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"Medication non-adherence rates typically range from 30% to 60%.“
"Half of the patients for whom appropriate medication is prescribed fail to receive the full benefits because of inadequate adherence to treatment."
"Poor adherence to treatment of chronic disease is a worldwide problem of striking magnitude.“
"Adherence to long-term therapy for chronic illnesses in developed countries averages 50%. In developing countries, the rates are even lower. It is undeniable that many patients experience difficulty in following treatment recommendations."
* "Medication Nonadherence: Finding Solutions to a Costly Medical Problem," Gottlieb, Drug Benefit Trends 12(6)** Adherence to Long-Term Therapies: Evidence for Action, World Health Organization, 2003
APTEO = French acronym for « l’Acceptance des Patients vis-à-vis de leur Traitement : Etude Online » (or "patient acceptance of their treatment: online survey")
Objective: to evaluate, for a variety of chronic diseases, the level of patients’ acceptance of their medication in real life using a patient online community
English for CanadaEnglish for the UKEnglish for the USAFrench for CanadaFrench for SwitzerlandGerman for GermanyGerman for SwitzerlandItalian for Italy
Portuguese for BrazilRussian for RussiaSlovakSpanish for ArgentinaSpanish for ColombiaSpanish for MexicoSpanish for SpainSpanish for the USA
How do patients accept their treatment?Score "Acceptance/General"
Box = interquartile range (Q3-Q1); + = mean; — = median; upper and lower bars = observed max and min values. Boxplots are ranked based on mean Acceptance/General score.
How do patients accept their treatment?Score "Acceptance/General"
Box = interquartile range (Q3-Q1); + = mean; — = median; upper and lower bars = observed max and min values. Boxplots are ranked based on mean Acceptance/General score.
How do patients accept their treatment?Score "Acceptance/General"
Box = interquartile range (Q3-Q1); + = mean; — = median; upper and lower bars = observed max and min values. Boxplots are ranked based on mean Acceptance/General score.
How do patients accept their treatment?Score "Acceptance/General"
Box = interquartile range (Q3-Q1); + = mean; — = median; upper and lower bars = observed max and min values. Boxplots are ranked based on mean Acceptance/General score.
How do patients accept their treatment?Score "Acceptance/General"
Box = interquartile range (Q3-Q1); + = mean; — = median; upper and lower bars = observed max and min values. Boxplots are ranked based on mean Acceptance/General score.
How do patients accept their treatment?Score "Acceptance/General"
Box = interquartile range (Q3-Q1); + = mean; — = median; upper and lower bars = observed max and min values. Boxplots are ranked based on mean Acceptance/General score.
48.2 Long time in the past 36 11 – 49Long time in the future 49 23 – 58Routine 15 6 – 19
Acceptance/Regimen Constraints(52.9 – 76.7)
52.9 Remember to take 37 17 – 39Find time to collect 24 8 – 25Remember to take with oneself 37 7 – 37Always having on oneself 38 7 – 38Frequency 33 9 – 39
Acceptance/Numerous Medications
Numerous medications 31 12 – 55
Acceptance/Side Effects(35.4 – 81.4)
68.5 Side effects 37 22 – 76Unpleasant side effects 39 22 – 74Disabling side effects 32 16 – 66Medication due to side effects 7 2 – 37Risk of serious side effects 23 8 – 58
48.2 Long time in the past 36 11 – 49Long time in the future 49 23 – 58Routine 15 6 – 19
Acceptance/Regimen Constraints(52.9 – 76.7)
52.9 Remember to take 37 17 – 39Find time to collect 24 8 – 25Remember to take with oneself 37 7 – 37Always having on oneself 38 7 – 38Frequency 33 9 – 39
Acceptance/Numerous Medications
Numerous medications 31 12 – 55
Acceptance/Side Effects(35.4 – 81.4)
68.5 Side effects 37 55 – 76Unpleasant side effects 39 22 – 74Disabling side effects 32 16 – 66Medication due to side effects 7 2 – 37Risk of serious side effects 23 8 – 58
48.2 Long time in the past 36 11 – 49Long time in the future 49 23 – 58Routine 15 6 – 19
Acceptance/Regimen Constraints(52.9 – 76.7)
52.9 Remember to take 37 17 – 39Find time to collect 24 8 – 25Remember to take with oneself 37 7 – 37Always having on oneself 38 7 – 38Frequency 33 9 – 39
Acceptance/Numerous Medications
Numerous medications 31 12 – 55
Acceptance/Side Effects(35.4 – 81.4)
68.5 Side effects 37 55 – 76Unpleasant side effects 39 22 – 74Disabling side effects 32 16 – 66Medication due to side effects 7 2 – 37Risk of serious side effects 23 8 – 58
48.2 Long time in the past 36 11 – 49Long time in the future 49 23 – 58Routine 15 6 – 19
Acceptance/Regimen Constraints(52.9 – 76.7)
52.9 Remember to take 37 17 – 39Find time to collect 24 8 – 25Remember to take with oneself 37 7 – 37Always having on oneself 38 7 – 38Frequency 33 9 – 39
Acceptance/Numerous Medications
Numerous medications 31 12 – 55
Acceptance/Side Effects(35.4 – 81.4)
68.5 Side effects 37 55 – 76Unpleasant side effects 39 22 – 74Disabling side effects 32 16 – 66Medication due to side effects 7 2 – 37Risk of serious side effects 23 8 – 58
48.2 Long time in the past 36 11 – 49Long time in the future 49 23 – 58Routine 15 6 – 19
Acceptance/Regimen Constraints(52.9 – 76.7)
52.9 Remember to take 37 17 – 39Find time to collect 24 8 – 25Remember to take with oneself 37 7 – 37Always having on oneself 38 7 – 38Frequency 33 9 – 39
Acceptance/Numerous Medications
Numerous medications 31 12 – 55
Acceptance/Side Effects(35.4 – 81.4)
68.5 Side effects 37 22 – 76Unpleasant side effects 39 22 – 74Disabling side effects 32 16 – 66Medication due to side effects 7 2 – 37Risk of serious side effects 23 8 – 58
53.5 Long time in the past 34 11 – 49Long time in the future 53 23 – 58Routine 12 6 – 19
Acceptance/Regimen Constraints(52.9 – 76.7)
71.1 Remember to take 35 17 – 39Find time to collect 12 8 – 25Remember to take with oneself 17 7 – 37Always having on oneself 13 7 – 38Frequency 17 9 – 39
Acceptance/Numerous Medications
Numerous medications 28 12 – 55
Acceptance/Side Effects(35.4 – 81.4)
35.4 Side effects 76 22 – 76Unpleasant side effects 74 22 – 74Disabling side effects 66 16 – 66Medication due to side effects 37 2 – 37Risk of serious side effects 42 8 – 58
47.4 Long time in the past 41 11 – 49Long time in the future 55 23 – 58Routine 18 6 – 19
Acceptance/Regimen Constraints(52.9 – 76.7)
62.1 Remember to take 32 17 – 39Find time to collect 23 8 – 25Remember to take with oneself 27 7 – 37Always having on oneself 23 7 – 38Frequency 29 9 – 39
Acceptance/Numerous Medications
Numerous medications 52 12 – 55
Acceptance/Side Effects(35.4 – 81.4)
51.5 Side effects 58 22 – 76Unpleasant side effects 59 22 – 74Disabling side effects 50 16 – 66Medication due to side effects 21 2 – 37Risk of serious side effects 27 8 – 58
Applications for Health Care Providers: addressing strategic and tactic questions
Prioritization: What sort of innovation/solution is likely to match market unmet needs?
Segmentation: Which subgroup of patients could benefit most?
Personalized solutions: Through finely granulated identification of barriers, efficiently spend resource on adequate solutions:
Give potential risks meaningfulness and reality (eg monitoring blood glucose in Type 1 diabetes patients)Give potential benefits a reality! (eg chemotherapy in breast cancer)Adapt solution to patient values (remember the invention of therapeutic window for AIDS patients – it was past century!)Overcome practical barriers (eg eye-drop devices for elderly, or prescribe combos)Address their needs! (eg switch to more active drugs in Rhumatoïd Arthritis)