The LAGEP (Laboratory of Automatic Control and Chemical Engineering) develops its research activities at the interface of Engineering and Health Sciences leading as well to base research as well as to transfer towards the important industrial sector in the region Rhône-Alpes. Its objective is to gather the experts in Automatic Control, Chemical Engineering and Pharmaceutical Engineering from both the University and the CNRS (Centre National de la Recherche Scientifique) for the development of research activities in their domain of expertise as well as cross-domain activities organized in the four research themes presented below. THEMATIC GROUPS NONLINEAR SYSTEMS AND PROCESSES The research topic of the SNLEP team concerns the theorical development and implementation of tools in order to: Analyze, Modelize, Simulate, Control and Optimize Systems in Process Engineering. Our theoretical developments are motivated by practical applications encountered through collaborations with industrial and academic partners. More specifically, our work focuses on model design and reduction, parametric identification, observation, diagnosis and control. PHARMACEUTICAL ENGINEERING The design of new formulations containing active molecules is the key point to enhance the efficiency. These formulations can be fabricated in the form of capsules or tablets using various engineering processes in order to control the active molecules location and distribution inside the used matrix. The active molecules or the final drug should answer various criteria driven by the targeted diseases, application way and patient’s age. • Pharmaceutical science (formulation and • Solid elaboration (lyophilisation and crystallisation) • Capsules preparation, colloidal physics and physical chemistry • Modelling and process engineering, • Life science (biodisponibility, skin penetration) SOLID ENGINEERING The ‘Solid Engineering’ group is focused on the study of the solid manufacturing processes from the initial state (obtained by dissolution, wet granulation, raw material division) to the final dry state. Solid particles are mainly obtained by such processes as crystallization-precipitation, agglomeration, conductive, convective or spray drying, freeze-drying. The scope of the group activities goes from the study of the internal fundamental mechanisms (heat and mass transfer, solid phase transition, polymorphism, desolvatation) to the process monitoring and control in an industrial context. PROCESS DYNAMICS AND CONTROL OF SYSTEMS OF CONSERVATION LAWS The design of energy efficient, reliable and intensive processes requires the development of dynamical models of complex, network structured processes. Different multi-scale processes are considered such as adsorption, reactive extrusion processes, heat pumps, thermal storages using phase changes in fluids and cristallization in emulsion processes, involving mass and heat transport in heterogeneous and reactive media with moving interface. Nonlinear control laws are developped based on their formulation as port Hamiltonian systems or input-output contact systems. Control laws for systems of conservation laws are developed based on the semi-group theory, Riemann invariants with recent developments for systems with moving interfaces. HATEM FESSI Professor, Université Claude Bernard Lyon 1 | LABORATORY CHEMICAL ENGINEERING AND AUTOMATIC CONTROL (LAGEP) UMR 5007, UNIVERSITÉ CLAUDE BERNARD LYON 1 – CNRS – CPE LYON | Figures Centre, top: experimentation using Buchi atomizer Centre, bottom: Hair decontamination studies Right, top: Density Measurement of caffeine tablets by X-rays Right, bottom: nanoparticles PLA.