokines L-4,L-10 expression increase to prevent diabetes

Th2 type cytokines therapy and mechanism

1.downstream APC

2. inhibit Th1 proliferation

3.inhibit L-1,TNF-2 and other

cytokines(L-6,L-8) produced

4.inhibit matrix metal protein

produce

Prevent diabetes of NOD mice

• I-A27allelic gene56,57 mutation produce Th2 cell of pancretic islet β cell antigen specificity T cell no response prevent the disease

Other therapy for Th1/Th2 cytokine balance

(1)Mucosa tolerance: The TCR/CD3 complex of Th cell recognize MH

C-peptide complex of APC,change TCR、 antigen peptide and MHC

(2)Nirogen monoxide(NO) downstream Th1cell and upstream Th2 cell decrease the apoptosis of Th2 cell

Prospect

• Regulate the ratio of Th1 and Th2 by medicine,we can cure some diseases without clearly known mechanisms.For example:SLE

• With the development of the immunology,we all expected

these methods can be used to clinic , then these diseases will be cured.